CA3043681A1 - Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer - Google Patents
Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer Download PDFInfo
- Publication number
- CA3043681A1 CA3043681A1 CA3043681A CA3043681A CA3043681A1 CA 3043681 A1 CA3043681 A1 CA 3043681A1 CA 3043681 A CA3043681 A CA 3043681A CA 3043681 A CA3043681 A CA 3043681A CA 3043681 A1 CA3043681 A1 CA 3043681A1
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- CA
- Canada
- Prior art keywords
- lung cancer
- small cell
- cell lung
- egfr
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662423146P | 2016-11-16 | 2016-11-16 | |
| US62/423,146 | 2016-11-16 | ||
| US201762571114P | 2017-10-11 | 2017-10-11 | |
| US62/571,114 | 2017-10-11 | ||
| PCT/IB2017/056952 WO2018091999A1 (en) | 2016-11-16 | 2017-11-07 | Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3043681A1 true CA3043681A1 (en) | 2018-05-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3043681A Abandoned CA3043681A1 (en) | 2016-11-16 | 2017-11-07 | Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190275049A1 (enExample) |
| EP (1) | EP3541389A1 (enExample) |
| JP (1) | JP2018090566A (enExample) |
| CA (1) | CA3043681A1 (enExample) |
| TW (1) | TW201822769A (enExample) |
| WO (1) | WO2018091999A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220280511A1 (en) * | 2019-09-30 | 2022-09-08 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Cdk4/6 inhibitors for the treatment of psoriasis |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3548030A4 (en) | 2016-12-05 | 2020-08-12 | G1 Therapeutics, Inc. | PRESERVATION OF THE IMMUNE RESPONSE DURING CHEMOTHERAPEUTIC DIETS |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| KR20200108867A (ko) | 2018-01-08 | 2020-09-21 | 쥐원 쎄라퓨틱스, 인크. | G1t38 우수한 투여 요법 |
| JP7698418B2 (ja) * | 2018-03-13 | 2025-06-25 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｅｇｆｒ活性化変異を有するがんを治療するための方法 |
| JP7682104B2 (ja) * | 2019-05-15 | 2025-05-23 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 非小細胞肺がんを処置するための方法および組成物 |
| CN114430681A (zh) * | 2019-09-23 | 2022-05-03 | 贝达医药公司 | 使用egfr和cdk4/6抑制剂的组合治疗egfr突变相关的癌症 |
| CN111557943A (zh) * | 2020-04-30 | 2020-08-21 | 天津医科大学总医院 | Pd0332991联合奥希替尼在制备治疗nsclc药物中的应用 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| WO2022253222A1 (zh) * | 2021-06-04 | 2022-12-08 | 洪明奇 | 医药组合物治疗肺癌的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20063909B (en) | 2002-01-22 | 2006-08-25 | Warner Lambert Co | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES |
| DE602004017474D1 (de) | 2003-07-11 | 2008-12-11 | Warner Lambert Co | Isethionat salz eines selektiven cdk4 inhibitors |
| WO2008032157A2 (en) | 2006-09-08 | 2008-03-20 | Pfizer Products Inc. | Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
| SG11201505680RA (en) | 2013-02-21 | 2015-09-29 | Pfizer | Solid forms of a selective cdk4/6 inhibitor |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| CN105294682B (zh) * | 2014-07-26 | 2017-07-07 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
| AR104068A1 (es) * | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
-
2017
- 2017-11-07 WO PCT/IB2017/056952 patent/WO2018091999A1/en not_active Ceased
- 2017-11-07 US US16/349,941 patent/US20190275049A1/en not_active Abandoned
- 2017-11-07 EP EP17808168.3A patent/EP3541389A1/en not_active Withdrawn
- 2017-11-07 CA CA3043681A patent/CA3043681A1/en not_active Abandoned
- 2017-11-14 JP JP2017219019A patent/JP2018090566A/ja active Pending
- 2017-11-15 TW TW106139406A patent/TW201822769A/zh unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220280511A1 (en) * | 2019-09-30 | 2022-09-08 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Cdk4/6 inhibitors for the treatment of psoriasis |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018091999A1 (en) | 2018-05-24 |
| JP2018090566A (ja) | 2018-06-14 |
| US20190275049A1 (en) | 2019-09-12 |
| EP3541389A1 (en) | 2019-09-25 |
| TW201822769A (zh) | 2018-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190513 |
|
| FZDE | Discontinued |
Effective date: 20221229 |
|
| FZDE | Discontinued |
Effective date: 20221229 |