|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4714681A
(en)
|
1981-07-01 |
1987-12-22 |
The Board Of Reagents, The University Of Texas System Cancer Center |
Quadroma cells and trioma cells and methods for the production of same
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4925648A
(en)
|
1988-07-29 |
1990-05-15 |
Immunomedics, Inc. |
Detection and treatment of infectious and inflammatory lesions
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
ES2096590T3
(es)
|
1989-06-29 |
1997-03-16 |
Medarex Inc |
Reactivos biespecificos para la terapia del sida.
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
DE69130709T3
(de)
|
1990-10-05 |
2005-12-22 |
Celldex Therapeutics, Inc. |
Gezielte immunostimulierung mit bispezifischen stoffen
|
|
EP0557300B1
(en)
|
1990-10-29 |
1997-11-19 |
Chiron Corporation |
Bispecific antibodies, method of production, and uses thereof
|
|
DE69214709T2
(de)
|
1991-04-26 |
1997-02-20 |
Surface Active Ltd |
Neue Antikörper und Verfahren zu ihrer Verwendung
|
|
EP0627940B1
(en)
|
1992-03-05 |
2003-05-07 |
Board of Regents, The University of Texas System |
Use of immunoconjugates for the diagnosis and/or therapy of vascularized tumors
|
|
US6111166A
(en)
|
1994-09-19 |
2000-08-29 |
Medarex, Incorporated |
Transgenic mice expressing human Fcα and β receptors
|
|
MY141867A
(en)
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
GB0226583D0
(en)
|
2002-11-14 |
2002-12-18 |
Cyclacel Ltd |
Compounds
|
|
PT1847539E
(pt)
|
2002-12-24 |
2009-10-06 |
Astrazeneca Ab |
Derivados de quinazolina
|
|
JP2006517949A
(ja)
|
2003-02-17 |
2006-08-03 |
ファルマシア・イタリア・ソシエタ・ペル・アツィオーニ |
キナーゼ阻害剤としての四環系ピラゾール誘導体、前記誘導体の製造方法、および前記誘導体を含む医薬組成物
|
|
GB0315657D0
(en)
|
2003-07-03 |
2003-08-13 |
Astex Technology Ltd |
Pharmaceutical compounds
|
|
TWI372050B
(en)
|
2003-07-03 |
2012-09-11 |
Astex Therapeutics Ltd |
(morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
|
|
US7141568B2
(en)
|
2003-07-09 |
2006-11-28 |
Pfizer Italia S.R.L. |
Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
JP4741491B2
(ja)
|
2003-08-07 |
2011-08-03 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
抗増殖剤としての２，４−ピリミジンジアミン化合物および使用
|
|
RS50568B8
(sr)
|
2004-05-14 |
2019-08-30 |
Millennium Pharm Inc |
Jedinjenja i postupci za inhibiciju mitotičke progresije inhibiranjem aurora kinaze
|
|
JP4812763B2
(ja)
|
2004-05-18 |
2011-11-09 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
|
|
WO2006003440A1
(en)
|
2004-07-05 |
2006-01-12 |
Astex Therapeutics Limited |
3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors
|
|
DE602005024274D1
(de)
|
2004-07-16 |
2010-12-02 |
Sunesis Pharmaceuticals Inc |
Als aurora-kinase-inhibitoren nutzbare thienopyrimidine
|
|
MX2007003533A
(es)
*
|
2004-10-01 |
2007-05-23 |
Medarex Inc |
Metodos de tratar linfomas cd30 positivas.
|
|
ATE421996T1
(de)
|
2004-11-15 |
2009-02-15 |
Rigel Pharmaceuticals Inc |
Verfahren zur herstellung optisch aktiver n- carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase
|
|
GB2420559B
(en)
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
EP2395000A1
(en)
|
2004-12-30 |
2011-12-14 |
Astex Therapeutics Limited |
Benzimidazole compounds that modulate the activity of CDK, GSK and aurora kinases
|
|
JP2008526723A
(ja)
|
2004-12-30 |
2008-07-24 |
アステックス、セラピューティックス、リミテッド |
Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体
|
|
WO2006070202A1
(en)
|
2004-12-30 |
2006-07-06 |
Astex Therapeutics Limited |
Pyrazole derivatives having kinase modulating activity
|
|
EP1836199A1
(en)
|
2004-12-30 |
2007-09-26 |
Astex Therapeutics Limited |
Thiazole and isothiazole derivatives that modulate the activity of cdk, gsk and aurora kinases
|
|
US7485661B2
(en)
|
2005-01-18 |
2009-02-03 |
Pfizer Italia S.R.L. |
Heterobicyclic pyrazole derivatives as kinase inhibitors
|
|
CA2622352C
(en)
|
2005-09-30 |
2014-05-27 |
Miikana Therapeutics, Inc. |
Substituted pyrazole compounds
|
|
TW200734327A
(en)
|
2005-11-03 |
2007-09-16 |
Vertex Pharma |
Aminopyrimidines useful as kinase inhibitors
|
|
TW200808311A
(en)
|
2006-03-30 |
2008-02-16 |
Nerviano Medical Sciences Srl |
Use of a kinase inhibitor for the treatment of particular resistant tumors
|
|
GB0609530D0
(en)
|
2006-05-12 |
2006-06-21 |
Cyclacel Ltd |
Combination
|
|
WO2007132221A1
(en)
|
2006-05-12 |
2007-11-22 |
Cyclacel Limited |
Combined anticancer pyrimidine-thiazole aurora kinase inhibitors
|
|
WO2007132220A1
(en)
|
2006-05-12 |
2007-11-22 |
Cyclacel Limited |
Combination of a 2-substituted-4-heter0aryl-pyrimidine amine with a cytotoxic drug and use thereof in the treatment of a proliferative disorder
|
|
US7718648B2
(en)
|
2006-08-09 |
2010-05-18 |
Millennium Pharmaceuticals, Inc. |
Pyridobenzazepine compounds and methods for inhibiting mitotic progression
|
|
CL2007003244A1
(es)
|
2006-11-16 |
2008-04-04 |
Millennium Pharm Inc |
Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
|
|
MX2011006725A
(es)
*
|
2008-12-22 |
2011-09-15 |
Millennium Pharm Inc |
Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20.
|
|
CA2749115C
(en)
|
2009-01-09 |
2022-06-21 |
Seattle Genetics, Inc. |
Weekly dosing regimens for anti-cd30 vc-pab-mmae antibody drug-conjugates
|
|
JO3635B1
(ar)
|
2009-05-18 |
2020-08-27 |
Millennium Pharm Inc |
مركبات صيدلانية صلبة وطرق لانتاجها
|
|
JO3434B1
(ar)
|
2009-07-31 |
2019-10-20 |
Millennium Pharm Inc |
مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
|
|
CN102770024A
(zh)
|
2010-02-19 |
2012-11-07 |
米伦纽姆医药公司 |
4-{[9-氯-7-(2-氟-6-甲氧基苯基)-5h-嘧啶并[5,4-d][2]苯并氮杂卓-2基]氨基}-2-甲氧基苯甲酸钠的结晶形式
|
|
US20130004481A1
(en)
*
|
2011-01-12 |
2013-01-03 |
Boehringer Ingelheim International Gmbh |
Anticancer therapy
|