JP2023002662A5 - - Google Patents
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- Publication number
- JP2023002662A5 JP2023002662A5 JP2022166618A JP2022166618A JP2023002662A5 JP 2023002662 A5 JP2023002662 A5 JP 2023002662A5 JP 2022166618 A JP2022166618 A JP 2022166618A JP 2022166618 A JP2022166618 A JP 2022166618A JP 2023002662 A5 JP2023002662 A5 JP 2023002662A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- pharmaceutical composition
- cough
- chronic cough
- putative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010011224 Cough Diseases 0.000 claims 19
- 208000013116 chronic cough Diseases 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 5
- 206010070488 Upper-airway cough syndrome Diseases 0.000 claims 4
- 229940126409 proton pump inhibitor Drugs 0.000 claims 4
- 239000000612 proton pump inhibitor Substances 0.000 claims 4
- 150000003431 steroids Chemical class 0.000 claims 4
- 238000011285 therapeutic regimen Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361869174P | 2013-08-23 | 2013-08-23 | |
| US61/869,174 | 2013-08-23 | ||
| JP2019055849A JP7210348B2 (ja) | 2013-08-23 | 2019-03-25 | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019055849A Division JP7210348B2 (ja) | 2013-08-23 | 2019-03-25 | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023002662A JP2023002662A (ja) | 2023-01-10 |
| JP2023002662A5 true JP2023002662A5 (enExample) | 2023-02-17 |
| JP7423725B2 JP7423725B2 (ja) | 2024-01-29 |
Family
ID=52480919
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536497A Active JP6546592B2 (ja) | 2013-08-23 | 2014-08-22 | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
| JP2019055849A Active JP7210348B2 (ja) | 2013-08-23 | 2019-03-25 | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
| JP2022166618A Active JP7423725B2 (ja) | 2013-08-23 | 2022-10-18 | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536497A Active JP6546592B2 (ja) | 2013-08-23 | 2014-08-22 | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
| JP2019055849A Active JP7210348B2 (ja) | 2013-08-23 | 2019-03-25 | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9284279B2 (enExample) |
| EP (2) | EP3865134A1 (enExample) |
| JP (3) | JP6546592B2 (enExample) |
| KR (1) | KR102196885B1 (enExample) |
| CN (1) | CN105682659B (enExample) |
| AU (1) | AU2014308606B2 (enExample) |
| CA (1) | CA2921395C (enExample) |
| CL (3) | CL2016000400A1 (enExample) |
| CR (1) | CR20160093A (enExample) |
| IL (1) | IL244131B (enExample) |
| MX (1) | MX367657B (enExample) |
| MY (1) | MY195728A (enExample) |
| NI (1) | NI201600029A (enExample) |
| NZ (1) | NZ716977A (enExample) |
| PE (1) | PE20160431A1 (enExample) |
| PH (1) | PH12016500357A1 (enExample) |
| RU (1) | RU2650118C2 (enExample) |
| SG (1) | SG11201601145RA (enExample) |
| UA (1) | UA118851C2 (enExample) |
| WO (1) | WO2015027212A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6546592B2 (ja) * | 2013-08-23 | 2019-07-17 | アファレント ファーマシューティカルズ インコーポレイテッド | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
| EP3725311A1 (en) | 2014-02-10 | 2020-10-21 | Respivant Sciences GmbH | Methods for the treatment of lung diseases with mast cell stabilizers |
| EP3653207A1 (en) | 2014-02-10 | 2020-05-20 | Respivant Sciences GmbH | Mast cell stabilizers treatment for systemic disorders |
| WO2017011729A1 (en) | 2015-07-16 | 2017-01-19 | Patara Pharma, LLC | Combination therapies for the treatment of lung diseases |
| EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| HUE061764T2 (hu) * | 2015-09-29 | 2023-08-28 | Afferent Pharmaceuticals Inc | Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében |
| US9907795B2 (en) * | 2016-01-08 | 2018-03-06 | Nerre Therapeutics Limited | Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents |
| US10662162B2 (en) * | 2016-03-25 | 2020-05-26 | Afferent Pharmaceuticals, Inc. | Pyrimidines and variants thereof, and uses therefor |
| CN110139646A (zh) | 2016-08-31 | 2019-08-16 | 瑞思皮万特科学有限责任公司 | 用于治疗由特发性肺纤维化引起的慢性咳嗽的色甘酸组合物 |
| WO2018067341A1 (en) | 2016-10-07 | 2018-04-12 | Patara Pharma, LLC | Cromolyn compositions for treatment of pulmonary fibrosis |
| EP3554504B1 (en) | 2016-12-15 | 2022-10-26 | Afferent Pharmaceuticals Inc. | Substituted pyrazole-pyrimidines, variants thereof, and uses thereof |
| RU2021120039A (ru) * | 2016-12-20 | 2021-08-03 | Эфферент Фармасьютикалз, Инк. | Кристаллические соли и полиморфы антагониста p2x3 |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| CN108904507A (zh) * | 2018-02-11 | 2018-11-30 | 赖英杰 | P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用 |
| CA3093409A1 (en) | 2018-03-15 | 2019-09-19 | Danmir Therapeutics, Llc | 3",5"-dialkoxybenzoyl-3'-amino-3'-deoxyadenosine-5'-triphosphates and pharmaceutical uses thereof |
