EA201401062A1 - Бициклические пиразиноновые производные - Google Patents

Бициклические пиразиноновые производные

Info

Publication number
EA201401062A1
EA201401062A1 EA201401062A EA201401062A EA201401062A1 EA 201401062 A1 EA201401062 A1 EA 201401062A1 EA 201401062 A EA201401062 A EA 201401062A EA 201401062 A EA201401062 A EA 201401062A EA 201401062 A1 EA201401062 A1 EA 201401062A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bicyclic
pirazine
derivatives
pirazine derivatives
diseases
Prior art date
Application number
EA201401062A
Other languages
English (en)
Other versions
EA027416B1 (ru
Inventor
Дитер Дорш
Ханс-Петер Бухшталлер
Жерар Муане
Ансгар Вегенер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013911&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201401062(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201401062A1 publication Critical patent/EA201401062A1/ru
Publication of EA027416B1 publication Critical patent/EA027416B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединения формулы Iв которой R, X и Y имеют значения, указанные в п.1 формулы изобретения, являются ингибиторами танкиразы и могут применяться, среди прочего, для лечения заболеваний, таких как злокачественное новообразование, сердечно-сосудистые заболевания, поражения центральной нервной системы и различные формы воспаления.
EA201401062A 2012-03-28 2013-03-19 Бициклические пиразиноновые производные EA027416B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12002215 2012-03-28
PCT/EP2013/000827 WO2013143663A1 (en) 2012-03-28 2013-03-19 Bicyclic pyrazinone derivatives

Publications (2)

Publication Number Publication Date
EA201401062A1 true EA201401062A1 (ru) 2015-04-30
EA027416B1 EA027416B1 (ru) 2017-07-31

Family

ID=48013911

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401062A EA027416B1 (ru) 2012-03-28 2013-03-19 Бициклические пиразиноновые производные

Country Status (32)

Country Link
US (1) US9120805B2 (ru)
EP (1) EP2831077B1 (ru)
JP (1) JP6096879B2 (ru)
KR (1) KR102070567B1 (ru)
CN (1) CN104169284B (ru)
AR (1) AR090496A1 (ru)
AU (1) AU2013242492B2 (ru)
CA (1) CA2868620C (ru)
CL (1) CL2014002557A1 (ru)
CO (1) CO7111292A2 (ru)
DK (1) DK2831077T3 (ru)
EA (1) EA027416B1 (ru)
EC (1) ECSP14024526A (ru)
ES (1) ES2585044T3 (ru)
HK (1) HK1203961A1 (ru)
HR (1) HRP20160908T1 (ru)
HU (1) HUE030067T2 (ru)
IL (1) IL234713A (ru)
MX (1) MX351149B (ru)
MY (1) MY172308A (ru)
NZ (1) NZ630489A (ru)
PE (1) PE20142186A1 (ru)
PH (1) PH12014501829B1 (ru)
PL (1) PL2831077T3 (ru)
PT (1) PT2831077T (ru)
RS (1) RS54997B1 (ru)
SG (1) SG11201405750YA (ru)
SI (1) SI2831077T1 (ru)
TW (1) TWI576346B (ru)
UA (1) UA112795C2 (ru)
WO (1) WO2013143663A1 (ru)
ZA (1) ZA201407828B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102104144B1 (ko) 2012-03-07 2020-04-23 디 인스티튜트 오브 캔서 리서치:로얄 캔서 하스피틀 3-아릴-5-치환-이소퀴놀린-1-온 화합물 및 그의 치료적 용도
UA112795C2 (uk) 2012-03-28 2016-10-25 Мерк Патент Гмбх Біциклічні піразинонові похідні
EP2864330A1 (en) * 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG Pyrrolopyrazone inhibitors of tankyrase
CA2922469A1 (en) 2013-09-11 2015-03-19 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
NO3087076T3 (ru) * 2013-12-23 2018-02-24
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
KR101739003B1 (ko) 2014-07-11 2017-05-23 에스티팜 주식회사 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도
MX2017007284A (es) 2014-12-05 2017-08-25 Array Biopharma Inc Pirazolo [1,5-a] pirazinas 4,6-sustituidas como inhibidores de janus cinasas.
CN107922409A (zh) 2015-08-17 2018-04-17 鲁宾有限公司 作为parp抑制剂的杂芳基衍生物
JP6505956B2 (ja) 2016-02-24 2019-04-24 ファイザー・インク ＪＡＫ阻害剤としてのピラゾロ［１，５−ａ］ピラジン−４−イル誘導体
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
EP3668858A1 (en) 2017-08-14 2020-06-24 Pfizer Inc Pyrazolo[1,5-a]pyrazin-4-yl and related derivatives
BR112020021612A2 (pt) * 2018-05-17 2021-01-26 Bayer Aktiengesellschaft derivados substituídos de di-hidropirazolo pirazina carboxamida

