IL230060A - Oral administration compounds of 4 - ((6 - (3s, 1r - chloro-3-phenyl-indan-1-ram) -1,2,2-trimethyl-piperazine and their salts in the treatment of schizophrenia - Google Patents
Oral administration compounds of 4 - ((6 - (3s, 1r - chloro-3-phenyl-indan-1-ram) -1,2,2-trimethyl-piperazine and their salts in the treatment of schizophreniaInfo
- Publication number
- IL230060A IL230060A IL230060A IL23006013A IL230060A IL 230060 A IL230060 A IL 230060A IL 230060 A IL230060 A IL 230060A IL 23006013 A IL23006013 A IL 23006013A IL 230060 A IL230060 A IL 230060A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- dose
- schizophrenia
- treatment
- weekly
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 87
- 238000011282 treatment Methods 0.000 title claims description 18
- 201000000980 schizophrenia Diseases 0.000 title claims description 16
- 150000003839 salts Chemical class 0.000 title description 17
- BYPMJBXPNZMNQD-PZJWPPBQSA-N Zicronapine Chemical compound C1C(C)(C)N(C)CCN1[C@H]1C2=CC(Cl)=CC=C2[C@H](C=2C=CC=CC=2)C1 BYPMJBXPNZMNQD-PZJWPPBQSA-N 0.000 title description 6
- 208000028017 Psychotic disease Diseases 0.000 claims description 31
- 230000003442 weekly effect Effects 0.000 claims description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 239000012458 free base Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 208000024891 symptom Diseases 0.000 claims description 8
- 208000020186 Schizophreniform disease Diseases 0.000 claims description 6
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 6
- 208000022610 schizoaffective disease Diseases 0.000 claims description 6
- 230000003111 delayed effect Effects 0.000 claims description 4
- 229960003878 haloperidol Drugs 0.000 claims description 3
- 229960004170 clozapine Drugs 0.000 claims description 2
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 claims description 2
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 1
- 229960004372 aripiprazole Drugs 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960005017 olanzapine Drugs 0.000 claims 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims 1
- 229950009875 osanetant Drugs 0.000 claims 1
- DZOJBGLFWINFBF-UMSFTDKQSA-N osanetant Chemical compound C([C@](C1)(CCCN2CCC(CC2)(N(C(C)=O)C)C=2C=CC=CC=2)C=2C=C(Cl)C(Cl)=CC=2)CCN1C(=O)C1=CC=CC=C1 DZOJBGLFWINFBF-UMSFTDKQSA-N 0.000 claims 1
- 229960004431 quetiapine Drugs 0.000 claims 1
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims 1
- 229960001534 risperidone Drugs 0.000 claims 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims 1
- 229960000652 sertindole Drugs 0.000 claims 1
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 claims 1
- 229960000607 ziprasidone Drugs 0.000 claims 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 claims 1
- 101150049660 DRD2 gene Proteins 0.000 description 20
- 230000027455 binding Effects 0.000 description 14
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 12
- 230000000561 anti-psychotic effect Effects 0.000 description 9
- 238000003556 assay Methods 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 6
- 210000003169 central nervous system Anatomy 0.000 description 6
- 229960003638 dopamine Drugs 0.000 description 6
- 229950001518 raclopride Drugs 0.000 description 6
- 239000002287 radioligand Substances 0.000 description 6
- 238000007792 addition Methods 0.000 description 5
- 208000020925 Bipolar disease Diseases 0.000 description 4
- 108090000511 Dopamine D1 Receptors Proteins 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 150000007522 mineralic acids Chemical class 0.000 description 4
- 230000009871 nonspecific binding Effects 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 230000009870 specific binding Effects 0.000 description 4
- 102000056834 5-HT2 Serotonin Receptors Human genes 0.000 description 3
- 108091005479 5-HT2 receptors Proteins 0.000 description 3
