BR112015022197A8 - uso de um composto para fabricação de um medicamento ou composição farmacêutica para o tratamento de cataplexia - Google Patents

uso de um composto para fabricação de um medicamento ou composição farmacêutica para o tratamento de cataplexia Download PDF

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Publication number
BR112015022197A8
BR112015022197A8 BR112015022197A BR112015022197A BR112015022197A8 BR 112015022197 A8 BR112015022197 A8 BR 112015022197A8 BR 112015022197 A BR112015022197 A BR 112015022197A BR 112015022197 A BR112015022197 A BR 112015022197A BR 112015022197 A8 BR112015022197 A8 BR 112015022197A8
Authority
BR
Brazil
Prior art keywords
cataplexy
medicament
manufacture
compound
pharmaceutical composition
Prior art date
Application number
BR112015022197A
Other languages
English (en)
Other versions
BR112015022197B1 (pt
BR112015022197A2 (pt
Inventor
Bream Gary
A Khayrallah Moise
E Butts Stephen
Original Assignee
Aerial Biopharma Llc
Sk Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51530017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015022197(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aerial Biopharma Llc, Sk Biopharmaceuticals Co Ltd filed Critical Aerial Biopharma Llc
Publication of BR112015022197A2 publication Critical patent/BR112015022197A2/pt
Publication of BR112015022197A8 publication Critical patent/BR112015022197A8/pt
Publication of BR112015022197B1 publication Critical patent/BR112015022197B1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/02—Carbamic acids; Salts of carbamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups

Abstract

treatment of cataplexy abstract the present invention relates to a method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds. _____________________________________________________ resumo patente de invenção: "tratamento de cataplexia". a presente invenção se refere a um método para o tratamento de cataplexia em um indivíduo com necessidade do mesmo, compreendendo administrar ao indivíduo a uma quantidade terapeuticamente eficaz de determinados compostos carbamato.
BR112015022197-1A 2013-03-13 2014-03-12 Uso de um composto para o tratamento de cataplexia BR112015022197B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361778998P 2013-03-13 2013-03-13
US61/778,998 2013-03-13
PCT/US2014/023969 WO2014164969A1 (en) 2013-03-13 2014-03-12 Treatment of cataplexy

Publications (3)

Publication Number Publication Date
BR112015022197A2 BR112015022197A2 (pt) 2017-07-18
BR112015022197A8 true BR112015022197A8 (pt) 2019-11-26
BR112015022197B1 BR112015022197B1 (pt) 2022-06-07

Family

ID=51530017

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022197-1A BR112015022197B1 (pt) 2013-03-13 2014-03-12 Uso de um composto para o tratamento de cataplexia

Country Status (22)

