JP2012520866A - 高用量のウルソデオキシコール酸で非アルコール性脂肪性肝炎を治療する方法 - Google Patents
高用量のウルソデオキシコール酸で非アルコール性脂肪性肝炎を治療する方法 Download PDFInfo
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- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017522264A (ja) * | 2014-07-29 | 2017-08-10 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2018514534A (ja) * | 2015-04-27 | 2018-06-07 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の組成物および使用方法 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| KR101401628B1 (ko) * | 2012-12-24 | 2014-06-02 | 삼성제약공업주식회사 | 간기능 개선용 정제 및 그 제조 방법 |
| US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| CA3066987A1 (en) * | 2017-06-21 | 2018-12-27 | Novartis Ag | Licofligozin for the treatment of non-alcoholic steatohepatitis |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| KR101887561B1 (ko) * | 2017-11-15 | 2018-09-06 | 주식회사 대웅제약 | 간염 바이러스에 의해 유발된 간 섬유화의 개선을 위한 약학 조성물 |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| RU2686042C1 (ru) * | 2018-09-04 | 2019-04-23 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | Способ лечения неалкогольной жировой болезни печени при метаболическом синдроме |
| WO2020056158A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| MX2022000802A (es) | 2019-07-30 | 2022-02-16 | Kobiolabs Inc | Kit para predecir o diagnosticar enfermedad de higado graso no alcoholico, y metodo para diagnosticar enfermedad de higado graso no alcoholico. |
| EP4006552A2 (en) * | 2019-07-30 | 2022-06-01 | Kobiolabs, Inc. | Kit for predicting or diagnosing nonalcoholic fatty liver disease, and method for diagnosing nonalcoholic fatty liver disease |
| CN115038459A (zh) * | 2020-01-28 | 2022-09-09 | 希尔帕医疗保健有限公司 | 熊去氧胆酸的给药方法 |
| WO2022083713A1 (en) * | 2020-10-23 | 2022-04-28 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating fatty liver disease, diabetes and hyperlipidemia |
| CN115137732A (zh) * | 2021-03-29 | 2022-10-04 | 中国科学院大连化学物理研究所 | Gpr120受体激动剂及熊去氧胆酸的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
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2010
- 2010-03-16 RU RU2011139643/15A patent/RU2011139643A/ru not_active Application Discontinuation
- 2010-03-16 CA CA2755708A patent/CA2755708A1/en not_active Abandoned
- 2010-03-16 EP EP10714958A patent/EP2408457A1/en not_active Ceased
- 2010-03-16 MX MX2011009757A patent/MX2011009757A/es not_active Application Discontinuation
- 2010-03-16 JP JP2012500328A patent/JP2012520866A/ja active Pending
- 2010-03-16 AU AU2010224587A patent/AU2010224587A1/en not_active Abandoned
- 2010-03-16 WO PCT/IB2010/000551 patent/WO2010106420A1/en not_active Ceased
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- 2010-03-16 KR KR1020117024296A patent/KR20120008034A/ko not_active Withdrawn
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- 2011-09-18 IL IL215195A patent/IL215195A0/en unknown
- 2011-10-17 ZA ZA2011/07578A patent/ZA201107578B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
Non-Patent Citations (4)
| Title |
|---|
| JPN5012009298; ＬＩＮＤＯＲ Ｋ Ｄ: 'ＵＲＳＯＤＥＯＸＹＣＨＯＬＩＣ ＡＣＩＤ ＦＯＲ ＴＲＥＡＴＭＥＮＴ ＯＦ ＮＯＮＡＬＣＯＨＯＬＩＣ ＳＴＥＡＴＯＨＥＰＡＴＩＴＩＳ：ＲＥＳＵＬＴＳ ＯＦ Ａ ＲＡＮＤＯＭＩＺＥＤ ＴＲＩＡＬ' ＨＥＰＡＴＯＬＯＧＹ Ｖ３９, 2004, Ｐ７７０-７７８ * |
| JPN5012009299; ＣＵＬＬＥＮ Ｓ Ｎ: 'ＨＩＧＨ ＤＯＳＥ ＵＲＳＯＤＥＯＸＹＣＨＯＬＩＣ ＡＣＩＤ ＦＯＲ ＴＨＥ ＴＲＥＡＴＭＥＮＴ ＯＦ ＰＲＩＭＡＲＹ ＳＣＬＥＲＯＳＩＮＧ ＣＨＯＬＡＮＧＩＴＩＳ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＨＥＰＡＴＯＬＯＧＹ Ｖ４８, 2008, Ｐ７９２-８００ * |
| JPN6014015985; Ｏｒｐｈａｎｅｔ Ｊｏｕｒｎａｌ ｏｆ Ｒａｒｅ Ｄｉｓｅａｓｅｓ １：４１, 200611 * |
| JPN6014015986; 治療学 ｖｏｌ．３９，ｎｏ．９, 2005, ｐ．３２（９２８）-３６（９３２） * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017522264A (ja) * | 2014-07-29 | 2017-08-10 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2020073546A (ja) * | 2014-07-29 | 2020-05-14 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2022020854A (ja) * | 2014-07-29 | 2022-02-01 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP7285903B2 (ja) | 2014-07-29 | 2023-06-02 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2023099689A (ja) * | 2014-07-29 | 2023-07-13 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2018514534A (ja) * | 2015-04-27 | 2018-06-07 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の組成物および使用方法 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2755708A1 (en) | 2010-09-23 |
| WO2010106420A1 (en) | 2010-09-23 |
| CN102361642A (zh) | 2012-02-22 |
| US20120071451A1 (en) | 2012-03-22 |
| AU2010224587A1 (en) | 2011-09-22 |
| KR20120008034A (ko) | 2012-01-25 |
| EP2408457A1 (en) | 2012-01-25 |
| IL215195A0 (en) | 2011-12-29 |
| RU2011139643A (ru) | 2013-04-27 |
| ZA201107578B (en) | 2013-06-26 |
| MX2011009757A (es) | 2012-02-28 |
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