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 230000009798 acute exacerbation Effects 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000000164 antipsychotic agent Substances 0.000 description 3
- 239000012131 assay buffer Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 210000001638 cerebellum Anatomy 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000011418 maintenance treatment Methods 0.000 description 3
- 238000000159 protein binding assay Methods 0.000 description 3
- 230000000698 schizophrenic effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229950009086 zicronapine Drugs 0.000 description 3
- WAOQONBSWFLFPE-VIFPVBQESA-N 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Chemical compound CCN1CCC[C@H]1CNC(=O)C1=C(O)C(Cl)=CC(Cl)=C1OC WAOQONBSWFLFPE-VIFPVBQESA-N 0.000 description 2
- 108010072564 5-HT2A Serotonin Receptor Proteins 0.000 description 2
- 208000021465 Brief psychotic disease Diseases 0.000 description 2
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 2
- 108090001111 Dopamine D2 Receptors Proteins 0.000 description 2
- 102000004980 Dopamine D2 Receptors Human genes 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000027776 Extrapyramidal disease Diseases 0.000 description 2
- 206010026749 Mania Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000019568 Shared Paranoid disease Diseases 0.000 description 2
- 208000028810 Shared psychotic disease Diseases 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000001577 neostriatum Anatomy 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000002600 positron emission tomography Methods 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 210000002637 putamen Anatomy 0.000 description 2
- -1 see table 5 Chemical class 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 description 1
- SKTFQHRVFFOHTQ-UHFFFAOYSA-N 8-bromo-1,3-dimethyl-7h-purine-2,6-dione Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC(Br)=N2 SKTFQHRVFFOHTQ-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000009132 Catalepsy Diseases 0.000 description 1
- 208000024254 Delusional disease Diseases 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 101150104779 HTR2A gene Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000783617 Homo sapiens 5-hydroxytryptamine receptor 2A Proteins 0.000 description 1
- 101001131829 Homo sapiens P protein Proteins 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000019022 Mood disease Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 208000027089 Parkinsonian disease Diseases 0.000 description 1
- 206010034010 Parkinsonism Diseases 0.000 description 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Natural products O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 1
- 206010047853 Waxy flexibility Diseases 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 206010001584 alcohol abuse Diseases 0.000 description 1
- 208000025746 alcohol use disease Diseases 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229940127573 compound 38 Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
- 239000012971 dimethylpiperazine Substances 0.000 description 1
- 102000047119 human OCA2 Human genes 0.000 description 1
- 230000003379 hyperdopaminergic effect Effects 0.000 description 1
- 208000031424 hyperprolactinemia Diseases 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 150000002468 indanes Chemical group 0.000 description 1
- 230000003455 independent Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 108010024941 iodothyronine deiodinase type II Proteins 0.000 description 1
- 230000002197 limbic effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 150000002690 malonic acid derivatives Chemical class 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 239000003176 neuroleptic agent Substances 0.000 description 1
- 230000000701 neuroleptic effect Effects 0.000 description 1
- PIDFDZJZLOTZTM-KHVQSSSXSA-N ombitasvir Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC1=CC=C([C@H]2N([C@@H](CC2)C=2C=CC(NC(=O)[C@H]3N(CCC3)C(=O)[C@@H](NC(=O)OC)C(C)C)=CC=2)C=2C=CC(=CC=2)C(C)(C)C)C=C1 PIDFDZJZLOTZTM-KHVQSSSXSA-N 0.000 description 1
