JP2011520981A5 - - Google Patents

Info

Publication number

JP2011520981A5

JP2011520981A5 JP2011510712A JP2011510712A JP2011520981A5 JP 2011520981 A5 JP2011520981 A5 JP 2011520981A5 JP 2011510712 A JP2011510712 A JP 2011510712A JP 2011510712 A JP2011510712 A JP 2011510712A JP 2011520981 A5 JP2011520981 A5 JP 2011520981A5

Authority

JP

Japan

Prior art keywords

agents

use according

leptin

composition

inflammatory drug

Prior art date

2009-05-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 14
• 102000016267 Leptin Human genes 0.000 claims 12
• 108010092277 Leptin Proteins 0.000 claims 12
• 229940039781 leptin Drugs 0.000 claims 12
• 239000000203 mixture Substances 0.000 claims 9
• 239000002260 anti-inflammatory agent Substances 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 8
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 229940124597 therapeutic agent Drugs 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 5
• 238000009825 accumulation Methods 0.000 claims 4
• 239000003242 anti bacterial agent Substances 0.000 claims 4
• 210000004556 brain Anatomy 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 208000015122 neurodegenerative disease Diseases 0.000 claims 4
• 230000026731 phosphorylation Effects 0.000 claims 4
• 238000006366 phosphorylation reaction Methods 0.000 claims 4
• 230000001225 therapeutic effect Effects 0.000 claims 4
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 239000000556 agonist Substances 0.000 claims 2
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• 239000000739 antihistaminic agent Substances 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 239000003963 antioxidant agent Substances 0.000 claims 2
• 239000003904 antiprotozoal agent Substances 0.000 claims 2
• 239000003443 antiviral agent Substances 0.000 claims 2
• 230000037396 body weight Effects 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 229940088597 hormone Drugs 0.000 claims 2
• 239000005556 hormone Substances 0.000 claims 2
• 230000006951 hyperphosphorylation Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 210000002682 neurofibrillary tangle Anatomy 0.000 claims 2
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
• 230000003637 steroidlike Effects 0.000 claims 2
• 239000011782 vitamin Substances 0.000 claims 2
• 229940088594 vitamin Drugs 0.000 claims 2
• 229930003231 vitamin Natural products 0.000 claims 2
• 235000013343 vitamin Nutrition 0.000 claims 2
• 150000003722 vitamin derivatives Chemical class 0.000 claims 2
• 102000014156 AMP-Activated Protein Kinases Human genes 0.000 claims 1
• 108010011376 AMP-Activated Protein Kinases Proteins 0.000 claims 1
• 102000001253 Protein Kinase Human genes 0.000 claims 1
• 239000012190 activator Substances 0.000 claims 1
• 230000003920 cognitive function Effects 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 230000006866 deterioration Effects 0.000 claims 1
• 230000006870 function Effects 0.000 claims 1
• 230000003340 mental effect Effects 0.000 claims 1
• 230000003924 mental process Effects 0.000 claims 1
• 230000006996 mental state Effects 0.000 claims 1
• 230000003278 mimic effect Effects 0.000 claims 1
• 230000004112 neuroprotection Effects 0.000 claims 1
• 230000008447 perception Effects 0.000 claims 1
• 108060006633 protein kinase Proteins 0.000 claims 1