KR102070567B1 - 바이시클릭 피라지논 유도체 - Google Patents

바이시클릭 피라지논 유도체 Download PDF

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Publication number
KR102070567B1
KR102070567B1 KR1020147029895A KR20147029895A KR102070567B1 KR 102070567 B1 KR102070567 B1 KR 102070567B1 KR 1020147029895 A KR1020147029895 A KR 1020147029895A KR 20147029895 A KR20147029895 A KR 20147029895A KR 102070567 B1 KR102070567 B1 KR 102070567B1
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South Korea
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het
phenyl
unsubstituted
formula
mmol
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KR1020147029895A
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English (en)
Korean (ko)
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KR20140140099A (ko
Inventor
디에터 도르슈
한스-페터 부흐슈탈러
제라르 무아네
안스가르 베게너
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메르크 파텐트 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020147029895A 2012-03-28 2013-03-19 바이시클릭 피라지논 유도체 Expired - Fee Related KR102070567B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12002215.7 2012-03-28
EP12002215 2012-03-28
PCT/EP2013/000827 WO2013143663A1 (en) 2012-03-28 2013-03-19 Bicyclic pyrazinone derivatives

Publications (2)

Publication Number Publication Date
KR20140140099A KR20140140099A (ko) 2014-12-08
KR102070567B1 true KR102070567B1 (ko) 2020-01-29

Family

ID=48013911

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147029895A Expired - Fee Related KR102070567B1 (ko) 2012-03-28 2013-03-19 바이시클릭 피라지논 유도체

Country Status (31)

Country Link
US (1) US9120805B2 (enExample)
EP (1) EP2831077B1 (enExample)
JP (1) JP6096879B2 (enExample)
KR (1) KR102070567B1 (enExample)
CN (1) CN104169284B (enExample)
AR (1) AR090496A1 (enExample)
AU (1) AU2013242492B2 (enExample)
CA (1) CA2868620C (enExample)
CL (1) CL2014002557A1 (enExample)
CO (1) CO7111292A2 (enExample)
DK (1) DK2831077T3 (enExample)
EA (1) EA027416B1 (enExample)
EC (1) ECSP14024526A (enExample)
ES (1) ES2585044T3 (enExample)
HR (1) HRP20160908T1 (enExample)
HU (1) HUE030067T2 (enExample)
IL (1) IL234713A (enExample)
MX (1) MX351149B (enExample)
MY (1) MY172308A (enExample)
NZ (1) NZ630489A (enExample)
PE (1) PE20142186A1 (enExample)
PH (1) PH12014501829B1 (enExample)
PL (1) PL2831077T3 (enExample)
PT (1) PT2831077T (enExample)
RS (1) RS54997B1 (enExample)
SG (1) SG11201405750YA (enExample)
SI (1) SI2831077T1 (enExample)
TW (1) TWI576346B (enExample)
UA (1) UA112795C2 (enExample)
WO (1) WO2013143663A1 (enExample)
ZA (1) ZA201407828B (enExample)

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RU2696572C2 (ru) 2012-03-07 2019-08-05 Инститьют Оф Кансер Ресёрч: Ройял Кансер Хоспитал (Зе) 3-арил-5-замещенные соединения изохинолин-1-она и их терапевтическое применение
HRP20160908T1 (hr) 2012-03-28 2016-09-23 Merck Patent Gmbh Biciklički derivati pirazinona
CA2870062A1 (en) * 2012-06-20 2013-12-27 F.Hoffmann-La Roche Ag Pyrrolopyrazone inhibitors of tankyrase
CA2922469A1 (en) 2013-09-11 2015-03-19 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
HUE037606T2 (hu) 2013-12-23 2018-09-28 Merck Patent Gmbh Imidazopirazinon-származékok
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
KR101739003B1 (ko) * 2014-07-11 2017-05-23 에스티팜 주식회사 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
KR20170090476A (ko) 2014-12-05 2017-08-07 어레이 바이오파마 인크. 야누스 키나제 저해제로서의 4,6-치환된-피라졸로[1,5-a]피라진
CN107922409A (zh) 2015-08-17 2018-04-17 鲁宾有限公司 作为parp抑制剂的杂芳基衍生物
MX383747B (es) 2016-02-24 2025-03-14 Pfizer Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de quinasas janus (jak)
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
SG11202010679SA (en) * 2018-05-17 2020-11-27 Bayer Ag Substituted dihydropyrazolo pyrazine carboxamide derivatives
GB2632307A (en) * 2023-08-02 2025-02-05 Duke Street Bio Ltd PARP1 inhibitor compounds
GB2632441A (en) * 2023-08-08 2025-02-12 Duke Street Bio Ltd Deuterated PARP1 inhibitor compounds
WO2025084446A1 (ko) * 2023-10-16 2025-04-24 에스티팜 주식회사 트리아졸로피리미디논 유도체의 결정형

