KR102070567B1 - 바이시클릭 피라지논 유도체 - Google Patents

바이시클릭 피라지논 유도체 Download PDF

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Publication number
KR102070567B1
KR102070567B1 KR1020147029895A KR20147029895A KR102070567B1 KR 102070567 B1 KR102070567 B1 KR 102070567B1 KR 1020147029895 A KR1020147029895 A KR 1020147029895A KR 20147029895 A KR20147029895 A KR 20147029895A KR 102070567 B1 KR102070567 B1 KR 102070567B1
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het
phenyl
unsubstituted
formula
mmol
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English (en)
Korean (ko)
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KR20140140099A (ko
Inventor
디에터 도르슈
한스-페터 부흐슈탈러
제라르 무아네
안스가르 베게너
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메르크 파텐트 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020147029895A 2012-03-28 2013-03-19 바이시클릭 피라지논 유도체 Expired - Fee Related KR102070567B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12002215.7 2012-03-28
EP12002215 2012-03-28
PCT/EP2013/000827 WO2013143663A1 (en) 2012-03-28 2013-03-19 Bicyclic pyrazinone derivatives

Publications (2)

Publication Number Publication Date
KR20140140099A KR20140140099A (ko) 2014-12-08
KR102070567B1 true KR102070567B1 (ko) 2020-01-29

Family

ID=48013911

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147029895A Expired - Fee Related KR102070567B1 (ko) 2012-03-28 2013-03-19 바이시클릭 피라지논 유도체

Country Status (31)

Country Link
US (1) US9120805B2 (enExample)
EP (1) EP2831077B1 (enExample)
JP (1) JP6096879B2 (enExample)
KR (1) KR102070567B1 (enExample)
CN (1) CN104169284B (enExample)
AR (1) AR090496A1 (enExample)
AU (1) AU2013242492B2 (enExample)
CA (1) CA2868620C (enExample)
CL (1) CL2014002557A1 (enExample)
CO (1) CO7111292A2 (enExample)
DK (1) DK2831077T3 (enExample)
EA (1) EA027416B1 (enExample)
EC (1) ECSP14024526A (enExample)
ES (1) ES2585044T3 (enExample)
HR (1) HRP20160908T1 (enExample)
HU (1) HUE030067T2 (enExample)
IL (1) IL234713A (enExample)
MX (1) MX351149B (enExample)
MY (1) MY172308A (enExample)
NZ (1) NZ630489A (enExample)
PE (1) PE20142186A1 (enExample)
PH (1) PH12014501829A1 (enExample)
PL (1) PL2831077T3 (enExample)
PT (1) PT2831077T (enExample)
RS (1) RS54997B1 (enExample)
SG (1) SG11201405750YA (enExample)
SI (1) SI2831077T1 (enExample)
TW (1) TWI576346B (enExample)
UA (1) UA112795C2 (enExample)
WO (1) WO2013143663A1 (enExample)
ZA (1) ZA201407828B (enExample)

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DK2822656T3 (en) 2012-03-07 2017-01-30 Inst Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
HUE030067T2 (en) 2012-03-28 2017-04-28 Merck Patent Gmbh Bicyclic pyrazinone derivatives
KR20150011838A (ko) * 2012-06-20 2015-02-02 에프. 호프만-라 로슈 아게 탄키라아제 억제제로서의 피롤로피라존
CN105722835B (zh) 2013-09-11 2018-07-31 癌症研究协会:皇家癌症医院 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用
MX364859B (es) 2013-12-23 2019-05-09 Merck Patent Gmbh Derivados de imidazopirazinona.
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
KR101739003B1 (ko) * 2014-07-11 2017-05-23 에스티팜 주식회사 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도
KR20170090476A (ko) * 2014-12-05 2017-08-07 어레이 바이오파마 인크. 야누스 키나제 저해제로서의 4,6-치환된-피라졸로[1,5-a]피라진
HK1255269A1 (zh) 2015-08-17 2019-08-09 Lupin Limited 作为parp抑制剂的杂芳基衍生物
RS60261B1 (sr) 2016-02-24 2020-06-30 Pfizer Pirazolo[1,5-a]pirazin-4-il derivativi kao jak-inhibitori
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
US11254668B2 (en) 2017-08-14 2022-02-22 Pfizer Inc. Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
MX2020012201A (es) * 2018-05-17 2021-01-29 Bayer Ag Derivados sustituidos de la carboxamida dihidropirazolo pirazina.
GB2632307A (en) * 2023-08-02 2025-02-05 Duke Street Bio Ltd PARP1 inhibitor compounds
GB2632441A (en) * 2023-08-08 2025-02-12 Duke Street Bio Ltd Deuterated PARP1 inhibitor compounds
WO2025084446A1 (ko) * 2023-10-16 2025-04-24 에스티팜 주식회사 트리아졸로피리미디논 유도체의 결정형

