|
US3709898A
(en)
|
1971-02-09 |
1973-01-09 |
Upjohn Co |
Process for the production of triazolobenzodiazepines and intermediates
|
|
US3681343A
(en)
|
1971-05-11 |
1972-08-01 |
Upjohn Co |
6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines
|
|
US3812259A
(en)
|
1971-08-09 |
1974-05-21 |
Upjohn Co |
Animal feed and process
|
|
CH622019A5
(en)
|
1975-10-23 |
1981-03-13 |
Upjohn Co |
Process for the preparation of aminotriazolobenzodiazepines
|
|
FR2329668A1
(fr)
|
1975-10-27 |
1977-05-27 |
Upjohn Co |
Procede de preparation d'aminotriazolobenzodiazepines
|
|
US4210644A
(en)
|
1978-02-23 |
1980-07-01 |
The Johns Hopkins University |
Male contraception
|
|
US4379454A
(en)
|
1981-02-17 |
1983-04-12 |
Alza Corporation |
Dosage for coadministering drug and percutaneous absorption enhancer
|
|
EP0087850A1
(en)
*
|
1982-01-04 |
1983-09-07 |
The Upjohn Company |
Benzodiazepines for anti-hypertensive use
|
|
DE3435973A1
(de)
*
|
1984-10-01 |
1986-04-10 |
Boehringer Ingelheim KG, 6507 Ingelheim |
Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
|
|
US4743249A
(en)
|
1986-02-14 |
1988-05-10 |
Ciba-Geigy Corp. |
Dermal and transdermal patches having a discontinuous pattern adhesive layer
|
|
DE3724164A1
(de)
|
1986-07-25 |
1988-01-28 |
Boehringer Ingelheim Kg |
Neue 1,4-benzodiazepine, ihre herstellung und verwendung
|
|
US4906169A
(en)
|
1986-12-29 |
1990-03-06 |
Rutgers, The State University Of New Jersey |
Transdermal estrogen/progestin dosage unit, system and process
|
|
US5023084A
(en)
|
1986-12-29 |
1991-06-11 |
Rutgers, The State University Of New Jersey |
Transdermal estrogen/progestin dosage unit, system and process
|
|
EP0315698B1
(en)
*
|
1987-05-28 |
1993-03-03 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Thieno(triazolo)diazepine compounds and medicinal application of the same
|
|
US4816540A
(en)
|
1987-06-12 |
1989-03-28 |
Yasuhiko Onishi |
Cationic graft-copolymer
|
|
US5422119A
(en)
|
1987-09-24 |
1995-06-06 |
Jencap Research Ltd. |
Transdermal hormone replacement therapy
|
|
US5035891A
(en)
|
1987-10-05 |
1991-07-30 |
Syntex (U.S.A.) Inc. |
Controlled release subcutaneous implant
|
|
JPH0676326B2
(ja)
|
1988-05-24 |
1994-09-28 |
吉富製薬株式会社 |
循環器系疾患治療薬
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0368175A1
(de)
|
1988-11-06 |
1990-05-16 |
Boehringer Ingelheim Kg |
3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.
|
|
EP0387613A1
(de)
|
1989-03-03 |
1990-09-19 |
Boehringer Ingelheim Kg |
Neue Thienodiazepine
|
|
US4973468A
(en)
|
1989-03-22 |
1990-11-27 |
Cygnus Research Corporation |
Skin permeation enhancer compositions
|
|
EP0407955A1
(de)
|
1989-07-12 |
1991-01-16 |
Boehringer Ingelheim Kg |
Neue Hetrazepine mit PAF-antagonistischer Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE4010528A1
(de)
|
1990-04-02 |
1991-10-17 |
Boehringer Ingelheim Kg |
Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
|
|
US5198223A
(en)
|
1990-10-29 |
1993-03-30 |
Alza Corporation |
Transdermal formulations, methods and devices
|
|
US5593988A
(en)
|
1991-10-11 |
1997-01-14 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Therapeutic agent for osteoporosis and diazepine compound
|
|
EP0661284A1
(en)
*
|
1992-09-18 |
1995-07-05 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Thienodiazepine compound and medicinal use thereof
|
|
WO1994022872A1
(fr)
|
1993-03-30 |
1994-10-13 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Inhibiteur d'adhesion cellulaire et compose a base de thienotriazolodiazepine
|
|
WO1995032963A1
(en)
|
1994-06-01 |
1995-12-07 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Thienylazole compound and thienotriazolodiazepine compound
|
|
AU4296196A
(en)
*
|
1995-01-06 |
1996-07-24 |
F. Hoffmann-La Roche Ag |
