JP2018168191A5 - - Google Patents
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- JP2018168191A5 JP2018168191A5 JP2018129624A JP2018129624A JP2018168191A5 JP 2018168191 A5 JP2018168191 A5 JP 2018168191A5 JP 2018129624 A JP2018129624 A JP 2018129624A JP 2018129624 A JP2018129624 A JP 2018129624A JP 2018168191 A5 JP2018168191 A5 JP 2018168191A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- excipient
- powder
- ray diffraction
- diffraction pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021203538A JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2023150905A JP2023179498A (ja) | 2012-12-12 | 2023-09-19 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2025171607A JP2026010061A (ja) | 2012-12-12 | 2025-10-10 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261736543P | 2012-12-12 | 2012-12-12 | |
| US61/736,543 | 2012-12-12 | ||
| US201261737007P | 2012-12-13 | 2012-12-13 | |
| US61/737,007 | 2012-12-13 | ||
| US201361788208P | 2013-03-15 | 2013-03-15 | |
| US61/788,208 | 2013-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547524A Division JP6447508B2 (ja) | 2012-12-12 | 2013-12-12 | ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021203538A Division JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018168191A JP2018168191A (ja) | 2018-11-01 |
| JP2018168191A5 true JP2018168191A5 (enExample) | 2019-02-14 |
| JP7042175B2 JP7042175B2 (ja) | 2022-03-25 |
Family
ID=50929140
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547524A Active JP6447508B2 (ja) | 2012-12-12 | 2013-12-12 | ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2018129624A Active JP7042175B2 (ja) | 2012-12-12 | 2018-07-09 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2021203538A Active JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2023150905A Pending JP2023179498A (ja) | 2012-12-12 | 2023-09-19 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2025171607A Pending JP2026010061A (ja) | 2012-12-12 | 2025-10-10 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547524A Active JP6447508B2 (ja) | 2012-12-12 | 2013-12-12 | ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021203538A Active JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2023150905A Pending JP2023179498A (ja) | 2012-12-12 | 2023-09-19 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2025171607A Pending JP2026010061A (ja) | 2012-12-12 | 2025-10-10 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US9493470B2 (enExample) |
| JP (5) | JP6447508B2 (enExample) |
| CN (2) | CN105188701A (enExample) |
| CA (3) | CA2815506C (enExample) |
| CL (1) | CL2015001643A1 (enExample) |
| HK (1) | HK1218878A1 (enExample) |
| MX (11) | MX391445B (enExample) |
| NZ (1) | NZ709648A (enExample) |
| WO (2) | WO2014093579A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5200939B2 (ja) | 2005-12-23 | 2013-06-05 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 二環式ヘテロアリール化合物 |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| CA2815506C (en) | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| US9725454B2 (en) | 2013-07-04 | 2017-08-08 | Sandoz Ag | Crystalline forms of ponatinib hydrochloride |
| CN104496940B (zh) * | 2014-01-06 | 2017-03-15 | 广东东阳光药业有限公司 | 一种制备bcr‑abl抑制剂中间体的方法 |
| CN110291081B (zh) * | 2016-12-15 | 2023-01-31 | 阿瑞雅德制药公司 | 作为c-kit抑制剂的苯并咪唑化合物 |
| US10221184B2 (en) | 2017-01-20 | 2019-03-05 | Apicore Us Llc | Polymorphs of ponatinib hydrochloride |
| US11072620B2 (en) | 2017-06-20 | 2021-07-27 | Apotex Inc. | Crystalline forms of Ponatinib hydrochloride |
| KR102753323B1 (ko) * | 2018-04-02 | 2025-01-09 | 스텔스 바이오테라퓨틱스 인코포레이티드 | 엘라미프레티드의 합성에 유용한 결정질 디펩티드 |
| WO2019246479A1 (en) | 2018-06-22 | 2019-12-26 | Johnson Matthey Public Limited Company | Form of ponatinib |
| AU2019374142A1 (en) | 2018-11-01 | 2021-05-27 | Syros Pharmaceuticals, Inc. | Methods of treating cancer in biomarker-identified patients with non-covalent inhibitors of cyclin-dependent kinase 7 (CDK7) |
| WO2020223235A1 (en) | 2019-04-29 | 2020-11-05 | Incyte Corporation | Mini-tablet dosage forms of ponatinib |
| CN111004240B (zh) * | 2019-12-13 | 2020-12-01 | 山东铂源药业有限公司 | 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法 |
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| US5099067A (en) * | 1988-08-05 | 1992-03-24 | Northwestern University | Use of ammonium formate as a hydrogen transfer reagent for reduction of chiral nitro compounds with retention of configuration |
| AU1465301A (en) * | 1999-11-08 | 2001-06-06 | Schering Corporation | Process for preparing n-(4-hydroxy-phenyl)-n'-(4'-aminophenyl)-piperazine |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| DE10021246A1 (de) | 2000-04-25 | 2001-10-31 | Schering Ag | Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel |
| IL159811A0 (en) | 2001-07-13 | 2004-06-20 | Neurogen Corp | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
| AR041992A1 (es) | 2002-11-06 | 2005-06-08 | Smithkline Beecham Corp | Compuesto de piridinil benzoheterociclico, composicion farmaceutica que lo comprende y su uso para prepararla |
