JP2015511609A5 - - Google Patents
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- Publication number
- JP2015511609A5 JP2015511609A5 JP2015502129A JP2015502129A JP2015511609A5 JP 2015511609 A5 JP2015511609 A5 JP 2015511609A5 JP 2015502129 A JP2015502129 A JP 2015502129A JP 2015502129 A JP2015502129 A JP 2015502129A JP 2015511609 A5 JP2015511609 A5 JP 2015511609A5
- Authority
- JP
- Japan
- Prior art keywords
- proportions
- pharmaceutically acceptable
- medicament
- solvates
- stereoisomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000003800 pharynx Anatomy 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12002215.7 | 2012-03-28 | ||
| EP12002215 | 2012-03-28 | ||
| PCT/EP2013/000827 WO2013143663A1 (en) | 2012-03-28 | 2013-03-19 | Bicyclic pyrazinone derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511609A JP2015511609A (ja) | 2015-04-20 |
| JP2015511609A5 true JP2015511609A5 (enExample) | 2016-05-19 |
| JP6096879B2 JP6096879B2 (ja) | 2017-03-15 |
Family
ID=48013911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015502129A Active JP6096879B2 (ja) | 2012-03-28 | 2013-03-19 | 二環式ピラジノン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9120805B2 (enExample) |
| EP (1) | EP2831077B1 (enExample) |
| JP (1) | JP6096879B2 (enExample) |
| KR (1) | KR102070567B1 (enExample) |
| CN (1) | CN104169284B (enExample) |
| AR (1) | AR090496A1 (enExample) |
| AU (1) | AU2013242492B2 (enExample) |
| CA (1) | CA2868620C (enExample) |
| CL (1) | CL2014002557A1 (enExample) |
| CO (1) | CO7111292A2 (enExample) |
| DK (1) | DK2831077T3 (enExample) |
| EA (1) | EA027416B1 (enExample) |
| EC (1) | ECSP14024526A (enExample) |
| ES (1) | ES2585044T3 (enExample) |
| HR (1) | HRP20160908T1 (enExample) |
| HU (1) | HUE030067T2 (enExample) |
| IL (1) | IL234713A (enExample) |
| MX (1) | MX351149B (enExample) |
| MY (1) | MY172308A (enExample) |
| NZ (1) | NZ630489A (enExample) |
| PE (1) | PE20142186A1 (enExample) |
| PH (1) | PH12014501829A1 (enExample) |
| PL (1) | PL2831077T3 (enExample) |
| PT (1) | PT2831077T (enExample) |
| RS (1) | RS54997B1 (enExample) |
| SG (1) | SG11201405750YA (enExample) |
| SI (1) | SI2831077T1 (enExample) |
| TW (1) | TWI576346B (enExample) |
| UA (1) | UA112795C2 (enExample) |
| WO (1) | WO2013143663A1 (enExample) |
| ZA (1) | ZA201407828B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2822656T3 (en) | 2012-03-07 | 2017-01-30 | Inst Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| HUE030067T2 (en) | 2012-03-28 | 2017-04-28 | Merck Patent Gmbh | Bicyclic pyrazinone derivatives |
| KR20150011838A (ko) * | 2012-06-20 | 2015-02-02 | 에프. 호프만-라 로슈 아게 | 탄키라아제 억제제로서의 피롤로피라존 |
| CN105722835B (zh) | 2013-09-11 | 2018-07-31 | 癌症研究协会:皇家癌症医院 | 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 |
| MX364859B (es) | 2013-12-23 | 2019-05-09 | Merck Patent Gmbh | Derivados de imidazopirazinona. |
| KR20160007347A (ko) | 2014-07-11 | 2016-01-20 | 에스티팜 주식회사 | 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도 |
| WO2016006974A2 (en) * | 2014-07-11 | 2016-01-14 | St Pharm Co., Ltd. | Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof |
| WO2016006975A2 (en) * | 2014-07-11 | 2016-01-14 | St Pharm Co., Ltd. | Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof |
| KR101739003B1 (ko) * | 2014-07-11 | 2017-05-23 | 에스티팜 주식회사 | 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도 |
| KR20170090476A (ko) * | 2014-12-05 | 2017-08-07 | 어레이 바이오파마 인크. | 야누스 키나제 저해제로서의 4,6-치환된-피라졸로[1,5-a]피라진 |
| HK1255269A1 (zh) | 2015-08-17 | 2019-08-09 | Lupin Limited | 作为parp抑制剂的杂芳基衍生物 |
| RS60261B1 (sr) | 2016-02-24 | 2020-06-30 | Pfizer | Pirazolo[1,5-a]pirazin-4-il derivativi kao jak-inhibitori |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| US11254668B2 (en) | 2017-08-14 | 2022-02-22 | Pfizer Inc. | Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives |
| MX2020012201A (es) * | 2018-05-17 | 2021-01-29 | Bayer Ag | Derivados sustituidos de la carboxamida dihidropirazolo pirazina. |
| GB2632307A (en) * | 2023-08-02 | 2025-02-05 | Duke Street Bio Ltd | PARP1 inhibitor compounds |