| CA3096505A1 (en) * | 2018-04-23 | 2019-10-31 | Merck Sharp & Dohme Corp. | Novel process for synthesis of a phenoxy diaminopyrimidine compound |
| CA3100096A1 (en) | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| JP2021523919A (ja) * | 2018-05-15 | 2021-09-09 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 神経線維感作に関連する疾患を治療するための１，３−チアゾール−２−イル置換ベンズアミド |
| MX2021000908A (es) | 2018-07-23 | 2021-06-08 | Trevi Therapeutics Inc | Tratamiento de la tos cronica, la dificultad respiratoria y la disnea. |
| PL3862000T3 (pl) * | 2018-10-05 | 2024-03-18 | Shionogi & Co., Ltd | Lek na przewlekły kaszel |
| WO2020174283A1 (en) | 2019-02-25 | 2020-09-03 | Bellus Health Cough Inc. | Treatment with p2x3 modulators |
| US20220211703A1 (en) * | 2019-04-30 | 2022-07-07 | Beijing Tide Pharmaceutical Co., Ltd. | Method for treating cough by using diaminopyrimidine compound |
| ES3056709T3 (en) * | 2019-04-30 | 2026-02-24 | Beijing Tide Pharmaceutical Co Ltd | Salt of diaminopyrimidine compounds, and solid form thereof, preparation method therefor and use thereof |
| MX2022002941A (es) | 2019-09-19 | 2022-04-06 | Shionogi & Co | Cristal de derivado de 1,3,5-triazina o solvato del mismo y metodo para producir el mismo. |
| MX2022008554A (es) | 2020-01-10 | 2022-08-10 | Trevi Therapeutics Inc | Metodos de administracion de nalbufina. |
| CN111635368B (zh) * | 2020-06-12 | 2021-06-29 | 东莞市东阳光仿制药研发有限公司 | 一种胺化合物的制备方法 |
| WO2024080126A1 (ja) | 2022-10-12 | 2024-04-18 | ソフトバンクグループ株式会社 | 情報処理システム、情報処理装置、制御装置及びプログラム |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1725540T5 (da) * | 2004-03-05 | 2012-10-22 | Hoffmann La Roche | Diaminopyrimidiner som p2x3- og p2x2/3-antagonister |
| JP2008507368A (ja) * | 2004-07-22 | 2008-03-13 | デュスカ サイエンティフィック カンパニー | 肺疾患を診断、モニタリングおよび治療するための方法 |
| ES2562056T3 (es) | 2005-09-01 | 2016-03-02 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores P2X3 y P2X2/3 |
| CN101296907B (zh) | 2005-09-01 | 2013-03-27 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类 |
| WO2007025898A1 (en) | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Process for synthesis of aryloxy diaminopyrimidines |
| CA2620034C (en) * | 2005-09-01 | 2013-10-01 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| EP2079713B1 (en) * | 2006-10-04 | 2014-04-16 | F. Hoffmann-La Roche AG | Process for synthesis of phenoxy diaminopyrimidine derivatives |
| WO2008104474A1 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Diaminopyrimidines |
| US9550763B2 (en) * | 2012-02-09 | 2017-01-24 | Shionogi & Co., Ltd. | Heterocyclic ring and carbocyclic derivative |
| JP6546592B2 (ja) | 2013-08-23 | 2019-07-17 | アファレント ファーマシューティカルズ インコーポレイテッド | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
| US9133647B2 (en) * | 2013-10-11 | 2015-09-15 | Nexkey, Inc. | NFC or BLE based contactless lock with charge monitoring of its energy storage |
-
2014
- 2014-08-22 JP JP2016536497A patent/JP6546592B2/ja active Active
- 2014-08-22 PE PE2016000285A patent/PE20160431A1/es unknown
- 2014-08-22 EP EP21159088.0A patent/EP3865134A1/en active Pending
- 2014-08-22 EP EP14838254.2A patent/EP3035932A4/en not_active Withdrawn
- 2014-08-22 NZ NZ716977A patent/NZ716977A/en unknown
- 2014-08-22 WO PCT/US2014/052389 patent/WO2015027212A1/en not_active Ceased
- 2014-08-22 UA UAA201601740A patent/UA118851C2/uk unknown
- 2014-08-22 CR CR20160093A patent/CR20160093A/es unknown
- 2014-08-22 US US14/466,713 patent/US9284279B2/en active Active
- 2014-08-22 CN CN201480058491.3A patent/CN105682659B/zh active Active
- 2014-08-22 CA CA2921395A patent/CA2921395C/en active Active
- 2014-08-22 SG SG11201601145RA patent/SG11201601145RA/en unknown
- 2014-08-22 RU RU2016105581A patent/RU2650118C2/ru active
- 2014-08-22 MY MYPI2016000327A patent/MY195728A/en unknown
- 2014-08-22 KR KR1020167007167A patent/KR102196885B1/ko active Active
- 2014-08-22 AU AU2014308606A patent/AU2014308606B2/en active Active
- 2014-08-22 MX MX2016002289A patent/MX367657B/es active IP Right Grant
-
2016
- 2016-02-02 US US15/013,798 patent/US9724346B2/en active Active
- 2016-02-15 IL IL244131A patent/IL244131B/en active IP Right Grant
- 2016-02-22 CL CL2016000400A patent/CL2016000400A1/es unknown
- 2016-02-22 NI NI201600029A patent/NI201600029A/es unknown
- 2016-02-23 PH PH12016500357A patent/PH12016500357A1/en unknown
-
2017
- 2017-08-01 US US15/665,595 patent/US10206922B2/en active Active
-
2018
- 2018-08-08 CL CL2018002138A patent/CL2018002138A1/es unknown
- 2018-08-08 CL CL2018002137A patent/CL2018002137A1/es unknown
-
2019
- 2019-03-25 JP JP2019055849A patent/JP7210348B2/ja active Active
-
2022
- 2022-10-18 JP JP2022166618A patent/JP7423725B2/ja active Active
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