EA201691336A1 - Способ лечения фибрилляции предсердий - Google Patents

Способ лечения фибрилляции предсердий

Info

Publication number
EA201691336A1
EA201691336A1 EA201691336A EA201691336A EA201691336A1 EA 201691336 A1 EA201691336 A1 EA 201691336A1 EA 201691336 A EA201691336 A EA 201691336A EA 201691336 A EA201691336 A EA 201691336A EA 201691336 A1 EA201691336 A1 EA 201691336A1
Authority
EA
Eurasian Patent Office
Prior art keywords
atrial
atrial fibrillation
ventricular
salts
pharmaceutically acceptable
Prior art date
Application number
EA201691336A
Other languages
English (en)
Inventor
Чарльз Антзелевитч
Луиз Белардинелли
Александр Бурашников
Джон Шрайок
Деван Зенг
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43736345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201691336(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201691336A1 publication Critical patent/EA201691336A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Настоящее изобретение относится к способу лечения или предотвращения фибрилляции предсердий и/или трепетания предсердий, включающему совместное введение синергетически терапевтического количества дронедарона или его фармацевтически приемлемой соли, или солей, и синергетически терапевтического количества ранолазина или его фармацевтически приемлемой соли или солей. Также предложены способы модулирования желудочкового и предсердного ритма и частоты желудочковых и предсердных сокращений. Настоящее изобретение также относится к фармацевтическим составам, подходящим для такого комбинированного введения.
EA201691336A 2009-12-21 2010-12-20 Способ лечения фибрилляции предсердий EA201691336A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28873909P 2009-12-21 2009-12-21

Publications (1)

Publication Number Publication Date
EA201691336A1 true EA201691336A1 (ru) 2017-05-31

Family

ID=43736345

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201290451A EA025445B1 (ru) 2009-12-21 2010-12-20 Способ лечения фибрилляции предсердий
EA201691336A EA201691336A1 (ru) 2009-12-21 2010-12-20 Способ лечения фибрилляции предсердий

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201290451A EA025445B1 (ru) 2009-12-21 2010-12-20 Способ лечения фибрилляции предсердий

Country Status (37)

Country Link
US (3) US8513254B2 (ru)
EP (2) EP2515900B1 (ru)
JP (2) JP5723889B2 (ru)
KR (2) KR20120107995A (ru)
CN (3) CN102665713B (ru)
AP (1) AP3536A (ru)
AR (1) AR079552A1 (ru)
AU (1) AU2010339753B2 (ru)
BR (1) BR112012015499A2 (ru)
CA (1) CA2784028C (ru)
CL (1) CL2012001597A1 (ru)
CR (1) CR20120353A (ru)
CY (1) CY1116511T1 (ru)
DK (1) DK2515900T3 (ru)
EA (2) EA025445B1 (ru)
EC (1) ECSP12012004A (ru)
ES (2) ES2540093T3 (ru)
HK (1) HK1170675A1 (ru)
HR (1) HRP20150644T1 (ru)
HU (1) HUE026916T2 (ru)
IL (1) IL220152A (ru)
ME (1) ME02179B (ru)
MX (2) MX2012007052A (ru)
NO (1) NO2749282T3 (ru)
NZ (2) NZ627181A (ru)
PE (1) PE20121520A1 (ru)
PL (2) PL2749282T3 (ru)
PT (2) PT2749282T (ru)
RS (1) RS54118B1 (ru)
SG (3) SG181541A1 (ru)
SI (2) SI2515900T1 (ru)
SM (1) SMT201500171B (ru)
TW (1) TWI508726B (ru)
UA (1) UA109887C2 (ru)
UY (1) UY33119A (ru)
WO (1) WO2011084733A1 (ru)
ZA (1) ZA201204608B (ru)

