JP2014517050A5 - - Google Patents

Download PDF

Info

Publication number
JP2014517050A5
JP2014517050A5 JP2014516318A JP2014516318A JP2014517050A5 JP 2014517050 A5 JP2014517050 A5 JP 2014517050A5 JP 2014516318 A JP2014516318 A JP 2014516318A JP 2014516318 A JP2014516318 A JP 2014516318A JP 2014517050 A5 JP2014517050 A5 JP 2014517050A5
Authority
JP
Japan
Prior art keywords
week
compound
dose
disorder
schizophrenia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014516318A
Other languages
English (en)
Japanese (ja)
Other versions
JP6140151B2 (ja
JP2014517050A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/061779 external-priority patent/WO2012175531A1/en
Publication of JP2014517050A publication Critical patent/JP2014517050A/ja
Publication of JP2014517050A5 publication Critical patent/JP2014517050A5/ja
Application granted granted Critical
Publication of JP6140151B2 publication Critical patent/JP6140151B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014516318A 2011-06-20 2012-06-20 統合失調症の処置において４−（（１ｒ，３ｓ）−６−クロロ−３−フェニル−インダン−１−イル）−１，２，２−トリメチル−ピペラジンおよびその塩を投与する方法 Active JP6140151B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161498653P 2011-06-20 2011-06-20
DKPA201100465 2011-06-20
DKPA201100465 2011-06-20
US61/498,653 2011-06-20
PCT/EP2012/061779 WO2012175531A1 (en) 2011-06-20 2012-06-20 Method of administration of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia

Publications (3)

Publication Number Publication Date
JP2014517050A JP2014517050A (ja) 2014-07-17
JP2014517050A5 true JP2014517050A5 (enExample) 2016-11-17
JP6140151B2 JP6140151B2 (ja) 2017-05-31

Family

ID=58794324

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014516318A Active JP6140151B2 (ja) 2011-06-20 2012-06-20 統合失調症の処置において４−（（１ｒ，３ｓ）−６−クロロ−３−フェニル−インダン−１−イル）−１，２，２−トリメチル−ピペラジンおよびその塩を投与する方法

Country Status (23)

