JP2010518122A5 - - Google Patents
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- Publication number
- JP2010518122A5 JP2010518122A5 JP2009549268A JP2009549268A JP2010518122A5 JP 2010518122 A5 JP2010518122 A5 JP 2010518122A5 JP 2009549268 A JP2009549268 A JP 2009549268A JP 2009549268 A JP2009549268 A JP 2009549268A JP 2010518122 A5 JP2010518122 A5 JP 2010518122A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treprostinil
- pulmonary fibrosis
- kit
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 32
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 24
- 229960005032 treprostinil Drugs 0.000 claims 22
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 10
- 208000006673 asthma Diseases 0.000 claims 6
- 239000002552 dosage form Substances 0.000 claims 6
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000027932 Collagen disease Diseases 0.000 claims 2
- 206010073310 Occupational exposures Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000013061 administrable dose form Substances 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000018631 connective tissue disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 101100326804 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-2 gene Proteins 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90032007P | 2007-02-09 | 2007-02-09 | |
| US94021807P | 2007-05-25 | 2007-05-25 | |
| PCT/US2008/053467 WO2008098196A1 (en) | 2007-02-09 | 2008-02-08 | Treprostinil treatment for interstitial lung disease and asthma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013116923A Division JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518122A JP2010518122A (ja) | 2010-05-27 |
| JP2010518122A5 true JP2010518122A5 (enExample) | 2011-03-10 |
Family
ID=39357950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549268A Withdrawn JP2010518122A (ja) | 2007-02-09 | 2008-02-08 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
| JP2013116923A Pending JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013116923A Pending JP2013189459A (ja) | 2007-02-09 | 2013-06-03 | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20080280986A1 (enExample) |
| EP (2) | EP2120961A1 (enExample) |
| JP (2) | JP2010518122A (enExample) |
| KR (1) | KR20090117781A (enExample) |
| CN (2) | CN101678033A (enExample) |
| CA (1) | CA2678258A1 (enExample) |
| WO (1) | WO2008098196A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697790A (zh) | 2003-05-22 | 2012-10-03 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| DE602005020269D1 (de) * | 2004-04-12 | 2010-05-12 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| US20070023047A1 (en) * | 2005-07-26 | 2007-02-01 | Moshe Zalsman | Face mask particularly useful as medical face mask |
| ES2798263T3 (es) | 2005-12-08 | 2020-12-10 | Insmed Inc | Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares |
| CA2654492C (en) | 2006-05-15 | 2017-06-27 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| WO2009078965A1 (en) | 2007-12-17 | 2009-06-25 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| JP6219016B2 (ja) * | 2008-05-08 | 2017-10-25 | ユナイテッド セラピューティクス コーポレーション | トレプロスチニル一水和物 |
| CN102421288B (zh) * | 2009-05-07 | 2015-04-22 | 联合治疗公司 | 前列环素类似物的固体剂型 |
| AU2010280684B2 (en) * | 2009-08-07 | 2016-07-28 | Scipharm Sarl | Composition for the treatment of cystic fibrosis |
| KR20160132501A (ko) * | 2010-03-15 | 2016-11-18 | 유나이티드 세러퓨틱스 코오포레이션 | 폐고혈압의 치료 |
| CN103261142B (zh) | 2010-06-03 | 2014-12-10 | 联合治疗公司 | 曲前列环素的制备 |
| US20120010159A1 (en) * | 2010-07-09 | 2012-01-12 | United Therapeutics Corporation | Combination therapies with cox-2 inhibitors and treprostinil |
| RS55624B1 (sr) * | 2011-02-07 | 2017-06-30 | Scipharm Sàrl | Nova kompozicija za lečenje cistične fibroze |
| WO2012107364A1 (en) * | 2011-02-07 | 2012-08-16 | Scipharm Sàrl | Novel composition for the treatment of cystic fibrosis |
| ES2581762T3 (es) | 2011-03-02 | 2016-09-07 | United Therapeutics Corporation | Síntesis de producto intermedio para la producción de treprostinil |
| AU2012296953B2 (en) | 2011-08-12 | 2016-10-20 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
| BR112014003225A2 (pt) | 2011-08-12 | 2017-03-01 | Ascendis Pharma As | profármacos de treprostinil ligados a veículo |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| ES2733998T3 (es) * | 2012-10-29 | 2019-12-03 | Cardio Incorporated | Agente terapéutico específico de enfermedad pulmonar |
| CA2891487A1 (en) | 2012-11-29 | 2014-06-05 | Insmed Incorporated | Stabilized vancomycin formulations |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| WO2014159050A1 (en) | 2013-03-14 | 2014-10-02 | United Therapeutics Corporation | Solid forms of treprostinil |