Hydroxymethylimidazodiazepines and their esters
|
|
US5730723A
(en)
|
1995-10-10 |
1998-03-24 |
Visionary Medical Products Corporation, Inc. |
Gas pressured needle-less injection device and method
|
|
ATE230600T1
(de)
|
1995-09-09 |
2003-01-15 |
Hoffmann La Roche |
Verwendung eines thienotriazoldiazepins zur erhöhung des apolopoproteins a-i niveaus
|
|
GB9607549D0
(en)
|
1996-04-11 |
1996-06-12 |
Weston Medical Ltd |
Spring-powered dispensing device
|
|
CN1227555A
(zh)
|
1996-06-12 |
1999-09-01 |
日本烟草产业株式会社 |
细胞因子生成抑制剂、三氮䓬化合物及其中间体
|
|
US5693641A
(en)
|
1996-08-16 |
1997-12-02 |
Berlex Laboratories Inc. |
Bicyclic pyrimidine derivatives and their use as anti-coagulants
|
|
PT989131E
(pt)
|
1996-09-13 |
2003-03-31 |
Mitsubishi Pharma Corp |
Compostos de trienotriazolodiazepina e suas utilizacoes com fins medicinais
|
|
US6444664B1
(en)
|
1997-04-18 |
2002-09-03 |
Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) |
Method for controlling the plasma level of lipoproteins to treat alzheimeris disease
|
|
JPH11228576A
(ja)
|
1997-12-10 |
1999-08-24 |
Japan Tobacco Inc |
アポトーシス抑制剤
|
|
IT1298087B1
(it)
|
1998-01-08 |
1999-12-20 |
Fiderm S R L |
Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
|
|
FR2779652B1
(fr)
|
1998-06-15 |
2001-06-08 |
Sod Conseils Rech Applic |
Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
|
|
US7589167B2
(en)
|
2000-02-22 |
2009-09-15 |
J. David Gladstone Institutes |
ZA loops of bromodomains
|
|
CA2412776C
(en)
|
2000-06-16 |
2011-03-15 |
Mitsubishi Pharma Corporation |
Compositions controlling release ph range and/or speed
|
|
AU2001270297A1
(en)
|
2000-06-30 |
2002-01-14 |
Neurogen Corporation |
2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands
|
|
US20060142257A1
(en)
*
|
2001-01-19 |
2006-06-29 |
Eberhard Nieschlag |
Male contraceptive formulation comprising norethisterone
|
|
US6979682B2
(en)
|
2001-02-23 |
2005-12-27 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Platelet-activating factor antagonist inhibition of angiogenesis and tumor growth induced by basic fibroblast
|
|
US20030216758A1
(en)
|
2001-12-28 |
2003-11-20 |
Angiotech Pharmaceuticals, Inc. |
Coated surgical patches
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
US6861422B2
(en)
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
WO2005002526A2
(en)
|
2003-07-01 |
2005-01-13 |
President And Fellows Of Harvard College |
Method and compositions for treatment of viral infections
|
|
JP2007505858A
(ja)
|
2003-09-18 |
2007-03-15 |
ノバルティス アクチエンゲゼルシャフト |
増殖性障害の処置に有用な2,4−ジ(フェニルアミノ)ピリミジン
|
|
EP1528056A1
(en)
|
2003-10-29 |
2005-05-04 |
Academisch Ziekenhuis bij de Universiteit van Amsterdam |
Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
|
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
US7759485B2
(en)
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
|
US20060074088A1
(en)
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
|
US20060035903A1
(en)
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
|
CN1759834B
(zh)
|
2004-09-17 |
2010-06-23 |
中国医学科学院医药生物技术研究所 |
黄连素或其与辛伐他汀联合在制备用于预防或治疗与血脂有关疾病或症状的产品中用途
|
|
EP1887008B1
(en)
*
|
2005-05-30 |
2021-04-21 |
Mitsubishi Tanabe Pharma Corporation |
Thienotriazolodiazepine compound and a medicinal use thereof
|
|
JP2009503014A
(ja)
|
2005-08-03 |
2009-01-29 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
呼吸器系疾患の治療におけるジヒドロプテリジノン
|
|
NZ567851A
(en)
|
2005-11-01 |
2011-09-30 |
Targegen Inc |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
US8133900B2
(en)
|
2005-11-01 |
2012-03-13 |
Targegen, Inc. |
Use of bi-aryl meta-pyrimidine inhibitors of kinases
|
|
MX2008008320A
(es)
|
2005-12-23 |
2008-09-03 |
Smithkline Beecham Corp |
Inhibidores de azaindol de aurora cinasas.
