JP2013507415A5 - - Google Patents
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- JP2013507415A5 JP2013507415A5 JP2012533589A JP2012533589A JP2013507415A5 JP 2013507415 A5 JP2013507415 A5 JP 2013507415A5 JP 2012533589 A JP2012533589 A JP 2012533589A JP 2012533589 A JP2012533589 A JP 2012533589A JP 2013507415 A5 JP2013507415 A5 JP 2013507415A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- composition
- administered
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25085209P | 2009-10-12 | 2009-10-12 | |
| US61/250,852 | 2009-10-12 | ||
| PCT/EP2010/065149 WO2011054620A1 (en) | 2009-10-12 | 2010-10-11 | Combinations of a pi3k inhibitor and a mek inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014202819A Division JP5745678B2 (ja) | 2009-10-12 | 2014-10-01 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507415A JP2013507415A (ja) | 2013-03-04 |
| JP2013507415A5 true JP2013507415A5 (enExample) | 2014-04-24 |
Family
ID=43072663
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533589A Ceased JP2013507415A (ja) | 2009-10-12 | 2010-10-11 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
| JP2014202819A Expired - Fee Related JP5745678B2 (ja) | 2009-10-12 | 2014-10-01 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014202819A Expired - Fee Related JP5745678B2 (ja) | 2009-10-12 | 2014-10-01 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20110086837A1 (enExample) |
| EP (1) | EP2488178B1 (enExample) |
| JP (2) | JP2013507415A (enExample) |
| KR (1) | KR101489045B1 (enExample) |
| CN (1) | CN102740851B (enExample) |
| AR (1) | AR078588A1 (enExample) |
| AU (1) | AU2010314287A1 (enExample) |
| BR (1) | BR112012008483A2 (enExample) |
| CA (1) | CA2776944A1 (enExample) |
| CL (1) | CL2012000913A1 (enExample) |
| CO (1) | CO6531463A2 (enExample) |
| CR (1) | CR20120173A (enExample) |
| EC (1) | ECSP12011865A (enExample) |
| ES (1) | ES2609767T3 (enExample) |
| IL (1) | IL219105A0 (enExample) |
| MA (1) | MA33974B1 (enExample) |
| MX (1) | MX345155B (enExample) |
| NZ (1) | NZ599939A (enExample) |
| PE (1) | PE20121816A1 (enExample) |
| PH (1) | PH12012500709A1 (enExample) |
| RU (1) | RU2563193C2 (enExample) |
| TW (1) | TWI428336B (enExample) |
| WO (1) | WO2011054620A1 (enExample) |
| ZA (1) | ZA201202618B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011000440A (es) | 2008-07-11 | 2011-02-24 | Novartis Ag | Combinacion de (a) un inhibidor de fosfoinositido 3-cinasa y (b) un modulador de la ruta de ras/raf/mek. |
| EA024252B1 (ru) | 2009-01-08 | 2016-08-31 | Кьюрис, Инк. | Ингибиторы фосфоинозитид-3-киназ с цинксвязывающей группой |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| CA2830822C (en) | 2011-04-01 | 2018-10-02 | Curis, Inc. | A thienopyrimidine phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
| AR087405A1 (es) | 2011-08-01 | 2014-03-19 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek |
| US9675595B2 (en) | 2011-08-31 | 2017-06-13 | Novartis Ag | Synergistic combinations of PI3K- and MEK-inhibitors |
| CN103957902A (zh) | 2011-10-13 | 2014-07-30 | 基因泰克公司 | 药理学诱导的胃酸过少的治疗 |
| EP2776051A4 (en) * | 2011-10-28 | 2015-06-17 | Hoffmann La Roche | THERAPEUTIC COMBINATIONS AND METHOD FOR THE TREATMENT OF MELANOMA |
| WO2013082511A1 (en) | 2011-12-02 | 2013-06-06 | Genentech, Inc. | Methods for overcoming tumor resistance to vegf antagonists |
| PE20142020A1 (es) * | 2012-04-06 | 2014-12-24 | Sanofi Sa | Metodos para tratar el cancer usando inhibidor de pi3k e inhibidor de mek |
| JP6093757B2 (ja) * | 2012-04-19 | 2017-03-08 | 国立大学法人九州大学 | 医薬組成物 |
| US9107926B2 (en) | 2012-06-08 | 2015-08-18 | Genentech, Inc. | Mutant selectivity and combinations of a phosphoinositide 3-kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| EP2879708A4 (en) | 2012-08-02 | 2016-03-16 | Genentech Inc | ANTIBODY AND ANTI-ETBR IMMUNOCONJUGATES |
| US9463251B2 (en) | 2012-08-02 | 2016-10-11 | Genentech, Inc. | Anti-ETBR antibodies and immunoconjugates |
| RS59113B1 (sr) * | 2012-08-17 | 2019-09-30 | Hoffmann La Roche | Kombinovane terapije za melanom koje uključuju davanje kobimetiniba i vemurafiniba |
| SG11201507477XA (en) * | 2013-03-14 | 2015-10-29 | Genentech Inc | Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| ES2779975T3 (es) | 2014-02-07 | 2020-08-21 | Verastem Inc | Métodos y composiciones para tratar el crecimiento celular anormal |
| SG10202007111TA (en) | 2014-07-15 | 2020-09-29 | Genentech Inc | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| WO2016040806A1 (en) * | 2014-09-11 | 2016-03-17 | The Regents Of The University Of California | mTORC1 INHIBITORS |
| ES3014591T3 (en) | 2018-09-11 | 2025-04-23 | Curis Inc | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
