ME02179B - Metoda za lečenje atrijalne fibrilacije - Google Patents

Metoda za lečenje atrijalne fibrilacije

Info

Publication number
ME02179B
ME02179B MEP-2015-113A MEP11315A ME02179B ME 02179 B ME02179 B ME 02179B ME P11315 A MEP11315 A ME P11315A ME 02179 B ME02179 B ME 02179B
Authority
ME
Montenegro
Prior art keywords
ranolazine
dronedarone
salt
per day
formulation
Prior art date
Application number
MEP-2015-113A
Other languages
English (en)
Inventor
Charles Antzelevitch
Luiz Belardinelli
Alexander Burashnikov
John Shryock
Dewan Zeng
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43736345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02179(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ME02179B publication Critical patent/ME02179B/me

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)

Claims (17)

1.Ranolazin za primenu u metodi za lečenje ili prevenciju atrijalne fibrilacije ili atrijalnog flatera kod humanog pacijenta kod koga postoji takva potreba, pri čemu metod obuhvata administraciju pacijentu terapijski efikasne količine dronedarona ili njegove farmaceutski prihvatUive soli i terapijski efikasne količine ranolazina.
2.Ranolazin za primenu prema patentnom zahtevu l , gde su dronedaron ili nJegova so ranolazin administrirani odvojeno ili zajedno kao kombinovana dozna jedinica, gde je poželjno daje kombinovana dozna jedinica, tableta.
3.Ranolazin za pnmenu prema patentnom zahtevu l , gde su dronedaron ili nJegova so ranolazin administrirani intravenski ili oralno.
4.Ranolazin za primenu prema bilo kom od patentnih zahteva 1-3, gde je količina ranolazina koja je administrirana od oko 50 mg do oko 3000 mg dnevno, poželjno od oko 50 mg do oko 1500 mg dnevno.
5.Ranolazin za primenu prema bilo kom od patentnih zahteva 1-4, gde je količina dronedarona ili njegove soli koja je administrirana od oko 50 mg do oko 800 mg dnevno, poželjno od oko 50 mg do oko 600 mg dnevno i još poželjnije od oko 50 mg do oko 400 mg dnevno.
6.Ranolazin za primenu prema bilo kom od patentnih zahteva 1-5, gde je količina dronedarona ili njegove soli koja je administrirana od oko 50 mg do oko 300 mg dnevno, a količina ranolazina koja je administrirana od oko 300 mg do oko 1000 mg dnevno.
7.Ranolazin za primenu prema patentnom zahtevu 6, gde je količina dronedarona ili njegove soli koja je administrirana od oko 50 mg do oko 200 mg dnevno.
8.Ranolazin za primenu prema bilo kom od patentnih zahteva 1-7, gde je so dronedarona, dronedaron hidrohlorid.
9. Farmaceutska formulacija koja sadrži ranolazin prihvatljivu so, i farmaceutski prihvatljivi nosač. dronedaron ili njegovu farmaceutski prihvatljivu so, i farmaceutski prihvatljivi nosač.
10.Farmaceutska formulacija patentnog zahteva 9, koja Je fomulisana za intravensku administraciju ili oralnu aministraciju.
11.Farmaceutska formulacija patentnog zahteva 9, gde je formulacija u obliku tablete ili kapsule.
12.Formulacija patentnog zahteva ll , gde tableta ili kapsula sadrži od oko 25 mg do oko 600 mg, poželjno od oko 50 mg do oko 200 mg dronedarona ili njegove soli.
13. Formulacija patentnog zahteva ll ili 12, gde tableta ili kapsula sadrži od oko 50 mg do oko 1000 mg, poželjno od oko 100 mg do oko 750 mg ranolazina.
14.Formulacija patentnog zahteva ll, gde tableta ili kapsula sadrži od oko l OO mg do oko 750 mg ranolazina i oko 50 mg do oko 200 mg dronedarona ili njegove soli.
15.Formulacija prema bilo kom od patentnih zahteva 9-14, gde je so dronedarona, dronedaron hidrohlorid.
16.Formulacija prema bilo kom od patentnih zahteva 9-15, gde je ranolazin formulisan za produženo oslobađanje.
17. Formulacija prema bilo kom od patentnih zahteva 9-15, gde je dronedaron ili njegova so formulisan za momentalno oslobađanje ili produženo oslobađanje.
MEP-2015-113A 2009-12-21 2010-12-20 Metoda za lečenje atrijalne fibrilacije ME02179B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28873909P 2009-12-21 2009-12-21
EP20100798436 EP2515900B1 (en) 2009-12-21 2010-12-20 Method of treating atrial fibrillation
PCT/US2010/061257 WO2011084733A1 (en) 2009-12-21 2010-12-20 Method of treating atrial fibrillation