Country Link
US (1) US9610287B2 (enExample)
EP (1) EP2720698B1 (enExample)
JP (1) JP6140151B2 (enExample)
KR (1) KR101900989B1 (enExample)
CN (1) CN103608015A (enExample)
AU (1) AU2012274150B2 (enExample)
BR (1) BR112013032178A2 (enExample)
CA (1) CA2838055C (enExample)
DK (1) DK2720698T3 (enExample)
ES (1) ES2694298T3 (enExample)
HR (1) HRP20181684T1 (enExample)
IL (1) IL230060A (enExample)
JO (1) JO3421B1 (enExample)
LT (1) LT2720698T (enExample)
MX (1) MX349754B (enExample)
PL (1) PL2720698T3 (enExample)
RS (1) RS57944B1 (enExample)
RU (1) RU2613177C2 (enExample)
SI (1) SI2720698T1 (enExample)
SM (1) SMT201800567T1 (enExample)
TW (1) TWI552751B (enExample)
WO (1) WO2012175531A1 (enExample)
ZA (1) ZA201309617B (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
EP2133360A3 (en) 1999-11-17 2010-03-03 Mendel Biotechnology, Inc. Environmental stress tolerance genes
US6458538B1 (en) 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
WO2002015675A1 (en) 2000-08-22 2002-02-28 Mendel Biotechnology, Inc. Genes for modifying plant traits iv
US7045283B2 (en) 2000-10-18 2006-05-16 The Regents Of The University Of California Methods of high-throughput screening for internalizing antibodies
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
EP1412750B1 (en) 2001-06-26 2012-05-23 Senomyx, Inc. T1r2-t1r3 hetero-oligomeric sweet taste receptors and cell lines that express said receptors and use thereof for identification of sweet taste compounds
US7871619B2 (en) 2001-11-30 2011-01-18 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
ATE541047T1 (de) 2002-08-01 2012-01-15 Univ California Therapeutische monoklonale antikörper zur neutralisierung von botulinum neurotoxinen
US20040081653A1 (en) 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
AU2003285856A1 (en) 2002-09-18 2004-04-23 Mendel Biotechnology, Inc. Polynucleotides and polypeptides in plants
AU2004263823B2 (en) 2003-05-30 2008-09-18 Agensys, Inc. Prostate stem cell antigen (PSCA) variants and subsequences thereof
US7794948B2 (en) 2003-11-07 2010-09-14 Vermilllion, Inc. Biomarkers for alzheimer's disease
AU2004304665B2 (en) 2003-12-24 2009-03-12 Novo Nordisk A/S Transgenic non-human mammal comprising a polynucleotide encoding human or humanized C5aR
EP1734996B1 (en) 2004-04-02 2013-05-22 The Regents of The University of California Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
RU2381234C2 (ru) 2004-05-28 2010-02-10 Эдженсис, Инк. Антитела и родственные молекулы, связывающиеся с белками psca
ES2660765T3 (es) 2004-06-21 2018-03-26 The Board Of Trustees Of The Leland Stanford Junior University Genes y rutas expresadas de forma diferencial en trastorno bipolar y/o trastorno depresivo mayor
US7850960B2 (en) 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
WO2007094754A2 (en) 2005-01-27 2007-08-23 The Regents Of The University Of Califordnia Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
EP3300739A3 (en) 2005-03-31 2018-07-18 Agensys, Inc. Antibodies and related molecules that bind to 161p2f10b proteins
DK3117833T3 (en) 2005-07-19 2019-03-18 Stemgen S P A Inhibition of Tumor-rich Potential of Tumor Stem Cells with LIF
JP5342878B2 (ja) 2005-10-20 2013-11-13 セノミクス・インコーポレーテッド キメラヒト甘味‐旨味および旨味‐甘味味覚受容体
US20100028358A1 (en) 2005-11-07 2010-02-04 Wolfram Ruf Compositions and Methods for Controlling Tissue Factor Signaling Specificity
EP2564864B8 (en) 2005-11-12 2015-05-13 The Board of Trustees of The Leland Stanford Junior University FGF2-related methods for diagnosing and treating depression
CN103301475B (zh) 2005-12-28 2016-08-03 斯克里普斯研究所 药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用
US20100278821A1 (en) 2006-03-21 2010-11-04 The Regents Of The University Of California N-cadherin: target for cancer diagnosis and therapy
EP2004230A4 (en) 2006-03-21 2009-05-20 Univ California N-CADHERINE AND LY6 E: OBJECTIVES FOR CANCER DIAGNOSIS AND THERAPY
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
EP2061900A2 (en) 2006-08-25 2009-05-27 Oncotherapy Science, Inc. Prognostic markers and therapeutic targets for lung cancer
WO2008030986A2 (en) 2006-09-06 2008-03-13 The Regents Of The University Of California Molecular diagnosis and classification of malignant melanoma
EP2095100B1 (en) 2006-11-22 2016-09-21 President and Fellows of Harvard College Method of operating a nanowire field effect transistor sensor
WO2009023059A2 (en) 2007-06-01 2009-02-19 The Trustees Of Princeton University Treatment of viral infections by modulation of host cell metabolic pathways
AU2008286361B2 (en) 2007-08-13 2013-09-26 Takeda Pharmaceutical Company Limited IVIG modulation of chemokines for treatment of multiple sclerosis, Alzheimer's disease, and Parkinson's disease
HUE025137T2 (en) 2007-08-21 2016-01-28 Senomyx Inc Compositions are bitter taste blocking (blocking) compounds
US7858759B2 (en) 2007-10-04 2010-12-28 Zymogenetics, Inc. Anti-zB7H6 antibody-drug conjugates
CA2703165A1 (en) 2007-10-22 2009-04-30 The Regents Of The University Of California Biomarkers for prenatal diagnosis of congenital cytomegalovirus
CA2703519C (en) 2007-11-09 2017-04-18 The Salk Institute For Biological Studies Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors
JP5951254B2 (ja) 2008-03-17 2016-07-13 ザ スクリプス リサーチ インスティテュート 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
AU2009239491B2 (en) 2008-04-21 2014-07-17 Lawrence Livermore National Security, Llc Selective high-affinity polydentate ligands and methods of making such
