JP2008521928A5 - - Google Patents
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- JP2008521928A5 JP2008521928A5 JP2007544545A JP2007544545A JP2008521928A5 JP 2008521928 A5 JP2008521928 A5 JP 2008521928A5 JP 2007544545 A JP2007544545 A JP 2007544545A JP 2007544545 A JP2007544545 A JP 2007544545A JP 2008521928 A5 JP2008521928 A5 JP 2008521928A5
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- 201000010099 disease Diseases 0.000 claims description 10
- 230000001613 neoplastic Effects 0.000 claims description 10
- 239000003112 inhibitor Substances 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 108010034143 Inflammasomes Proteins 0.000 claims description 5
- 101700079133 KLK7 Proteins 0.000 claims description 4
- 101700076891 PAPA Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 239000011885 synergistic combination Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 32
- 201000011510 cancer Diseases 0.000 claims 18
- 239000002246 antineoplastic agent Substances 0.000 claims 12
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 9
- 201000009251 multiple myeloma Diseases 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 7
- 239000000460 chlorine Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 210000003169 Central Nervous System Anatomy 0.000 claims 6
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 229910052740 iodine Chemical group 0.000 claims 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 4
- 239000011630 iodine Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrugs Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- GXJABQQUPOEUTA-RDJZCZTQSA-N Bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 3
- 210000000133 Brain Stem Anatomy 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 3
- 229960003957 Dexamethasone Drugs 0.000 claims 3
- 229960004679 Doxorubicin Drugs 0.000 claims 3
- 206010017758 Gastric cancer Diseases 0.000 claims 3
- 206010024324 Leukaemias Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010025650 Malignant melanoma Diseases 0.000 claims 3
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 3
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 3
- 206010025310 Other lymphomas Diseases 0.000 claims 3
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 3
- 206010038038 Rectal cancer Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- UEJJHQNACJXSKW-UHFFFAOYSA-N Thalidomide Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 3
- 229960003433 Thalidomide Drugs 0.000 claims 3
- 206010046766 Uterine cancer Diseases 0.000 claims 3
- 229960001467 bortezomib Drugs 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 201000011231 colorectal cancer Diseases 0.000 claims 3
- 230000002124 endocrine Effects 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 201000003733 ovarian melanoma Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 201000001275 rectum cancer Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 201000009381 skin hemangioma Diseases 0.000 claims 3
- 201000003708 skin melanoma Diseases 0.000 claims 3
- 201000011549 stomach cancer Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000002195 synergetic Effects 0.000 claims 1
- 0 CC(C1CC*)(C2(C(C3C=CCCC3)O)NC1=O)OC2=O Chemical compound CC(C1CC*)(C2(C(C3C=CCCC3)O)NC1=O)OC2=O 0.000 description 8
Description
本発明の別の態様は、少なくとも２つのプロテアソーム阻害薬の相乗的組合せを腫瘍性疾患患者に投与することを包含する、腫瘍性疾患の治療方法である。
Claims (37)
- 腫瘍性疾患患者における腫瘍性疾患を治療するための医薬であって、式（Ｉ）：
の化合物又はその薬学的に許容可能な塩若しくはプロドラッグを含み、該腫瘍性疾患が少なくとも１つの他の化学療法剤に対する耐性になりやすい、医薬。 - Ｘが塩素である、請求項１に記載の医薬。
- 前記式（Ｉ）の化合物が式（ＩＩ）：
- 前記腫瘍性疾患が癌である、請求項１〜３のいずれか１項に記載の医薬。
- 前記癌が乳癌、肉腫、白血病、卵巣癌、子宮癌、膀胱癌、前立腺癌、結腸癌、直腸癌、胃癌、肺癌、リンパ腫、多発性骨髄腫、膵臓癌、肝臓癌、腎臓癌、内分泌癌、皮膚癌、黒色腫、血管腫、及び脳又は中枢神経系（ＣＮＳ）癌から成る群から選択される、請求項４に記載の医薬。
- 前記癌が多発性骨髄腫、結腸直腸癌、前立腺癌、乳腺癌、非小細胞肺癌及び卵巣癌又は黒色腫から成る群から選択される、請求項５に記載の医薬。
- 前記癌が多発性骨髄腫である、請求項６に記載の医薬。
- 前記患者がヒトである、請求項１〜７のいずれか１項に記載の医薬。
- 前記他の化学療法剤がデキサメタゾン、ドキソルビシン及びサリドマイドから成る群から選択される、請求項１〜８のいずれか１項に記載の医薬。
- 前記他の化学療法剤がプロテアソーム阻害薬である、請求項１〜８のいずれか１項に記載の医薬。
- 前記他の化学療法剤がボルテゾミブである、請求項１０に記載の医薬。
