JP2012520866A5 - - Google Patents
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- Publication number
- JP2012520866A5 JP2012520866A5 JP2012500328A JP2012500328A JP2012520866A5 JP 2012520866 A5 JP2012520866 A5 JP 2012520866A5 JP 2012500328 A JP2012500328 A JP 2012500328A JP 2012500328 A JP2012500328 A JP 2012500328A JP 2012520866 A5 JP2012520866 A5 JP 2012520866A5
- Authority
- JP
- Japan
- Prior art keywords
- udca
- pharmaceutically acceptable
- acceptable salt
- treatment
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims 30
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims 30
- 229960001661 ursodiol Drugs 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 26
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 229940125708 antidiabetic agent Drugs 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical group O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims 1
- 229940123464 Thiazolidinedione Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002641 glycemic effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16095509P | 2009-03-17 | 2009-03-17 | |
| US61/160,955 | 2009-03-17 | ||
| PCT/IB2010/000551 WO2010106420A1 (en) | 2009-03-17 | 2010-03-16 | Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012520866A JP2012520866A (ja) | 2012-09-10 |
| JP2012520866A5 true JP2012520866A5 (enExample) | 2013-05-02 |
Family
ID=42167374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500328A Pending JP2012520866A (ja) | 2009-03-17 | 2010-03-16 | 高用量のウルソデオキシコール酸で非アルコール性脂肪性肝炎を治療する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120071451A1 (enExample) |
| EP (1) | EP2408457A1 (enExample) |
| JP (1) | JP2012520866A (enExample) |
| KR (1) | KR20120008034A (enExample) |
| CN (1) | CN102361642A (enExample) |
| AU (1) | AU2010224587A1 (enExample) |
| CA (1) | CA2755708A1 (enExample) |
| IL (1) | IL215195A0 (enExample) |
| MX (1) | MX2011009757A (enExample) |
| RU (1) | RU2011139643A (enExample) |
| WO (1) | WO2010106420A1 (enExample) |
| ZA (1) | ZA201107578B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| KR101401628B1 (ko) * | 2012-12-24 | 2014-06-02 | 삼성제약공업주식회사 | 간기능 개선용 정제 및 그 제조 방법 |
| US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| EP3712254A1 (en) | 2014-05-28 | 2020-09-23 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| CN110179792A (zh) * | 2014-07-29 | 2019-08-30 | 深圳君圣泰生物技术有限公司 | 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用 |
| WO2016061464A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intetine using pluripotent stem cells and methods of making and using same |
| PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| US10925854B2 (en) * | 2015-11-19 | 2021-02-23 | Sinew Pharma Inc. | Methods and compositions for preventing or treating fatty liver, protecting liver function or ameliorating liver diseases caused by fatty liver or other associated disorders |
| CA3016641A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| KR102546194B1 (ko) | 2016-11-04 | 2023-06-21 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| KR102807995B1 (ko) | 2016-12-05 | 2025-05-16 | 칠드런즈 호스피탈 메디칼 센터 | 결장 유사장기 및 이를 제조 및 사용하는 방법 |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| US11179364B2 (en) * | 2017-06-21 | 2021-11-23 | Novartis Ag | Licofligozin for the treatment of non-alcoholic steatohepatitis |
| WO2019074793A1 (en) | 2017-10-10 | 2019-04-18 | Children's Hospital Medical Center | OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME |
| KR101887561B1 (ko) * | 2017-11-15 | 2018-09-06 | 주식회사 대웅제약 | 간염 바이러스에 의해 유발된 간 섬유화의 개선을 위한 약학 조성물 |
| WO2019126626A1 (en) | 2017-12-21 | 2019-06-27 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| CA3106634A1 (en) | 2018-07-26 | 2020-01-30 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| RU2686042C1 (ru) * | 2018-09-04 | 2019-04-23 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | Способ лечения неалкогольной жировой болезни печени при метаболическом синдроме |
| US12428622B2 (en) | 2018-09-12 | 2025-09-30 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| JP7303372B2 (ja) * | 2019-07-30 | 2023-07-04 | コバイオラブス，インコーポレーテッド | 肝損傷予防、改善、または治療用組成物、および肝損傷予防、改善、または治療方法 |
| KR102395036B1 (ko) * | 2019-07-30 | 2022-05-09 | 주식회사 고바이오랩 | 비알코올성 지방간 질환의 예측 또는 진단용 키트, 및 진단방법 |
| PH12022551256A1 (en) * | 2020-01-28 | 2023-11-20 | Shilpa Medicare Ltd | Method for administration of ursodeoxycholic acid |
| EP4232045A4 (en) * | 2020-10-23 | 2024-09-04 | Shenzhen Hightide Biopharmaceutical Ltd. | BERBERINE URSODEOXYCHOLATE COMPOSITIONS AND RELATED METHODS FOR THE TREATMENT OF FATTY LIVER, DIABETES AND HYPERLIPIDEMIA |
| CN115137732A (zh) * | 2021-03-29 | 2022-10-04 | 中国科学院大连化学物理研究所 | Gpr120受体激动剂及熊去氧胆酸的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
-
2010
- 2010-03-16 KR KR1020117024296A patent/KR20120008034A/ko not_active Withdrawn
- 2010-03-16 JP JP2012500328A patent/JP2012520866A/ja active Pending
- 2010-03-16 AU AU2010224587A patent/AU2010224587A1/en not_active Abandoned
- 2010-03-16 WO PCT/IB2010/000551 patent/WO2010106420A1/en not_active Ceased
- 2010-03-16 CN CN2010800119928A patent/CN102361642A/zh active Pending
- 2010-03-16 EP EP10714958A patent/EP2408457A1/en not_active Ceased
- 2010-03-16 MX MX2011009757A patent/MX2011009757A/es not_active Application Discontinuation
- 2010-03-16 CA CA2755708A patent/CA2755708A1/en not_active Abandoned
- 2010-03-16 RU RU2011139643/15A patent/RU2011139643A/ru not_active Application Discontinuation
-
2011
- 2011-08-24 US US13/217,042 patent/US20120071451A1/en not_active Abandoned
- 2011-09-18 IL IL215195A patent/IL215195A0/en unknown
- 2011-10-17 ZA ZA2011/07578A patent/ZA201107578B/en unknown
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