|
|
AU2007207053B2
(en)
|
2006-01-17 |
2012-05-24 |
F. Hoffmann-La Roche Ag |
Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine useful for the treatment of Alzheimer's disease via GABA receptors
|
|
CA2652648C
(en)
|
2006-02-14 |
2016-10-25 |
Vertex Pharmaceuticals Incorporated |
Dihydrodiazepines useful as inhibitors of protein kinases
|
|
US20070218135A1
(en)
|
2006-03-14 |
2007-09-20 |
Glenmark Pharmaceuticals Limited |
Sustained release matrix pharmaceutical composition
|
|
MX2008014008A
(es)
|
2006-05-03 |
2009-03-25 |
Novartis Ag |
Uso de compuestos organicos.
|
|
NZ576278A
(en)
|
2006-10-19 |
2011-12-22 |
Signal Pharm Llc |
Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
|
|
US8338464B2
(en)
|
2006-11-30 |
2012-12-25 |
Albert Einstein College Of Medicine Of Yeshiva University |
Small molecule inhibitors of BCL6
|
|
ES2804801T3
(es)
|
2006-12-26 |
2021-02-09 |
Lantheus Medical Imaging Inc |
Ligandos para la formación de imágenes de la inervación cardíaca
|
|
WO2008137081A1
(en)
|
2007-05-02 |
2008-11-13 |
The Trustees Of Columbia University In The City Of New York |
Substituted ( 5, 6 ) -dihydronaphraalenyl compounds as reversible male contraceptives
|
|
KR20080107050A
(ko)
|
2007-06-05 |
2008-12-10 |
울산대학교 산학협력단 |
항-cd137 단일클론 항체를 포함하는 만성이식편대숙주 질환의 예방 또는 치료용 약학적 조성물
|
|
US7935964B2
(en)
|
2007-06-19 |
2011-05-03 |
Samsung Electronics Co., Ltd. |
Oxide semiconductors and thin film transistors comprising the same
|
|
EP2234986A2
(en)
|
2007-12-20 |
2010-10-06 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
EP2239264A4
(en)
*
|
2007-12-28 |
2012-01-11 |
Mitsubishi Tanabe Pharma Corp |
ANTITUMORAL MEDIUM
|
|
US20110098288A1
(en)
|
2008-03-11 |
2011-04-28 |
Jeremy Major |
Sulfonamides as zap-70 inhibitors
|
|
WO2010015340A1
(en)
|
2008-08-06 |
2010-02-11 |
Bayer Schering Pharma Aktiengesellschaft |
Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment
|
|
CA2741934C
(en)
|
2008-10-30 |
2016-09-13 |
Circomed Llc |
Thienotriazolodiazepine derivatives active on apo a
|
|
EP2379559B1
(en)
|
2009-01-06 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
|
|
MX2011007741A
(es)
|
2009-01-23 |
2011-09-06 |
Takeda Pharmaceutical |
Inhibidores de poli(adenosina difosfato plaquetaria (adp)-ribosa) polimerasa poli adenosina difosfato plaquetaria ribosa (parp).
|
|
GB0919431D0
(en)
|
2009-11-05 |
2009-12-23 |
Glaxosmithkline Llc |
Novel compounds
|
|
GB0919432D0
(en)
|
2009-11-05 |
2009-12-23 |
Glaxosmithkline Llc |
Use
|
|
MY160456A
(en)
|
2009-11-05 |
2017-03-15 |
Glaxosmithkline Llc |
Benzodiazepine bromodomain inhibitor
|
|
GB0919423D0
(en)
|
2009-11-05 |
2009-12-23 |
Glaxosmithkline Llc |
Novel compounds
|
|
GB0919426D0
(en)
|
2009-11-05 |
2009-12-23 |
Glaxosmithkline Llc |
Novel compounds
|
|
GB0919434D0
(en)
|
2009-11-05 |
2009-12-23 |
Glaxosmithkline Llc |
Novel compounds
|
|
KR20120097508A
(ko)
|
2009-11-05 |
2012-09-04 |
글락소스미스클라인 엘엘씨 |
벤조디아제핀 브로모도메인 억제제
|
|
US20120329803A1
(en)
|
2010-02-17 |
2012-12-27 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones, method for production and use thereof
|
|
US8981083B2
(en)
|
2010-05-14 |
2015-03-17 |
Dana Farber Cancer Institute, Inc. |
Compositions and methods for treating neoplasia, inflammatory disease and other disorders
|
|
MX373121B
(es)
|
2010-05-14 |
2020-04-30 |
Dana Farber Cancer Inst Inc |
Composiciones y metodos para el tratamiento de leucemia.