- 腫瘍性疾患患者における腫瘍性疾患を治療するための医薬であって、少なくとも１つの付加的な化学療法剤と組合わせて、式（Ｉ）：
の化合物又はその薬学的に許容可能な塩若しくはプロドラッグを含む医薬。 - Ｘが塩素である、請求項１２に記載の医薬。
- 前記式（Ｉ）の化合物が式（ＩＩ）：
- 前記腫瘍性疾患が癌である、請求項１２〜１４のいずれか１項に記載の医薬。
- 前記癌が乳癌、肉腫、白血病、卵巣癌、子宮癌、膀胱癌、前立腺癌、結腸癌、直腸癌、胃癌、肺癌、リンパ腫、多発性骨髄腫、膵臓癌、肝臓癌、腎臓癌、内分泌癌、皮膚癌、黒色腫、血管腫、及び脳又は中枢神経系（ＣＮＳ）癌から成る群から選択される、請求項１５に記載の医薬。
- 前記癌が多発性骨髄腫、結腸直腸癌、前立腺癌、乳腺癌、非小細胞肺癌及び卵巣癌又は黒色腫から成る群から選択される、請求項１６に記載の医薬。
- 前記癌が多発性骨髄腫である、請求項１７に記載の医薬。
- 前記患者がヒトである、請求項１２〜１８のいずれか１項に記載の医薬。
- 前記他の化学療法剤がデキサメタゾン、ドキソルビシン及びサリドマイドから成る群から選択される、請求項１２〜１９のいずれか１項に記載の医薬。
- 前記他の化学療法剤がプロテアソーム阻害薬である、請求項１２〜１９のいずれか１項に記載の医薬。
- 前記他の化学療法剤がボルテゾミブである、請求項２１に記載の医薬。
- 前記組合せが相乗的である、請求項１２〜２２のいずれか１項に記載の医薬。
- 前記組合せが相加的である、請求項１２〜２２のいずれか１項に記載の医薬。
- 式（Ｉ）：
の化合物又はその薬学的に許容可能な塩若しくはプロドラッグ、および少なくとも１つの付加的化学療法剤を含む薬学的組成物。 - Ｘが塩素である、請求項２５に記載の薬学的組成物。
- 前記式（Ｉ）の化合物が式（ＩＩ）：
- 前記他の化学療法剤がデキサメタゾン、ドキソルビシン及びサリドマイドから成る群から選択される、請求項２５〜２７のいずれか１項に記載の薬学的組成物。
- 前記他の化学療法剤がプロテアソーム阻害薬である、請求項２５〜２７のいずれか１項に記載の薬学的組成物。
- 前記他の化学療法剤がボルテゾミブである、請求項２９に記載の薬学的組成物。
- 少なくとも２つのプロテアソーム阻害薬の相乗的組合せを含む、腫瘍性疾患患者における腫瘍性疾患を治療するための医薬。
- 前記腫瘍性疾患が癌である、請求項３１に記載の医薬。
- 前記癌が乳癌、肉腫、白血病、卵巣癌、子宮癌、膀胱癌、前立腺癌、結腸癌、直腸癌、胃癌、肺癌、リンパ腫、多発性骨髄腫、膵臓癌、肝臓癌、腎臓癌、内分泌癌、皮膚癌、黒色腫、血管腫、及び脳又は中枢神経系（ＣＮＳ）癌から成る群から選択される、請求項３２に記載の医薬。
- 前記癌が多発性骨髄腫、結腸直腸癌、前立腺癌、乳腺癌、非小細胞肺癌及び卵巣癌又は黒色腫から成る群から選択される、請求項３３に記載の医薬。
- 前記癌が多発性骨髄腫である、請求項３４に記載の医薬。
- 前記患者がヒトである、請求項３１〜３５のいずれか１項に記載の医薬。
- 少なくとも１つの前記プロテアソーム阻害薬が、式（Ｉ）：
の化合物又はその薬学的に許容可能な塩若しくはプロドラッグから成る群から選択される、請求項３１〜３６のいずれか１項に記載の医薬。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63316104P | 2004-12-03 | 2004-12-03 | |
| US60/633,161 | 2004-12-03 | ||
| PCT/US2005/043668 WO2006060676A1 (en) | 2004-12-03 | 2005-12-02 | Compositions and methods for treating neoplastic diseases |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198263A Division JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Division JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521928A JP2008521928A (ja) | 2008-06-26 |
| JP2008521928A5 true JP2008521928A5 (ja) | 2009-01-22 |
| JP5676071B2 JP5676071B2 (ja) | 2015-02-25 |
Family
ID=36118298
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544545A Active JP5676071B2 (ja) | 2004-12-03 | 2005-12-02 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2012198263A Active JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Active JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012198263A Active JP5837469B2 (ja) | 2004-12-03 | 2012-09-10 | 腫瘍性疾患を治療するための組成物及び方法 |
| JP2014228602A Active JP5963830B2 (ja) | 2004-12-03 | 2014-11-11 | 腫瘍性疾患を治療するための組成物及び方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US20070225350A1 (ja) |
| EP (1) | EP1830838B1 (ja) |
| JP (3) | JP5676071B2 (ja) |
| KR (1) | KR101282191B1 (ja) |
| CN (2) | CN101155582B (ja) |
| AU (1) | AU2005311709B2 (ja) |
| BR (1) | BRPI0517135B1 (ja) |
| CA (1) | CA2588923C (ja) |
| DK (1) | DK1830838T3 (ja) |
| ES (1) | ES2396762T3 (ja) |
| HK (1) | HK1113462A1 (ja) |
| IL (3) | IL183506A (ja) |
| MX (1) | MX2007006526A (ja) |
| NZ (1) | NZ555439A (ja) |
| PL (1) | PL1830838T3 (ja) |
| SG (1) | SG157365A1 (ja) |
| WO (1) | WO2006060676A1 (ja) |
| ZA (1) | ZA200704402B (ja) |
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| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7144723B2 (en) * | 2000-11-16 | 2006-12-05 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product discovery |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| DE602004031614D1 (de) * | 2003-06-20 | 2011-04-14 | Nereus Pharmaceuticals Inc | Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs |
| US8217072B2 (en) * | 2003-06-20 | 2012-07-10 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| JP2007535559A (ja) * | 2004-04-30 | 2007-12-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | ［３．２．０］複素環式化合物及びその使用法 |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
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| CA2937005A1 (en) * | 2005-03-22 | 2006-09-28 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
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