JP2018090566A - 非小細胞肺癌の治療のためのｅｇｆｒ ｔ７９０ｍ阻害剤およびｃｄｋ阻害剤の組合せ - Google Patents

非小細胞肺癌の治療のためのｅｇｆｒ ｔ７９０ｍ阻害剤およびｃｄｋ阻害剤の組合せ Download PDF

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JP2018090566A
JP2018090566A JP2017219019A JP2017219019A JP2018090566A JP 2018090566 A JP2018090566 A JP 2018090566A JP 2017219019 A JP2017219019 A JP 2017219019A JP 2017219019 A JP2017219019 A JP 2017219019A JP 2018090566 A JP2018090566 A JP 2018090566A
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lung cancer
small cell
cell lung
inhibitor
pharmaceutically acceptable
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JP2018090566A5 (enExample
Inventor
アイリス ゴールドバーグ ゼラナ
Iris Goldberg Zelanna
アイリス ゴールドバーグ ゼラナ
ワング ユリ
Yuli Wang
ワング ユリ
ローレンス バインリヒ スコット
Lawrence Weinrich Scott
ローレンス バインリヒ スコット
デイヴィッド ウィルナー キース
David Wilner Keith
デイヴィッド ウィルナー キース
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Pfizer Corp Belgium
Pfizer Inc
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Pfizer Corp Belgium
Pfizer Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017219019A 2016-11-16 2017-11-14 非小細胞肺癌の治療のためのｅｇｆｒ ｔ７９０ｍ阻害剤およびｃｄｋ阻害剤の組合せ Pending JP2018090566A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662423146P 2016-11-16 2016-11-16
US62/423146 2016-11-16
US201762571114P 2017-10-11 2017-10-11
US62/571114 2017-10-11

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JP2018090566A true JP2018090566A (ja) 2018-06-14
JP2018090566A5 JP2018090566A5 (enExample) 2020-12-24

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US (1) US20190275049A1 (enExample)
EP (1) EP3541389A1 (enExample)
JP (1) JP2018090566A (enExample)
CA (1) CA3043681A1 (enExample)
TW (1) TW201822769A (enExample)
WO (1) WO2018091999A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021517894A (ja) * 2018-03-13 2021-07-29 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System Ｅｇｆｒ活性化変異を有するがんを治療するための方法

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WO2018106729A1 (en) 2016-12-05 2018-06-14 G1 Therapeutics, Inc. Preservation of immune response during chemotherapy regimens
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
WO2019136451A1 (en) 2018-01-08 2019-07-11 G1 Therapeutics, Inc. G1t38 superior dosage regimes
WO2020232292A1 (en) * 2019-05-15 2020-11-19 Board Of Regents, The University Of Texas System Methods and compositions for treating non-small cell lung cancer
EP4034121A4 (en) * 2019-09-23 2023-10-18 Beta Pharma, Inc. TREATMENT OF EGFR MUTANT-RELATED CANCERS USING A COMBINATION OF EGFR AND CDK4/6 INHIBITORS
EP3797776B1 (en) * 2019-09-30 2025-07-23 Universitätsmedizin Mainz Cdk4/6 inhibitors for the treatment of psoriasis
CN111557943A (zh) * 2020-04-30 2020-08-21 天津医科大学总医院 Pd0332991联合奥希替尼在制备治疗nsclc药物中的应用
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
TWI804333B (zh) * 2021-06-04 2023-06-01 中國醫藥大學 醫藥組合物治療肺癌之用途

Citations (3)

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WO2015075598A1 (en) * 2013-11-21 2015-05-28 Pfizer Inc. 2,6-substituted purine derivatives and their use in the treatment of proliferative disorders
WO2016015598A1 (en) * 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
WO2016151063A1 (en) * 2015-03-26 2016-09-29 F. Hoffmann-La Roche Ag Combinations of a phosphoinositide 3-kinase inhibitor compound and a cdk4/6 inhibitor compound for the treatment of cancer

Family Cites Families (4)

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JP4291696B2 (ja) 2002-01-22 2009-07-08 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ２−（ピリジン−２−イルアミノ）−ピリド［２，３−ｄ］ピリミジン−７−オン
JP4053073B2 (ja) 2003-07-11 2008-02-27 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 選択的ｃｄｋ４阻害剤のイセチオン酸塩
AU2007297286A1 (en) 2006-09-08 2008-03-20 Pfizer Products Inc. Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
CA2900322C (en) 2013-02-21 2019-03-26 Pfizer Inc. Solid forms of the selective cdk4/6 inhibitor compound acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8h-pyrido[2,3-d]pyrimidin-7-one

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015075598A1 (en) * 2013-11-21 2015-05-28 Pfizer Inc. 2,6-substituted purine derivatives and their use in the treatment of proliferative disorders
WO2016015598A1 (en) * 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
WO2016151063A1 (en) * 2015-03-26 2016-09-29 F. Hoffmann-La Roche Ag Combinations of a phosphoinositide 3-kinase inhibitor compound and a cdk4/6 inhibitor compound for the treatment of cancer

Non-Patent Citations (2)

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Title
MINGHUI LIU, ET AL.: "PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment wit", ONCOTARGET, vol. 7, no. 51, JPN6021035008, 4 November 2016 (2016-11-04), pages 84951 - 84964, XP055376992, ISSN: 0004600579, DOI: 10.18632/oncotarget.13069 *
PHARMA MEDICA, vol. 32, no. 5, JPN6021035007, 2014, pages 37 - 46, ISSN: 0004755307 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021517894A (ja) * 2018-03-13 2021-07-29 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System Ｅｇｆｒ活性化変異を有するがんを治療するための方法
JP7698418B2 (ja) 2018-03-13 2025-06-25 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｅｇｆｒ活性化変異を有するがんを治療するための方法

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WO2018091999A1 (en) 2018-05-24
TW201822769A (zh) 2018-07-01
US20190275049A1 (en) 2019-09-12
CA3043681A1 (en) 2018-05-24
EP3541389A1 (en) 2019-09-25

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