Publications (1)

Publication Number Publication Date
ME02179B true ME02179B (me) 2015-10-20

Family

ID=43736345

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2015-113A ME02179B (me) 2009-12-21 2010-12-20 Metoda za lečenje atrijalne fibrilacije

Country Status (36)

Country Link
US (3) US8513254B2 (me)
EP (2) EP2749282B1 (me)
JP (2) JP5723889B2 (me)
KR (2) KR20160108611A (me)
CN (3) CN102665713B (me)
AP (1) AP3536A (me)
AR (1) AR079552A1 (me)
AU (1) AU2010339753B2 (me)
BR (1) BR112012015499A2 (me)
CA (1) CA2784028C (me)
CL (1) CL2012001597A1 (me)
CR (1) CR20120353A (me)
CY (1) CY1116511T1 (me)
DK (1) DK2515900T3 (me)
EA (2) EA201691336A1 (me)
EC (1) ECSP12012004A (me)
ES (2) ES2540093T3 (me)
HR (1) HRP20150644T1 (me)
HU (1) HUE026916T2 (me)
IL (1) IL220152A (me)
ME (1) ME02179B (me)
MX (2) MX2012007052A (me)
NO (1) NO2749282T3 (me)
NZ (2) NZ600718A (me)
PE (1) PE20121520A1 (me)
PL (2) PL2515900T3 (me)
PT (2) PT2515900E (me)
RS (1) RS54118B1 (me)
SG (3) SG181541A1 (me)
SI (2) SI2749282T1 (me)
SM (1) SMT201500171B (me)
TW (1) TWI508726B (me)
UA (1) UA109887C2 (me)
UY (1) UY33119A (me)
WO (1) WO2011084733A1 (me)
ZA (1) ZA201204608B (me)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2486712C (en) 2002-05-21 2012-01-03 Cv Therapeutics, Inc. Method of treating diabetes
ME02847B (me) 2009-07-27 2018-01-20 Gilead Sciences Inc Fuzionisana heterociklična jedinjenja kao modulatori jonskih kanala
CN104873389B (zh) 2009-07-29 2017-12-05 Icu医学有限公司 流体传输装置及使用方法
WO2011135582A2 (en) * 2010-04-28 2011-11-03 Cadila Healthcare Limited Pharmaceutical compositions of dronedarone
BR112012033402A2 (pt) 2010-07-02 2017-01-24 Gilead Sciences Inc moduladores de canais de íons conforme os compostos heterocíclicos fundidos
ES2648820T3 (es) 2011-05-10 2018-01-08 Gilead Sciences, Inc. Compuestos heterocíclicos condensados como moduladores de los canales de sodio
NO3175985T3 (me) 2011-07-01 2018-04-28
TWI478908B (zh) 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
WO2013112932A1 (en) * 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
US20140364417A1 (en) * 2013-05-03 2014-12-11 Gilead Sciences, Inc. Method of treating atrial fibrillation
KR20160027078A (ko) * 2013-08-02 2016-03-09 길리애드 사이언시즈, 인코포레이티드 라놀라진 및 드로네다론의 제약 조성물
WO2015073922A2 (en) 2013-11-15 2015-05-21 Northwestern University Inhibition of oxidative stress in atrial fibrillation
EP3083608B1 (en) 2013-12-19 2018-07-18 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
CN104951870B (zh) * 2015-06-01 2018-11-13 南通科瑞斯生物医药科技有限公司 药物临床前心脏风险评估方法
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
CA3016081A1 (en) 2016-03-04 2017-09-08 Gilead Sciences, Inc. Compositions and combinations of autotaxin inhibitors
US10575744B2 (en) 2017-02-24 2020-03-03 Medtronic Cryocath Lp Pericardial balloon mapping
US10799703B2 (en) * 2017-12-22 2020-10-13 Medtronic, Inc. Evaluation of his bundle pacing therapy
EP3530182B1 (en) * 2018-02-27 2020-12-09 Nokia Technologies Oy Apparatus and method for determining a change in left ventricular twist of a subject's heart
CA3103522C (en) * 2018-07-16 2023-11-21 Gilead Sciences, Inc. Capsid inhibitors for the treatment of hiv
EP3914709A4 (en) * 2019-01-24 2023-05-03 Northwestern University Gene therapy treatment of atrial fibrillation
US11712188B2 (en) * 2019-05-07 2023-08-01 Medtronic, Inc. Posterior left bundle branch engagement
IL290088B2 (en) 2019-08-01 2023-10-01 Incarda Therapeutics Inc A pharmaceutical preparation containing flacainide, cyclodextrin and acid, a dosage unit of the preparation and a kit containing the preparation
PL4445900T3 (pl) 2021-12-03 2025-09-22 Gilead Sciences, Inc. Związki terapeutyczne przeciwko zakażeniu wirusem hiv
KR20240113832A (ko) 2021-12-03 2024-07-23 길리애드 사이언시즈, 인코포레이티드 Hiv 바이러스 감염 치료용 화합물

