|
US7763609B2
(en)
|
2003-12-15 |
2010-07-27 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
ES2537898T3
(es)
|
2005-10-25 |
2015-06-15 |
Shionogi & Co., Ltd. |
Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1
|
|
AU2008245082B8
(en)
|
2007-04-24 |
2012-09-13 |
Shionogi & Co., Ltd. |
Aminodihydrothiazine derivatives substituted with a cyclic group
|
|
EP2151435A4
(en)
|
2007-04-24 |
2011-09-14 |
Shionogi & Co |
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
|
|
BRPI0906962B8
(pt)
|
2008-01-18 |
2021-05-25 |
Eisai R&D Man Co Ltd |
composto de aminodiidrotiazina fundido
|
|
US8637504B2
(en)
|
2008-06-13 |
2014-01-28 |
Shionogi & Co., Ltd. |
Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
|
|
AU2009277485B2
(en)
*
|
2008-07-28 |
2013-05-02 |
Eisai R&D Management Co., Ltd. |
Spiroaminodihydrothiazine derivatives
|
|
KR20110076965A
(ko)
*
|
2008-09-30 |
2011-07-06 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
신규한 축합 아미노 디하이드로티아진 유도체
|
|
WO2010047372A1
(ja)
|
2008-10-22 |
2010-04-29 |
塩野義製薬株式会社 |
Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体
|
|
GB0912777D0
(en)
|
2009-07-22 |
2009-08-26 |
Eisai London Res Lab Ltd |
Fused aminodihydropyrimidone derivatives
|
|
GB0912778D0
(en)
|
2009-07-22 |
2009-08-26 |
Eisai London Res Lab Ltd |
Fused aminodihydro-oxazine derivatives
|
|
WO2011044187A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
WO2011044184A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
|
|
UA108363C2
(uk)
|
2009-10-08 |
2015-04-27 |
|
Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
|
|
WO2011044185A2
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
|
|
RU2012129168A
(ru)
|
2009-12-11 |
2014-01-20 |
Сионоги Энд Ко. Лтд. |
Производные оксазина
|
|
US20120245155A1
(en)
*
|
2009-12-11 |
2012-09-27 |
Shionogi & Co., Ltd. |
Fused heterocyclic compound having amino group
|
|
AR081587A1
(es)
|
2010-06-09 |
2012-10-03 |
Janssen Pharmaceutica Nv |
DERIVADOS DE 5,6-DIHIDRO-2H-[1,4]OXAZIN-3-IL-AMINA UTILES COMO INHIBIDORES DE LA b-SECRETASA (BACE)
|
|
US9018219B2
(en)
|
2010-10-29 |
2015-04-28 |
Shionogi & Co., Ltd. |
Fused aminodihydropyrimidine derivative
|
|
CA2816285A1
(en)
|
2010-10-29 |
2012-05-03 |
Shionogi & Co., Ltd. |
Naphthyridine derivative
|
|
ES2648143T3
(es)
|
2010-12-22 |
2017-12-28 |
Janssen Pharmaceutica Nv |
Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8-ilamina útiles como inhibidores de la beta-secretasa (BACE)
|
|
GB201100181D0
(en)
*
|
2011-01-06 |
2011-02-23 |
Eisai Ltd |
Fused aminodihydrothiazine derivatives
|
|
GB201101140D0
(en)
|
2011-01-21 |
2011-03-09 |
Eisai Ltd |
Fused aminodihydrothiazine derivatives
|
|
GB201101139D0
(en)
|
2011-01-21 |
2011-03-09 |
Eisai Ltd |
Fused aminodihydrothiazine derivatives
|
|
EP2665716B1
(en)
*
|
2011-01-21 |
2017-03-08 |
Eisai R&D Management Co., Ltd. |
Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives
|
|
JP5853035B2
(ja)
|
2011-03-09 |
2016-02-09 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ |
β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な３，４−ジヒドロ−ピロロ［１，２−ａ］ピラジン−１−イルアミン誘導体
|
|
WO2012138734A1
(en)
|
2011-04-07 |
2012-10-11 |
Merck Sharp & Dohme Corp. |
C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
EP2694521B1
(en)
|
2011-04-07 |
2015-11-25 |
Merck Sharp & Dohme Corp. |
Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
WO2012147763A1
(ja)
|
2011-04-26 |
2012-11-01 |
塩野義製薬株式会社 |
オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
|
|
US8604024B2
(en)
|
2011-05-24 |
2013-12-10 |
Bristol-Myers Squibb Company |
Compounds for the reduction of beta-amyloid production
|
|
TW201302763A
(zh)
|
2011-05-24 |
2013-01-16 |
必治妥美雅史谷比公司 |
用於減少β－類澱粉產生之化合物
|
|
US8927535B2
(en)
*
|
2011-07-06 |
2015-01-06 |
Hoffman-La Roche Inc. |
Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors
|
|
RU2014111055A
(ru)
|
2011-08-22 |
2015-09-27 |
Мерк Шарп И Доум Корп. |
2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение
|
|
WO2013030713A1
(en)
|
2011-08-31 |
2013-03-07 |
Pfizer Inc. |
Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
|
|
JO3143B1
(ar)
|
2012-04-03 |
2017-09-20 |
Lilly Co Eli |
مركبات تتراهيدرو بيرولو ثيازين
|
|
HUE030534T2
(hu)
|
2012-04-27 |
2017-05-29 |
Eisai R&D Man Co Ltd |
Eljárás 5-(difluormetil)pirazin-2-karbonsav elõállítására és elõállítási intermediere
|
|
WO2013164730A1
(en)
|
2012-05-04 |
2013-11-07 |
Pfizer Inc. |
Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2.
