CA3043681A1 - Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer - Google Patents
Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer Download PDFInfo
- Publication number
- CA3043681A1 CA3043681A1 CA3043681A CA3043681A CA3043681A1 CA 3043681 A1 CA3043681 A1 CA 3043681A1 CA 3043681 A CA3043681 A CA 3043681A CA 3043681 A CA3043681 A CA 3043681A CA 3043681 A1 CA3043681 A1 CA 3043681A1
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- CA
- Canada
- Prior art keywords
- lung cancer
- small cell
- cell lung
- egfr
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662423146P | 2016-11-16 | 2016-11-16 | |
| US62/423,146 | 2016-11-16 | ||
| US201762571114P | 2017-10-11 | 2017-10-11 | |
| US62/571,114 | 2017-10-11 | ||
| PCT/IB2017/056952 WO2018091999A1 (en) | 2016-11-16 | 2017-11-07 | Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3043681A1 true CA3043681A1 (en) | 2018-05-24 |
Family
ID=60543611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3043681A Abandoned CA3043681A1 (en) | 2016-11-16 | 2017-11-07 | Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190275049A1 (enExample) |
| EP (1) | EP3541389A1 (enExample) |
| JP (1) | JP2018090566A (enExample) |
| CA (1) | CA3043681A1 (enExample) |
| TW (1) | TW201822769A (enExample) |
| WO (1) | WO2018091999A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220280511A1 (en) * | 2019-09-30 | 2022-09-08 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Cdk4/6 inhibitors for the treatment of psoriasis |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL311265A (en) | 2016-12-05 | 2024-05-01 | G1 Therapeutics Inc | Preservation of immune response during chemotherapy regimens |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| CN111837146B (zh) | 2018-01-08 | 2024-10-15 | G1治疗公司 | G1t38优异剂量方案 |
| CN111867586A (zh) * | 2018-03-13 | 2020-10-30 | 得克萨斯州大学系统董事会 | 用于治疗具有egfr激活突变的癌症的方法 |
| KR20220009446A (ko) * | 2019-05-15 | 2022-01-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 비-소세포 폐암의 치료를 위한 방법 및 조성물 |
| CN114430681A (zh) * | 2019-09-23 | 2022-05-03 | 贝达医药公司 | 使用egfr和cdk4/6抑制剂的组合治疗egfr突变相关的癌症 |
| CN111557943A (zh) * | 2020-04-30 | 2020-08-21 | 天津医科大学总医院 | Pd0332991联合奥希替尼在制备治疗nsclc药物中的应用 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| EP4349340A1 (en) * | 2021-06-04 | 2024-04-10 | Mien-Chie Hung | Use of pharmaceutical composition for treating lung cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20040660B1 (hr) | 2002-01-22 | 2012-10-31 | Warner-Lambert Company Llc | 2-(PIRIDIN-2-ILAMINO)-PIRIDO[2,3-d]PIRIMIDIN-7-ONI |
| KR100816945B1 (ko) | 2003-07-11 | 2008-03-25 | 워너-램버트 캄파니 엘엘씨 | 선택적인 사이클린 의존성 키나제 4 억제제로서의이세싸이오네이트 염 |
| BRPI0716880A2 (pt) | 2006-09-08 | 2013-10-15 | Pfizer Prod Inc | Síntese de 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas |
| MX386473B (es) | 2013-02-21 | 2025-03-18 | Pfizer | Formas solidas de un inhibidor de cdk4/6 selectivo |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| CA2954189A1 (en) * | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof |
| AR104068A1 (es) * | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
-
2017
- 2017-11-07 US US16/349,941 patent/US20190275049A1/en not_active Abandoned
- 2017-11-07 CA CA3043681A patent/CA3043681A1/en not_active Abandoned
- 2017-11-07 WO PCT/IB2017/056952 patent/WO2018091999A1/en not_active Ceased
- 2017-11-07 EP EP17808168.3A patent/EP3541389A1/en not_active Withdrawn
- 2017-11-14 JP JP2017219019A patent/JP2018090566A/ja active Pending
- 2017-11-15 TW TW106139406A patent/TW201822769A/zh unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220280511A1 (en) * | 2019-09-30 | 2022-09-08 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Cdk4/6 inhibitors for the treatment of psoriasis |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3541389A1 (en) | 2019-09-25 |
| US20190275049A1 (en) | 2019-09-12 |
| WO2018091999A1 (en) | 2018-05-24 |
| TW201822769A (zh) | 2018-07-01 |
| JP2018090566A (ja) | 2018-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190513 |
|
| FZDE | Discontinued |
Effective date: 20221229 |
|
| FZDE | Discontinued |
Effective date: 20221229 |