Country Link
US (6) US9359290B2 (pt)
EP (1) EP2968208B1 (pt)
JP (2) JP6530741B2 (pt)
KR (1) KR102192554B1 (pt)
CN (1) CN105431142B (pt)
AU (1) AU2014248849B2 (pt)
BR (1) BR112015022197B1 (pt)
CA (1) CA2905457A1 (pt)
DK (1) DK2968208T3 (pt)
ES (1) ES2927675T3 (pt)
HK (1) HK1219236A1 (pt)
HR (1) HRP20221018T1 (pt)
HU (1) HUE060060T2 (pt)
MX (1) MX2015012644A (pt)
MY (1) MY177740A (pt)
PH (1) PH12015502075A1 (pt)
PT (1) PT2968208T (pt)
RU (2) RU2689984C2 (pt)
SG (1) SG11201507121RA (pt)
SI (1) SI2968208T1 (pt)
TW (2) TWI684450B (pt)
WO (1) WO2014164969A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1890684T3 (pl) * 2005-06-08 2014-05-30 Sk Biopharmaceuticals Co Ltd Leczenie zaburzeń snu i czuwania
EP2445490B1 (en) 2009-06-22 2023-02-08 SK Biopharmaceuticals Co., Ltd. Methods for treating or preventing fatigue
PT2968208T (pt) * 2013-03-13 2022-10-28 Aerial Biopharma Llc Tratamento da cataplexia
PL3021838T3 (pl) 2013-07-18 2021-03-08 Jazz Pharmaceuticals Ireland Limited Leczenie otyłości
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
WO2018048871A1 (en) 2016-09-06 2018-03-15 Jazz Pharmaceuticals International Iii Limited Solvate form of (r)-2-amino-3-phenylpropyl carbamate
WO2018067971A1 (en) 2016-10-06 2018-04-12 Jazz Pharmaceuticals International Iii Limited Carbamoyl phenylalaninol compounds and uses therof
MX2019014409A (es) 2017-06-02 2022-03-17 Jazz Pharmaceuticals Ireland Ltd Métodos y composiciones para tratar somnolencia excesiva.
EP3661911A4 (en) 2017-07-31 2021-04-14 Jazz Pharmaceuticals Ireland Limited CARBAMOYL-PHENYLALANINOL ANALOGS AND USES THEREOF
US20190076409A1 (en) * 2017-09-12 2019-03-14 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of narcolepsy
US20210106522A1 (en) 2018-01-29 2021-04-15 Cognos Therapeutics, Inc. Intratumoral delivery of bortezomib
US20190381056A1 (en) 2018-06-17 2019-12-19 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
US11020402B2 (en) 2018-10-15 2021-06-01 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
WO2021113163A1 (en) * 2019-12-03 2021-06-10 Axsome Therapeutics, Inc. Use of reboxetine to treat nervous system disorders
EP3866768A4 (en) * 2018-10-15 2022-01-05 Axsome Therapeutics, Inc. USING REBOXETINE TO TREAT NARCOLEPSY
US20200147093A1 (en) 2018-10-15 2020-05-14 Axsome Therapeutics, Inc. Use of esreboxetine to treat nervous system disorders such as fibromyalgia
CA3127871A1 (en) 2019-03-01 2020-09-10 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
KR20220108122A (ko) * 2019-12-03 2022-08-02 액섬 테라퓨틱스, 인크. 신경계 장애 치료를 위한 레복세틴의 용도
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US178429A (en) * 1876-06-06 Improvement in hulling-machines
JPS58156351A (ja) * 1982-03-11 1983-09-17 Sumitomo Chem Co Ltd メタクリル酸合成触媒の再生方法
CZ285762B6 (cs) 1993-06-10 1999-11-17 Eli Lilly And Company Farmaceutický prostředek vhodný pro prevenci dávení a zvracení a pro ošetřování sexuální dysfunkce savců a jeho použití
KR100197892B1 (ko) 1994-09-09 1999-06-15 남창우 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법
US5756817C1 (en) 1995-02-11 2001-04-17 Sk Corp O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same
KR0173862B1 (ko) 1995-02-11 1999-04-01 조규향 O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
KR0173863B1 (ko) 1995-04-10 1999-04-01 조규향 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
ES2170878T3 (es) 1996-10-10 2002-08-16 Sk Corp Compuestos de o-carbamoil-fenilalaninol y sus sales farmaceuticamente utiles.
AU4674797A (en) 1996-10-22 1998-05-15 Ortho Pharmaceutical Corporation Phenylalaninol derivatives for the treatment of central nervous system disorders
US6204245B1 (en) * 1999-09-17 2001-03-20 The Regents Of The University Of California Treatment of narcolepsy with immunosuppressants
GB0109103D0 (en) * 2001-04-11 2001-05-30 Pfizer Ltd Novel compounds
US20030207857A1 (en) 2001-04-11 2003-11-06 Adam Mavis D. Phenyl heterocyclyl ethers
US20050080268A1 (en) 2003-10-08 2005-04-14 Yong-Moon Choi Process of preparing O-carbamoyl compounds in the presence of active amine group
ATE490959T1 (de) 2004-03-31 2010-12-15 Janssen Pharmaceutica Nv Heterocyclische nichtimidazolverbindungen als modulatoren des histamin-h3-rezeptors
KR20070100686A (ko) * 2004-09-07 2007-10-11 오르펀 메디칼, 인크. 개선된 ｇｈｂ 조성물
JP2008518921A (ja) 2004-10-28 2008-06-05 エスケー ホルディングス カンパニー リミテッド うつ病のための補助療法
PL1890684T3 (pl) 2005-06-08 2014-05-30 Sk Biopharmaceuticals Co Ltd Leczenie zaburzeń snu i czuwania
JP5298334B2 (ja) 2005-06-22 2013-09-25 エスケー ホルディングス カンパニー リミテッド 性機能障害を治療する方法
EA019935B1 (ru) 2005-07-26 2014-07-30 Янссен Фармацевтика Н.В. Способы лечения алкогольной абстиненции
FR2903904A1 (fr) * 2006-07-21 2008-01-25 Bioprojet Soc Civ Ile Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3
JP2010506845A (ja) 2006-10-13 2010-03-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ フェニルアルキルアミノカルバメート組成物
WO2008055314A1 (en) * 2006-11-10 2008-05-15 Dimerix Bioscience Pty Ltd Thyrotropin releasing hormone receptor-orexin receptor hetero-dimers/-oligomers
EP2445490B1 (en) 2009-06-22 2023-02-08 SK Biopharmaceuticals Co., Ltd. Methods for treating or preventing fatigue
US8232315B2 (en) 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
AU2010316106B2 (en) 2009-11-06 2015-10-22 Sk Biopharmaceuticals Co., Ltd. Methods for treating attention-deficit/hyperactivity disorder
MX350745B (es) 2009-11-06 2017-09-14 Sk Biopharmaceuticals Co Ltd * El uso de un compuesto de carbamoilo para el tratamiento del sindrome de fibromialgia.
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
PT2968208T (pt) * 2013-03-13 2022-10-28 Aerial Biopharma Llc Tratamento da cataplexia

