JP2014528474A5 - - Google Patents
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- Publication number
- JP2014528474A5 JP2014528474A5 JP2014535738A JP2014535738A JP2014528474A5 JP 2014528474 A5 JP2014528474 A5 JP 2014528474A5 JP 2014535738 A JP2014535738 A JP 2014535738A JP 2014535738 A JP2014535738 A JP 2014535738A JP 2014528474 A5 JP2014528474 A5 JP 2014528474A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- dexmedetomidine
- composition according
- pediatric patient
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 claims description 25
- 229960004253 dexmedetomidine Drugs 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 21
- 208000028389 Nerve injury Diseases 0.000 claims description 6
- 230000008764 nerve damage Effects 0.000 claims description 6
- 206010039897 Sedation Diseases 0.000 claims description 5
- 230000036592 analgesia Effects 0.000 claims description 5
- 230000036280 sedation Effects 0.000 claims description 5
- 238000001356 surgical procedure Methods 0.000 claims description 5
- 238000001802 infusion Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 230000002612 cardiopulmonary effect Effects 0.000 claims description 2
- 230000001054 cortical effect Effects 0.000 claims description 2
- 230000007850 degeneration Effects 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 239000000932 sedative agent Substances 0.000 claims description 2
- 230000001624 sedative effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547626P | 2011-10-14 | 2011-10-14 | |
| US61/547,626 | 2011-10-14 | ||
| US13/343,693 US20130096170A1 (en) | 2011-10-14 | 2012-01-04 | Methods of treating pediatric patients using dexmedetomidine |
| US13/343,693 | 2012-01-04 | ||
| US13/471,403 | 2012-05-14 | ||
| US13/471,403 US8324260B1 (en) | 2011-10-14 | 2012-05-14 | Methods of treating pediatric patients using dexmedetomidine |
| PCT/US2012/057652 WO2013055528A1 (en) | 2011-10-14 | 2012-09-27 | Methods of treating pediatric patients using dexmedetomidine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017189989A Division JP6640164B2 (ja) | 2011-10-14 | 2017-09-29 | デクスメデトミジンを用いて小児患者を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528474A JP2014528474A (ja) | 2014-10-27 |
| JP2014528474A5 true JP2014528474A5 (enExample) | 2015-11-12 |
| JP6270727B2 JP6270727B2 (ja) | 2018-01-31 |
Family
ID=47226666
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535738A Active JP6270727B2 (ja) | 2011-10-14 | 2012-09-27 | デクスメデトミジンを用いて小児患者を治療する方法 |
| JP2017189989A Active JP6640164B2 (ja) | 2011-10-14 | 2017-09-29 | デクスメデトミジンを用いて小児患者を治療する方法 |
| JP2019234042A Pending JP2020073529A (ja) | 2011-10-14 | 2019-12-25 | デクスメデトミジンを用いて小児患者を治療する方法 |
| JP2021163378A Withdrawn JP2022008828A (ja) | 2011-10-14 | 2021-10-04 | デクスメデトミジンを用いて小児患者を治療する方法 |
| JP2023181585A Pending JP2023179764A (ja) | 2011-10-14 | 2023-10-23 | デクスメデトミジンを用いて小児患者を治療する方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017189989A Active JP6640164B2 (ja) | 2011-10-14 | 2017-09-29 | デクスメデトミジンを用いて小児患者を治療する方法 |
| JP2019234042A Pending JP2020073529A (ja) | 2011-10-14 | 2019-12-25 | デクスメデトミジンを用いて小児患者を治療する方法 |
| JP2021163378A Withdrawn JP2022008828A (ja) | 2011-10-14 | 2021-10-04 | デクスメデトミジンを用いて小児患者を治療する方法 |
| JP2023181585A Pending JP2023179764A (ja) | 2011-10-14 | 2023-10-23 | デクスメデトミジンを用いて小児患者を治療する方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US20130096170A1 (enExample) |
