EA201401062A1 - Бициклические пиразиноновые производные - Google Patents

Бициклические пиразиноновые производные

Info

Publication number
EA201401062A1
EA201401062A1 EA201401062A EA201401062A EA201401062A1 EA 201401062 A1 EA201401062 A1 EA 201401062A1 EA 201401062 A EA201401062 A EA 201401062A EA 201401062 A EA201401062 A EA 201401062A EA 201401062 A1 EA201401062 A1 EA 201401062A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bicyclic
pirazine
derivatives
pirazine derivatives
diseases
Prior art date
Application number
EA201401062A
Other languages
English (en)
Other versions
EA027416B1 (ru
Inventor
Дитер Дорш
Ханс-Петер Бухшталлер
Жерар Муане
Ансгар Вегенер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013911&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201401062(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201401062A1 publication Critical patent/EA201401062A1/ru
Publication of EA027416B1 publication Critical patent/EA027416B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединения формулы Iв которой R, X и Y имеют значения, указанные в п.1 формулы изобретения, являются ингибиторами танкиразы и могут применяться, среди прочего, для лечения заболеваний, таких как злокачественное новообразование, сердечно-сосудистые заболевания, поражения центральной нервной системы и различные формы воспаления.
EA201401062A 2012-03-28 2013-03-19 Бициклические пиразиноновые производные EA027416B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12002215 2012-03-28
PCT/EP2013/000827 WO2013143663A1 (en) 2012-03-28 2013-03-19 Bicyclic pyrazinone derivatives

Publications (2)

Publication Number Publication Date
EA201401062A1 true EA201401062A1 (ru) 2015-04-30
EA027416B1 EA027416B1 (ru) 2017-07-31

Family

ID=48013911

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401062A EA027416B1 (ru) 2012-03-28 2013-03-19 Бициклические пиразиноновые производные

Country Status (32)

Country Link
US (1) US9120805B2 (ru)
EP (1) EP2831077B1 (ru)
JP (1) JP6096879B2 (ru)
KR (1) KR102070567B1 (ru)
CN (1) CN104169284B (ru)
AR (1) AR090496A1 (ru)
AU (1) AU2013242492B2 (ru)
CA (1) CA2868620C (ru)
CL (1) CL2014002557A1 (ru)
CO (1) CO7111292A2 (ru)
DK (1) DK2831077T3 (ru)
EA (1) EA027416B1 (ru)
EC (1) ECSP14024526A (ru)
ES (1) ES2585044T3 (ru)
HK (1) HK1203961A1 (ru)
HR (1) HRP20160908T1 (ru)
HU (1) HUE030067T2 (ru)
IL (1) IL234713A (ru)
MX (1) MX351149B (ru)
MY (1) MY172308A (ru)
NZ (1) NZ630489A (ru)
PE (1) PE20142186A1 (ru)
PH (1) PH12014501829A1 (ru)
PL (1) PL2831077T3 (ru)
PT (1) PT2831077T (ru)
RS (1) RS54997B1 (ru)
SG (1) SG11201405750YA (ru)
SI (1) SI2831077T1 (ru)
TW (1) TWI576346B (ru)
UA (1) UA112795C2 (ru)
WO (1) WO2013143663A1 (ru)
ZA (1) ZA201407828B (ru)

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CN104302358B (zh) 2012-03-07 2017-12-05 癌症研究协会:皇家癌症医院 3‑芳基‑5‑取代的异喹啉‑1‑酮化合物和它们的治疗用途
CN104169284B (zh) 2012-03-28 2017-03-29 默克专利股份公司 双环吡嗪酮衍生物
KR20150011838A (ko) * 2012-06-20 2015-02-02 에프. 호프만-라 로슈 아게 탄키라아제 억제제로서의 피롤로피라존
WO2015036759A1 (en) 2013-09-11 2015-03-19 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
NO3087076T3 (ru) * 2013-12-23 2018-02-24
KR101739003B1 (ko) 2014-07-11 2017-05-23 에스티팜 주식회사 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
PT3227297T (pt) 2014-12-05 2021-04-09 Array Biopharma Inc Pirazol[1,5-a]pirazinas, substituídas nas posições 4 e 6, como inibidores de cinases janus
CU20180019A7 (es) 2015-08-17 2018-06-05 Lupin Ltd Derivados de heteroarilo como inhibidores de parp
CN109071546B (zh) 2016-02-24 2021-03-02 辉瑞大药厂 作为jak抑制剂的吡唑并[1,5-a]吡嗪-4-基衍生物
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
EA202092779A1 (ru) 2018-05-17 2021-02-02 Байер Акциенгезельшафт Замещенные дигидропиразолопиразинкарбоксамидные производные

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JP5496680B2 (ja) * 2006-12-28 2014-05-21 アッヴィ・インコーポレイテッド ポリ（ａｄｐ−リボース）ポリメラーゼの阻害剤
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CN104169284B (zh) 2012-03-28 2017-03-29 默克专利股份公司 双环吡嗪酮衍生物
KR20150011838A (ko) * 2012-06-20 2015-02-02 에프. 호프만-라 로슈 아게 탄키라아제 억제제로서의 피롤로피라존

Also Published As

Publication number Publication date
PH12014501829B1 (en) 2014-11-10
CA2868620C (en) 2020-02-25
CN104169284B (zh) 2017-03-29
EA027416B1 (ru) 2017-07-31
HRP20160908T1 (hr) 2016-09-23
MX351149B (es) 2017-10-04
AU2013242492B2 (en) 2016-12-15
SI2831077T1 (sl) 2016-09-30
AR090496A1 (es) 2014-11-19
JP6096879B2 (ja) 2017-03-15
KR20140140099A (ko) 2014-12-08
AU2013242492A1 (en) 2014-11-13
HK1203961A1 (en) 2015-11-06
ZA201407828B (en) 2015-12-23
PE20142186A1 (es) 2014-12-29
MX2014011420A (es) 2014-11-25
CA2868620A1 (en) 2013-10-03
CL2014002557A1 (es) 2014-12-19
SG11201405750YA (en) 2014-10-30
HUE030067T2 (en) 2017-04-28
UA112795C2 (uk) 2016-10-25
EP2831077B1 (en) 2016-04-27
US9120805B2 (en) 2015-09-01
ES2585044T3 (es) 2016-10-03
CO7111292A2 (es) 2014-11-10
ECSP14024526A (es) 2015-09-30
PH12014501829A1 (en) 2014-11-10
IL234713A (en) 2016-09-29
EP2831077A1 (en) 2015-02-04
TWI576346B (zh) 2017-04-01
DK2831077T3 (en) 2016-08-15
PL2831077T3 (pl) 2016-10-31
RS54997B1 (sr) 2016-11-30
MY172308A (en) 2019-11-21
KR102070567B1 (ko) 2020-01-29
JP2015511609A (ja) 2015-04-20
TW201343650A (zh) 2013-11-01
CN104169284A (zh) 2014-11-26
PT2831077T (pt) 2016-08-12
US20150057264A1 (en) 2015-02-26
WO2013143663A1 (en) 2013-10-03
NZ630489A (en) 2016-04-29

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM