CA3043681A1 - Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer - Google Patents

Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer Download PDF

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Publication number
CA3043681A1
CA3043681A1 CA3043681A CA3043681A CA3043681A1 CA 3043681 A1 CA3043681 A1 CA 3043681A1 CA 3043681 A CA3043681 A CA 3043681A CA 3043681 A CA3043681 A CA 3043681A CA 3043681 A1 CA3043681 A1 CA 3043681A1
Authority
CA
Canada
Prior art keywords
lung cancer
small cell
cell lung
egfr
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3043681A
Other languages
English (en)
French (fr)
Inventor
Zelanna Iris GOLDBERG
Yuli Wang
Scott Lawrence Weinrich
Keith David Wilner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA3043681A1 publication Critical patent/CA3043681A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3043681A 2016-11-16 2017-11-07 Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer Abandoned CA3043681A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662423146P 2016-11-16 2016-11-16
US62/423,146 2016-11-16
US201762571114P 2017-10-11 2017-10-11
US62/571,114 2017-10-11
PCT/IB2017/056952 WO2018091999A1 (en) 2016-11-16 2017-11-07 Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer

Publications (1)

Publication Number Publication Date
CA3043681A1 true CA3043681A1 (en) 2018-05-24

Family

ID=60543611

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3043681A Abandoned CA3043681A1 (en) 2016-11-16 2017-11-07 Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer

Country Status (6)

Country Link
US (1) US20190275049A1 (enExample)
EP (1) EP3541389A1 (enExample)
JP (1) JP2018090566A (enExample)
CA (1) CA3043681A1 (enExample)
TW (1) TW201822769A (enExample)
WO (1) WO2018091999A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220280511A1 (en) * 2019-09-30 2022-09-08 Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet Cdk4/6 inhibitors for the treatment of psoriasis
CN116875554A (zh) * 2023-03-14 2023-10-13 广州中医药大学第一附属医院 一种耐阿美替尼的非小细胞肺癌细胞株h-1975/ar及其应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL317919A (en) 2016-12-05 2025-02-01 G1 Therapeutics Inc Preservation of immune response during chemotherapy regimens
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
WO2019136451A1 (en) 2018-01-08 2019-07-11 G1 Therapeutics, Inc. G1t38 superior dosage regimes
CN111867586A (zh) * 2018-03-13 2020-10-30 得克萨斯州大学系统董事会 用于治疗具有egfr激活突变的癌症的方法
US20220265847A1 (en) * 2019-05-15 2022-08-25 Board Of Regents, The University Of Texas System Methods and compositions for treating non-small cell lung cancer
AU2020352528A1 (en) * 2019-09-23 2022-04-21 Beta Pharma, Inc. Treatment of EGFR mutant-related cancers using a combination of EGFR and CDK4/6 inhibitors
CN111557943A (zh) * 2020-04-30 2020-08-21 天津医科大学总医院 Pd0332991联合奥希替尼在制备治疗nsclc药物中的应用
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
TWI804333B (zh) * 2021-06-04 2023-06-01 中國醫藥大學 醫藥組合物治療肺癌之用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ534069A (en) 2002-01-22 2007-03-30 Warner Lambert Co 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones to be used to treat neurodegenerative disorders, viruses and cancer
DE602004017474D1 (de) 2003-07-11 2008-12-11 Warner Lambert Co Isethionat salz eines selektiven cdk4 inhibitors
KR20090052385A (ko) 2006-09-08 2009-05-25 화이자 프로덕츠 인크. 2-（피리딘-2-일아미노）-피리도［2,3-ｄ］피리미딘-7-온의합성
DK3431475T3 (da) 2013-02-21 2021-05-25 Pfizer Faste former af en selektiv CDK4/6-hæmmer
UA115388C2 (uk) 2013-11-21 2017-10-25 Пфайзер Інк. 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
WO2016015597A1 (en) * 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. Compounds as cdk small-molecule inhibitors and uses thereof
AR104068A1 (es) * 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220280511A1 (en) * 2019-09-30 2022-09-08 Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet Cdk4/6 inhibitors for the treatment of psoriasis
CN116875554A (zh) * 2023-03-14 2023-10-13 广州中医药大学第一附属医院 一种耐阿美替尼的非小细胞肺癌细胞株h-1975/ar及其应用

Also Published As

Publication number Publication date
US20190275049A1 (en) 2019-09-12
WO2018091999A1 (en) 2018-05-24
JP2018090566A (ja) 2018-06-14
EP3541389A1 (en) 2019-09-25
TW201822769A (zh) 2018-07-01

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190513

FZDE Discontinued

Effective date: 20221229