TW201822769A - 用於治療非小細胞肺癌之egfr t790m 抑制劑及cdk抑制劑之組合 - Google Patents
用於治療非小細胞肺癌之egfr t790m 抑制劑及cdk抑制劑之組合 Download PDFInfo
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- TW201822769A TW201822769A TW106139406A TW106139406A TW201822769A TW 201822769 A TW201822769 A TW 201822769A TW 106139406 A TW106139406 A TW 106139406A TW 106139406 A TW106139406 A TW 106139406A TW 201822769 A TW201822769 A TW 201822769A
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- lung cancer
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- cell lung
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- 239000006187 pill Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US201662423146P | 2016-11-16 | 2016-11-16 | |
| US62/423,146 | 2016-11-16 | ||
| US201762571114P | 2017-10-11 | 2017-10-11 | |
| US62/571,114 | 2017-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201822769A true TW201822769A (zh) | 2018-07-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| TW106139406A TW201822769A (zh) | 2016-11-16 | 2017-11-15 | 用於治療非小細胞肺癌之egfr t790m 抑制劑及cdk抑制劑之組合 |
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| Country | Link |
|---|---|
| US (1) | US20190275049A1 (enExample) |
| EP (1) | EP3541389A1 (enExample) |
| JP (1) | JP2018090566A (enExample) |
| CA (1) | CA3043681A1 (enExample) |
| TW (1) | TW201822769A (enExample) |
| WO (1) | WO2018091999A1 (enExample) |
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| IL317919A (en) | 2016-12-05 | 2025-02-01 | G1 Therapeutics Inc | Preservation of immune response during chemotherapy regimens |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| WO2019136451A1 (en) | 2018-01-08 | 2019-07-11 | G1 Therapeutics, Inc. | G1t38 superior dosage regimes |
| CN111867586A (zh) * | 2018-03-13 | 2020-10-30 | 得克萨斯州大学系统董事会 | 用于治疗具有egfr激活突变的癌症的方法 |
| US20220265847A1 (en) * | 2019-05-15 | 2022-08-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating non-small cell lung cancer |
| AU2020352528A1 (en) * | 2019-09-23 | 2022-04-21 | Beta Pharma, Inc. | Treatment of EGFR mutant-related cancers using a combination of EGFR and CDK4/6 inhibitors |
| EP3797776B1 (en) * | 2019-09-30 | 2025-07-23 | Universitätsmedizin Mainz | Cdk4/6 inhibitors for the treatment of psoriasis |
| CN111557943A (zh) * | 2020-04-30 | 2020-08-21 | 天津医科大学总医院 | Pd0332991联合奥希替尼在制备治疗nsclc药物中的应用 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| TWI804333B (zh) * | 2021-06-04 | 2023-06-01 | 中國醫藥大學 | 醫藥組合物治療肺癌之用途 |
| CN116875554A (zh) * | 2023-03-14 | 2023-10-13 | 广州中医药大学第一附属医院 | 一种耐阿美替尼的非小细胞肺癌细胞株h-1975/ar及其应用 |
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| NZ534069A (en) | 2002-01-22 | 2007-03-30 | Warner Lambert Co | 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones to be used to treat neurodegenerative disorders, viruses and cancer |
| DE602004017474D1 (de) | 2003-07-11 | 2008-12-11 | Warner Lambert Co | Isethionat salz eines selektiven cdk4 inhibitors |
| KR20090052385A (ko) | 2006-09-08 | 2009-05-25 | 화이자 프로덕츠 인크. | 2-（피리딘-2-일아미노）-피리도［2,3-ｄ］피리미딘-7-온의합성 |
| DK3431475T3 (da) | 2013-02-21 | 2021-05-25 | Pfizer | Faste former af en selektiv CDK4/6-hæmmer |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| WO2016015597A1 (en) * | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | Compounds as cdk small-molecule inhibitors and uses thereof |
| AR104068A1 (es) * | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
-
2017
- 2017-11-07 EP EP17808168.3A patent/EP3541389A1/en not_active Withdrawn
- 2017-11-07 US US16/349,941 patent/US20190275049A1/en not_active Abandoned
- 2017-11-07 WO PCT/IB2017/056952 patent/WO2018091999A1/en not_active Ceased
- 2017-11-07 CA CA3043681A patent/CA3043681A1/en not_active Abandoned
- 2017-11-14 JP JP2017219019A patent/JP2018090566A/ja active Pending
- 2017-11-15 TW TW106139406A patent/TW201822769A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190275049A1 (en) | 2019-09-12 |
| WO2018091999A1 (en) | 2018-05-24 |
| JP2018090566A (ja) | 2018-06-14 |
| EP3541389A1 (en) | 2019-09-25 |
| CA3043681A1 (en) | 2018-05-24 |
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