JP2010518122A5 - - Google Patents
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- Publication number
- JP2010518122A5 JP2010518122A5 JP2009549268A JP2009549268A JP2010518122A5 JP 2010518122 A5 JP2010518122 A5 JP 2010518122A5 JP 2009549268 A JP2009549268 A JP 2009549268A JP 2009549268 A JP2009549268 A JP 2009549268A JP 2010518122 A5 JP2010518122 A5 JP 2010518122A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treprostinil
- pulmonary fibrosis
- kit
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 32
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 24
- 229960005032 treprostinil Drugs 0.000 claims 22
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 10
- 208000006673 asthma Diseases 0.000 claims 6
- 239000002552 dosage form Substances 0.000 claims 6
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000027932 Collagen disease Diseases 0.000 claims 2
- 206010073310 Occupational exposures Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000013061 administrable dose form Substances 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000018631 connective tissue disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 101100326804 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-2 gene Proteins 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90032007P | 2007-02-09 | 2007-02-09 | |
| US94021807P | 2007-05-25 | 2007-05-25 | |
| PCT/US2008/053467 WO2008098196A1 (en) | 2007-02-09 | 2008-02-08 | Treprostinil treatment for interstitial lung disease and asthma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013116923A Division JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518122A JP2010518122A (ja) | 2010-05-27 |
| JP2010518122A5 true JP2010518122A5 (enExample) | 2011-03-10 |
Family
ID=39357950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549268A Withdrawn JP2010518122A (ja) | 2007-02-09 | 2008-02-08 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
| JP2013116923A Pending JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013116923A Pending JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20080280986A1 (enExample) |
| EP (2) | EP2120961A1 (enExample) |
| JP (2) | JP2010518122A (enExample) |
| KR (1) | KR20090117781A (enExample) |
| CN (2) | CN101678033A (enExample) |
| CA (1) | CA2678258A1 (enExample) |
| WO (1) | WO2008098196A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2622471T5 (es) * | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| CN101287457B (zh) * | 2004-04-12 | 2011-11-16 | 联合治疗公司 | Treprostinil用于治疗神经性糖尿病的足部溃疡的用途 |
| US20070023047A1 (en) * | 2005-07-26 | 2007-02-01 | Moshe Zalsman | Face mask particularly useful as medical face mask |
| EP1962805B1 (en) | 2005-12-08 | 2016-07-06 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| JP5797376B2 (ja) | 2006-05-15 | 2015-10-21 | ユナイテッド セラピューティクス コーポレーション | 定量吸入器を用いたトレプロスチニル投与 |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| EP3287434A1 (en) | 2007-12-17 | 2018-02-28 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in remodulin ® |
| CA2723540C (en) * | 2008-05-08 | 2016-01-05 | United Therapeutics Corporation | Treprostinil monohydrate |
| KR101544246B1 (ko) * | 2009-05-07 | 2015-08-12 | 유나이티드 세러퓨틱스 코오포레이션 | 프로스타시클린 유사체의 고체 제제 |
| ES2451790T3 (es) * | 2009-08-07 | 2014-03-28 | Scipharm Sàrl | Composición para el tratamiento de la fibrosis quística |
| JP5681276B2 (ja) | 2010-03-15 | 2015-03-04 | ユナイテッド セラピューティクス コーポレイション | 肺高血圧症のための治療 |
| CA3029711A1 (en) | 2010-06-03 | 2011-12-08 | United Therapeutics Corporation | Treprostinil production |
| US20120010159A1 (en) * | 2010-07-09 | 2012-01-12 | United Therapeutics Corporation | Combination therapies with cox-2 inhibitors and treprostinil |
| WO2012107364A1 (en) * | 2011-02-07 | 2012-08-16 | Scipharm Sàrl | Novel composition for the treatment of cystic fibrosis |
| BR112013019335B1 (pt) * | 2011-02-07 | 2022-05-31 | Scipharm Sàrl | Nova composição, método para aumentar o nível de camp em um célula e combinação terapêutica, para o tratamento da fibrose cística |
| WO2012118943A1 (en) | 2011-03-02 | 2012-09-07 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| HK1198358A1 (en) * | 2011-08-12 | 2015-04-10 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
| HK1198359A1 (en) | 2011-08-12 | 2015-04-10 | Ascendis Pharma A/S | Carrier-linked treprostinil prodrugs |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| US20150272874A1 (en) * | 2012-10-29 | 2015-10-01 | Cardio Incorporated | Pulmonary disease-specific therapeutic agent |
