JP2012502105A5 - - Google Patents
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- Publication number
- JP2012502105A5 JP2012502105A5 JP2011526972A JP2011526972A JP2012502105A5 JP 2012502105 A5 JP2012502105 A5 JP 2012502105A5 JP 2011526972 A JP2011526972 A JP 2011526972A JP 2011526972 A JP2011526972 A JP 2011526972A JP 2012502105 A5 JP2012502105 A5 JP 2012502105A5
- Authority
- JP
- Japan
- Prior art keywords
- iloperidone
- patient
- cyp2d6
- disorder
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XMXHEBAFVSFQEX-UHFFFAOYSA-N iloperidone Chemical compound COC1=CC(C(C)=O)=CC=C1OCCCN1CCC(C=2C3=CC=C(F)C=C3ON=2)CC1 XMXHEBAFVSFQEX-UHFFFAOYSA-N 0.000 claims 18
- 229960003162 iloperidone Drugs 0.000 claims 18
- 238000000034 method Methods 0.000 claims 8
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 7
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 7
- 208000020016 psychiatric disease Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 108700028369 Alleles Proteins 0.000 claims 4
- -1 P88 Chemical compound 0.000 claims 4
- 239000008186 active pharmaceutical agent Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002503 metabolic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000024254 Delusional disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 208000025307 bipolar depression Diseases 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 208000002851 paranoid schizophrenia Diseases 0.000 claims 1
- 208000022610 schizoaffective disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/208,027 | 2008-09-10 | ||
| US12/208,027 US20100063093A1 (en) | 2007-03-28 | 2008-09-10 | Methods for the administration of iloperidone |
| PCT/US2009/056517 WO2010030783A1 (en) | 2008-09-10 | 2009-09-10 | Methods for the administration of iloperidone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012502105A JP2012502105A (ja) | 2012-01-26 |
| JP2012502105A5 true JP2012502105A5 (enExample) | 2012-11-01 |
Family
ID=41280442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011526972A Pending JP2012502105A (ja) | 2008-09-10 | 2009-09-10 | イロペリドンの投与方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20100063093A1 (enExample) |
| EP (2) | EP2331098B1 (enExample) |
| JP (1) | JP2012502105A (enExample) |
| AU (1) | AU2009291717A1 (enExample) |
| CA (1) | CA2736245C (enExample) |
| ES (1) | ES2688476T3 (enExample) |
| SI (1) | SI2331098T1 (enExample) |
| WO (1) | WO2010030783A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1799865B1 (en) | 2004-09-30 | 2012-06-06 | Vanda Pharmaceuticals Inc. | Methods for the administration of iloperidone |
| US20100063093A1 (en) * | 2007-03-28 | 2010-03-11 | Curt Wolfgang | Methods for the administration of iloperidone |
| CA2865845C (en) * | 2012-03-14 | 2020-02-18 | Vanda Pharmaceuticals Inc. | An iloperidone metabolite for use in the treatment of psychiatric disorders |
| CA2976383C (en) * | 2015-02-17 | 2023-05-23 | Vanda Pharmaceuticals Inc. | Iloperidone for the treatment of schizophrenia |
| US11214827B2 (en) * | 2018-08-30 | 2022-01-04 | Vanda Pharmaceuticals Inc. | Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5130238A (en) * | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| GB9001181D0 (en) * | 1990-01-18 | 1990-03-21 | Imp Cancer Res Tech | Genetic assay |
