JP5676071B2 - 腫瘍性疾患を治療するための組成物及び方法 - Google Patents

腫瘍性疾患を治療するための組成物及び方法 Download PDF

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JP5676071B2
JP5676071B2 JP2007544545A JP2007544545A JP5676071B2 JP 5676071 B2 JP5676071 B2 JP 5676071B2 JP 2007544545 A JP2007544545 A JP 2007544545A JP 2007544545 A JP2007544545 A JP 2007544545A JP 5676071 B2 JP5676071 B2 JP 5676071B2
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cancer
formula
compound
cells
medicament
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JP2008521928A (ja
JP2008521928A5 (enExample
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シー． アンダーソン，ケニス
シー． アンダーソン，ケニス
チャウハン，ダーミンダー
エー． パラディーノ，マイケル
エー． パラディーノ，マイケル
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ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド
ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド
トリフェイズ リサーチ アンド ディベロップメント ワン コーポレイション
トリフェイズ リサーチ アンド ディベロップメント ワン コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007544545A 2004-12-03 2005-12-02 腫瘍性疾患を治療するための組成物及び方法 Expired - Lifetime JP5676071B2 (ja)

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US63316104P 2004-12-03 2004-12-03
US60/633,161 2004-12-03
PCT/US2005/043668 WO2006060676A1 (en) 2004-12-03 2005-12-02 Compositions and methods for treating neoplastic diseases

Related Child Applications (2)

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JP2012198263A Division JP5837469B2 (ja) 2004-12-03 2012-09-10 腫瘍性疾患を治療するための組成物及び方法
JP2014228602A Division JP5963830B2 (ja) 2004-12-03 2014-11-11 腫瘍性疾患を治療するための組成物及び方法

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JP2008521928A JP2008521928A (ja) 2008-06-26
JP2008521928A5 JP2008521928A5 (enExample) 2009-01-22
JP5676071B2 true JP5676071B2 (ja) 2015-02-25

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JP2007544545A Expired - Lifetime JP5676071B2 (ja) 2004-12-03 2005-12-02 腫瘍性疾患を治療するための組成物及び方法
JP2012198263A Expired - Lifetime JP5837469B2 (ja) 2004-12-03 2012-09-10 腫瘍性疾患を治療するための組成物及び方法
JP2014228602A Expired - Fee Related JP5963830B2 (ja) 2004-12-03 2014-11-11 腫瘍性疾患を治療するための組成物及び方法

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JP2014228602A Expired - Fee Related JP5963830B2 (ja) 2004-12-03 2014-11-11 腫瘍性疾患を治療するための組成物及び方法

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US (5) US20070225350A1 (enExample)
EP (1) EP1830838B1 (enExample)
JP (3) JP5676071B2 (enExample)
KR (1) KR101282191B1 (enExample)
CN (2) CN103230394B (enExample)
AU (1) AU2005311709B2 (enExample)
BR (1) BRPI0517135B1 (enExample)
CA (1) CA2588923C (enExample)
DK (1) DK1830838T3 (enExample)
ES (1) ES2396762T3 (enExample)
IL (3) IL183506A (enExample)
MX (1) MX2007006526A (enExample)
NZ (1) NZ555439A (enExample)
PL (1) PL1830838T3 (enExample)
SG (1) SG157365A1 (enExample)
WO (1) WO2006060676A1 (enExample)
ZA (1) ZA200704402B (enExample)

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CA2588923C (en) 2015-02-03
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CN101155582A (zh) 2008-04-02
US20230210817A1 (en) 2023-07-06
HK1113462A1 (en) 2008-10-03
US10610517B2 (en) 2020-04-07
SG157365A1 (en) 2009-12-29
IL241756A0 (en) 2015-11-30
JP5837469B2 (ja) 2015-12-24
US20070225350A1 (en) 2007-09-27
CN103230394B (zh) 2016-04-20
CN101155582B (zh) 2013-04-24
US8722724B2 (en) 2014-05-13
CN103230394A (zh) 2013-08-07
IL183506A (en) 2015-10-29
MX2007006526A (es) 2007-09-19
KR20080003306A (ko) 2008-01-07
AU2005311709B2 (en) 2011-07-28
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CA2588923A1 (en) 2006-06-08
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EP1830838A1 (en) 2007-09-12
US20200206190A1 (en) 2020-07-02
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US20140349965A1 (en) 2014-11-27
US20090036390A1 (en) 2009-02-05
PL1830838T3 (pl) 2013-07-31
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EP1830838B1 (en) 2012-10-03
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NZ555439A (en) 2010-12-24
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