|
|
GB201212871D0
(en)
|
2012-07-20 |
2012-09-05 |
Eisai Ltd |
Novel compounds
|
|
JP2015529239A
(ja)
|
2012-09-20 |
2015-10-05 |
ファイザー・インク |
アルキル置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
|
|
JP2016501827A
(ja)
|
2012-10-24 |
2016-01-21 |
塩野義製薬株式会社 |
Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
|
|
CA2886507C
(en)
*
|
2012-10-26 |
2016-09-20 |
Eli Lilly And Company |
Bace inhibitors
|
|
CA2893256A1
(en)
|
2012-12-11 |
2014-06-19 |
Pfizer Inc. |
Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
|
|
EP2935256B1
(en)
|
2012-12-19 |
2018-01-24 |
Bristol-Myers Squibb Company |
4,6-diarylaminothiazines as bace1 inhibitors and their use for the reduction of beta-amyloid production
|
|
CA2893333C
(en)
|
2012-12-19 |
2017-10-24 |
Pfizer Inc. |
Carbocyclic-and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
|
|
US9309263B2
(en)
|
2013-01-29 |
2016-04-12 |
Amgen Inc. |
Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof
|
|
EP3653609B1
(en)
|
2013-02-12 |
2024-04-03 |
Buck Institute for Research on Aging |
Hydantoins that modulate bace-mediated app processing
|
|
WO2014125394A1
(en)
|
2013-02-13 |
2014-08-21 |
Pfizer Inc. |
HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
|
|
US9233981B1
(en)
|
2013-02-15 |
2016-01-12 |
Pfizer Inc. |
Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
|
|
AU2014223334C1
(en)
*
|
2013-03-01 |
2018-10-18 |
Amgen Inc. |
Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
|
EP2964644B1
(en)
|
2013-03-08 |
2018-12-26 |
Amgen, Inc. |
Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
|
TWI593692B
(zh)
|
2013-03-12 |
2017-08-01 |
美國禮來大藥廠 |
四氫吡咯并噻嗪化合物
|
|
EP3008067B1
(en)
|
2013-06-12 |
2017-03-29 |
Janssen Pharmaceutica N.V. |
4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace)
|
|
BR112015030597A2
(pt)
|
2013-06-12 |
2017-07-25 |
Janssen Pharmaceutica Nv |
derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace)
|
|
TWI639607B
(zh)
*
|
2013-06-18 |
2018-11-01 |
美國禮來大藥廠 |
Ｂａｃｅ抑制劑
|
|
US9096615B2
(en)
|
2013-07-30 |
2015-08-04 |
Amgen Inc. |
Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof
|
|
JP6111002B1
(ja)
|
2014-04-10 |
2017-04-05 |
ファイザー・インク |
２−アミノ−６−メチル−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル−１，３−チアゾール−４−イルアミド
|
|
MX381482B
(es)
|
2014-08-08 |
2025-03-12 |
Amgen Inc |
Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso.