| CA2891487A1 (en) | 2012-11-29 | 2014-06-05 | Insmed Incorporated | Stabilized vancomycin formulations |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP4137127A1 (en) | 2013-01-11 | 2023-02-22 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| CA3212313A1 (en) | 2013-03-14 | 2014-10-02 | United Therapeutics Corporation | Solid forms of treprostinil |
| WO2014150203A1 (en) | 2013-03-15 | 2014-09-25 | United Therapeutics Corporation | Salts of treprostinil |
| CA2908244C (en) | 2013-03-25 | 2021-04-20 | United Therapeutics Corporation | Process of making prostacyclin compounds with linker thiol and pegylated forms |
| KR102296259B1 (ko) | 2013-10-25 | 2021-08-30 | 인스메드 인코포레이티드 | 프로스타사이클린 화합물, 조성물 및 이의 사용 방법 |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| PT3142643T (pt) | 2014-05-15 | 2019-10-28 | Insmed Inc | Métodos para o tratamento de infeções mico bacterianas pulmonares não tuberculares |
| US20170088897A1 (en) * | 2014-06-03 | 2017-03-30 | Novartis Ag | Pulmonary hypertension biomarker |
| WO2015192030A1 (en) | 2014-06-13 | 2015-12-17 | United Therapeutics Corporation | Treprostinil formulations |
| CA2964804C (en) | 2014-10-20 | 2019-04-02 | United Therapeutics Corporation | Synthesis of intermediate for producing prostacyclin derivatives |
| AU2015349969B2 (en) | 2014-11-18 | 2020-02-06 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| US10632129B2 (en) | 2014-12-03 | 2020-04-28 | Steadymed Ltd. | Preservative-free treprostinil formulations and methods and devices for use with same |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| EP3515430A1 (en) | 2016-09-26 | 2019-07-31 | United Therapeutics Corporation | Treprostinil prodrugs |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| CN108379557A (zh) * | 2018-01-15 | 2018-08-10 | 吉林大学 | 使用白介素因子-37治疗特发性肺纤维化 |
| EP3773505A4 (en) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | PROCESS FOR THE CONTINUOUS MANUFACTURING OF LIPOSOMAL MEDICINAL PRODUCTS |
| ES2976468T3 (es) | 2018-09-18 | 2024-08-01 | Lilly Co Eli | Sal de treprostinil erbumina |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| EP4017588A1 (en) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| JP2023523557A (ja) * | 2020-04-17 | 2023-06-06 | ユナイテッド セラピューティクス コーポレイション | 間質性肺疾患の治療における使用のためのトレプロスチニル |
| CN116113415A (zh) | 2020-06-09 | 2023-05-12 | 联合治疗公司 | 曲前列尼尔的富马酰基二酮哌啶前药 |
| AU2021401921A1 (en) | 2020-12-14 | 2023-07-06 | United Therapeutics Corporation | Methods of treating disease with treprostinil prodrugs |
| AU2022229367A1 (en) | 2021-03-03 | 2023-09-14 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| PT90888B (pt) * | 1988-06-17 | 1994-12-30 | Wellcome Found | Processo para a preparacao de composicoes farmaceuticas contendo prostaglandinas |
| GB8814438D0 (en) * | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| CA2312729C (en) * | 1997-11-14 | 2006-05-23 | United Therapeutics Corporation | Use of 9-deoxy-2', 9-.alpha.-methano-3- oxa-4,5,6- trinor-3, 7-(1',3'-interphenylene) -13,14-dihydro- prostaglandin f1 to treat peripheral vascular disease |
| US6521212B1 (en) | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| WO2000055314A2 (en) * | 1999-03-18 | 2000-09-21 | United Therapeutics Corporation | Inhibitors of endothelin-1 synthesis |
| US6756047B2 (en) * | 2000-05-12 | 2004-06-29 | The University Of Toledo | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| ES2622471T5 (es) * | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| JP5797376B2 (ja) * | 2006-05-15 | 2015-10-21 | ユナイテッド セラピューティクス コーポレーション | 定量吸入器を用いたトレプロスチニル投与 |
-
2008
- 2008-02-08 EP EP08729432A patent/EP2120961A1/en not_active Withdrawn
- 2008-02-08 EP EP12162497A patent/EP2491932A3/en not_active Withdrawn
- 2008-02-08 CN CN200880004381A patent/CN101678033A/zh active Pending
- 2008-02-08 US US12/028,471 patent/US20080280986A1/en not_active Abandoned
- 2008-02-08 KR KR1020097018462A patent/KR20090117781A/ko not_active Ceased
- 2008-02-08 JP JP2009549268A patent/JP2010518122A/ja not_active Withdrawn
- 2008-02-08 CA CA002678258A patent/CA2678258A1/en not_active Abandoned
- 2008-02-08 CN CN2012100599979A patent/CN102648916A/zh active Pending
- 2008-02-08 WO PCT/US2008/053467 patent/WO2008098196A1/en not_active Ceased
-
2012
- 2012-01-30 US US13/360,961 patent/US20120129941A1/en not_active Abandoned
- 2012-12-10 US US13/709,270 patent/US20130096200A1/en not_active Abandoned
-
2013
- 2013-06-03 JP JP2013116923A patent/JP2013189459A/ja active Pending
- 2013-09-18 US US14/030,500 patent/US20140018431A1/en not_active Abandoned
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