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4567264A (en) 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US5364620A (en) 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US4902514A (en) 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
ATE218344T1 (de) 1989-06-23 2002-06-15 Syntex Llc Ranolazin und verwandte piperazine zur behandlung von schockzuständen
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
US5455045A (en) 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
ZA953078B (en) * 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
FR2764800B1 (fr) 1997-06-23 1999-09-10 Sanofi Sa Composition pharmaceutique solide contenant des derives de benzofuranne
US6303607B1 (en) 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US20020042405A1 (en) * 2000-07-27 2002-04-11 Schuh Joseph R. Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
FR2817750B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Composition pharmaceutique de dronedarone pour administration parenterale
EP1347756B1 (en) 2000-12-27 2006-03-08 Genzyme Corporation Controlled release of anti-arrhythmic agents from a biodegradable hydrogel for local application to the heart
WO2003009839A1 (en) * 2001-07-20 2003-02-06 Karo Bio Ab Benzofuranes and their use in the treatment of atrial fibrillation
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US7772232B2 (en) 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
WO2006074398A2 (en) 2005-01-06 2006-07-13 Cv Therapeutics, Inc. Sustained release pharmaceutical formulations comprising ranolazine
WO2007053610A2 (en) 2005-11-01 2007-05-10 The Regents Of The University Of California Methods of treating atrial fibrillation wtih pirfenidone
EP2117508A1 (en) * 2007-02-13 2009-11-18 CV Therapeutics Inc. Intravenous solutions comprising ranolazine
US20090247535A1 (en) * 2008-03-26 2009-10-01 Duke University Use of ranolazine for non-cardiovascular disorders
EP2133074A1 (en) * 2008-06-10 2009-12-16 Sanofi-Aventis Use of dronedarone for the preparation of a medicament intended for the prevention of permanent atrial fibrillation
US20100056536A1 (en) 2008-09-04 2010-03-04 Charles Antzelevitch Method of treating atrial fibrillation