| CN110420330B (zh) * | 2019-07-19 | 2020-05-29 | 南京医科大学 | 一种pi3k与mth1靶向药组合物的制药用途 |
| JP2022547358A (ja) | 2019-09-13 | 2022-11-14 | ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル | 治療組成物、組み合わせ、及び使用方法 |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470356A1 (de) * | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| BE754606A (fr) * | 1969-08-08 | 1971-02-08 | Thomae Gmbh Dr K | Nouvelles 2-aminoalcoylamino-thieno(3,2-d)pyrimidines et leurs procedesde fabrication |
| BE759493A (fr) * | 1969-11-26 | 1971-05-25 | Thomae Gmbh Dr K | Nouvelles 2-(5-nitro-2-furyl)-thieno(3,2-d) pyrimidines et procedes pour les fabriquer |
| US3763156A (en) * | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
| CH592668A5 (enExample) * | 1973-10-02 | 1977-10-31 | Delalande Sa | |
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| US4510139A (en) * | 1984-01-06 | 1985-04-09 | Sterling Drug Inc. | Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity |
| WO1995026956A1 (en) * | 1994-04-01 | 1995-10-12 | Shionogi & Co., Ltd. | Oxime derivative and bactericide containing the same as active ingredient |
| US6974878B2 (en) * | 2001-03-21 | 2005-12-13 | Symyx Technologies, Inc. | Catalyst ligands, catalytic metal complexes and processes using same |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| EE05450B1 (et) * | 2000-07-19 | 2011-08-15 | Warner-Lambert Company | 4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| EP1606283B1 (en) * | 2003-03-03 | 2008-10-08 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US20050049276A1 (en) * | 2003-07-23 | 2005-03-03 | Warner-Lambert Company, Llc | Imidazopyridines and triazolopyridines |
| US7538120B2 (en) * | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
| US7144907B2 (en) * | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| EP1674452A4 (en) * | 2003-09-19 | 2007-10-10 | Chugai Pharmaceutical Co Ltd | NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND ITS USE AS MEK INHIBITOR |
| US7517994B2 (en) * | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| HRP20110498T1 (hr) * | 2005-10-07 | 2011-08-31 | Exelixis | Azetidini kao inhibitori mek za liječenje proliferativnih bolesti |
| BRPI0710874A2 (pt) * | 2006-04-26 | 2012-02-14 | Hoffmann La Roche | compostos de tienopirimidina, processos de produção dos referidos compostos, composições farmacêuticas contendo os mesmos, kit, produto, e usos dos compostos |
| WO2008021389A2 (en) * | 2006-08-16 | 2008-02-21 | Exelixis, Inc. | Using pi3k and mek modulators in treatments of cancer |
| AU2007329352B2 (en) * | 2006-12-07 | 2013-01-17 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| EP2205242B1 (en) * | 2007-09-12 | 2015-04-15 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| CN103841976A (zh) * | 2011-04-01 | 2014-06-04 | 基因泰克公司 | Akt和mek抑制剂化合物的组合及其使用方法 |
-
2010
- 2010-10-11 PH PH1/2012/500709A patent/PH12012500709A1/en unknown
- 2010-10-11 JP JP2012533589A patent/JP2013507415A/ja not_active Ceased
- 2010-10-11 AU AU2010314287A patent/AU2010314287A1/en not_active Abandoned
- 2010-10-11 TW TW099134615A patent/TWI428336B/zh not_active IP Right Cessation
- 2010-10-11 EP EP10768448.2A patent/EP2488178B1/en not_active Not-in-force
- 2010-10-11 PE PE2012000470A patent/PE20121816A1/es not_active Application Discontinuation
- 2010-10-11 US US12/902,062 patent/US20110086837A1/en not_active Abandoned
- 2010-10-11 NZ NZ599939A patent/NZ599939A/en not_active IP Right Cessation
- 2010-10-11 WO PCT/EP2010/065149 patent/WO2011054620A1/en not_active Ceased
- 2010-10-11 RU RU2012118974/15A patent/RU2563193C2/ru not_active IP Right Cessation
- 2010-10-11 BR BR112012008483A patent/BR112012008483A2/pt not_active IP Right Cessation
- 2010-10-11 CN CN2010800563069A patent/CN102740851B/zh not_active Expired - Fee Related
- 2010-10-11 MX MX2012004286A patent/MX345155B/es active IP Right Grant
- 2010-10-11 ES ES10768448.2T patent/ES2609767T3/es active Active
- 2010-10-11 MA MA34821A patent/MA33974B1/fr unknown
- 2010-10-11 KR KR1020127012069A patent/KR101489045B1/ko not_active Expired - Fee Related
- 2010-10-11 CA CA2776944A patent/CA2776944A1/en not_active Abandoned
- 2010-10-12 AR ARP100103706A patent/AR078588A1/es not_active Application Discontinuation
-
2012
- 2012-04-05 IL IL219105A patent/IL219105A0/en unknown
- 2012-04-10 CR CR20120173A patent/CR20120173A/es unknown
- 2012-04-11 CL CL2012000913A patent/CL2012000913A1/es unknown
- 2012-04-11 ZA ZA2012/02618A patent/ZA201202618B/en unknown
- 2012-04-20 CO CO12065784A patent/CO6531463A2/es not_active Application Discontinuation
- 2012-05-03 EC ECSP12011865 patent/ECSP12011865A/es unknown
-
2014
- 2014-10-01 JP JP2014202819A patent/JP5745678B2/ja not_active Expired - Fee Related