|
|
JP5913292B2
(ja)
|
2010-05-14 |
2016-04-27 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
代謝を調節する組成物および方法
|
|
CA2799381A1
(en)
|
2010-05-14 |
2011-11-17 |
Dana-Farber Cancer Institute, Inc. |
Male contraceptive compositions and methods of use
|
|
US9085582B2
(en)
|
2010-06-22 |
2015-07-21 |
Glaxosmithkline Llc |
Benzotriazolodiazepine compounds inhibitors of bromodomains
|
|
US20120014979A1
(en)
|
2010-07-16 |
2012-01-19 |
Alexander Dent |
Use of bcl6 inhibitors for treating autoimmune diseases
|
|
AR084070A1
(es)
|
2010-12-02 |
2013-04-17 |
Constellation Pharmaceuticals Inc |
Inhibidores del bromodominio y usos de los mismos
|
|
US9249161B2
(en)
|
2010-12-02 |
2016-02-02 |
Constellation Pharmaceuticals, Inc. |
Bromodomain inhibitors and uses thereof
|
|
EP2677865A4
(en)
|
2011-02-23 |
2015-04-22 |
Icahn School Med Mount Sinai |
BROMODOMAIN INHIBITORS AS MODULATORS OF GENE EXPRESSION
|
|
EP3323820B1
(en)
|
2011-02-28 |
2023-05-10 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
WO2013033270A2
(en)
|
2011-08-29 |
2013-03-07 |
Coferon, Inc. |
Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same
|
|
WO2013033269A1
(en)
|
2011-08-29 |
2013-03-07 |
Coferon, Inc. |
Bioorthogonal monomers capable of dimerizing and targeting bromodomains and methods of using same
|
|
WO2013097052A1
(en)
|
2011-12-30 |
2013-07-04 |
Abbott Laboratories |
Bromodomain inhibitors
|
|
AU2013221230A1
(en)
|
2012-02-17 |
2014-10-02 |
Ansun Biopharma, Inc. |
Methods, compounds and compositions for treatment of parainfluenza virus in immunocompromised patients
|
|
EP2830629A4
(en)
|
2012-03-28 |
2016-01-20 |
Icahn School Of Medicine Mount Sinai |
COMPOSITIONS AND METHOD FOR THE REACTIVATION OF LATENT IMMUNE FIZIENZVIRUS
|
|
WO2014071247A1
(en)
|
2012-11-02 |
2014-05-08 |
Dana-Farber Cancer Institute, Inc. |
Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors
|
|
US9714946B2
(en)
|
2013-03-14 |
2017-07-25 |
Dana-Farber Cancer Institute, Inc. |
Bromodomain binding reagents and uses thereof
|
|
BR112016001457A2
(pt)
|
2013-07-25 |
2017-08-29 |
Dana Farber Cancer Inst Inc |
Inibidores de fatores de transcrição e usos dos mesmos
|
|
CA2922503C
(en)
|
2013-09-19 |
2021-10-26 |
Dana-Farber Cancer Institute, Inc. |
Methods of bh3 profiling
|
|
WO2015081284A1
(en)
|
2013-11-26 |
2015-06-04 |
Coferon, Inc. |
Bivalent bromodomain ligands, and methods of using same
|
|
MX2016009974A
(es)
|
2014-01-31 |
2016-10-31 |
Dana Farber Cancer Inst Inc |
Derivados de diaminopirimidina bencensulfona y sus usos.
|
|
WO2015117087A1
(en)
|
2014-01-31 |
2015-08-06 |
Dana-Farber Cancer Institute, Inc. |
Uses of diazepane derivatives
|
|
KR20160111036A
(ko)
|
2014-01-31 |
2016-09-23 |
다나-파버 캔서 인스티튜트 인크. |
디아제판 유도체 및 그의 용도
|