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CZ291386B6 (cs) 1996-02-13 2003-02-12 Zeneca Limited Chinazolinové deriváty jako inhibitory VEGF, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
SE9702706D0 (sv) 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
MXPA02011770A (es) 2000-05-31 2003-04-10 Astrazeneca Ab Derivados de indol con actividad de dano vascular.
CN1255391C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管破坏剂的colchinol衍生物
AU2001266232B2 (en) 2000-07-07 2005-09-15 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
EP2032140A1 (en) * 2006-05-31 2009-03-11 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
EP2114948B1 (en) * 2006-12-28 2014-06-25 AbbVie Inc. Inhibitors of poly(adp-ribose)polymerase
JP5545955B2 (ja) 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
DE102007032349A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung
WO2009130232A1 (en) * 2008-04-24 2009-10-29 Glaxo Group Limited Pyrazolo [1, 5 -a] pyrazine derivatives as antagonists of v1b receptors
WO2009130231A1 (en) 2008-04-24 2009-10-29 Glaxo Group Limited Pyrrolo [1, 2-a] pyrazine derivatives as vasopressin vib receptor antagonists
JP5579724B2 (ja) 2008-10-17 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環
CA2787714C (en) 2010-01-22 2019-04-09 Joaquin Pastor Fernandez Inhibitors of pi3 kinase
CN102933584A (zh) * 2010-04-16 2013-02-13 Abbvie公司 激酶的吡咯并吡嗪酮抑制剂
CN102229611B (zh) * 2011-04-26 2012-12-12 山东大学 2,6-二芳基吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其应用
UA112795C2 (uk) 2012-03-28 2016-10-25 Мерк Патент Гмбх Біциклічні піразинонові похідні
EP2864330A1 (en) * 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG Pyrrolopyrazone inhibitors of tankyrase

Also Published As

Publication number Publication date
TW201343650A (zh) 2013-11-01
PL2831077T3 (pl) 2016-10-31
RS54997B1 (sr) 2016-11-30
CO7111292A2 (es) 2014-11-10
JP2015511609A (ja) 2015-04-20
AU2013242492A1 (en) 2014-11-13
PT2831077T (pt) 2016-08-12
MY172308A (en) 2019-11-21
SG11201405750YA (en) 2014-10-30
UA112795C2 (uk) 2016-10-25
KR20140140099A (ko) 2014-12-08
AR090496A1 (es) 2014-11-19
PH12014501829A1 (en) 2014-11-10
DK2831077T3 (en) 2016-08-15
CN104169284B (zh) 2017-03-29
ECSP14024526A (es) 2015-09-30
ES2585044T3 (es) 2016-10-03
EP2831077A1 (en) 2015-02-04
US9120805B2 (en) 2015-09-01
CA2868620C (en) 2020-02-25
MX2014011420A (es) 2014-11-25
CA2868620A1 (en) 2013-10-03
NZ630489A (en) 2016-04-29
JP6096879B2 (ja) 2017-03-15
AU2013242492B2 (en) 2016-12-15
WO2013143663A1 (en) 2013-10-03
HK1203961A1 (en) 2015-11-06
PE20142186A1 (es) 2014-12-29
MX351149B (es) 2017-10-04
ZA201407828B (en) 2015-12-23
EA027416B1 (ru) 2017-07-31
TWI576346B (zh) 2017-04-01
EP2831077B1 (en) 2016-04-27
HRP20160908T1 (hr) 2016-09-23
KR102070567B1 (ko) 2020-01-29
US20150057264A1 (en) 2015-02-26
IL234713A (en) 2016-09-29
HUE030067T2 (en) 2017-04-28
SI2831077T1 (sl) 2016-09-30
CN104169284A (zh) 2014-11-26
CL2014002557A1 (es) 2014-12-19
PH12014501829B1 (en) 2014-11-10

Similar Documents

Publication Publication Date Title
EA201401062A1 (ru) Бициклические пиразиноновые производные
EA201401212A1 (ru) Производные пирролотриазинона
EA201400879A1 (ru) Производные тетрагидрохиназолинона в качестве ингибиторов tank и parp
EA201590230A1 (ru) Соединения пиразолопиримидина в качестве ингибиторов киназ
EA201400333A1 (ru) Бензонитрильные производные в качестве ингибиторов киназ
MX362939B (es) Derivados de (aza-)isoquinolinona.
EA201301302A1 (ru) Производные пиридина и пиразина
MX362855B (es) Derivados de quinazolinona como inhidores poli (adp-ribosa) polimerasa (parp).
MX362215B (es) Derivados 2-aminopirido-[4,3-d]pirimidin-5-ona y su uso como inhibidores de wee-1.
EA201291143A1 (ru) Пиразолилхиназолиновые ингибиторы киназы
EA201492216A1 (ru) Ингибиторы бромодомена и их применение
EA201301301A1 (ru) Производные тиазола
EA201491623A1 (ru) Замещенные пирролидин-2-карбоксамиды
EA201591591A1 (ru) Соединения карбазола, применяемые в качестве ингибиторов бромодомена
EA201290807A1 (ru) Циклобутановые и метилциклобутановые производные в качестве ингибиторов янус-киназы
EA201691032A1 (ru) Производные изохромена в качестве ингибиторов фосфоинозитид-3-киназ
EA201300610A1 (ru) Хиназолинкарбоксамидазетидины
EA201590183A1 (ru) Производные азаиндола, выступающие в качестве ингибиторов pi3k
MX2016001136A (es) Derivados de oxoquinazolinil-butanamida.
EA201491376A1 (ru) Производные 1h-пирроло[2,3-b]пиридина и их применение в качестве ингибиторов киназы
MX2016014436A (es) Derivados de heterociclil-butanamida.
MX2016001134A (es) Derivados 1,3-disustituidos de ciclopentano.
MX364859B (es) Derivados de imidazopirazinona.
EA201790603A1 (ru) Ингибиторы гистондеметилазы
EA201290744A1 (ru) Имидазо[1,2-b][1,2,4]триазины в качестве c-met ингибиторов

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM