JP2012520866A - 高用量のウルソデオキシコール酸で非アルコール性脂肪性肝炎を治療する方法 - Google Patents
高用量のウルソデオキシコール酸で非アルコール性脂肪性肝炎を治療する方法 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- Veterinary Medicine (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| EP (1) | EP2408457A1 (enExample) |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017522264A (ja) * | 2014-07-29 | 2017-08-10 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2018514534A (ja) * | 2015-04-27 | 2018-06-07 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の組成物および使用方法 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| KR101401628B1 (ko) * | 2012-12-24 | 2014-06-02 | 삼성제약공업주식회사 | 간기능 개선용 정제 및 그 제조 방법 |
| US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| ES2860423T3 (es) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida |
| CA2963704A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| CN109415685B (zh) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| SG10202104575WA (en) | 2016-11-04 | 2021-06-29 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
| US12281334B2 (en) | 2017-04-14 | 2025-04-22 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| JP2020524684A (ja) * | 2017-06-21 | 2020-08-20 | ノバルティス アーゲー | 非アルコール性脂肪性肝炎の治療のためのリコフリゴジン |
| WO2019074793A1 (en) | 2017-10-10 | 2019-04-18 | Children's Hospital Medical Center | OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME |
| KR101887561B1 (ko) * | 2017-11-15 | 2018-09-06 | 주식회사 대웅제약 | 간염 바이러스에 의해 유발된 간 섬유화의 개선을 위한 약학 조성물 |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| CA3106634A1 (en) | 2018-07-26 | 2020-01-30 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| RU2686042C1 (ru) * | 2018-09-04 | 2019-04-23 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | Способ лечения неалкогольной жировой болезни печени при метаболическом синдроме |
| CN112823012A (zh) | 2018-09-12 | 2021-05-18 | 儿童医院医学中心 | 用于产生造血干细胞及其衍生物的类器官组合物 |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| US12534709B2 (en) | 2019-05-31 | 2026-01-27 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| CA3141807A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| CN114207143A (zh) * | 2019-07-30 | 2022-03-18 | Ko生物技术有限公司 | 预测或诊断非酒精性脂肪肝病的试剂盒及诊断非酒精性脂肪肝病的方法 |
| WO2021020923A1 (ko) * | 2019-07-30 | 2021-02-04 | 주식회사 고바이오랩 | 간 손상 예방, 개선, 또는 치료용 조성물 및 간 손상 예방, 개선, 또는 치료방법 |
| PH12022551256A1 (en) * | 2020-01-28 | 2023-11-20 | Shilpa Medicare Ltd | Method for administration of ursodeoxycholic acid |
| WO2022083713A1 (en) * | 2020-10-23 | 2022-04-28 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating fatty liver disease, diabetes and hyperlipidemia |
| CN115137732A (zh) * | 2021-03-29 | 2022-10-04 | 中国科学院大连化学物理研究所 | Gpr120受体激动剂及熊去氧胆酸的应用 |
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| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
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2010
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- 2010-03-16 MX MX2011009757A patent/MX2011009757A/es not_active Application Discontinuation
- 2010-03-16 CN CN2010800119928A patent/CN102361642A/zh active Pending
- 2010-03-16 CA CA2755708A patent/CA2755708A1/en not_active Abandoned
- 2010-03-16 KR KR1020117024296A patent/KR20120008034A/ko not_active Withdrawn
- 2010-03-16 AU AU2010224587A patent/AU2010224587A1/en not_active Abandoned
- 2010-03-16 EP EP10714958A patent/EP2408457A1/en not_active Ceased
- 2010-03-16 WO PCT/IB2010/000551 patent/WO2010106420A1/en not_active Ceased
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- 2011-09-18 IL IL215195A patent/IL215195A0/en unknown
- 2011-10-17 ZA ZA2011/07578A patent/ZA201107578B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
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| JPN5012009298; ＬＩＮＤＯＲ Ｋ Ｄ: 'ＵＲＳＯＤＥＯＸＹＣＨＯＬＩＣ ＡＣＩＤ ＦＯＲ ＴＲＥＡＴＭＥＮＴ ＯＦ ＮＯＮＡＬＣＯＨＯＬＩＣ ＳＴＥＡＴＯＨＥＰＡＴＩＴＩＳ：ＲＥＳＵＬＴＳ ＯＦ Ａ ＲＡＮＤＯＭＩＺＥＤ ＴＲＩＡＬ' ＨＥＰＡＴＯＬＯＧＹ Ｖ３９, 2004, Ｐ７７０-７７８ * |
| JPN5012009299; ＣＵＬＬＥＮ Ｓ Ｎ: 'ＨＩＧＨ ＤＯＳＥ ＵＲＳＯＤＥＯＸＹＣＨＯＬＩＣ ＡＣＩＤ ＦＯＲ ＴＨＥ ＴＲＥＡＴＭＥＮＴ ＯＦ ＰＲＩＭＡＲＹ ＳＣＬＥＲＯＳＩＮＧ ＣＨＯＬＡＮＧＩＴＩＳ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＨＥＰＡＴＯＬＯＧＹ Ｖ４８, 2008, Ｐ７９２-８００ * |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017522264A (ja) * | 2014-07-29 | 2017-08-10 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2020073546A (ja) * | 2014-07-29 | 2020-05-14 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2022020854A (ja) * | 2014-07-29 | 2022-02-01 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP7285903B2 (ja) | 2014-07-29 | 2023-06-02 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2023099689A (ja) * | 2014-07-29 | 2023-07-13 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2018514534A (ja) * | 2015-04-27 | 2018-06-07 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の組成物および使用方法 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010106420A1 (en) | 2010-09-23 |
| US20120071451A1 (en) | 2012-03-22 |
| AU2010224587A1 (en) | 2011-09-22 |
| ZA201107578B (en) | 2013-06-26 |
| IL215195A0 (en) | 2011-12-29 |
| CA2755708A1 (en) | 2010-09-23 |
| KR20120008034A (ko) | 2012-01-25 |
| MX2011009757A (es) | 2012-02-28 |
| CN102361642A (zh) | 2012-02-22 |
| EP2408457A1 (en) | 2012-01-25 |
| RU2011139643A (ru) | 2013-04-27 |
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