JP2009514881A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009514881A5 JP2009514881A5 JP2008539071A JP2008539071A JP2009514881A5 JP 2009514881 A5 JP2009514881 A5 JP 2009514881A5 JP 2008539071 A JP2008539071 A JP 2008539071A JP 2008539071 A JP2008539071 A JP 2008539071A JP 2009514881 A5 JP2009514881 A5 JP 2009514881A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- composition
- compound
- compound according
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N Camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 2
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 2
- 229960001433 Erlotinib Drugs 0.000 claims 2
- AAKJLRGGTJKAMG-UHFFFAOYSA-N Erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 2
- 229940080856 Gleevec Drugs 0.000 claims 2
- KTUFNOKKBVMGRW-UHFFFAOYSA-N Imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 2
- 239000002067 L01XE06 - Dasatinib Substances 0.000 claims 2
- 239000005536 L01XE08 - Nilotinib Substances 0.000 claims 2
- 206010025650 Malignant melanoma Diseases 0.000 claims 2
- HHZIURLSWUIHRB-UHFFFAOYSA-N Nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 2
- 229960001592 Paclitaxel Drugs 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 229940120982 Tarceva Drugs 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 229960002448 dasatinib Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229960002411 imatinib Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 229960001346 nilotinib Drugs 0.000 claims 2
- 230000002062 proliferating Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 229930003347 taxol Natural products 0.000 claims 2
- LXZZYRPGZAFOLE-UHFFFAOYSA-L transplatin Chemical compound [H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H] LXZZYRPGZAFOLE-UHFFFAOYSA-L 0.000 claims 2
- ZROHGHOFXNOHSO-BNTLRKBRSA-L (1R,2R)-cyclohexane-1,2-diamine;oxalate;platinum(2+) Chemical compound [H][N]([C@@H]1CCCC[C@H]1[N]1([H])[H])([H])[Pt]11OC(=O)C(=O)O1 ZROHGHOFXNOHSO-BNTLRKBRSA-L 0.000 claims 1
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 229940100197 ANTIMETABOLITES Drugs 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 210000000481 Breast Anatomy 0.000 claims 1
- 229960004562 Carboplatin Drugs 0.000 claims 1
- OLESAACUTLOWQZ-UHFFFAOYSA-L Carboplatin Chemical compound O=C1O[Pt]([N]([H])([H])[H])([N]([H])([H])[H])OC(=O)C11CCC1 OLESAACUTLOWQZ-UHFFFAOYSA-L 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 210000001072 Colon Anatomy 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N DAUNOMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- 229940121647 EGFR inhibitors Drugs 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N Gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 229960000908 Idarubicin Drugs 0.000 claims 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin hydrochloride Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
- 229940084651 Iressa Drugs 0.000 claims 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 102000001253 Protein Kinases Human genes 0.000 claims 1
- 108060006633 Protein Kinases Proteins 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 229940063683 Taxotere Drugs 0.000 claims 1
- 229960004528 Vincristine Drugs 0.000 claims 1
- 229960000237 Vorinostat Drugs 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N Vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000240 adjuvant Effects 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 229940045698 antineoplastic Taxanes Drugs 0.000 claims 1
- 239000005441 aurora Substances 0.000 claims 1