| EP (2) | EP2766014B1 (enExample) |
| JP (5) | JP6270727B2 (enExample) |
| KR (3) | KR20200019791A (enExample) |
| CN (2) | CN103957906A (enExample) |
| AU (3) | AU2012321246C1 (enExample) |
| BR (1) | BR112014008983A2 (enExample) |
| CA (2) | CA2978258A1 (enExample) |
| CY (1) | CY1121041T1 (enExample) |
| DK (1) | DK2766014T3 (enExample) |
| ES (1) | ES2685814T3 (enExample) |
| HK (1) | HK1200333A1 (enExample) |
| HR (1) | HRP20181378T1 (enExample) |
| HU (1) | HUE039671T2 (enExample) |
| IL (2) | IL232070A0 (enExample) |
| IN (1) | IN2014KN00996A (enExample) |
| LT (1) | LT2766014T (enExample) |
| MX (1) | MX362626B (enExample) |
| PL (1) | PL2766014T3 (enExample) |
| PT (1) | PT2766014T (enExample) |
| RS (1) | RS57660B1 (enExample) |
| SI (1) | SI2766014T1 (enExample) |
| WO (1) | WO2013055528A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130096170A1 (en) | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
| US8242158B1 (en) * | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
| EP3054931B1 (en) * | 2013-10-07 | 2020-12-23 | Teikoku Pharma USA, Inc. | Transdermal delivery device for managing pain comprising dexmedetomidine transdermal compositions |
| WO2015054061A1 (en) * | 2013-10-07 | 2015-04-16 | Teikoku Pharma Usa, Inc. | Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine |
| KR101827980B1 (ko) | 2013-10-07 | 2018-02-13 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법 |
| US20150098997A1 (en) | 2013-10-07 | 2015-04-09 | Teikoku Pharma Usa, Inc. | Methods and Compositions for Treating Attention Deficit Hyperactivity Disorder, Anxiety and Insomnia Using Dexmedetomidine Transdermal Compositions |
| US11017330B2 (en) * | 2014-05-20 | 2021-05-25 | Elasticsearch B.V. | Method and system for analysing data |
| JP6657216B2 (ja) * | 2014-08-18 | 2020-03-04 | エレクトロニック、ペイン、アセスメント、テクノロジーズ、（イーピーエイティー）、プロプライエタリー、リミテッドＥｌｅｃｔｒｏｎｉｃ Ｐａｉｎ Ａｓｓｅｓｓｍｅｎｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ （Ｅｐａｔ） Ｐｔｙ Ｌｔｄ | 疼痛評価方法及びシステム |
| CN104784174A (zh) * | 2015-03-06 | 2015-07-22 | 北京大学第一医院 | 右美托咪定的药物新用途 |
| US9717796B1 (en) * | 2016-04-20 | 2017-08-01 | Slypharma, Llc | Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container |
| KR20230048156A (ko) * | 2016-10-31 | 2023-04-10 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법 |
| CN106539778A (zh) * | 2016-12-08 | 2017-03-29 | 武汉大学 | 一种小儿麻醉术前含服口腔泡腾片及其制备方法 |
| US11839604B2 (en) | 2016-12-31 | 2023-12-12 | Bioxcel Therapeutics, Inc. | Use of sublingual dexmedetomidine for the treatment of agitation |
| US11783046B2 (en) | 2017-04-26 | 2023-10-10 | Elasticsearch B.V. | Anomaly and causation detection in computing environments |
| US11621969B2 (en) | 2017-04-26 | 2023-04-04 | Elasticsearch B.V. | Clustering and outlier detection in anomaly and causation detection for computing environments |
| CN108042533B (zh) * | 2017-12-25 | 2020-11-13 | 苏州格兰科医药科技有限公司 | 右美托米定在制备用于预防和/或抑制创伤性脑损伤后的神经元死亡的药物组合物中的用途 |
| WO2020006119A1 (en) * | 2018-06-27 | 2020-01-02 | Bioxcel Therapeutics, Inc. | Methods for treating agitation using dexmedetomidine hydrochloride |
| PT3813802T (pt) | 2018-06-27 | 2025-01-15 | Arx Llc | Formulações de películas contendo dexmedetomidina e métodos de produção das mesmas |
| EP3849530A4 (en) * | 2018-09-12 | 2022-06-22 | Hough Ear Institute | Methods for treating hearing loss incident to cochlear implant surgery |