Citations (2)

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US20090209523A1 (en) 2006-05-31 2009-08-20 Philip Jones Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp)
US20110053929A1 (en) 2007-07-11 2011-03-03 Bayer Schering Pharma Aktiengesellschaft Imidazo-, pyrazolopyrazines and imidazotriazines and their use

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GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
SE9702706D0 (sv) 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
KR20030014425A (ko) 2000-07-07 2003-02-17 앤지오젠 파마슈티칼스 리미티드 혈관 손상제인 콜치놀 유도체
EE200300015A (et) 2000-07-07 2004-10-15 Angiogene Pharmaceuticals Limited Kolhinooli derivaadid kui angiogeneesi inhibiitorid
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JP5545955B2 (ja) 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
WO2009130232A1 (en) 2008-04-24 2009-10-29 Glaxo Group Limited Pyrazolo [1, 5 -a] pyrazine derivatives as antagonists of v1b receptors
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JP5579724B2 (ja) 2008-10-17 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環
CA2787714C (en) 2010-01-22 2019-04-09 Joaquin Pastor Fernandez Inhibitors of pi3 kinase
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HRP20160908T1 (hr) 2012-03-28 2016-09-23 Merck Patent Gmbh Biciklički derivati pirazinona
CA2870062A1 (en) * 2012-06-20 2013-12-27 F.Hoffmann-La Roche Ag Pyrrolopyrazone inhibitors of tankyrase

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Publication number Priority date Publication date Assignee Title
US20090209523A1 (en) 2006-05-31 2009-08-20 Philip Jones Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp)
US20110053929A1 (en) 2007-07-11 2011-03-03 Bayer Schering Pharma Aktiengesellschaft Imidazo-, pyrazolopyrazines and imidazotriazines and their use

Also Published As

Publication number Publication date
TW201343650A (zh) 2013-11-01
SI2831077T1 (sl) 2016-09-30
PE20142186A1 (es) 2014-12-29
AU2013242492A1 (en) 2014-11-13
US9120805B2 (en) 2015-09-01
SG11201405750YA (en) 2014-10-30
EP2831077A1 (en) 2015-02-04
PT2831077T (pt) 2016-08-12
EP2831077B1 (en) 2016-04-27
PH12014501829A1 (en) 2014-11-10
ES2585044T3 (es) 2016-10-03
CN104169284B (zh) 2017-03-29
PL2831077T3 (pl) 2016-10-31
RS54997B1 (sr) 2016-11-30
TWI576346B (zh) 2017-04-01
CN104169284A (zh) 2014-11-26
NZ630489A (en) 2016-04-29
JP2015511609A (ja) 2015-04-20
MX2014011420A (es) 2014-11-25
US20150057264A1 (en) 2015-02-26
EA201401062A1 (ru) 2015-04-30
CO7111292A2 (es) 2014-11-10
PH12014501829B1 (en) 2014-11-10
ECSP14024526A (es) 2015-09-30
WO2013143663A1 (en) 2013-10-03
CL2014002557A1 (es) 2014-12-19
AU2013242492B2 (en) 2016-12-15
CA2868620A1 (en) 2013-10-03
CA2868620C (en) 2020-02-25
HK1203961A1 (en) 2015-11-06
MX351149B (es) 2017-10-04
EA027416B1 (ru) 2017-07-31
MY172308A (en) 2019-11-21
HRP20160908T1 (hr) 2016-09-23
AR090496A1 (es) 2014-11-19
JP6096879B2 (ja) 2017-03-15
DK2831077T3 (en) 2016-08-15
KR20140140099A (ko) 2014-12-08
HUE030067T2 (en) 2017-04-28
IL234713A (en) 2016-09-29
UA112795C2 (uk) 2016-10-25
ZA201407828B (en) 2015-12-23

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