- 201000005216 brain cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002496 gastric Effects 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 0 C*C(*)C1(CN(C)C1)O Chemical compound C*C(*)C1(CN(C)C1)O 0.000 description 3
Claims (17)
- R5がCH2CF3である、請求項3に記載の化合物。
- Cyがシクロプロピルである、請求項6に記載の化合物。
- R2がメチルである、請求項1〜7のいずれか1項に記載の化合物。
- 請求項1〜9のいずれか1項に記載の化合物と、薬学的に受容可能なキャリア、アジュバントまたはビヒクルとを含む、組成物。
- 生体サンプルにおいてAuroraプロテインキナーゼ活性を阻害する方法であって、該生体サンプルと請求項1〜9のいずれか1項に記載の化合物とを接触させる工程を含む、方法。
- 患者における増殖性障害を処置するための組成物であって、請求項1〜9のいずれか1項に記載の化合物を含む、組成物。
- 前記増殖性障害が、処置の必要な患者における黒色腫、骨髄腫、白血病、リンパ腫、神経芽細胞腫、または結腸癌、乳癌、胃癌、卵巣癌、頸部癌、肺癌、中枢神経系(CNS)の癌、腎癌(renal cancer)、前立腺癌、膀胱癌、膵臓癌、脳癌(神経膠腫)、頭部および頸部の癌、腎癌(kidney cancer)、肝臓癌から選択される癌、黒色腫、肉腫、または甲状腺癌から選択され、前記組成物が、請求項1〜9のいずれか1項に記載の化合物を含む、請求項12に記載の組成物。
- 処置の必要な被検体において癌を処置するための組成物であって、該組成物は、請求項1〜9のいずれか1項に記載の化合物またはその薬学的に受容可能な塩を含み、該組成物は、別の治療薬剤と逐次投与されるか、または同時に投与されることを特徴とする、組成物。
- 前記治療薬剤が、タキサン、bcr−ablインヒビター、EGFRインヒビター、DNA損傷剤および代謝拮抗物質から選択される、請求項14に記載の組成物。
- 前記治療薬剤が、パクリタキセル、グリーベック、ダサチニブ、ニロチニブ、タルセバ、イレッサ、シスプラチン、オキサリプラチン、カルボプラチン、アントラサイクリン、AraCおよび5−FUから選択される、請求項14に記載の組成物。
- 前記治療薬剤が、カンプトテシン、ドキソルビシン、イダルビシン、シスプラチン、タキソール、タキソテール、ビンクリスチン、タルセバ、MEKインヒビター、U0126、KSPインヒビター、ボリノスタット、グリーベック、ダサチニブおよびニロチニブから選択される、請求項14に記載の組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73295105P | 2005-11-03 | 2005-11-03 | |
US60/732,951 | 2005-11-03 | ||
US73355705P | 2005-11-04 | 2005-11-04 | |
US60/733,557 | 2005-11-04 | ||
PCT/US2006/042994 WO2007056164A2 (en) | 2005-11-03 | 2006-11-03 | Aminopyrimidines useful as kinase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009514881A JP2009514881A (ja) | 2009-04-09 |
JP2009514881A5 true JP2009514881A5 (ja) | 2010-12-16 |
JP5249771B2 JP5249771B2 (ja) | 2013-07-31 |
Family
ID=38023840
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008539071A Expired - Fee Related JP5249771B2 (ja) | 2005-11-03 | 2006-11-03 | キナーゼインヒビターとして有用なアミノピリミジン |
JP2008539091A Expired - Fee Related JP5328361B2 (ja) | 2005-11-03 | 2006-11-03 | キナーゼインヒビターとして有用なアミノピリミジン |
JP2008539070A Expired - Fee Related JP5249770B2 (ja) | 2005-11-03 | 2006-11-03 | キナーゼインヒビターとして有用なアミノピリジン |
JP2012271604A Pending JP2013049731A (ja) | 2005-11-03 | 2012-12-12 | キナーゼインヒビターとして有用なアミノピリミジン |
JP2012276504A Pending JP2013075904A (ja) | 2005-11-03 | 2012-12-19 | キナーゼインヒビターとして有用なアミノピリジン |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008539091A Expired - Fee Related JP5328361B2 (ja) | 2005-11-03 | 2006-11-03 | キナーゼインヒビターとして有用なアミノピリミジン |
JP2008539070A Expired - Fee Related JP5249770B2 (ja) | 2005-11-03 | 2006-11-03 | キナーゼインヒビターとして有用なアミノピリジン |
JP2012271604A Pending JP2013049731A (ja) | 2005-11-03 | 2012-12-12 | キナーゼインヒビターとして有用なアミノピリミジン |
JP2012276504A Pending JP2013075904A (ja) | 2005-11-03 | 2012-12-19 | キナーゼインヒビターとして有用なアミノピリジン |
Country Status (18)
Country | Link |
---|---|
US (7) | US7767672B2 (ja) |
EP (3) | EP1954277B1 (ja) |
JP (5) | JP5249771B2 (ja) |
KR (3) | KR20080067694A (ja) |
CN (3) | CN101316843B (ja) |
AR (3) | AR057874A1 (ja) |
AU (3) | AU2006311831C1 (ja) |
BR (3) | BRPI0619704A2 (ja) |
CA (3) | CA2627857A1 (ja) |
ES (2) | ES2435081T3 (ja) |
IL (3) | IL191043A0 (ja) |
MX (3) | MX2008005814A (ja) |
NO (3) | NO20082517L (ja) |
NZ (4) | NZ594383A (ja) |
RU (5) | RU2427578C2 (ja) |
SG (2) | SG166827A1 (ja) |
TW (3) | TW200736249A (ja) |
WO (3) | WO2007056221A2 (ja) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP1317450B1 (en) | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
SE0104140D0 (sv) * | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
WO2004072029A2 (en) | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
RU2405780C2 (ru) * | 2005-02-16 | 2010-12-10 | Астразенека Аб | Химические соединения |
BRPI0610184A2 (pt) * | 2005-05-16 | 2012-09-25 | Astrazeneca Ab | composto, sal farmaceuticamente aceitável de um composto, processo para preparar um composto ou um sal farmaceuticamente aceitável do mesmo, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de cáncer e para a produção de um efeito anti-proliferativo em um animal de sanque quente, e, composição farmacêutica |
US7795279B2 (en) * | 2005-10-18 | 2010-09-14 | Janssen Pharmaceutica Nv | Method of inhibiting FLT3 kinase |
DK1945631T3 (da) * | 2005-10-28 | 2012-10-22 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer |
CA2627857A1 (en) | 2005-11-03 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
AU2006315334B2 (en) * | 2005-11-16 | 2011-05-19 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
EP2016074B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
CA2668429A1 (en) | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
CA2673353A1 (en) | 2006-12-19 | 2008-06-26 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
ES2435997T3 (es) | 2007-03-09 | 2013-12-26 | Vertex Pharmaceuticals, Inc. | Aminopirimidinas útiles como inhibidores de las proteínas cinasas |
EP2134709A1 (en) | 2007-03-09 | 2009-12-23 | Vertex Pharmaceuticals, Inc. | Aminopyridines useful as inhibitors of protein kinases |
NZ579485A (en) * | 2007-03-09 | 2012-02-24 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
CA2683785A1 (en) | 2007-04-13 | 2008-10-23 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
JP2010524911A (ja) * | 2007-04-18 | 2010-07-22 | アストラゼネカ アクチボラグ | 5−アミノピラゾール−3−イル−3H−イミダゾ[4,5−b]ピリジン誘導体と癌の治療のためのその使用 |
EP2155730A2 (en) * | 2007-05-02 | 2010-02-24 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
CN101801959A (zh) * | 2007-05-02 | 2010-08-11 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的氨基嘧啶类化合物 |
JP5389785B2 (ja) | 2007-05-02 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用なチアゾールおよびピラゾール |
UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
US20100204231A1 (en) * | 2007-05-04 | 2010-08-12 | Astrazeneca Ab | Amino-thiazolyl-pyrimidine derivatives and their use for the treatment of cancer |
CN101687852A (zh) * | 2007-05-24 | 2010-03-31 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的噻唑类和吡唑类化合物 |
EP2166849A4 (en) * | 2007-06-11 | 2010-09-15 | Miikana Therapeutics Inc | SUBSTITUTED PYRAZOL COMPOUNDS |
CA2694499A1 (en) * | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
CA2695753A1 (en) * | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as protein kinases inhibitors |
EP3078662A1 (en) | 2007-09-21 | 2016-10-12 | Array Biopharma, Inc. | Pyridin-2-yl-amino-1,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus |
WO2009086012A1 (en) * | 2007-12-20 | 2009-07-09 | Curis, Inc. | Aurora inhibitors containing a zinc binding moiety |
WO2009114703A2 (en) * | 2008-03-12 | 2009-09-17 | Fox Chase Cancer Center | Combination therapy for the treatment of cancer |
US8324199B2 (en) * | 2008-03-13 | 2012-12-04 | Bristol-Myers Squibb Company | Pyridazine derivatives as factor xia inhibitors |
BRPI0908708A2 (pt) * | 2008-03-17 | 2019-09-24 | Scripps Research Inst | métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desdiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de células tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de célula tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, composição, e, kit |