| EP3849532A4 (en) * | 2018-09-13 | 2022-06-08 | Taiwan Liposome Company, Ltd. | SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A SEDATIVE MEDICINE AND THEIR USES |
| CA3123033A1 (en) * | 2018-12-13 | 2020-06-18 | Dignity Health | System and method for detection and monitoring of over sedation to prevent harm to patients |
| US10817669B2 (en) | 2019-01-14 | 2020-10-27 | International Business Machines Corporation | Automatic classification of adverse event text fragments |
| CN109793709A (zh) * | 2019-02-22 | 2019-05-24 | 青岛农业大学 | 一种斑海豹用复方注射剂及其制备方法 |
| US11000488B2 (en) * | 2019-03-22 | 2021-05-11 | Syntrix Biosystems Inc. | Treating pain using desmetramadol |
| WO2021016112A2 (en) | 2019-07-19 | 2021-01-28 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| WO2021211507A1 (en) * | 2020-04-17 | 2021-10-21 | Bioventures, Llc | Methods and systems for predicting the effect of inhaled and infused anesthetics |
| KR102815903B1 (ko) | 2021-12-21 | 2025-05-30 | 충남대학교산학협력단 | 감염 환자에서 반코마이신 최적 용량을 결정하는 방법 |
| EP4386768A1 (en) * | 2022-12-13 | 2024-06-19 | Koninklijke Philips N.V. | Active sleep apnea case finding and scheduling system and method of operation thereof |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| WO2025176701A1 (en) * | 2024-02-19 | 2025-08-28 | Rigshospitalet | Novel pediatric composition of nasal dexmedetomidine |
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| US4407957A (en) | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
| JPS6058890A (ja) | 1983-09-13 | 1985-04-05 | Mizusawa Ind Chem Ltd | 感熱記録紙用填剤 |
| FI844786A0 (fi) | 1984-12-04 | 1984-12-04 | Farmos Oy | Terapeutiskt utnyttjbar foerening. |
| GB2206880B (en) | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| US5344840A (en) | 1988-02-29 | 1994-09-06 | Orion-Yhtyma Oy | 4-substituted imidazole derivatives useful in perioperative care |
| US5217718A (en) | 1989-08-18 | 1993-06-08 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| US5124157A (en) | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| FI894911A0 (fi) | 1989-10-17 | 1989-10-17 | Farmos Oy | En terapeutiskt vaerdefull foerening. |
| US5304569A (en) | 1989-11-13 | 1994-04-19 | Orion-Yhtyma Oy | Compositions and their use in lowering intraocular pressure |
| HK1001832A1 (en) | 1991-04-25 | 1998-07-10 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
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| GB2281206A (en) | 1993-08-25 | 1995-03-01 | Orion Yhtymae Oy | Use of dexmedetomidine |
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| US6716867B1 (en) * | 1998-04-01 | 2004-04-06 | Orion Corporation | Use of dexmedetomidine for ICU sedation |
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| PE20001396A1 (es) | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista |
| GB9913677D0 (en) | 1999-06-11 | 1999-08-11 | Imperial College | Formulation |
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| AU2010248776B2 (en) | 2009-05-15 | 2013-06-06 | Baudax Bio, Inc. | Sublingual dexmedetomidine compositions and methods of use thereof |
| US8410140B2 (en) | 2009-06-01 | 2013-04-02 | The Regents Of The University Of Michigan | Anesthetic methods and compositions |
| WO2011075621A1 (en) | 2009-12-17 | 2011-06-23 | Alpha Synergy Development, Inc. | Compositions and methods for ophthalmic delivery of nasal decongestants |