- 239000006191 orally-disintegrating tablet Substances 0.000 description 1
- 125000005489 p-toluenesulfonic acid group Chemical class 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 208000002851 paranoid schizophrenia Diseases 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000003215 serotonin 5-HT2 receptor antagonist Substances 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498653P | 2011-06-20 | 2011-06-20 | |
| DKPA201100465 | 2011-06-20 | ||
| PCT/EP2012/061779 WO2012175531A1 (en) | 2011-06-20 | 2012-06-20 | Method of administration of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL230060A true IL230060A (en) | 2017-10-31 |
Family
ID=58794324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL230060A IL230060A (en) | 2011-06-20 | 2013-12-19 | Oral administration compounds of 4 - ((6 - (3s, 1r - chloro-3-phenyl-indan-1-ram) -1,2,2-trimethyl-piperazine and their salts in the treatment of schizophrenia |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9610287B2 (enExample) |
| EP (1) | EP2720698B1 (enExample) |
| JP (1) | JP6140151B2 (enExample) |
| KR (1) | KR101900989B1 (enExample) |
| CN (1) | CN103608015A (enExample) |
| AU (1) | AU2012274150B2 (enExample) |
| BR (1) | BR112013032178A2 (enExample) |
| CA (1) | CA2838055C (enExample) |
| DK (1) | DK2720698T3 (enExample) |
| ES (1) | ES2694298T3 (enExample) |
| HR (1) | HRP20181684T1 (enExample) |
| IL (1) | IL230060A (enExample) |
| JO (1) | JO3421B1 (enExample) |
| LT (1) | LT2720698T (enExample) |
| MX (1) | MX349754B (enExample) |
| PL (1) | PL2720698T3 (enExample) |
| RS (1) | RS57944B1 (enExample) |
| RU (1) | RU2613177C2 (enExample) |
| SI (1) | SI2720698T1 (enExample) |
| SM (1) | SMT201800567T1 (enExample) |
| TW (1) | TWI552751B (enExample) |
| WO (1) | WO2012175531A1 (enExample) |
| ZA (1) | ZA201309617B (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| BR0015634A (pt) | 1999-11-17 | 2002-12-31 | Mendel Biotechnology Inc | Planta, polinucleotìdeo, vetor, célula, composição, polipeptìdeo, métodos para produzir uma planta e para identificar um fator que é modulado por, ou interage com, um polipeptìdeo codificado por um polinucleotìdeo, uma molécula que module a atividade ou a expressão de um polinucleotìdeo ou polipeptìdeo de interesse e uma sequência similar ou homóloga a um ou mais polinucleotìdeos e sistema integrado, meio computadorizado ou legìvel em computador |
| US6458538B1 (en) | 1999-12-14 | 2002-10-01 | Ptc Therapeutics, Inc. | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay |
| TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| AU2001286617A1 (en) | 2000-08-22 | 2002-03-04 | Luc Adam | Genes for modifying plant traits iv |
| US7045283B2 (en) | 2000-10-18 | 2006-05-16 | The Regents Of The University Of California | Methods of high-throughput screening for internalizing antibodies |
| US7883856B2 (en) | 2001-04-05 | 2011-02-08 | Senomyx Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| EP2293067B1 (en) | 2001-06-26 | 2016-04-20 | Senomyx, Inc. | T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US7871619B2 (en) | 2001-11-30 | 2011-01-18 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| EP2436774A3 (en) | 2002-08-01 | 2012-06-13 | The Regents of The University of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| WO2004016733A2 (en) | 2002-08-16 | 2004-02-26 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer |
| BR0314389A (pt) | 2002-09-18 | 2005-07-12 | Mendel Biotechnology Inc | Polinucleotìdeos e polipeptìdeos em plantas |
| EP2319524B1 (en) | 2003-05-30 | 2013-08-21 | Agensys, Inc. | Prostate stem cell antigen (PSCA) variants and subsequences thereof |
| EP1694816B1 (en) | 2003-11-07 | 2013-08-28 | Ciphergen Biosystems, Inc. | Biomarkers for alzheimer's disease |
| AU2004304665B2 (en) | 2003-12-24 | 2009-03-12 | Novo Nordisk A/S | Transgenic non-human mammal comprising a polynucleotide encoding human or humanized C5aR |