|
|
CR20170187A
(es)
|
2014-11-10 |
2018-02-01 |
H Lundbeck As |
2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer
|
|
JO3458B1
(ar)
|
2014-11-10 |
2020-07-05 |
H Lundbeck As |
2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1
|
|
MA40941A
(fr)
|
2014-11-10 |
2017-09-19 |
H Lundbeck As |
2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
|
|
JP2017538753A
(ja)
|
2014-12-18 |
2017-12-28 |
ヤンセン ファーマシューティカ エヌ．ベー． |
２，３，４，５−テトラヒドロピリジン−６−アミンおよび３，４−ジヒドロ−２Ｈ−ピロール−５−アミンの化合物のβセクレターゼ阻害剤
|
|
AR103680A1
(es)
|
2015-02-23 |
2017-05-24 |
Lilly Co Eli |
Inhibidores selectivos de bace1
|
|
US9938266B2
(en)
|
2015-03-19 |
2018-04-10 |
Eli Lilly And Company |
Selective BACE1 inhibitors
|
|
AR104241A1
(es)
|
2015-04-29 |
2017-07-05 |
Lilly Co Eli |
Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos
|
|
US10246429B2
(en)
|
2015-08-06 |
2019-04-02 |
Amgen Inc. |
Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
|
TW201717948A
(zh)
|
2015-08-10 |
2017-06-01 |
Ｈ 朗德貝克公司 |
包括給予２－胺基－３，５，５－三氟－３，４，５，６－四氫吡啶的聯合治療
|
|
JP2018527338A
(ja)
*
|
2015-08-12 |
2018-09-20 |
ハー・ルンドベック・アクチエゼルスカベット |
ＢＡＣＥ１阻害剤としての２−アミノ−７ａ−フェニル−３，４，４ａ，５，７，７ａ−ヘキサヒドロフロ［３，４−ｂ］ピリジン
|
|
RU2018104868A
(ru)
|
2015-08-12 |
2019-09-13 |
Х. Лундбекк А/С |
2-амино-3-фтор-3-(фторметил)-6-метил-6-фенил-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1
|
|
JP2018531923A
(ja)
*
|
2015-09-24 |
2018-11-01 |
ファイザー・インク |
Ｎ−［２−（２−アミノ−６，６−二置換−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル）−１，３−チアゾール−４−イル］アミド
|
|
WO2017051303A1
(en)
|
2015-09-24 |
2017-03-30 |
Pfizer Inc. |
Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
|
|
EP3353174A1
(en)
|
2015-09-24 |
2018-08-01 |
Pfizer Inc |
N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl]amides useful as bace inhibitors
|
|
JOP20170106A1
(ar)
*
|
2016-05-20 |
2017-11-20 |
Lilly Co Eli |
مركبات تترا هيدرو فوروكسازين واستخداماتها كمثبطات bace1 انتقائية
|
|
MX2019005247A
(es)
*
|
2016-11-04 |
2019-06-24 |
Janssen Pharmaceutica Nv |
Compuestos 4,4a,5,7-tetrahidro-3h-furo[3,4-b]piridinilicos.
|
|
MX387729B
(es)
|
2016-12-15 |
2025-03-18 |
Amgen Inc |
Derivados de dióxido de 1,4-tiazina y dióxido 1,2,4-tiadiazina como inhibidores de beta-secretasa y métodos de uso.
|
|
MX388697B
(es)
|
2016-12-15 |
2025-03-20 |
Amgen Inc |
Derivados de tiazina como inhibidores de beta-secretasa y metodos de uso.
|
|
AU2017376445B2
(en)
|
2016-12-15 |
2021-09-30 |
Amgen Inc. |
Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
|
|
AU2017376441B2
(en)
|
2016-12-15 |
2021-10-14 |
Amgen Inc. |
Oxazine derivatives as beta-secretase inhibitors and methods of use
|
|
MX386618B
(es)
|
2016-12-15 |
2025-03-19 |
Amgen Inc |
Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y métodos de uso.
|
|
EP3592751A1
(en)
*
|
2017-03-07 |
2020-01-15 |
Janssen Pharmaceutica NV |
Inhibitors of beta secretase
|
|
MA47729A
(fr)
*
|
2017-03-07 |
2020-01-15 |
Janssen Pharmaceutica Nv |
Inhibiteurs de bêta-sécrétase
|
|
CA3051779A1
(en)
*
|
2017-03-07 |
2018-09-13 |
Janssen Pharmaceutica Nv |
Inhibitors of beta secretase
|
|
EA201992055A1
(ru)
*
|
2017-09-07 |
2020-01-30 |
Янссен Фармацевтика Нв |
Ингибиторы бета-секретазы
|
|
EA201992076A1
(ru)
*
|
2017-09-07 |
2020-03-19 |
Янссен Фармацевтика Нв |
Ингибиторы бета-секретазы
|
|
EA201992108A1
(ru)
*
|
2017-09-07 |
2020-01-27 |
Янссен Фармацевтика Нв |
Ингибиторы бета-секретазы
|
|
CN110590517A
(zh)
*
|
2019-09-24 |
2019-12-20 |
武汉嘉诺康医药技术有限公司 |
一种3，4-二羟基-2′-氯苯乙酮的制备方法
|