| US5846717A (en) * | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| WO2000055624A2 (en) | 1999-03-15 | 2000-09-21 | Leyland Jones Brian | Elisa kit for the determination of metabolic phenotypes |
| PL359022A1 (en) | 1999-04-07 | 2004-08-23 | Pfizer Products Inc. | Use of cyp2d6 inhibitors in combination therapies |
| US20010034023A1 (en) * | 1999-04-26 | 2001-10-25 | Stanton Vincent P. | Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing |
| US6960439B2 (en) * | 1999-06-28 | 2005-11-01 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| US7250252B2 (en) | 1999-12-30 | 2007-07-31 | David Aaron Katz | Amplification based polymorphism detection |
| DE60131970T2 (de) | 2000-04-13 | 2008-12-11 | Georgetown University | Genetische diagnose zur feststellung von qt-verlängerungen als unerwünschte reaktion auf arzneimittel |
| US6761895B2 (en) * | 2000-04-17 | 2004-07-13 | Yamanouchi Pharmaceutical Co., Ltd. | Drug delivery system for averting pharmacokinetic drug interaction and method thereof |
| WO2001096604A2 (en) * | 2000-06-12 | 2001-12-20 | Genicon Sciences Corporation | Assay for genetic polymorphisms using scattered light detectable labels |
| US20020022254A1 (en) | 2000-07-28 | 2002-02-21 | Karl Guegler | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
| EP1364334A2 (en) | 2000-11-30 | 2003-11-26 | Third Wave Technologies, Inc. | Systems and method for detection assay production and sale |
| GB0102841D0 (en) | 2001-02-05 | 2001-03-21 | Novartis Ag | Organic compounds |
| WO2002073196A2 (en) * | 2001-03-14 | 2002-09-19 | Mcgill University | Individualization of therapy with antipsychotics |
| US20030170651A1 (en) | 2001-06-05 | 2003-09-11 | Marco Guida | Method of identifying a polymorphism in CYP2D6 |
| WO2004009760A2 (en) | 2002-07-18 | 2004-01-29 | Bioventures, Inc. | Cytochrome p450 genetic variations |
| US7195877B2 (en) * | 2001-07-20 | 2007-03-27 | Bioventures, Inc. | Cytochrome P450 genetic variations |
| EP1281755A3 (en) * | 2001-07-31 | 2003-06-18 | Pfizer Products Inc. | Variants of the human cyp2d6 gene |
| EP1425030A2 (en) | 2001-08-24 | 2004-06-09 | Aryx Therapeutics | Non-oxidatively metabolized compounds and compositions, synthetic pathways therefor, and uses thereof |
| ES2398434T3 (es) | 2001-08-31 | 2013-03-19 | Novartis Ag | Isómeros ópticos de un metabolito de iloperidona |
| ES2358416T3 (es) * | 2001-10-30 | 2011-05-10 | Novartis Ag | Formulaciones de liberación prolongada de iloperidona y polímero en forma de estrella. |
| WO2003038123A2 (en) | 2001-10-31 | 2003-05-08 | Novartis Ag | Methods to treat diabetes and related conditions based on polymorphisms in the tcf1 gene |
| ATE503845T1 (de) | 2001-12-10 | 2011-04-15 | Novartis Pharma Gmbh | Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen |
| US20040096874A1 (en) * | 2002-04-11 | 2004-05-20 | Third Wave Technologies, Inc. | Characterization of CYP 2D6 genotypes |
| US20040091909A1 (en) * | 2002-07-05 | 2004-05-13 | Huang Doug Hui | High throughput cytochrome P450 genotyping |
| GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
| WO2004074456A2 (en) | 2003-02-20 | 2004-09-02 | Mayo Foundation For Medical Education And Research | Methods for selecting medications |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US20050032070A1 (en) * | 2003-08-05 | 2005-02-10 | Sebastian Raimundo | Polymorphisms in the human gene for CYP2D6 and their use in diagnostic and therapeutic applications |