Also Published As

Publication number Publication date
EA201290451A1 (ru) 2013-01-30
US20110183990A1 (en) 2011-07-28
CN104688739A (zh) 2015-06-10
NZ600718A (en) 2014-08-29
EP2749282A1 (en) 2014-07-02
KR20160108611A (ko) 2016-09-19
TWI508726B (zh) 2015-11-21
ZA201204608B (en) 2013-02-27
CA2784028C (en) 2016-08-23
AR079552A1 (es) 2012-02-01
SMT201500171B (it) 2015-09-07
EA201691336A1 (ru) 2017-05-31
MX2012007052A (es) 2012-07-30
US20130317038A1 (en) 2013-11-28
PT2749282T (pt) 2017-11-15
KR20120107995A (ko) 2012-10-04
CL2012001597A1 (es) 2013-06-28
CR20120353A (es) 2014-10-07
PL2515900T3 (pl) 2015-10-30
US8513254B2 (en) 2013-08-20
IL220152A0 (en) 2012-07-31
SG181541A1 (en) 2012-07-30
CN102665713B (zh) 2015-02-18
SG10201710751TA (en) 2018-02-27
HRP20150644T1 (hr) 2015-07-31
CN102665713A (zh) 2012-09-12
ES2646603T3 (es) 2017-12-14
PT2515900E (pt) 2015-07-30
ES2540093T3 (es) 2015-07-08
DK2515900T3 (en) 2015-07-27
ECSP12012004A (es) 2012-08-31
TW201136586A (en) 2011-11-01
PE20121520A1 (es) 2012-11-26
CA2784028A1 (en) 2011-07-14
NZ627181A (en) 2016-02-26
JP2015057449A (ja) 2015-03-26
HUE026916T2 (en) 2016-08-29
HK1170675A1 (en) 2013-03-08
AU2010339753A1 (en) 2012-07-12
NO2749282T3 (me) 2018-01-06
RS54118B1 (sr) 2015-12-31
US9056108B2 (en) 2015-06-16
EP2515900B1 (en) 2015-04-29
EP2515900A1 (en) 2012-10-31
SG10201408528RA (en) 2015-04-29
PL2749282T3 (pl) 2018-01-31
JP2013515007A (ja) 2013-05-02
IL220152A (en) 2016-11-30
EA025445B1 (ru) 2016-12-30
AU2010339753B2 (en) 2015-01-22
US20140323493A1 (en) 2014-10-30
CY1116511T1 (el) 2017-03-15
AP2012006331A0 (en) 2012-06-30
SI2749282T1 (sl) 2017-12-29
US8754087B2 (en) 2014-06-17
UY33119A (es) 2011-07-29
WO2011084733A1 (en) 2011-07-14
SI2515900T1 (sl) 2015-07-31
AP3536A (en) 2016-01-13
MX344329B (es) 2016-12-13
BR112012015499A2 (pt) 2016-05-03
UA109887C2 (uk) 2015-10-26
EP2749282B1 (en) 2017-08-09
CN104147010A (zh) 2014-11-19
JP5723889B2 (ja) 2015-05-27

Similar Documents

Publication Publication Date Title
ME02179B (me) Metoda za lečenje atrijalne fibrilacije
HRP20220902T3 (hr) Pripravci i njihova upotreba u liječenju multiple skleroze
FI3936130T3 (fi) Valbenatsiinin annostusohjelma hyperkineettisten liikehäiriöiden hoitoon
AR075735A1 (es) Composiciones farmaceuticas de liberacion inmediata que comprenden oxicodona y naloxona. uso
EA200900264A1 (ru) Композиции флибансерина и способ их приготовления
FI3782612T3 (fi) Sytidiinianalogien oraalisia formulaatioita ja menetelmiä niiden käyttämiseksi
JP2015038135A5 (me)
JP2015522630A5 (me)
JP2007532663A5 (me)
FI3435996T3 (fi) Elafibranori käytettäväksi primaarisen biliaarisen kolangiitin hoidossa
JP2015524444A5 (me)
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
HRP20250266T1 (hr) Nukleotid hemi-sulfat sol za liječenje virusa hepatitisa c
UA116334C2 (uk) Тверді форми дозування бендамустину
JP2015523407A5 (me)
ME02474B (me) Terapijski režimi
JP2015519329A5 (me)
UA107578C2 (uk) Комбінована терапія при лікуванні діабету
JP2012502047A5 (me)
WO2008142572A3 (en) Controlled release tablet formulation containing magnesium aluminometasilicate
NZ587202A (en) Methods for measuring a patient response upon administration of a drug and compositions thereof
MX2012000275A (es) Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.
JP2015510916A5 (me)
JP2013541583A5 (me)
JP2013518914A5 (me)