CN112237579B - 药物组合及其用途 - Google Patents
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- CN112237579B CN112237579B CN202010684014.5A CN202010684014A CN112237579B CN 112237579 B CN112237579 B CN 112237579B CN 202010684014 A CN202010684014 A CN 202010684014A CN 112237579 B CN112237579 B CN 112237579B
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组 | 媒介物 | 化合物C | 化合物23 | 组合 |
小鼠的中位生存时间(天) | 19 | 25.5 | 29 | 35 |
小鼠的延长存活时间(天) | - | 6.5 | 10 | 16 |
Claims (10)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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CN2019096843 | 2019-07-19 | ||
CNPCT/CN2019/096843 | 2019-07-19 | ||
CN2020105981362 | 2020-06-28 | ||
CN202010598136 | 2020-06-28 |
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CN112237579A CN112237579A (zh) | 2021-01-19 |
CN112237579B true CN112237579B (zh) | 2022-03-29 |
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CN202010684014.5A Active CN112237579B (zh) | 2019-07-19 | 2020-07-16 | 药物组合及其用途 |
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US (1) | US20220142975A1 (zh) |
EP (1) | EP3999056A4 (zh) |
CN (1) | CN112237579B (zh) |
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WO (1) | WO2021013028A1 (zh) |
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CN111249282B (zh) * | 2018-12-03 | 2023-08-29 | 苏州亚盛药业有限公司 | 癌症疗法 |
CN116421598A (zh) * | 2022-01-11 | 2023-07-14 | 苏州亚盛药业有限公司 | 用于治疗aml-mrc和mds的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012000304A1 (zh) * | 2010-07-01 | 2012-01-05 | 中国科学院广州生物医药与健康研究院 | 杂环炔苯类化合物及其药用组合物和应用 |
CN104341425A (zh) * | 2013-08-08 | 2015-02-11 | 上海医药集团股份有限公司 | 氘代乙炔衍生物、其药物组合物及应用 |
WO2015161032A1 (en) * | 2014-04-17 | 2015-10-22 | The Regents Of The University Of Michigan | Mdm2 inhibitors and therapeutic methods using the same |
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CN111035641B (zh) * | 2018-10-11 | 2022-04-12 | 暨南大学 | Gzd824及其药学上可接受的盐在治疗疾病中的新应用 |
-
2020
- 2020-07-16 US US17/421,131 patent/US20220142975A1/en active Pending
- 2020-07-16 WO PCT/CN2020/102275 patent/WO2021013028A1/en unknown
- 2020-07-16 TW TW109124078A patent/TW202116301A/zh unknown
- 2020-07-16 CN CN202010684014.5A patent/CN112237579B/zh active Active
- 2020-07-16 EP EP20843344.1A patent/EP3999056A4/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012000304A1 (zh) * | 2010-07-01 | 2012-01-05 | 中国科学院广州生物医药与健康研究院 | 杂环炔苯类化合物及其药用组合物和应用 |
CN104341425A (zh) * | 2013-08-08 | 2015-02-11 | 上海医药集团股份有限公司 | 氘代乙炔衍生物、其药物组合物及应用 |
WO2015161032A1 (en) * | 2014-04-17 | 2015-10-22 | The Regents Of The University Of Michigan | Mdm2 inhibitors and therapeutic methods using the same |
Non-Patent Citations (3)
Title |
---|
GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib;Xiaomei Ren等;《JOURNAL OF MEDICINAL CHEMISTRY》;20130109;第56卷;879-894 * |
MDM2-and FLT3-inhibitors in the treatment of FLT3-ITD acute myeloid leukemia,specificity and efficacy of NVP-HDM201 and midostaurin,;Katja Seipel等;《Haematologica》;20180705;第103卷(第11期);1862-1872 * |
Xiaomei Ren等.GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib.《JOURNAL OF MEDICINAL CHEMISTRY》.2013,第56卷 * |
Also Published As
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EP3999056A1 (en) | 2022-05-25 |
US20220142975A1 (en) | 2022-05-12 |
EP3999056A4 (en) | 2023-10-25 |
CN112237579A (zh) | 2021-01-19 |
TW202116301A (zh) | 2021-05-01 |
WO2021013028A1 (en) | 2021-01-28 |
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