JP2018090566A5 - - Google Patents
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- Publication number
- JP2018090566A5 JP2018090566A5 JP2017219019A JP2017219019A JP2018090566A5 JP 2018090566 A5 JP2018090566 A5 JP 2018090566A5 JP 2017219019 A JP2017219019 A JP 2017219019A JP 2017219019 A JP2017219019 A JP 2017219019A JP 2018090566 A5 JP2018090566 A5 JP 2018090566A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- acceptable salt
- lung cancer
- small cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 11
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 6
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 6
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical group FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 6
- -1 6-((3-methoxy-1-methyl-1H-pyrazole-4-yl) amino) -9-methyl-9H-purin-2-yl Chemical group 0.000 claims 5
- AHJRHEGDXFFMBM-UHFFFAOYSA-N palbociclib Chemical compound N1=C2N(C3CCCC3)C(=O)C(C(=O)C)=C(C)C2=CN=C1NC(N=C1)=CC=C1N1CCNCC1 AHJRHEGDXFFMBM-UHFFFAOYSA-N 0.000 claims 5
- 229960004390 palbociclib Drugs 0.000 claims 5
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000011885 synergistic combination Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662423146P | 2016-11-16 | 2016-11-16 | |
| US62/423146 | 2016-11-16 | ||
| US201762571114P | 2017-10-11 | 2017-10-11 | |
| US62/571114 | 2017-10-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018090566A JP2018090566A (ja) | 2018-06-14 |
| JP2018090566A5 true JP2018090566A5 (enExample) | 2020-12-24 |
Family
ID=60543611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017219019A Pending JP2018090566A (ja) | 2016-11-16 | 2017-11-14 | 非小細胞肺癌の治療のためのｅｇｆｒ ｔ７９０ｍ阻害剤およびｃｄｋ阻害剤の組合せ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190275049A1 (enExample) |
| EP (1) | EP3541389A1 (enExample) |
| JP (1) | JP2018090566A (enExample) |
| CA (1) | CA3043681A1 (enExample) |
| TW (1) | TW201822769A (enExample) |
| WO (1) | WO2018091999A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018106729A1 (en) | 2016-12-05 | 2018-06-14 | G1 Therapeutics, Inc. | Preservation of immune response during chemotherapy regimens |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| WO2019136451A1 (en) | 2018-01-08 | 2019-07-11 | G1 Therapeutics, Inc. | G1t38 superior dosage regimes |
| KR20200132902A (ko) * | 2018-03-13 | 2020-11-25 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Egfr 활성화 돌연변이를 갖는 암의 치료 방법 |
| WO2020232292A1 (en) * | 2019-05-15 | 2020-11-19 | Board Of Regents, The University Of Texas System | Methods and compositions for treating non-small cell lung cancer |
| EP4034121A4 (en) * | 2019-09-23 | 2023-10-18 | Beta Pharma, Inc. | TREATMENT OF EGFR MUTANT-RELATED CANCERS USING A COMBINATION OF EGFR AND CDK4/6 INHIBITORS |
| EP3797776B1 (en) * | 2019-09-30 | 2025-07-23 | Universitätsmedizin Mainz | Cdk4/6 inhibitors for the treatment of psoriasis |
| CN111557943A (zh) * | 2020-04-30 | 2020-08-21 | 天津医科大学总医院 | Pd0332991联合奥希替尼在制备治疗nsclc药物中的应用 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| TWI804333B (zh) * | 2021-06-04 | 2023-06-01 | 中國醫藥大學 | 醫藥組合物治療肺癌之用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4291696B2 (ja) | 2002-01-22 | 2009-07-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | ２−（ピリジン−２−イルアミノ）−ピリド［２，３−ｄ］ピリミジン−７−オン |
| JP4053073B2 (ja) | 2003-07-11 | 2008-02-27 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 選択的ｃｄｋ４阻害剤のイセチオン酸塩 |
| AU2007297286A1 (en) | 2006-09-08 | 2008-03-20 | Pfizer Products Inc. | Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
| CA2900322C (en) | 2013-02-21 | 2019-03-26 | Pfizer Inc. | Solid forms of the selective cdk4/6 inhibitor compound acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8h-pyrido[2,3-d]pyrimidin-7-one |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| AU2015296322B2 (en) * | 2014-07-26 | 2019-09-19 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof |
| AR104068A1 (es) * | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
-
2017
- 2017-11-07 CA CA3043681A patent/CA3043681A1/en not_active Abandoned
- 2017-11-07 EP EP17808168.3A patent/EP3541389A1/en not_active Withdrawn
- 2017-11-07 US US16/349,941 patent/US20190275049A1/en not_active Abandoned
- 2017-11-07 WO PCT/IB2017/056952 patent/WO2018091999A1/en not_active Ceased
- 2017-11-14 JP JP2017219019A patent/JP2018090566A/ja active Pending
- 2017-11-15 TW TW106139406A patent/TW201822769A/zh unknown
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