BR112015028581A2 - composição farmacêutica de dosagem baixa, utilização do ácido, método para o tratamento da doença inflamatória e composição farmacêutica - Google Patents
composição farmacêutica de dosagem baixa, utilização do ácido, método para o tratamento da doença inflamatória e composição farmacêuticaInfo
- Publication number
- BR112015028581A2 BR112015028581A2 BR112015028581A BR112015028581A BR112015028581A2 BR 112015028581 A2 BR112015028581 A2 BR 112015028581A2 BR 112015028581 A BR112015028581 A BR 112015028581A BR 112015028581 A BR112015028581 A BR 112015028581A BR 112015028581 A2 BR112015028581 A2 BR 112015028581A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- inflammatory disease
- low dosage
- treatment
- acid utilization
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 7
- 208000027866 inflammatory disease Diseases 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000002429 large intestine Anatomy 0.000 abstract 2
- -1 2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4h,5h-10-thia-1,4a-diaza-benzo[a]azulene-3-carbonyl Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
resumo composição farmacêutica de dosagem baixa, utilização do ácido, método para o tratamento da doença inflamatória e composição farmacêutica a presente invenção se refere a uma composição farmacêutica de dosagem baixa, de preferência, a composição oral compreende uma quantidade terapeuticamente eficaz do ácido [(2-hidroxi-4-oxo-6,7,8,9-tetraidro-4h,5h-10-tia-1,4a-diaza-benzo[a]azuleno-3-carbonil)-amino]-acético (composto a) no intervalo de 2,5 mg a 60 mg. a presente invenção também se refere a um método para o tratamento da doença inflamatória do intestino grosso em um mamífero através da administração de dita composição farmacêutica de dosagem baixa. além disso, a presente invenção se refere a uma utilização do composto a para a preparação de uma composição farmacêutica de dosagem baixa para o tratamento da doença inflamatória do intestino grosso em um mamífero.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1718MU2013 | 2013-05-14 | ||
| IN1718/MUM/2013 | 2013-05-14 | ||
| IN2309/MUM/2013 | 2013-07-09 | ||
| IN2309MU2013 | 2013-07-09 | ||
| PCT/IB2014/000707 WO2014184631A1 (en) | 2013-05-14 | 2014-05-12 | Use of a thiazolo pyrimidinone for the treatment of inflammatory bowel disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015028581A2 true BR112015028581A2 (pt) | 2017-07-25 |
| BR112015028581B1 BR112015028581B1 (pt) | 2022-05-03 |
Family
ID=50896342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015028581-3A BR112015028581B1 (pt) | 2013-05-14 | 2014-05-12 | Usos do ácido [(2-hidroxi-4-oxo-6,7,8,9-tetrahidro-4h,5h-10-tia1,4a-diaza-benzo[a]azuleno-3- carbonil)-amino]-acético |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9610247B2 (pt) |
| EP (1) | EP2996693B1 (pt) |
| JP (1) | JP6407974B2 (pt) |
| KR (1) | KR102239649B1 (pt) |
| CN (1) | CN105209043B (pt) |
| AU (1) | AU2014266968B2 (pt) |
| BR (1) | BR112015028581B1 (pt) |
| CA (1) | CA2912011C (pt) |
| CY (1) | CY1121280T1 (pt) |
| DK (1) | DK2996693T3 (pt) |
| EA (1) | EA030590B1 (pt) |
| ES (1) | ES2712705T3 (pt) |
| HR (1) | HRP20190315T1 (pt) |
| HU (1) | HUE042691T2 (pt) |
| IL (1) | IL242490B (pt) |
| LT (1) | LT2996693T (pt) |
| MX (1) | MX358198B (pt) |
| MY (1) | MY179215A (pt) |
| PH (1) | PH12015502560B1 (pt) |
| PL (1) | PL2996693T3 (pt) |
| PT (1) | PT2996693T (pt) |
| RS (1) | RS58423B1 (pt) |
| SG (1) | SG11201509275PA (pt) |
| SI (1) | SI2996693T1 (pt) |
| TW (1) | TWI661828B (pt) |
| UA (1) | UA117244C2 (pt) |
| WO (1) | WO2014184631A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017159585A1 (ja) * | 2016-03-14 | 2017-09-21 | 参天製薬株式会社 | メグルミン又はその塩からなる防腐剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009002533A1 (en) | 2007-06-27 | 2008-12-31 | The Brigham And Women's Hospital, Inc. | Inflammatory bowel disease therapies |
| TWI500623B (zh) * | 2009-10-13 | 2015-09-21 | Torrent Pharmaceuticals Ltd | 新穎稠合噻唑及噁唑嘧啶酮 |
| US8541430B2 (en) * | 2009-11-27 | 2013-09-24 | Torrent Pharmaceuticals Limited | Fused thiazolo and oxazolo pyrimidinones |
-
2014
- 2014-05-09 TW TW103116529A patent/TWI661828B/zh not_active IP Right Cessation
- 2014-05-12 EP EP14728622.3A patent/EP2996693B1/en active Active
- 2014-05-12 ES ES14728622T patent/ES2712705T3/es active Active
- 2014-05-12 UA UAA201512299A patent/UA117244C2/uk unknown
- 2014-05-12 HU HUE14728622A patent/HUE042691T2/hu unknown
- 2014-05-12 MX MX2015015682A patent/MX358198B/es active IP Right Grant
- 2014-05-12 PT PT14728622T patent/PT2996693T/pt unknown
- 2014-05-12 CN CN201480028313.6A patent/CN105209043B/zh active Active
- 2014-05-12 PL PL14728622T patent/PL2996693T3/pl unknown
- 2014-05-12 US US14/890,131 patent/US9610247B2/en active Active
- 2014-05-12 CA CA2912011A patent/CA2912011C/en active Active
- 2014-05-12 RS RS20190216A patent/RS58423B1/sr unknown
- 2014-05-12 KR KR1020157033744A patent/KR102239649B1/ko active IP Right Grant
- 2014-05-12 LT LTEP14728622.3T patent/LT2996693T/lt unknown
- 2014-05-12 SG SG11201509275PA patent/SG11201509275PA/en unknown
- 2014-05-12 BR BR112015028581-3A patent/BR112015028581B1/pt not_active IP Right Cessation
- 2014-05-12 DK DK14728622.3T patent/DK2996693T3/en active
- 2014-05-12 SI SI201431085T patent/SI2996693T1/sl unknown
- 2014-05-12 MY MYPI2015704098A patent/MY179215A/en unknown
- 2014-05-12 AU AU2014266968A patent/AU2014266968B2/en not_active Ceased
- 2014-05-12 EA EA201592159A patent/EA030590B1/ru not_active IP Right Cessation
- 2014-05-12 JP JP2016513452A patent/JP6407974B2/ja active Active
- 2014-05-12 WO PCT/IB2014/000707 patent/WO2014184631A1/en active Application Filing
-
2015
- 2015-11-08 IL IL242490A patent/IL242490B/en active IP Right Grant
- 2015-11-10 PH PH12015502560A patent/PH12015502560B1/en unknown
-
2017
- 2017-02-22 US US15/439,733 patent/US10471005B2/en not_active Expired - Fee Related
-
2019
- 2019-02-18 HR HRP20190315TT patent/HRP20190315T1/hr unknown
- 2019-02-21 CY CY20191100221T patent/CY1121280T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/05/2014, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 10A ANUIDADE. |