| US20080166357A1 (en) * | 2004-05-11 | 2008-07-10 | Stefan Golz | Diagnostics and Therapeutics for Diseases Associated with Dipeptidyl-Peptidase 6 (Dpp6) |
| US20100063093A1 (en) * | 2007-03-28 | 2010-03-11 | Curt Wolfgang | Methods for the administration of iloperidone |
| EP1799865B1 (en) | 2004-09-30 | 2012-06-06 | Vanda Pharmaceuticals Inc. | Methods for the administration of iloperidone |
| US20150259747A1 (en) | 2007-03-29 | 2015-09-17 | Vanda Pharmaceuticals Inc. | Method of predicting a predisposition to qt prolongation |
| WO2008121899A2 (en) * | 2007-03-29 | 2008-10-09 | Vanda Pharmaceuticals Inc. | Method of predicting a predisposition to qt prolongation |
| EP3075865B1 (en) | 2007-05-18 | 2018-05-09 | Vanda Pharmaceuticals Inc. | Genetic markers for efficacy of iloperidone in the treatment of psychotic symptoms |
| US8652776B2 (en) | 2007-09-10 | 2014-02-18 | Vanda Pharmaceuticals, Inc. | Prediction of QT prolongation based on SNP genotype |
| JP5535914B2 (ja) | 2007-09-10 | 2014-07-02 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Ｓｎｐ遺伝子型に基づく抗精神病薬治療 |
| ES2604102T3 (es) | 2009-04-06 | 2017-03-03 | Vanda Pharmaceuticals Inc. | Método de tratamiento basado en polimorfismos del gen KCNQ1 |
| WO2010117941A1 (en) | 2009-04-06 | 2010-10-14 | Vanda Pharmaceuticals, Inc. | Method of predicting a predisposition to qt prolongation based on abcc2 gene sequence or product thereof |
| EP2416779B1 (en) | 2009-04-06 | 2016-03-09 | Vanda Pharmaceuticals Inc. | Method of predicting a predisposition to qt prolongation based on bai3 gene sequence or product thereof |
| JP5881597B2 (ja) | 2009-04-06 | 2016-03-09 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Ｑｔ延長に対する素因を予測する方法 |
| JP2012526562A (ja) | 2009-05-15 | 2012-11-01 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Ｄｒｄ２又はａｎｋｋ１のｓｎｐ遺伝子型に基づく抗精神病治療 |
| CA2865845C (en) | 2012-03-14 | 2020-02-18 | Vanda Pharmaceuticals Inc. | An iloperidone metabolite for use in the treatment of psychiatric disorders |
| US11071728B2 (en) | 2015-12-11 | 2021-07-27 | Vanda Pharmaceuticals Inc. | Treatment of schizophrenia |
| US11214827B2 (en) | 2018-08-30 | 2022-01-04 | Vanda Pharmaceuticals Inc. | Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone |
| US11607408B2 (en) | 2019-10-15 | 2023-03-21 | Vanda Pharmaceuticals Inc. | Method of treatment of schizophrenia |
-
2008
- 2008-09-10 US US12/208,027 patent/US20100063093A1/en not_active Abandoned
-
2009
- 2009-09-10 ES ES09792421.1T patent/ES2688476T3/es active Active
- 2009-09-10 EP EP09792421.1A patent/EP2331098B1/en active Active
- 2009-09-10 AU AU2009291717A patent/AU2009291717A1/en not_active Abandoned
- 2009-09-10 JP JP2011526972A patent/JP2012502105A/ja active Pending
- 2009-09-10 CA CA2736245A patent/CA2736245C/en active Active
- 2009-09-10 WO PCT/US2009/056517 patent/WO2010030783A1/en not_active Ceased
- 2009-09-10 EP EP18187366.2A patent/EP3492081A1/en not_active Withdrawn
- 2009-09-10 SI SI200931877T patent/SI2331098T1/sl unknown
-
2013
- 2013-10-02 US US14/044,183 patent/US20140039008A1/en not_active Abandoned
-
2015
- 2015-09-08 US US14/847,784 patent/US20160053324A1/en not_active Abandoned
-
2019
- 2019-05-08 US US16/406,229 patent/US20190360047A1/en not_active Abandoned
-
2022
- 2022-04-08 US US17/716,968 patent/US12606869B2/en active Active
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