| US20050226865A1 (en) | 2004-04-02 | 2005-10-13 | Regents Of The University Of California | Methods and compositions for treating and preventing diseases associated with alphavbeta5 integrin |
| US7939251B2 (en) | 2004-05-06 | 2011-05-10 | Roche Molecular Systems, Inc. | SENP1 as a marker for cancer |
| MXPA06013834A (es) | 2004-05-28 | 2007-03-01 | Agensys Inc | Anticuerpos y moleculas relacionadas que enlazan a proteinas psca. |
| DK2453024T3 (en) | 2004-06-21 | 2018-02-12 | Univ Leland Stanford Junior | Genes and conduits that are differentially expressed in bipolar disorder and / or major depressive disorder |
| US7850960B2 (en) | 2004-12-30 | 2010-12-14 | University Of Washington | Methods for regulation of stem cells |
| JP2008528060A (ja) | 2005-01-27 | 2008-07-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ボツリヌス神経毒素を中和する治療的モノクローナル抗体 |
| EP3300739A3 (en) | 2005-03-31 | 2018-07-18 | Agensys, Inc. | Antibodies and related molecules that bind to 161p2f10b proteins |
| NZ565172A (en) | 2005-07-19 | 2012-12-21 | Stemgen S P A | Inhibition of the tumorigenic potential of tumor stem cells by LIF and BMPS |
| WO2007047988A2 (en) | 2005-10-20 | 2007-04-26 | Senomyx, Inc. | Chimeric human sweet-umami and umami-sweet taste receptors |
| UA94922C2 (ru) | 2005-11-07 | 2011-06-25 | Зе Скріпс Рісьорч Інстітьют | Способ регулирования специфичности сигнализации тканевого фактора у млекопитающего, которое нуждается в этом, способ идентификации агента, который специфически ингибирует сигнализацию тканевого фактора |
| WO2007059064A2 (en) | 2005-11-12 | 2007-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Fgf2-related methods for diagnosing and treating depression |
| US8288354B2 (en) | 2005-12-28 | 2012-10-16 | The Scripps Research Institute | Natural antisense and non-coding RNA transcripts as drug targets |
| WO2007109347A2 (en) | 2006-03-21 | 2007-09-27 | The Regents Of The University Of California | N-cadherin and ly6 e: targets for cancer diagnosis and therapy |
| US20100278821A1 (en) | 2006-03-21 | 2010-11-04 | The Regents Of The University Of California | N-cadherin: target for cancer diagnosis and therapy |
| US7572618B2 (en) | 2006-06-30 | 2009-08-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
| EP2061900A2 (en) | 2006-08-25 | 2009-05-27 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
| NZ575090A (en) | 2006-09-06 | 2012-02-24 | Univ California | Molecular diagnosis and classification of malignant melanoma using RGS1, ARPC2, FN1, SPP1 and WNT-2 polypeptide markers |
| WO2008127314A1 (en) | 2006-11-22 | 2008-10-23 | President And Fellows Of Harvard College | High-sensitivity nanoscale wire sensors |
| IN2009KN04568A (enExample) | 2007-06-01 | 2015-08-28 | Univ Princeton | |
| ES2416719T3 (es) | 2007-08-13 | 2013-08-02 | Baxter International Inc. | Modulación por IVIG de quimioquinas para el tratamiento de la esclerosis múltiple, la enfermedad de Alzheimer y la enfermedad de Parkinson |
| US7939671B2 (en) | 2007-08-21 | 2011-05-10 | Senomyx, Inc. | Compounds that inhibit (block) bitter taste in composition and use thereof |
| CA2971794C (en) | 2007-10-04 | 2020-03-24 | Zymogenetics, Inc. | B7 family member zb7h6 and related compositions and methods |
| EP2924435A3 (en) | 2007-10-22 | 2015-11-04 | The Regents of The University of California | Biomarkers for prenatal diagnosis of congenital cytomegalovirus |
| WO2010008411A1 (en) | 2007-11-09 | 2010-01-21 | The Salk Institute For Biological Studies | Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors |
| SG10202103401QA (en) | 2008-03-17 | 2021-05-28 | Scripps Research Inst | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| EP2268654B1 (en) | 2008-04-21 | 2017-01-25 | The Regents Of The University Of California | Selective high-affinity polydentate ligands and methods of making such |
| US20110262485A1 (en) | 2008-08-04 | 2011-10-27 | University Of Miami | Sting (stimulator of interferon genes), a regulator of innate immune responses |