Also Published As

Publication number Publication date
MX2015012644A (es) 2016-06-21
US9359290B2 (en) 2016-06-07
HRP20221018T1 (hr) 2023-01-06
US20190218174A1 (en) 2019-07-18
SG11201507121RA (en) 2015-10-29
PH12015502075B1 (en) 2016-01-18
BR112015022197B1 (pt) 2022-06-07
JP2016512531A (ja) 2016-04-28
RU2015143610A3 (pt) 2018-03-21
US20170137375A1 (en) 2017-05-18
CA2905457A1 (en) 2014-10-09
EP2968208A4 (en) 2016-10-12
KR20150139522A (ko) 2015-12-11
US11072579B2 (en) 2021-07-27
TWI684450B (zh) 2020-02-11
US20160250176A1 (en) 2016-09-01
US20140275244A1 (en) 2014-09-18
AU2014248849B2 (en) 2018-08-30
BR112015022197A2 (pt) 2017-07-18
WO2014164969A1 (en) 2014-10-09
JP6530741B2 (ja) 2019-06-12
ES2927675T3 (es) 2022-11-10
HUE060060T2 (hu) 2023-01-28
RU2689984C2 (ru) 2019-05-30
RU2015143610A (ru) 2017-04-20
PT2968208T (pt) 2022-10-28
TWI663971B (zh) 2019-07-01
EP2968208B1 (en) 2022-07-20
RU2019114940A (ru) 2019-06-28
JP2019147830A (ja) 2019-09-05
SI2968208T1 (sl) 2023-02-28
AU2014248849A1 (en) 2015-10-08
RU2019114940A3 (pt) 2019-12-25
US20230416195A1 (en) 2023-12-28
TW201919606A (zh) 2019-06-01
US20220017457A1 (en) 2022-01-20
CN105431142A (zh) 2016-03-23
MY177740A (en) 2020-09-23
US9585863B2 (en) 2017-03-07
US11713292B2 (en) 2023-08-01
EP2968208A1 (en) 2016-01-20
DK2968208T3 (da) 2022-08-22
US10259780B2 (en) 2019-04-16
TW201513856A (zh) 2015-04-16
KR102192554B1 (ko) 2020-12-18
PH12015502075A1 (en) 2016-01-18
CN105431142B (zh) 2019-04-26
HK1219236A1 (zh) 2017-03-31

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Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: SK BIOPHARMACEUTICALS CO., LTD. (KR) ; JAZZ PHARMACEUTICALS IRELAND LIMITED (IE)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/03/2014, OBSERVADAS AS CONDICOES LEGAIS