EP2324044A4 (en) 2008-08-04 2012-04-25 Univ Miami STING (STIMULATOR OF INTERFERON GENES) AS A REGULATOR OF BORROWING IMMUNE REACTIONS
US20110287026A1 (en) 2008-09-23 2011-11-24 President And Fellows Of Harvard College Sirt4 and uses thereof
US20110212083A1 (en) 2008-11-06 2011-09-01 University Of Miami Office Of Technology Transfer Role of soluble upar in the pathogenesis of proteinuric kidney disease
EP2352847B1 (en) 2008-11-10 2014-01-08 The United States of America, as represented by The Secretary, Department of Health and Human Services Gene signature for predicting prognosis of patients with solid tumors
AU2009322346B2 (en) 2008-12-03 2015-07-02 The Scripps Research Institute Stem cell cultures
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
AU2010241947B2 (en) 2009-03-27 2014-01-16 Gojo Industries, Inc. Compositions and methods for screening and using compounds antagonizing spore-surface interactions
JP5755647B2 (ja) 2009-07-24 2015-07-29 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア αｖβ５インテグリンに関連する疾患の処置および予防のための方法および組成物
EP3444613B1 (en) 2009-08-14 2021-05-19 The Regents of The University of California Methods of diagnosing and treating autism
US20120148604A1 (en) 2009-08-20 2012-06-14 Transposagen Biopharmaceuticals, Inc. Trp inhibitors and uses thereof
US9297796B2 (en) 2009-09-24 2016-03-29 President And Fellows Of Harvard College Bent nanowires and related probing of species
ES2365343B1 (es) 2009-11-19 2012-07-10 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de cd98 como marcador de receptividad endometrial.
WO2011094759A2 (en) 2010-02-01 2011-08-04 The Regents Of The University Of California Novel diagnostic and therapeutic targets associated with or regulated by n-cadherin expression and/or epithelial to mesenchymal transition (emt) in prostate cancer and other malignancies
WO2012052391A1 (en) 2010-10-19 2012-04-26 Glaxo Group Limited Polypeptide with jmjd3 catalytic activity
WO2012109495A1 (en) 2011-02-09 2012-08-16 Metabolic Solutions Development Company, Llc Cellular targets of thiazolidinediones
WO2012119989A2 (en) 2011-03-04 2012-09-13 Oryzon Genomics, S.A. Methods and antibodies for the diagnosis and treatment of cancer
US20120301904A1 (en) 2011-04-26 2012-11-29 Prosetta Antiviral, Inc Multiprotein assemblies
EP2825209B1 (en) 2012-03-14 2018-08-29 University of Central Florida Research Foundation, Inc. Neurofibromatoses therapeutic agents and screening for same
WO2013155223A1 (en) 2012-04-10 2013-10-17 The Regents Of The University Of California Compositions and methods for treating cancer
KR20150023287A (ko) 2012-04-24 2015-03-05 더 유니버시티 오브 마이애미 침습성 및 다중약물 내성 병원체에 대한 퍼포린 2 방어
WO2014018535A1 (en) 2012-07-25 2014-01-30 Salk Institute For Biological Studies Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine
EP2890370B1 (en) 2012-08-31 2019-10-09 The Regents of the University of California Agents useful for treating obesity, diabetes and related disorders
AU2013204200B2 (en) 2012-10-11 2016-10-20 Brandeis University Treatment of amyotrophic lateral sclerosis
US20140120116A1 (en) 2012-10-26 2014-05-01 The Chinese University Of Hong Kong Treatment of cancer using smad3 inhibitor
WO2014124339A2 (en) 2013-02-07 2014-08-14 The Regents Of The University Of California Use of translational profiling to identify target molecules for therapeutic treatment
WO2014144844A1 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University tRNA DERIVED SMALL RNAs (tsRNAs) INVOLVED IN CELL VIABILITY
WO2015089327A1 (en) 2013-12-11 2015-06-18 Biogen Idec Ma Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
CN105979780A (zh) 2013-12-11 2016-09-28 斯隆-凯特林癌症研究院 治疗前列腺癌的糖皮质激素抑制剂
WO2015136509A2 (en) 2014-03-14 2015-09-17 Genesis Theranostix Korlatolt Felelossegu Tarsasag Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy
US10196701B2 (en) 2015-06-01 2019-02-05 The Penn State Research Foundation Hepatitis B virus capsid assembly
US10782304B2 (en) 2015-06-24 2020-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for detecting protein-protein interactions
WO2018036503A1 (en) 2016-08-25 2018-03-01 The Chinese University Of Hong Kong Fecal bacterial markers for colorectal cancer
CN110291084A (zh) 2016-12-15 2019-09-27 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
EP3601326A4 (en) 2017-03-20 2020-12-16 The Broad Institute, Inc. COMPOUNDS AND METHODS OF REGULATING INSULIN SECRETION
WO2018187471A2 (en) 2017-04-04 2018-10-11 Loma Linda University Biologic for the treatment of cancer
WO2019207587A1 (en) 2018-04-26 2019-10-31 Technion Research & Development Foundation Limited A device and a method for determining cell indentation activity
EP3873488B1 (en) 2018-10-31 2025-03-19 The University of Sydney Pharmaceutical compositions for use in treating an hbv or hdv infection
WO2020097261A1 (en) 2018-11-06 2020-05-14 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services New compositions and methods for treating beta-globinopathies
WO2022105835A1 (en) 2020-11-19 2022-05-27 The Chinese University Of Hong Kong Assessing risk for colorectal adenoma recurrence by noninvasive means
US20260139028A1 (en) 2021-11-02 2026-05-21 The Regents Of The University Of California P-selectin mutants and modulation of integrin-mediated signaling
US20250092106A1 (en) 2022-01-25 2025-03-20 The Regents Of The University Of California Vegf mutants and modulation of integrin-mediated signaling
WO2024197185A1 (en) 2023-03-21 2024-09-26 The Broad Institute, Inc. Methods and compositions for dissecting organelle physiology

