JP2008521928A5 - - Google Patents
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- Publication number
- JP2008521928A5 JP2008521928A5 JP2007544545A JP2007544545A JP2008521928A5 JP 2008521928 A5 JP2008521928 A5 JP 2008521928A5 JP 2007544545 A JP2007544545 A JP 2007544545A JP 2007544545 A JP2007544545 A JP 2007544545A JP 2008521928 A5 JP2008521928 A5 JP 2008521928A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- medicament
- group
- medicament according
- chemotherapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 230000001613 neoplastic effect Effects 0.000 claims description 10
- 229940122390 Inflammasome inhibitor Drugs 0.000 claims description 5
- 101001091368 Rattus norvegicus Glandular kallikrein-7, submandibular/renal Proteins 0.000 claims description 4
- 101000898773 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Saccharopepsin Proteins 0.000 claims description 4
- 239000011885 synergistic combination Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 32
- 201000011510 cancer Diseases 0.000 claims 15
- 239000002246 antineoplastic agent Substances 0.000 claims 12
- 229940127089 cytotoxic agent Drugs 0.000 claims 12
- 208000034578 Multiple myelomas Diseases 0.000 claims 9
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 7
- 239000000460 chlorine Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 208000026310 Breast neoplasm Diseases 0.000 claims 6
- 206010009944 Colon cancer Diseases 0.000 claims 6
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 6
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 6
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 210000003169 central nervous system Anatomy 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 229910052740 iodine Chemical group 0.000 claims 4
- 239000011630 iodine Chemical group 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 3
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 3
- 229960001467 bortezomib Drugs 0.000 claims 3
- 210000000133 brain stem Anatomy 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 208000030381 cutaneous melanoma Diseases 0.000 claims 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 3
- 229960003957 dexamethasone Drugs 0.000 claims 3
- 229960004679 doxorubicin Drugs 0.000 claims 3
- 206010017758 gastric cancer Diseases 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 201000003733 ovarian melanoma Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 206010038038 rectal cancer Diseases 0.000 claims 3
- 201000001275 rectum cancer Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 201000009381 skin hemangioma Diseases 0.000 claims 3
- 201000003708 skin melanoma Diseases 0.000 claims 3
- 201000011549 stomach cancer Diseases 0.000 claims 3
- 229960003433 thalidomide Drugs 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 206010046766 uterine cancer Diseases 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 0 CC(C1CC*)(C2(C(C3C=CCCC3)O)NC1=O)OC2=O Chemical compound CC(C1CC*)(C2(C(C3C=CCCC3)O)NC1=O)OC2=O 0.000 description 8
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63316104P | 2004-12-03 | 2004-12-03 | |
| US60/633,161 | 2004-12-03 | ||
| PCT/US2005/043668 WO2006060676A1 (en) | 2004-12-03 | 2005-12-02 | Compositions and methods for treating neoplastic diseases |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198263A Division JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Division JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521928A JP2008521928A (ja) | 2008-06-26 |
| JP2008521928A5 true JP2008521928A5 (enExample) | 2009-01-22 |
| JP5676071B2 JP5676071B2 (ja) | 2015-02-25 |
Family
ID=36118298
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544545A Expired - Lifetime JP5676071B2 (ja) | 2004-12-03 | 2005-12-02 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2012198263A Expired - Lifetime JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Expired - Lifetime JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198263A Expired - Lifetime JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Expired - Lifetime JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20070225350A1 (enExample) |
| EP (1) | EP1830838B1 (enExample) |
| JP (3) | JP5676071B2 (enExample) |
| KR (1) | KR101282191B1 (enExample) |
| CN (2) | CN101155582B (enExample) |
| AU (1) | AU2005311709B2 (enExample) |
| BR (1) | BRPI0517135B1 (enExample) |
| CA (1) | CA2588923C (enExample) |
| DK (1) | DK1830838T3 (enExample) |
| ES (1) | ES2396762T3 (enExample) |
| IL (3) | IL183506A (enExample) |
| MX (1) | MX2007006526A (enExample) |
| NZ (1) | NZ555439A (enExample) |
| PL (1) | PL1830838T3 (enExample) |
| SG (1) | SG157365A1 (enExample) |
| WO (1) | WO2006060676A1 (enExample) |
| ZA (1) | ZA200704402B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| AU2002243228B2 (en) * | 2000-11-16 | 2007-08-02 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product discovery |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| US7176232B2 (en) * | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| DE602004031614D1 (de) * | 2003-06-20 | 2011-04-14 | Nereus Pharmaceuticals Inc | Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs |
| US8217072B2 (en) * | 2003-06-20 | 2012-07-10 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| EP2025679A3 (en) * | 2004-04-30 | 2009-07-08 | Nereus Pharmaceuticals, Inc. | [3.2.0] Heterocyclic compounds and methods of using the same |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| AU2005311709B2 (en) * | 2004-12-03 | 2011-07-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating neoplastic diseases |
| JP2008522975A (ja) * | 2004-12-03 | 2008-07-03 | ネレアス ファーマシューティカルズ インコーポレイテッド | ［３．２．０］複素環式化合物及びそれらのアナログを使用する方法 |
| SG171690A1 (en) * | 2005-03-22 | 2011-06-29 | Harvard College | Treatment of protein degradation disorders |
| AU2006311734A1 (en) * | 2005-11-04 | 2007-05-18 | Nereus Pharmaceuticals | Methods of sensitizing cancer to therapy-induced cytotoxicity |
| JP5441416B2 (ja) | 2006-02-14 | 2014-03-12 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二官能性ヒストンデアセチラーゼインヒビター |
| US8383855B2 (en) | 2006-02-14 | 2013-02-26 | President And Fellows Of Harvard College | Histone deacetylase inhibitors |
| KR20080109071A (ko) | 2006-04-06 | 2008-12-16 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 살리노스포라마이드 ａ 및 그의 유도체들의 전합성 |
| CA2654540C (en) | 2006-05-03 | 2017-01-17 | President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
| US7824698B2 (en) * | 2007-02-02 | 2010-11-02 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of Salinosporamide A |
| WO2008124699A1 (en) * | 2007-04-06 | 2008-10-16 | Nereus Pharmaceuticals, Inc. | A method of using proteasome inhibitors in combination with histone deacetylase inhibitors to treat cancer |
| US20080280968A1 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| WO2009134531A2 (en) | 2008-03-07 | 2009-11-05 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide a and analogs thereof |
| CA2723465A1 (en) | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Proteasome inhibitors |
| WO2009146546A1 (en) * | 2008-06-06 | 2009-12-10 | University Health Network | 8-hydroxyquinoline derivatives for the treatment of hematological malignancies |
| KR101708946B1 (ko) | 2008-07-23 | 2017-02-21 | 다나-파버 캔서 인스티튜트 인크. | 탈아세틸화제 억제제 및 그것의 용도 |
| CA2732823A1 (en) * | 2008-08-13 | 2010-02-18 | George Mason Intellectual Properties, Inc. | Ex vivo therapeutic screening of living bone marrow cells for multiple myeloma |
| WO2010099601A1 (en) * | 2009-03-05 | 2010-09-10 | University Health Network | Use of 5ahq and bortezomib for the treatment of hematological diseases |
| WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
| US10559380B2 (en) | 2011-12-30 | 2020-02-11 | Elwha Llc | Evidence-based healthcare information management protocols |
| US10679309B2 (en) | 2011-12-30 | 2020-06-09 | Elwha Llc | Evidence-based healthcare information management protocols |
| US20130173296A1 (en) * | 2011-12-30 | 2013-07-04 | Elwha LLC, a limited liability company of the State of Delaware | Evidence-based healthcare information management protocols |
| US10552581B2 (en) | 2011-12-30 | 2020-02-04 | Elwha Llc | Evidence-based healthcare information management protocols |
| US10528913B2 (en) | 2011-12-30 | 2020-01-07 | Elwha Llc | Evidence-based healthcare information management protocols |
| US10475142B2 (en) | 2011-12-30 | 2019-11-12 | Elwha Llc | Evidence-based healthcare information management protocols |
| WO2014071406A1 (en) * | 2012-11-05 | 2014-05-08 | Pronai Therapeutics, Inc. | Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression |
| CN108883081A (zh) * | 2015-11-06 | 2018-11-23 | 阿克西制药有限公司 | 蛋白酶体抑制剂治疗眼部疾病的用途 |
| JP2019524894A (ja) | 2016-08-19 | 2019-09-05 | セルジーン インターナショナル ツー エスアーエールエル | マリゾミブのモルフィック形態およびその使用 |
| CN110402144A (zh) * | 2017-01-31 | 2019-11-01 | 小利兰斯坦福大学托管委员会 | 抑制ngly1的剂及其使用方法 |
| JP7498475B2 (ja) * | 2020-01-31 | 2024-06-12 | 株式会社セラバイオファーマ | 多発性骨髄腫の治療剤 |
| CN113750215B (zh) * | 2021-09-24 | 2023-06-23 | 暨南大学 | 用于治疗肿瘤的联合药物 |
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- 2005-12-02 BR BRPI0517135-0A patent/BRPI0517135B1/pt active IP Right Grant
- 2005-12-02 WO PCT/US2005/043668 patent/WO2006060676A1/en not_active Ceased
- 2005-12-02 MX MX2007006526A patent/MX2007006526A/es active IP Right Grant
- 2005-12-02 NZ NZ555439A patent/NZ555439A/en active IP Right Revival
- 2005-12-02 JP JP2007544545A patent/JP5676071B2/ja not_active Expired - Lifetime
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- 2005-12-02 KR KR1020077015299A patent/KR101282191B1/ko not_active Expired - Lifetime
- 2005-12-02 EP EP05852783A patent/EP1830838B1/en not_active Expired - Lifetime
- 2005-12-02 CA CA2588923A patent/CA2588923C/en not_active Expired - Lifetime
- 2005-12-02 SG SG200907327-1A patent/SG157365A1/en unknown
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- 2005-12-02 CN CN201310024563.XA patent/CN103230394B/zh not_active Expired - Lifetime
- 2005-12-02 PL PL05852783T patent/PL1830838T3/pl unknown
- 2005-12-02 US US11/293,354 patent/US20070225350A1/en not_active Abandoned
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