| FR2959414B1 (fr) | 2010-04-30 | 2016-01-08 | Luc Quintin | Combinaison de molecules aux fins de traitement d'hypotension survenant au cours du choc septique, cardiogenique, ou anaphylactique refractaire, ou hemorragique terminal, apres correction de la volemie et de l'etat de mal asthmatique refractaire |
| US20130096170A1 (en) | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
| US8242158B1 (en) * | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
-
2012
- 2012-01-04 US US13/343,693 patent/US20130096170A1/en not_active Abandoned
- 2012-05-14 US US13/471,403 patent/US8324260B1/en active Active
- 2012-09-27 MX MX2014004548A patent/MX362626B/es active IP Right Grant
- 2012-09-27 CN CN201280058634.1A patent/CN103957906A/zh active Pending
- 2012-09-27 RS RS20181048A patent/RS57660B1/sr unknown
- 2012-09-27 LT LTEP12840033.0T patent/LT2766014T/lt unknown
- 2012-09-27 WO PCT/US2012/057652 patent/WO2013055528A1/en not_active Ceased
- 2012-09-27 PL PL12840033T patent/PL2766014T3/pl unknown
- 2012-09-27 SI SI201231349T patent/SI2766014T1/sl unknown
- 2012-09-27 HU HUE12840033A patent/HUE039671T2/hu unknown
- 2012-09-27 CN CN201811538616.9A patent/CN109700806A/zh active Pending
- 2012-09-27 AU AU2012321246A patent/AU2012321246C1/en not_active Ceased
- 2012-09-27 HR HRP20181378TT patent/HRP20181378T1/hr unknown
- 2012-09-27 DK DK12840033.0T patent/DK2766014T3/en active
- 2012-09-27 KR KR1020207004550A patent/KR20200019791A/ko not_active Ceased
- 2012-09-27 BR BR112014008983A patent/BR112014008983A2/pt not_active Application Discontinuation
- 2012-09-27 EP EP12840033.0A patent/EP2766014B1/en not_active Revoked
- 2012-09-27 JP JP2014535738A patent/JP6270727B2/ja active Active
- 2012-09-27 KR KR1020147012837A patent/KR20140094539A/ko not_active Ceased
- 2012-09-27 KR KR1020197007143A patent/KR20190029775A/ko not_active Ceased
- 2012-09-27 PT PT12840033T patent/PT2766014T/pt unknown
- 2012-09-27 EP EP18181747.9A patent/EP3446691A1/en not_active Withdrawn
- 2012-09-27 IN IN996KON2014 patent/IN2014KN00996A/en unknown
- 2012-09-27 ES ES12840033.0T patent/ES2685814T3/es active Active
- 2012-09-27 CA CA2978258A patent/CA2978258A1/en not_active Abandoned
- 2012-09-27 HK HK15100803.0A patent/HK1200333A1/xx unknown
- 2012-09-27 CA CA2851780A patent/CA2851780C/en not_active Expired - Fee Related
- 2012-12-24 US US13/726,479 patent/US8507542B2/en active Active
- 2012-12-24 US US13/726,496 patent/US9314449B2/en active Active
-
2013
- 2013-08-09 US US13/963,885 patent/US20140005243A1/en not_active Abandoned
-
2014
- 2014-04-10 IL IL232070A patent/IL232070A0/en unknown
-
2015
- 2015-11-16 US US14/942,880 patent/US20160067220A1/en not_active Abandoned
-
2017
- 2017-01-09 IL IL249991A patent/IL249991A0/en unknown
- 2017-07-20 AU AU2017206211A patent/AU2017206211B2/en not_active Ceased
- 2017-09-29 JP JP2017189989A patent/JP6640164B2/ja active Active
-
2018
- 2018-09-04 CY CY181100916T patent/CY1121041T1/el unknown
-
2019
- 2019-05-21 AU AU2019203564A patent/AU2019203564A1/en not_active Abandoned
- 2019-05-21 US US16/418,754 patent/US20190269657A1/en not_active Abandoned
- 2019-12-25 JP JP2019234042A patent/JP2020073529A/ja active Pending
-
2020
- 2020-11-11 US US17/095,391 patent/US20210137891A1/en not_active Abandoned
-
2021
- 2021-10-04 JP JP2021163378A patent/JP2022008828A/ja not_active Withdrawn
-
2023
- 2023-10-23 JP JP2023181585A patent/JP2023179764A/ja active Pending
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