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US20090209523A1 (en) 2006-05-31 2009-08-20 Philip Jones Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp)
US20110053929A1 (en) 2007-07-11 2011-03-03 Bayer Schering Pharma Aktiengesellschaft Imidazo-, pyrazolopyrazines and imidazotriazines and their use

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GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド ４―アニリノキナゾリン誘導体
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
SE9702706D0 (sv) 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
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JP2004502766A (ja) 2000-07-07 2004-01-29 アンギオジェン・ファーマシューティカルズ・リミテッド 血管損傷剤としてのコルヒノール誘導体
CA2410562A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
CN101616919B (zh) * 2006-12-28 2012-10-10 雅培制药有限公司 聚（adp核糖）聚合酶抑制剂
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HUE030067T2 (en) 2012-03-28 2017-04-28 Merck Patent Gmbh Bicyclic pyrazinone derivatives
KR20150011838A (ko) * 2012-06-20 2015-02-02 에프. 호프만-라 로슈 아게 탄키라아제 억제제로서의 피롤로피라존

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Publication number Priority date Publication date Assignee Title
US20090209523A1 (en) 2006-05-31 2009-08-20 Philip Jones Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp)
US20110053929A1 (en) 2007-07-11 2011-03-03 Bayer Schering Pharma Aktiengesellschaft Imidazo-, pyrazolopyrazines and imidazotriazines and their use

Also Published As

Publication number Publication date
CA2868620A1 (en) 2013-10-03
TW201343650A (zh) 2013-11-01
IL234713A (en) 2016-09-29
JP2015511609A (ja) 2015-04-20
EP2831077B1 (en) 2016-04-27
HRP20160908T1 (hr) 2016-09-23
CO7111292A2 (es) 2014-11-10
SG11201405750YA (en) 2014-10-30
PE20142186A1 (es) 2014-12-29
PT2831077T (pt) 2016-08-12
NZ630489A (en) 2016-04-29
EA027416B1 (ru) 2017-07-31
SI2831077T1 (sl) 2016-09-30
MX2014011420A (es) 2014-11-25
TWI576346B (zh) 2017-04-01
MX351149B (es) 2017-10-04
US20150057264A1 (en) 2015-02-26
UA112795C2 (uk) 2016-10-25
CN104169284A (zh) 2014-11-26
ECSP14024526A (es) 2015-09-30
JP6096879B2 (ja) 2017-03-15
CA2868620C (en) 2020-02-25
ES2585044T3 (es) 2016-10-03
EP2831077A1 (en) 2015-02-04
AR090496A1 (es) 2014-11-19
US9120805B2 (en) 2015-09-01
KR20140140099A (ko) 2014-12-08
CN104169284B (zh) 2017-03-29
PL2831077T3 (pl) 2016-10-31
RS54997B1 (sr) 2016-11-30
ZA201407828B (en) 2015-12-23
PH12014501829B1 (en) 2014-11-10
MY172308A (en) 2019-11-21
EA201401062A1 (ru) 2015-04-30
HK1203961A1 (en) 2015-11-06
HUE030067T2 (en) 2017-04-28
WO2013143663A1 (en) 2013-10-03
CL2014002557A1 (es) 2014-12-19
DK2831077T3 (en) 2016-08-15
AU2013242492B2 (en) 2016-12-15
AU2013242492A1 (en) 2014-11-13
PH12014501829A1 (en) 2014-11-10

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