| GB2632441A (en) * | 2023-08-08 | 2025-02-12 | Duke Street Bio Ltd | Deuterated PARP1 inhibitor compounds |
| WO2025084446A1 (ko) * | 2023-10-16 | 2025-04-24 | 에스티팜 주식회사 | 트리아졸로피리미디논 유도체의 결정형 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | ４―アニリノキナゾリン誘導体 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| SE9702706D0 (sv) | 1997-07-11 | 1997-07-11 | Pharmacia & Upjohn Ab | Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| JP2004502766A (ja) | 2000-07-07 | 2004-01-29 | アンギオジェン・ファーマシューティカルズ・リミテッド | 血管損傷剤としてのコルヒノール誘導体 |
| CA2410562A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| EP2032140A1 (en) * | 2006-05-31 | 2009-03-11 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp) |
| CN101616919B (zh) * | 2006-12-28 | 2012-10-10 | 雅培制药有限公司 | 聚（adp核糖）聚合酶抑制剂 |
| ATE542799T1 (de) | 2007-03-08 | 2012-02-15 | Janssen Pharmaceutica Nv | Chinolinonderivate als parp und tank-inhibitoren |
| DE102007032349A1 (de) * | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung |
| WO2009130232A1 (en) * | 2008-04-24 | 2009-10-29 | Glaxo Group Limited | Pyrazolo [1, 5 -a] pyrazine derivatives as antagonists of v1b receptors |
| WO2009130231A1 (en) | 2008-04-24 | 2009-10-29 | Glaxo Group Limited | Pyrrolo [1, 2-a] pyrazine derivatives as vasopressin vib receptor antagonists |
| EP2350084B1 (en) | 2008-10-17 | 2015-06-24 | Boehringer Ingelheim International GmbH | Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (pi3-kinases) inhibitor |
| CA2787714C (en) | 2010-01-22 | 2019-04-09 | Joaquin Pastor Fernandez | Inhibitors of pi3 kinase |
| CA2794861A1 (en) * | 2010-04-16 | 2011-10-20 | Abbvie Inc. | Pyrrolopyrazinone inhibitors of kinases |
| CN102229611B (zh) * | 2011-04-26 | 2012-12-12 | 山东大学 | 2,6-二芳基吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其应用 |
| HUE030067T2 (en) | 2012-03-28 | 2017-04-28 | Merck Patent Gmbh | Bicyclic pyrazinone derivatives |
| KR20150011838A (ko) * | 2012-06-20 | 2015-02-02 | 에프. 호프만-라 로슈 아게 | 탄키라아제 억제제로서의 피롤로피라존 |
-
2013
- 2013-03-19 HU HUE13712685A patent/HUE030067T2/en unknown
- 2013-03-19 RS RS20160596A patent/RS54997B1/sr unknown
- 2013-03-19 AU AU2013242492A patent/AU2013242492B2/en active Active
- 2013-03-19 PL PL13712685.0T patent/PL2831077T3/pl unknown
- 2013-03-19 UA UAA201411566A patent/UA112795C2/uk unknown
- 2013-03-19 MX MX2014011420A patent/MX351149B/es active IP Right Grant
- 2013-03-19 WO PCT/EP2013/000827 patent/WO2013143663A1/en not_active Ceased
- 2013-03-19 ES ES13712685.0T patent/ES2585044T3/es active Active
- 2013-03-19 HR HRP20160908TT patent/HRP20160908T1/hr unknown
- 2013-03-19 PE PE2014001502A patent/PE20142186A1/es active IP Right Grant
- 2013-03-19 DK DK13712685.0T patent/DK2831077T3/en active
- 2013-03-19 NZ NZ630489A patent/NZ630489A/en not_active IP Right Cessation
- 2013-03-19 PT PT137126850T patent/PT2831077T/pt unknown
- 2013-03-19 JP JP2015502129A patent/JP6096879B2/ja active Active
- 2013-03-19 SG SG11201405750YA patent/SG11201405750YA/en unknown
- 2013-03-19 EP EP13712685.0A patent/EP2831077B1/en active Active
- 2013-03-19 CN CN201380017205.4A patent/CN104169284B/zh active Active
- 2013-03-19 US US14/388,270 patent/US9120805B2/en active Active
- 2013-03-19 CA CA2868620A patent/CA2868620C/en active Active
- 2013-03-19 EA EA201401062A patent/EA027416B1/ru not_active IP Right Cessation
- 2013-03-19 KR KR1020147029895A patent/KR102070567B1/ko not_active Expired - Fee Related
- 2013-03-19 SI SI201330254A patent/SI2831077T1/sl unknown
- 2013-03-19 MY MYPI2014702730A patent/MY172308A/en unknown
- 2013-03-26 AR ARP130100972A patent/AR090496A1/es active IP Right Grant
- 2013-03-27 TW TW102110996A patent/TWI576346B/zh active
-
2014
- 2014-08-13 PH PH12014501829A patent/PH12014501829A1/en unknown
- 2014-08-20 CO CO14182299A patent/CO7111292A2/es unknown
- 2014-09-18 IL IL234713A patent/IL234713A/en active IP Right Grant
- 2014-09-25 CL CL2014002557A patent/CL2014002557A1/es unknown
- 2014-10-27 EC ECIEPI201424526A patent/ECSP14024526A/es unknown
- 2014-10-27 ZA ZA2014/07828A patent/ZA201407828B/en unknown
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