| GB0230089D0 (en) | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| WO2005051366A2 (en) | 2003-11-28 | 2005-06-09 | Novartis Ag | Diaryl urea derivatives in the treatment of protein kinase dependent diseases |
| NZ546782A (en) * | 2003-12-05 | 2010-04-30 | Biovitrum Ab | Improved synthesis of 2-substituted adenosines such as spongosine |
| JP2007517007A (ja) | 2003-12-24 | 2007-06-28 | アストラゼネカ アクチボラグ | Ｔｉｅ２（ＴＥＫ）活性を持つピリミジン |
| DE602004015509D1 (de) | 2003-12-24 | 2008-09-11 | Astrazeneca Ab | Pyrimidine mit tie2 (tek) aktivität |
| CA2560648C (en) | 2004-04-07 | 2013-01-22 | Applied Research Systems Ars Holding N.V. | 1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors |
| JP2008506702A (ja) | 2004-07-14 | 2008-03-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎を治療するための方法 |
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| GB0502418D0 (en) | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
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| WO2007021937A2 (en) | 2005-08-11 | 2007-02-22 | Ariad Pharmaceuticals, Inc. | Unsaturated heterocyclic derivatives |
| CN101389338B (zh) * | 2005-12-23 | 2013-06-26 | 阿里亚德医药股份有限公司 | 双环杂芳基化合物 |
| JP5200939B2 (ja) | 2005-12-23 | 2013-06-05 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 二環式ヘテロアリール化合物 |
| EP2024366B1 (en) | 2006-05-08 | 2015-09-16 | Ariad Pharmaceuticals, Inc. | Monocyclic heteroaryl compounds |
| KR20090018104A (ko) | 2006-05-08 | 2009-02-19 | 어리어드 파마슈티칼스, 인코포레이티드 | 아세틸렌계 헤테로아릴 화합물 |
| EP2107054A1 (en) | 2008-04-01 | 2009-10-07 | Università Degli Studi Di Milano - Bicocca | Antiproliferative compounds and therapeutic uses thereof |
| WO2010124047A1 (en) | 2009-04-23 | 2010-10-28 | Wyeth Llc | Bisaryl alkynylamides as negative allosteric modulators of metabotropic glutamate receptor 5 (mglur5) |
| US8329724B2 (en) * | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
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| BR112013024169A2 (pt) | 2011-04-07 | 2016-12-06 | Ariad Pharma Inc | método para o tratamento e prevenção da doença de parkinson |
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| JP2015514802A (ja) | 2012-04-25 | 2015-05-21 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｒａｆキナーゼ媒介疾患用の方法及び組成物 |
| CA2815506C (en) * | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
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2013
- 2013-05-09 CA CA2815506A patent/CA2815506C/en active Active
- 2013-05-09 CA CA3022250A patent/CA3022250A1/en not_active Abandoned
- 2013-05-09 CA CA3167093A patent/CA3167093A1/en active Pending
- 2013-12-12 US US14/651,577 patent/US9493470B2/en active Active
- 2013-12-12 WO PCT/US2013/074571 patent/WO2014093579A2/en not_active Ceased
- 2013-12-12 JP JP2015547524A patent/JP6447508B2/ja active Active
- 2013-12-12 WO PCT/US2013/074585 patent/WO2014093583A2/en not_active Ceased
- 2013-12-12 MX MX2018010998A patent/MX391445B/es unknown
- 2013-12-12 HK HK16106954.3A patent/HK1218878A1/zh unknown
- 2013-12-12 MX MX2015007578A patent/MX359147B/es active IP Right Grant
- 2013-12-12 CN CN201380072027.5A patent/CN105188701A/zh active Pending
- 2013-12-12 NZ NZ709648A patent/NZ709648A/en unknown
- 2013-12-12 CN CN202210369530.8A patent/CN115043843A/zh active Pending
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2015
- 2015-06-12 MX MX2021002258A patent/MX2021002258A/es unknown
- 2015-06-12 MX MX2021002256A patent/MX2021002256A/es unknown
- 2015-06-12 CL CL2015001643A patent/CL2015001643A1/es unknown
- 2015-06-12 MX MX2021002261A patent/MX2021002261A/es unknown
- 2015-06-12 MX MX2021002257A patent/MX2021002257A/es unknown
- 2015-06-12 MX MX2021002264A patent/MX2021002264A/es unknown
- 2015-06-12 MX MX2021002259A patent/MX2021002259A/es unknown
- 2015-06-12 MX MX2021002253A patent/MX2021002253A/es unknown
- 2015-06-12 MX MX2021002254A patent/MX2021002254A/es unknown
- 2015-06-12 MX MX2021002255A patent/MX2021002255A/es unknown
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2016
- 2016-11-02 US US15/341,898 patent/US10125136B2/en active Active
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2018
- 2018-07-09 JP JP2018129624A patent/JP7042175B2/ja active Active
- 2018-09-28 US US16/146,143 patent/US10662197B2/en active Active
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2020
- 2020-05-22 US US16/881,790 patent/US11279705B2/en active Active
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2021
- 2021-05-12 US US17/318,677 patent/US11192895B2/en active Active
- 2021-05-12 US US17/318,876 patent/US11384086B2/en active Active
- 2021-05-12 US US17/318,832 patent/US11192897B2/en active Active
- 2021-05-12 US US17/318,772 patent/US11192896B2/en active Active
- 2021-12-15 JP JP2021203538A patent/JP7352841B2/ja active Active
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2023
- 2023-02-27 US US18/175,272 patent/US20240083902A1/en not_active Abandoned
- 2023-09-19 JP JP2023150905A patent/JP2023179498A/ja active Pending
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2025
- 2025-10-10 JP JP2025171607A patent/JP2026010061A/ja active Pending