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JP4546824B2 (ja) 2002-05-21 2010-09-22 ギリアード・パロ・アルト・インコーポレイテッド 糖尿病を処置する方法
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WO2011135582A2 (en) * 2010-04-28 2011-11-03 Cadila Healthcare Limited Pharmaceutical compositions of dronedarone
EP2588197B1 (en) 2010-07-02 2014-11-05 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
TWI510480B (zh) 2011-05-10 2015-12-01 Gilead Sciences Inc 充當離子通道調節劑之稠合雜環化合物
TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
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WO2015073922A2 (en) 2013-11-15 2015-05-21 Northwestern University Inhibition of oxidative stress in atrial fibrillation
US9416128B2 (en) 2013-12-19 2016-08-16 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
CN104951870B (zh) * 2015-06-01 2018-11-13 南通科瑞斯生物医药科技有限公司 药物临床前心脏风险评估方法
WO2017147328A1 (en) 2016-02-23 2017-08-31 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
JP2019510752A (ja) 2016-03-04 2019-04-18 ギリアード サイエンシーズ， インコーポレイテッド オートタキシン阻害剤の組成物及び合剤
US10575744B2 (en) 2017-02-24 2020-03-03 Medtronic Cryocath Lp Pericardial balloon mapping
US10799703B2 (en) * 2017-12-22 2020-10-13 Medtronic, Inc. Evaluation of his bundle pacing therapy
EP3530182B1 (en) * 2018-02-27 2020-12-09 Nokia Technologies Oy Apparatus and method for determining a change in left ventricular twist of a subject's heart
US11865186B2 (en) * 2019-01-24 2024-01-09 Northwestern University Gene therapy treatment of atrial fibrillation

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Also Published As

Publication number Publication date
CY1116511T1 (el) 2017-03-15
UY33119A (es) 2011-07-29
SG10201710751TA (en) 2018-02-27
TW201136586A (en) 2011-11-01
EP2749282B1 (en) 2017-08-09
PL2515900T3 (pl) 2015-10-30
CN102665713B (zh) 2015-02-18
JP2015057449A (ja) 2015-03-26
IL220152A (en) 2016-11-30
CR20120353A (es) 2014-10-07
RS54118B1 (en) 2015-12-31
US20140323493A1 (en) 2014-10-30
NZ627181A (en) 2016-02-26
SI2515900T1 (sl) 2015-07-31
CA2784028A1 (en) 2011-07-14
PL2749282T3 (pl) 2018-01-31
ZA201204608B (en) 2013-02-27
WO2011084733A1 (en) 2011-07-14
AU2010339753B2 (en) 2015-01-22
SG181541A1 (en) 2012-07-30
KR20120107995A (ko) 2012-10-04
US8513254B2 (en) 2013-08-20
UA109887C2 (uk) 2015-10-26
EA201290451A1 (ru) 2013-01-30
AR079552A1 (es) 2012-02-01
AP2012006331A0 (en) 2012-06-30
MX2012007052A (es) 2012-07-30
SI2749282T1 (sl) 2017-12-29
AU2010339753A1 (en) 2012-07-12
PE20121520A1 (es) 2012-11-26
JP2013515007A (ja) 2013-05-02
CN104147010A (zh) 2014-11-19
AP3536A (en) 2016-01-13
DK2515900T3 (en) 2015-07-27
EA025445B1 (ru) 2016-12-30
US20110183990A1 (en) 2011-07-28
US9056108B2 (en) 2015-06-16
IL220152A0 (en) 2012-07-31
NZ600718A (en) 2014-08-29
HUE026916T2 (en) 2016-08-29
NO2749282T3 (ru) 2018-01-06
US20130317038A1 (en) 2013-11-28
ES2646603T3 (es) 2017-12-14
ES2540093T3 (es) 2015-07-08
EP2515900A1 (en) 2012-10-31
ECSP12012004A (es) 2012-08-31
PT2749282T (pt) 2017-11-15
CN104688739A (zh) 2015-06-10
HRP20150644T1 (hr) 2015-07-31
SG10201408528RA (en) 2015-04-29
TWI508726B (zh) 2015-11-21
CL2012001597A1 (es) 2013-06-28
PT2515900E (pt) 2015-07-30
KR20160108611A (ko) 2016-09-19
ME02179B (me) 2015-10-20
EP2749282A1 (en) 2014-07-02
US8754087B2 (en) 2014-06-17
HK1170675A1 (en) 2013-03-08
CA2784028C (en) 2016-08-23
EP2515900B1 (en) 2015-04-29
BR112012015499A2 (pt) 2016-05-03
MX344329B (es) 2016-12-13
CN102665713A (zh) 2012-09-12
SMT201500171B (it) 2015-09-07
JP5723889B2 (ja) 2015-05-27

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