| EP2970081A4 (en) | 2013-03-15 | 2016-10-12 | United Therapeutics Corp | SALTS OF TREPROSTINIL |
| WO2014160638A1 (en) | 2013-03-25 | 2014-10-02 | United Therapeutics Corporation | Process of making prostacyclin compounds with linker thiol and pegylated forms |
| US9469600B2 (en) | 2013-10-25 | 2016-10-18 | Insmed Incorporated | Prostacyclin compounds, compositions and methods of use thereof |
| WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| MX384843B (es) | 2014-05-15 | 2025-03-14 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas. |
| US20170088897A1 (en) * | 2014-06-03 | 2017-03-30 | Novartis Ag | Pulmonary hypertension biomarker |
| ES2908142T3 (es) * | 2014-06-13 | 2022-04-27 | United Therapeutics Corp | Formulaciones de treprostinil |
| CN107108427A (zh) | 2014-10-20 | 2017-08-29 | 联合治疗学有限公司 | 用于制备前列环素衍生物的中间体的合成 |
| US10343979B2 (en) | 2014-11-18 | 2019-07-09 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| CA2967899C (en) | 2014-12-03 | 2023-09-19 | Steadymed Ltd | Preservative-free treprostinil formulations and methods and devices for use with same |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| WO2018058124A1 (en) | 2016-09-26 | 2018-03-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| CN108379557A (zh) * | 2018-01-15 | 2018-08-10 | 吉林大学 | 使用白介素因子-37治疗特发性肺纤维化 |
| EP3773505B1 (en) | 2018-03-30 | 2026-04-29 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| EP3787602A4 (en) | 2018-05-02 | 2022-03-23 | Insmed Incorporated | PROCESS FOR THE MANUFACTURE OF LIPOSOMAL DRUG FORMULATIONS |
| CN112739679B (zh) | 2018-09-18 | 2024-03-12 | 伊莱利利公司 | 曲前列环素的特丁胺盐 |
| CN119632930A (zh) | 2019-04-29 | 2025-03-18 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| CN114616225A (zh) | 2019-08-23 | 2022-06-10 | 联合治疗公司 | 曲前列环素前药 |
| IL296567A (en) * | 2020-04-17 | 2022-11-01 | United Therapeutics Corp | Terfostinil for use in the treatment of interstitial lung disease |
| AU2021289336B2 (en) | 2020-06-09 | 2025-08-28 | Mannkind Corporation | Fumaryl diketopiperidine prodrugs of treprostinil |
| CN116437906B (zh) * | 2020-10-28 | 2026-07-03 | 英斯梅德股份有限公司 | 曲前列环素前药的干粉组合物和其使用方法 |
| AU2021396535A1 (en) * | 2020-12-07 | 2023-06-22 | Mannkind Corporation | Method and composition for treating pulmonary fibrosis |
| KR102849520B1 (ko) | 2020-12-14 | 2025-08-25 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| WO2022187352A1 (en) | 2021-03-03 | 2022-09-09 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| DK299089A (da) * | 1988-06-17 | 1989-12-18 | Wellcome Found | Anvendelse af prostaglandiner til fremstilling af laegemidler |
| GB8814438D0 (en) * | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| ES2214753T3 (es) * | 1997-11-14 | 2004-09-16 | United Therapeutics Corporation | Uso de 9-desoxi-2',9-alfa-metano-3-oxa-4,5,6-trinor-3,7-(1',3'-interfenilen)-13,14-dihidro-prostaglandina f1 para tratar la enfermedad vascular periferica. |
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| DE60037012T2 (de) * | 1999-03-18 | 2008-10-30 | Queen Mary And Westfield College | Inhibitoren der endothelin-1 synthese |
| US6756047B2 (en) * | 2000-05-12 | 2004-06-29 | The University Of Toledo | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| CN102697790A (zh) * | 2003-05-22 | 2012-10-03 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| CA2654492C (en) * | 2006-05-15 | 2017-06-27 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
-
2008
- 2008-02-08 CA CA002678258A patent/CA2678258A1/en not_active Abandoned
- 2008-02-08 WO PCT/US2008/053467 patent/WO2008098196A1/en not_active Ceased
- 2008-02-08 EP EP08729432A patent/EP2120961A1/en not_active Withdrawn
- 2008-02-08 JP JP2009549268A patent/JP2010518122A/ja not_active Withdrawn
- 2008-02-08 KR KR1020097018462A patent/KR20090117781A/ko not_active Ceased
- 2008-02-08 CN CN200880004381A patent/CN101678033A/zh active Pending
- 2008-02-08 US US12/028,471 patent/US20080280986A1/en not_active Abandoned
- 2008-02-08 CN CN2012100599979A patent/CN102648916A/zh active Pending
- 2008-02-08 EP EP12162497A patent/EP2491932A3/en not_active Withdrawn
-
2012
- 2012-01-30 US US13/360,961 patent/US20120129941A1/en not_active Abandoned
- 2012-12-10 US US13/709,270 patent/US20130096200A1/en not_active Abandoned
-
2013
- 2013-06-03 JP JP2013116923A patent/JP2013189459A/ja active Pending
- 2013-09-18 US US14/030,500 patent/US20140018431A1/en not_active Abandoned
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