| US20110287026A1 (en) | 2008-09-23 | 2011-11-24 | President And Fellows Of Harvard College | Sirt4 and uses thereof |
| WO2010054189A1 (en) | 2008-11-06 | 2010-05-14 | University Of Miami | Role of soluble upar in the pathogenesis of proteinuric kidney disease |
| EP2352847B1 (en) | 2008-11-10 | 2014-01-08 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Gene signature for predicting prognosis of patients with solid tumors |
| CA3128456A1 (en) | 2008-12-03 | 2010-06-10 | The Scripps Research Institute | Compounds and methods for stabilizing cell cultures |
| CA2747398C (en) | 2008-12-17 | 2023-06-20 | The Scripps Research Institute | Generation and maintenance of stem cells |
| DK2411410T3 (en) | 2009-03-27 | 2015-09-07 | Gojo Ind Inc | Compositions and methods for screening and use of compounds which counteract the track-surface interactions |
| JP5755647B2 (ja) | 2009-07-24 | 2015-07-29 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | αｖβ５インテグリンに関連する疾患の処置および予防のための方法および組成物 |
| CN105911275B (zh) | 2009-08-14 | 2018-06-29 | 加利福尼亚大学董事会 | 诊断自闭症的试剂盒 |
| US20120148604A1 (en) | 2009-08-20 | 2012-06-14 | Transposagen Biopharmaceuticals, Inc. | Trp inhibitors and uses thereof |
| US9297796B2 (en) | 2009-09-24 | 2016-03-29 | President And Fellows Of Harvard College | Bent nanowires and related probing of species |
| ES2365343B1 (es) | 2009-11-19 | 2012-07-10 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de cd98 como marcador de receptividad endometrial. |
| US20130137584A1 (en) | 2010-02-01 | 2013-05-30 | The Regents Of The University Of California | Novel diagnostic and therapeutic targets associated with or regulated by n-cadherin expression and/or epithelial to mesenchymal transition (emt) in prostate cancer and other malignancies |
| WO2012052391A1 (en) | 2010-10-19 | 2012-04-26 | Glaxo Group Limited | Polypeptide with jmjd3 catalytic activity |
| WO2012109495A1 (en) | 2011-02-09 | 2012-08-16 | Metabolic Solutions Development Company, Llc | Cellular targets of thiazolidinediones |
| WO2012119989A2 (en) | 2011-03-04 | 2012-09-13 | Oryzon Genomics, S.A. | Methods and antibodies for the diagnosis and treatment of cancer |
| US20120301904A1 (en) | 2011-04-26 | 2012-11-29 | Prosetta Antiviral, Inc | Multiprotein assemblies |
| US9408832B2 (en) | 2012-03-14 | 2016-08-09 | University Of Central Florida Research Foundation, Inc. | LIM kinasemodulating agents for neurofibromatoses therapy and methods for screening for same |
| EP2836482B1 (en) | 2012-04-10 | 2019-12-25 | The Regents of The University of California | Compositions and methods for treating cancer |
| JP2015516400A (ja) | 2012-04-24 | 2015-06-11 | ユニバーシティー オブ マイアミＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉａｍｉ | 侵襲的かつ多剤耐性の病原体に対するパーフォリン２の防御 |
| US20150164800A1 (en) | 2012-07-25 | 2015-06-18 | Xetrios Therapeutics, Inc. | Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidyl serine |
| EP2890370B1 (en) | 2012-08-31 | 2019-10-09 | The Regents of the University of California | Agents useful for treating obesity, diabetes and related disorders |
| AU2013204200B2 (en) | 2012-10-11 | 2016-10-20 | Brandeis University | Treatment of amyotrophic lateral sclerosis |
| US20140120116A1 (en) | 2012-10-26 | 2014-05-01 | The Chinese University Of Hong Kong | Treatment of cancer using smad3 inhibitor |
| US20140243356A1 (en) | 2013-02-07 | 2014-08-28 | The Regents Of The University Of California | Use of translational profiling to identify target molecules for therapeutic treatment |
| WO2014144844A1 (en) | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | tRNA DERIVED SMALL RNAs (tsRNAs) INVOLVED IN CELL VIABILITY |
| US10919929B2 (en) | 2013-12-11 | 2021-02-16 | Sloan-Kettering Institute For Cancer Research | Glucocorticoid inhibitors for treatment of prostate cancer |
| US10280169B2 (en) | 2013-12-11 | 2019-05-07 | Biogen Ma Inc. | Biaryl bruton's tyrosine kinase inhibitors |