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55192D0 (da) 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
CA2536073A1 (en) 2003-08-18 2005-02-24 H. Lundbeck A/S Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
KR20070014184A (ko) 2004-04-22 2007-01-31 베링거 인겔하임 인터내셔날 게엠베하 성기능 장애 치료용 신규 약제학적 조성물 ⅱ
JP5405825B2 (ja) * 2005-07-18 2014-02-05 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 薬剤含有インプラント及びその使用方法
MX2010012037A (es) * 2008-05-07 2010-11-30 Lundbeck & Co As H Composiciones y uso utiles para tratar trastornos cognitivos.
JP2012504560A (ja) * 2008-10-03 2012-02-23 ハー・ルンドベック・アクチエゼルスカベット 経口製剤
KR101435296B1 (ko) * 2009-06-24 2014-08-27 머크 샤프 앤 도메 비.브이. 아세나핀을 함유하는 주사가능한 제제 및 그를 사용한 치료 방법

Similar Documents

Publication Publication Date Title
RU2014101482A (ru) Способ применения 4-((1r,3s)-6-хлор-3-фенилиндан-1-ил)-1,2,2-триметилпиперазина и его солей в лечении шизофрении
EP3240538B1 (en) Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation
EP3060200B1 (en) Tyrosine derivatives and compositions comprising them
JP2015512406A5 (enExample)
JP2021073258A (ja) トラジピタントによる治療方法
JP2021080276A (ja) デクスメデトミジン製剤を使用する睡眠障害の予防または治療
MX344308B (es) Derivados de quinolina carboxamida y quinolina carbonitrilo como moduladores alostericos negativos de mglur2, composiciones y su uso.
JP2014502641A5 (enExample)
JP2015524444A5 (enExample)
JP2016505050A5 (enExample)
TW201211021A (en) Methods of use of cyclic amide derivatives to treat schizophrenia
JP2013536206A5 (enExample)
JP2012502105A5 (enExample)
CN115607545B (zh) 依达拉奉在自闭症谱系障碍治疗中的应用
EP3570841A1 (en) PPARy AGONIST FOR THE TREATMENT OF HUNTINGTON'S DISEASE
JP6420923B1 (ja) 医薬
JP2014037445A (ja) 抵抗性統合失調症およびその他のｃｎｓ疾患の治療
JP2009501205A (ja) 精神病治療用組成物
Huynh et al. Therapies under investigation for treating Parkinson's disease psychosis
TW202539621A (zh) 用於治療巴金森氏症的治療劑
KR20200099153A (ko) 외상 후 증후군 장애의 치료
WO2022060978A1 (en) Methods of treating parkinson's disease and related disorders with pde10a inhibitors
CN113365618A (zh) 改善睡眠或睡醒后表现
Consta daivobet gel on pBs
HK1261581B (en) Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation