EA201790603A1 - Ингибиторы гистондеметилазы - Google Patents

Ингибиторы гистондеметилазы

Info

Publication number
EA201790603A1
EA201790603A1 EA201790603A EA201790603A EA201790603A1 EA 201790603 A1 EA201790603 A1 EA 201790603A1 EA 201790603 A EA201790603 A EA 201790603A EA 201790603 A EA201790603 A EA 201790603A EA 201790603 A1 EA201790603 A1 EA 201790603A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer
compounds
compositions
useful
treatment
Prior art date
Application number
EA201790603A
Other languages
English (en)
Inventor
Амок Болоор
Тоуфайк Каноуни
Джеффри Алан Стэффорд
Джеймс Марвин Вил
Майкл Бреннан Уоллэс
Original Assignee
Селджен Квонтисел Рисёрч, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селджен Квонтисел Рисёрч, Инк. filed Critical Селджен Квонтисел Рисёрч, Инк.
Publication of EA201790603A1 publication Critical patent/EA201790603A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится, в целом, к композициям и способам лечения рака и неопластического заболевания. В настоящем документе представлены соединения замещенных производных пиридо[3,4-d]пиримидин-4-она и фармацевтические композиции, содержащие указанные соединения. Заявленные соединения и композиции являются полезными для ингибирования гистондеметилазы. Кроме того, заявленные соединения и композиции являются полезными для лечения рака, такого как рак предстательной железы, рак молочной железы, рак мочевого пузыря, рака легких и/или меланомы, и т.п.
EA201790603A 2014-09-17 2015-09-16 Ингибиторы гистондеметилазы EA201790603A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462051691P 2014-09-17 2014-09-17
PCT/US2015/050432 WO2016044429A1 (en) 2014-09-17 2015-09-16 Histone demethylase inhibitors

Publications (1)

Publication Number Publication Date
EA201790603A1 true EA201790603A1 (ru) 2017-10-31

Family

ID=55525128

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790603A EA201790603A1 (ru) 2014-09-17 2015-09-16 Ингибиторы гистондеметилазы

Country Status (17)

Country Link
US (6) US9643965B2 (ru)
EP (2) EP3453710B1 (ru)
JP (1) JP6552608B2 (ru)
KR (1) KR20170048591A (ru)
CN (1) CN107205391A (ru)
AU (1) AU2015317806A1 (ru)
BR (1) BR112017005511A2 (ru)
CA (1) CA2961610A1 (ru)
CL (1) CL2017000659A1 (ru)
CO (1) CO2017003538A2 (ru)
EA (1) EA201790603A1 (ru)
EC (1) ECSP17023551A (ru)
ES (1) ES2910226T3 (ru)
IL (1) IL251179A0 (ru)
MX (1) MX2017003466A (ru)
SG (1) SG11201702147TA (ru)
WO (1) WO2016044429A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE034906T2 (hu) 2013-03-15 2018-03-28 Quanticel Pharmaceuticals Inc Hiszton-demetiláz inhibitorok
EA201790603A1 (ru) * 2014-09-17 2017-10-31 Селджен Квонтисел Рисёрч, Инк. Ингибиторы гистондеметилазы
WO2017161012A1 (en) 2016-03-15 2017-09-21 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
SI3546456T1 (sl) 2016-11-28 2022-04-29 Teijin Pharma Limited Kristal derivata pirido(3,4-D)pirimidina ali njegovega solvata
WO2018183586A1 (en) 2017-03-29 2018-10-04 Purdue Research Foundation Inhibitors of kinase networks and uses thereof
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN115368252B (zh) * 2022-09-19 2024-01-12 西北农林科技大学 一种4-胺基酚类衍生物及应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033472A1 (fr) * 2001-10-17 2003-04-24 Kirin Beer Kabushiki Kaisha Derives de quinoline ou de quinazoline inhibant l'autophosphorylation de recepteurs du facteur de croissance des fibroblastes
US20040009981A1 (en) * 2002-03-15 2004-01-15 David Bebbington Compositions useful as inhibitors of protein kinases
CA2527017A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors
US7544677B2 (en) 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
FR2876103B1 (fr) 2004-10-01 2008-02-22 Aventis Pharma Sa Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
SG174772A1 (en) 2006-09-11 2011-10-28 Curis Inc Multi-functional small molecules as anti-proliferative agents
TW200922590A (en) 2007-09-10 2009-06-01 Curis Inc VEGFR inhibitors containing a zinc binding moiety
SI3023415T1 (en) 2012-10-02 2018-01-31 Gilead Sciences, Inc. Histone demethylase inhibitors
LT2934145T (lt) 2012-12-19 2018-02-26 Celgene Quanticel Research, Inc. Histono demetilazės inhibitoriai
ES2718495T3 (es) 2012-12-21 2019-07-02 Celgene Quanticel Res Inc Inhibidores de la histona desmetilasa
JP6320506B2 (ja) 2013-03-12 2018-05-09 セルジーン クオンティセル リサーチ，インク． ヒストンデメチラーゼ阻害剤
HUE034906T2 (hu) 2013-03-15 2018-03-28 Quanticel Pharmaceuticals Inc Hiszton-demetiláz inhibitorok
WO2014144850A1 (en) 2013-03-15 2014-09-18 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
ES2862648T3 (es) 2014-06-25 2021-10-07 Celgene Quanticel Res Inc Inhibidores de la histona desmetilasa
EA201790603A1 (ru) 2014-09-17 2017-10-31 Селджен Квонтисел Рисёрч, Инк. Ингибиторы гистондеметилазы
US10030017B2 (en) 2014-09-17 2018-07-24 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
WO2017161012A1 (en) 2016-03-15 2017-09-21 Celgene Quanticel Research, Inc. Histone demethylase inhibitors