| WO2015136509A2 (en) | 2014-03-14 | 2015-09-17 | Genesis Theranostix Korlatolt Felelossegu Tarsasag | Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy |
| US10196701B2 (en) | 2015-06-01 | 2019-02-05 | The Penn State Research Foundation | Hepatitis B virus capsid assembly |
| EP3314260B1 (en) | 2015-06-24 | 2021-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for detecting protein-protein interactions |
| WO2018036503A1 (en) | 2016-08-25 | 2018-03-01 | The Chinese University Of Hong Kong | Fecal bacterial markers for colorectal cancer |
| RU2019121922A (ru) | 2016-12-15 | 2021-01-18 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Композиции и способы лечения рака |
| EP3601326A4 (en) | 2017-03-20 | 2020-12-16 | The Broad Institute, Inc. | COMPOUNDS AND METHODS OF REGULATING INSULIN SECRETION |
| EP3606548A4 (en) | 2017-04-04 | 2021-03-24 | Loma Linda University | BIOLOGICAL PREPARATION FOR TREATMENT OF CANCER |
| WO2019207587A1 (en) | 2018-04-26 | 2019-10-31 | Technion Research & Development Foundation Limited | A device and a method for determining cell indentation activity |
| US20210395751A1 (en) | 2018-10-31 | 2021-12-23 | The University Of Sydney | Compositions and methods for treating viral infections |
| US11325978B2 (en) | 2018-11-06 | 2022-05-10 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for treating beta-globinopathies |
| EP4247427A4 (en) | 2020-11-19 | 2025-04-09 | The Chinese University of Hong Kong | Assessing risk for colorectal adenoma recurrence by noninvasive means |
| WO2023081167A2 (en) | 2021-11-02 | 2023-05-11 | The Regents Of The University Of California | P-selectin mutants and modulation of integrin-mediated signaling |
| WO2023146807A1 (en) | 2022-01-25 | 2023-08-03 | The Regents Of The University Of California | Vegf mutants and modulation of integrin-mediated signaling |
| WO2024197185A1 (en) | 2023-03-21 | 2024-09-26 | The Broad Institute, Inc. | Methods and compositions for dissecting organelle physiology |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK55192D0 (da) | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
| AU2004265021B2 (en) | 2003-08-18 | 2010-05-27 | H. Lundbeck A/S | Succinate and malonate salt of trans-4-(IR,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament |
| KR20070014184A (ko) | 2004-04-22 | 2007-01-31 | 베링거 인겔하임 인터내셔날 게엠베하 | 성기능 장애 치료용 신규 약제학적 조성물 ⅱ |
| KR101283946B1 (ko) * | 2005-07-18 | 2013-07-15 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 약물 함유 임플란트 및 그의 사용 방법 |
| CA2722374A1 (en) * | 2008-05-07 | 2009-11-12 | H. Lundbeck A/S | Method for treating cognitive deficits |
| BRPI0919165A2 (pt) * | 2008-10-03 | 2015-12-08 | Lundbeck & Co As H | composição farmacêutica,e, uso de um composto |
| EP2453870A2 (en) * | 2009-06-24 | 2012-05-23 | MSD Oss B.V. | Injectable formulations containing asenapine and method of treatment using same |
-
2012
- 2012-06-19 TW TW101121870A patent/TWI552751B/zh not_active IP Right Cessation
- 2012-06-19 JO JOP/2012/0162A patent/JO3421B1/ar active
- 2012-06-20 BR BR112013032178A patent/BR112013032178A2/pt not_active Application Discontinuation
- 2012-06-20 WO PCT/EP2012/061779 patent/WO2012175531A1/en not_active Ceased
- 2012-06-20 RU RU2014101482A patent/RU2613177C2/ru active
- 2012-06-20 MX MX2013014978A patent/MX349754B/es active IP Right Grant
- 2012-06-20 PL PL12729555T patent/PL2720698T3/pl unknown
- 2012-06-20 EP EP12729555.8A patent/EP2720698B1/en active Active
- 2012-06-20 HR HRP20181684TT patent/HRP20181684T1/hr unknown
- 2012-06-20 CN CN201280029452.1A patent/CN103608015A/zh active Pending
- 2012-06-20 SM SM20180567T patent/SMT201800567T1/it unknown
- 2012-06-20 US US14/126,499 patent/US9610287B2/en active Active
- 2012-06-20 DK DK12729555.8T patent/DK2720698T3/en active
- 2012-06-20 AU AU2012274150A patent/AU2012274150B2/en not_active Ceased
- 2012-06-20 RS RS20181311A patent/RS57944B1/sr unknown
- 2012-06-20 KR KR1020137033338A patent/KR101900989B1/ko not_active Expired - Fee Related
- 2012-06-20 ES ES12729555.8T patent/ES2694298T3/es active Active
- 2012-06-20 SI SI201231436T patent/SI2720698T1/sl unknown
- 2012-06-20 LT LTEP12729555.8T patent/LT2720698T/lt unknown
- 2012-06-20 JP JP2014516318A patent/JP6140151B2/ja active Active
- 2012-06-20 CA CA2838055A patent/CA2838055C/en not_active Expired - Fee Related
-
2013
- 2013-12-19 ZA ZA2013/09617A patent/ZA201309617B/en unknown
- 2013-12-19 IL IL230060A patent/IL230060A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PL2720698T3 (pl) | 2019-01-31 |
| CN103608015A (zh) | 2014-02-26 |
| KR20140033419A (ko) | 2014-03-18 |
| AU2012274150B2 (en) | 2016-10-06 |
| EP2720698B1 (en) | 2018-10-03 |
| ES2694298T3 (es) | 2018-12-19 |
| LT2720698T (lt) | 2018-11-12 |
| JP2014517050A (ja) | 2014-07-17 |
| SI2720698T1 (sl) | 2018-12-31 |
| EP2720698A1 (en) | 2014-04-23 |
| TWI552751B (zh) | 2016-10-11 |
| RU2014101482A (ru) | 2015-07-27 |
| DK2720698T3 (en) | 2018-11-26 |
| JO3421B1 (ar) | 2019-10-20 |
| SMT201800567T1 (it) | 2018-11-09 |
| JP6140151B2 (ja) | 2017-05-31 |
| TW201306840A (zh) | 2013-02-16 |
| WO2012175531A1 (en) | 2012-12-27 |
| AU2012274150A1 (en) | 2014-01-09 |
| US9610287B2 (en) | 2017-04-04 |
| KR101900989B1 (ko) | 2018-09-20 |
| RU2613177C2 (ru) | 2017-03-15 |
| MX349754B (es) | 2017-08-11 |
| BR112013032178A2 (pt) | 2016-12-20 |
| CA2838055A1 (en) | 2012-12-27 |
| US20140194409A1 (en) | 2014-07-10 |
| MX2013014978A (es) | 2014-04-10 |
| HRP20181684T1 (hr) | 2018-12-14 |
| ZA201309617B (en) | 2015-04-29 |
| CA2838055C (en) | 2021-01-26 |
| RS57944B1 (sr) | 2019-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2838055C (en) | Use of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperaz ine and the salts thereof in the treatment of psychosis | |
| Miyamoto et al. | Antipsychotic drugs | |
| Fernandez et al. | Treatment of psychosis in Parkinson’s disease: safety considerations | |
| Tarsy et al. | Effects of newer antipsychotics on extrapyramidal function | |
| TWI643620B (zh) | 用於預防或治療與神經退化性疾病相關之行爲及心理症狀或與精神病相關之衝動症狀而含有普瑞斯哌唑（Ｂｒｅｘｐｉｐｒａｚｏｌｅ）或其鹽之藥劑 | |
| Bhana et al. | Risperidone: a review of its use in the management of the behavioural and psychological symptoms of dementia | |
| Schmidt et al. | A double-blind, randomized, placebo-controlled study with JNJ-37822681, a novel, highly selective, fast dissociating D2 receptor antagonist in the treatment of acute exacerbation of schizophrenia | |
| CN103068388A (zh) | Glyt1化合物与抗精神病药的组合 | |
| Stahl | Prescriber's guide: Antidepressants: Stahl's essential psychopharmacology | |
| CN112955219A (zh) | 鲁潘立酮治疗阴性症状和病症、增加神经可塑性和促进神经保护的用途 | |
| Daniel et al. | Ziprasidone: comprehensive overview and clinical use of a novel antipsychotic | |
| Hadryś et al. | Amisulpride–is it as all other medicines or is it different? An update | |
| Mittur | Trazodone: properties and utility in multiple disorders | |
| Meltzer et al. | Asenapine | |
| Madhusoodanan et al. | Use of olanzapine for elderly patients with psychotic disorders: a review | |
| McIntyre | Asenapine: a review of acute and extension phase data in bipolar disorder | |
| HK1196083A (en) | Method of administration of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia | |
| HK1196083B (en) | Method of administration of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia | |
| Masand | Clinical effectiveness of atypical antipsychotics in elderly patients with psychosis | |
| Singh et al. | An overview on asenapine maleate: PK-PD, preclinical and clinical update | |
| Sánchez et al. | Preclinical effects of antipsychotic drugs | |
| Kuperberg et al. | Developments in the pharmacological treatment of schizophrenia | |
| Behere et al. | Antipsychotics | |
| Madhusoodanan | Treatment of Schizophrenia and Psychoses in Older Adults: Psychopharmacological | |
| Canan | Novel Antipsychotic Drugs Approved in 2015: Brexpiprazole, Cariprazine, Aripiprazole Lauroxil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |