JP2019507786A5 - - Google Patents
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- Publication number
- JP2019507786A5 JP2019507786A5 JP2018547431A JP2018547431A JP2019507786A5 JP 2019507786 A5 JP2019507786 A5 JP 2019507786A5 JP 2018547431 A JP2018547431 A JP 2018547431A JP 2018547431 A JP2018547431 A JP 2018547431A JP 2019507786 A5 JP2019507786 A5 JP 2019507786A5
- Authority
- JP
- Japan
- Prior art keywords
- dose
- cyanobenzoyl
- pyrazol
- cyclopropyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VGUSQKZDZHAAEE-UHFFFAOYSA-N 3-[5-amino-4-(3-cyanobenzoyl)pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide Chemical compound CC1=CC=C(C(=O)NC2CC2)C=C1N(C=1N)N=CC=1C(=O)C1=CC=CC(C#N)=C1 VGUSQKZDZHAAEE-UHFFFAOYSA-N 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- XXUNIGZDNWWYED-UHFFFAOYSA-N 2-methylbenzamide Chemical compound CC1=CC=CC=C1C(N)=O XXUNIGZDNWWYED-UHFFFAOYSA-N 0.000 claims description 3
- -1 3-cyanobenzoyl Chemical group 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- 230000007423 decrease Effects 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2016/050636 WO2017153702A1 (en) | 2016-03-08 | 2016-03-08 | Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507786A JP2019507786A (ja) | 2019-03-22 |
| JP2019507786A5 true JP2019507786A5 (enExample) | 2019-05-09 |
| JP6741774B2 JP6741774B2 (ja) | 2020-08-19 |
Family
ID=55586330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547431A Active JP6741774B2 (ja) | 2016-03-08 | 2016-03-08 | 慢性閉塞性肺疾患の急性増悪の治療のための投与レジメン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10603306B2 (enExample) |
| JP (1) | JP6741774B2 (enExample) |
| KR (2) | KR20180118667A (enExample) |
| AU (1) | AU2016397047B2 (enExample) |
| BR (1) | BR112018067454A2 (enExample) |
| CA (1) | CA3016488C (enExample) |
| MX (1) | MX385717B (enExample) |
| RU (1) | RU2713203C1 (enExample) |
| WO (1) | WO2017153702A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3016488C (en) * | 2016-03-08 | 2023-04-11 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
| GB201612238D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide |
| GB201612240D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide |
| KR102899004B1 (ko) * | 2017-12-11 | 2025-12-12 | 메레오 바이오파마 1 리미티드 | 만성 폐쇄성 폐 질환의 급성 악화의 치료에서의 3-[5-아미노-4-(3-시아노벤조일)-피라졸-1-일]-n-시클로프로필-4-메틸벤즈아미드의 용도 |
| AU2018381874B2 (en) | 2017-12-11 | 2024-08-15 | Mereo Biopharma 1 Limited | Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the prevention or reduction of acute exacerbations of chronic obstructive pulmonary disease |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| US6598603B1 (en) * | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
| WO2005009973A1 (en) | 2003-06-26 | 2005-02-03 | Novartis Ag | 5-membered heterocycle-based p38 kinase inhibitors |
| TWI556829B (zh) * | 2004-04-09 | 2016-11-11 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| GB0409703D0 (en) | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| US20050277602A1 (en) | 2004-05-21 | 2005-12-15 | Grunstein Michael M | Methods employing agonists of P38 map kinase for the treatment of asthma |
| CA2640665A1 (en) | 2006-02-10 | 2007-08-16 | Pfizer Products Inc. | Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives |
| GB0603684D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| SG11201404941WA (en) * | 2012-03-20 | 2014-10-30 | Novartis Ag | Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease |
| CA3016488C (en) * | 2016-03-08 | 2023-04-11 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
| KR20180119597A (ko) * | 2016-03-08 | 2018-11-02 | 메레오 바이오파마 1 리미티드 | 염증 상태의 급성 악화의 치료를 위한 투약법 |
-
2016
- 2016-03-08 CA CA3016488A patent/CA3016488C/en active Active
- 2016-03-08 US US16/082,765 patent/US10603306B2/en active Active
- 2016-03-08 RU RU2018132047A patent/RU2713203C1/ru active
- 2016-03-08 WO PCT/GB2016/050636 patent/WO2017153702A1/en not_active Ceased
- 2016-03-08 KR KR1020187026084A patent/KR20180118667A/ko not_active Ceased
- 2016-03-08 KR KR1020247020223A patent/KR102762199B1/ko active Active
- 2016-03-08 MX MX2018010782A patent/MX385717B/es unknown
- 2016-03-08 JP JP2018547431A patent/JP6741774B2/ja active Active
- 2016-03-08 AU AU2016397047A patent/AU2016397047B2/en active Active
- 2016-03-08 BR BR112018067454A patent/BR112018067454A2/pt not_active Application Discontinuation
-
2020
- 2020-02-18 US US16/793,922 patent/US11129810B2/en active Active