Also Published As

Publication number Publication date
CA2961610A1 (en) 2016-03-24
SG11201702147TA (en) 2017-04-27
EP3453710B1 (en) 2022-09-21
US10112940B2 (en) 2018-10-30
US20230117519A1 (en) 2023-04-20
CO2017003538A2 (es) 2017-07-28
EP3193601A1 (en) 2017-07-26
IL251179A0 (en) 2017-05-29
JP6552608B2 (ja) 2019-07-31
AU2015317806A1 (en) 2017-04-13
US11535616B2 (en) 2022-12-27
EP3193601B1 (en) 2022-01-05
US20200199122A1 (en) 2020-06-25
WO2016044429A1 (en) 2016-03-24
BR112017005511A2 (pt) 2018-08-14
KR20170048591A (ko) 2017-05-08
US9643965B2 (en) 2017-05-09
US20170240546A1 (en) 2017-08-24
US20210009585A1 (en) 2021-01-14
US20160083379A1 (en) 2016-03-24
US10611763B2 (en) 2020-04-07
ES2910226T3 (es) 2022-05-12
CN107205391A (zh) 2017-09-26
US10815234B2 (en) 2020-10-27
US20190023704A1 (en) 2019-01-24
MX2017003466A (es) 2017-07-13
ECSP17023551A (es) 2017-05-31
EP3453710A1 (en) 2019-03-13
CL2017000659A1 (es) 2018-05-11
JP2017529346A (ja) 2017-10-05
EP3193601A4 (en) 2018-07-04

Similar Documents

Publication Publication Date Title
EA201790085A1 (ru) Ингибиторы лизин-специфической деметилазы-1
EA201692513A1 (ru) Ингибиторы лизин-специфической деметилазы-1
EA201790603A1 (ru) Ингибиторы гистондеметилазы
PH12017502203A1 (en) Tyrosine kinase inhibitors
EA201790376A1 (ru) Ингибиторы лизин-специфической деметилазы-1
EA201790082A1 (ru) Ингибиторы лизин-специфической демитилазы-1
EA201591145A1 (ru) Ингибиторы гистондеметилазы
MX2020010496A (es) Inhibidores de desmetilasa-1 especifica de lisina.
EA201692483A1 (ru) Ингибиторы гистоновой метилазы
TW201613925A (en) Imidazopyrazines as LSD1 inhibitors
MA39986A (fr) Dérivés de purine en tant qu'inhibiteurs de cd73 pour le traitement du cancer
EA201692079A1 (ru) Ингибиторы лизин-специфической деметилазы-1
CR20200362A (es) CICLOPROPILAMINA COMO INHIBIDORES DE LA LSD1 (Divisional 2016-0395)
MX362215B (es) Derivados 2-aminopirido-[4,3-d]pirimidin-5-ona y su uso como inhibidores de wee-1.
MX2016002544A (es) Compuestos utiles como inmunomoduladores.
EA201592068A1 (ru) Ингибиторы энхансера zeste гомолога 2
EA201790502A1 (ru) Ингибиторы гистоновых диметилаз
EA201892802A1 (ru) Производные аденозина для применения при лечении рака
EA201692313A1 (ru) Производные индолизина в качестве ингибиторов фосфоинозитид-3-киназ
UA119458C2 (uk) Сполуки піридину пладієноліду та способи застосування
MX2016014436A (es) Derivados de heterociclil-butanamida.
MY180844A (en) Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
EA201790156A1 (ru) Азетидинилоксифенилпирролидиновые соединения
EA201790604A1 (ru) Ингибиторы гистондеметилазы
MX2018005515A (es) Derivados de 1,4-dicarbonil-piperidilo.