RU2010154502A (ru) * | 2008-06-11 | 2012-07-20 | Астразенека Аб (Se) | Трициклические 2,4-диамино-l,3,5-триазиновые производные, пригодные для лечения злокачественного новообразования и миелопролиферативных нарушений |
NZ621143A (en) * | 2008-09-05 | 2016-08-26 | Celgene Avilomics Res Inc | Algorithm for designing irreversible inhibitors |
KR20110071098A (ko) * | 2008-09-30 | 2011-06-28 | 아스트라제네카 아베 | 복소환 jak 키나제 억제제 |
BRPI0923579A2 (pt) | 2008-12-22 | 2020-01-14 | Millennium Pharm Inc | combinação de inibidores de aurora quinase e anticorpos anti-cd20 |
JP2012529527A (ja) * | 2009-06-09 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | ウレイドフェニル置換トリアジン誘導体類及びそれらの治療応用 |
CN102713618B (zh) * | 2009-09-16 | 2015-07-15 | 新基阿维罗米克斯研究公司 | 蛋白激酶复合物和抑制剂 |
CA2785738A1 (en) | 2009-12-30 | 2011-07-07 | Avila Therapeutics, Inc. | Ligand-directed covalent modification of protein |
WO2012000103A1 (en) | 2010-07-02 | 2012-01-05 | University Health Network | Methods of targeting pten mutant diseases and compositions therefor |
US9120749B2 (en) * | 2010-07-30 | 2015-09-01 | Oncotherapy Science, Inc. | Quinoline derivatives and MELK inhibitors containing the same |
US9382229B2 (en) | 2011-02-15 | 2016-07-05 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
CN105254616B (zh) | 2011-07-27 | 2017-10-17 | 阿斯利康(瑞典)有限公司 | 取代的n‑(2‑甲氧基‑5‑硝基苯基)嘧啶‑2‑胺化合物及其盐 |
JP2014524456A (ja) | 2011-08-25 | 2014-09-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | セリン/スレオニンpak1阻害剤 |
EP2754659A4 (en) * | 2011-09-05 | 2015-08-26 | Zhejiang Hisun Pharm Co Ltd | 4-SUBSTITUTED- (3-SUBSTITUTED-1H-PYRAZOLE-5-AMINO) -PYRIMIDINES DERIVATIVES HAVING PROTEIN KINASE INHIBITION ACTIVITY AND USE THEREOF |
CN104185420B (zh) | 2011-11-30 | 2017-06-09 | 埃默里大学 | 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂 |
CN104011050A (zh) | 2011-12-22 | 2014-08-27 | 霍夫曼-拉罗奇有限公司 | 作为丝氨酸/苏氨酸激酶抑制剂的2,4-二氨基-嘧啶衍生物 |
JP6134376B2 (ja) | 2012-03-16 | 2017-05-24 | アクシキン ファーマシューティカルズ インコーポレーテッド | 3,5−ジアミノピラゾールキナーゼ阻害剤 |
EP2841428B1 (en) | 2012-04-24 | 2018-08-22 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
WO2013173506A2 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
US9539259B2 (en) | 2012-05-23 | 2017-01-10 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
MX367055B (es) | 2012-06-26 | 2019-08-02 | Del Mar Pharmaceuticals | El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa. |
WO2014071378A1 (en) * | 2012-11-05 | 2014-05-08 | Nant Holdings Ip, Llc | Substituted indol-5-ol derivatives and their therapeutical applications |
DK3527563T3 (da) | 2013-03-12 | 2021-12-06 | Vertex Pharma | Dna-pk-inhibitorer |
JP2016514703A (ja) | 2013-03-15 | 2016-05-23 | ナントバイオサイエンス、インコーポレイテッド | 置換インドール−5−オール誘導体及びそれらの治療適用 |
US11491154B2 (en) | 2013-04-08 | 2022-11-08 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
RU2675270C2 (ru) | 2013-10-17 | 2018-12-18 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы и содержащие их фармацевтические композиции |
US10335494B2 (en) | 2013-12-06 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-CD30 antibodies |
MX2017008526A (es) | 2014-12-23 | 2017-10-25 | Axikin Pharmaceuticals Inc | Inhibidores de 3,5-diaminopirazol quinasa. |
EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
CA3038657A1 (en) | 2016-09-27 | 2018-04-05 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors |
PL3555074T3 (pl) * | 2016-12-14 | 2022-11-07 | Intervet International B.V. | Aminopirazole jako selektywne inhibitory kinaz janusowych |
BR112019013593A2 (pt) | 2016-12-28 | 2020-01-07 | Minoryx Therapeutics S.L. | Compostos de isoquinolina, métodos para sua preparação, e usos terapêuticos dos mesmos em afecções associadas à alteração da atividade de beta galactosidase |
CN106841420A (zh) * | 2016-12-30 | 2017-06-13 | 广州中大南沙科技创新产业园有限公司 | 一种LC‑MS/MS测定大鼠血浆中Ly‑7u浓度的方法 |
WO2019195658A1 (en) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Sting levels as a biomarker for cancer immunotherapy |
CN110132795A (zh) * | 2019-05-20 | 2019-08-16 | 华核(天津)新技术开发有限公司 | 放射性去污效率测试方法 |
WO2021041532A1 (en) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
AU2021230288A1 (en) * | 2020-03-06 | 2022-09-01 | National Health Research Institutes | Pyrimidine compounds and their pharmaceutical uses |
WO2021222637A1 (en) | 2020-04-30 | 2021-11-04 | United States Government As Represented By The Department Of Veterans Affairs | Krüppel-like factor 15 (klf15) small molecule agonists in kidney disease |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3133081A (en) * | 1964-05-12 | J-aminoindazole derivatives | ||
US3935183A (en) * | 1970-01-26 | 1976-01-27 | Imperial Chemical Industries Limited | Indazole-azo phenyl compounds |
BE754242A (fr) * | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
US3998951A (en) * | 1974-03-13 | 1976-12-21 | Fmc Corporation | Substituted 2-arylquinazolines as fungicides |
DE2458965C3 (de) * | 1974-12-13 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel |
MA18829A1 (fr) | 1979-05-18 | 1980-12-31 | Ciba Geigy Ag | Derives de la pyrimidine,procedes pour leur preparation,compositions pharmaceutiques contenant ces composes et leur utilisation therapeutique |
DOP1981004033A (es) | 1980-12-23 | 1990-12-29 | Ciba Geigy Ag | Procedimiento para proteger plantas de cultivo de la accion fitotoxica de herbicidas. |
SE8102194L (sv) | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna |
SE8102193L (sv) | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och dess anvendning |
JPS58124773A (ja) | 1982-01-20 | 1983-07-25 | Mitsui Toatsu Chem Inc | 5−メチルチオピリミジン誘導体とその製造法と農園芸用殺菌剤 |
EP0136976A3 (de) | 1983-08-23 | 1985-05-15 | Ciba-Geigy Ag | Verwendung von Phenylpyrimidinen als Pflanzenregulatoren |
DE3725638A1 (de) | 1987-08-03 | 1989-02-16 | Bayer Ag | Neue aryloxy (bzw. thio)aminopyrimidine |
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5597920A (en) | 1992-04-30 | 1997-01-28 | Neurogen Corporation | Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes |
JPH0665237A (ja) | 1992-05-07 | 1994-03-08 | Nissan Chem Ind Ltd | 置換ピラゾール誘導体および農園芸用殺菌剤 |
WO1995009851A1 (en) | 1993-10-01 | 1995-04-13 | Ciba-Geigy Ag | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
KR970706813A (ko) | 1994-11-10 | 1997-12-01 | 찰스 홈시 | 단백질 키나아제의 억제물질로서 유용한 제약용 피라졸 조성물(pharmaceutical pyrazole compositions useful as inhibitors of protein kinases) |
IL117659A (en) | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
US5935966A (en) | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
AU726058B2 (en) | 1995-09-01 | 2000-10-26 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
US6716575B2 (en) * | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
WO1998002434A1 (en) | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
JPH10130150A (ja) | 1996-09-05 | 1998-05-19 | Dainippon Pharmaceut Co Ltd | 酢酸アミド誘導体からなる医薬 |
GB9619284D0 (en) | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
US6251911B1 (en) | 1996-10-02 | 2001-06-26 | Novartis Ag | Pyrimidine derivatives and processes for the preparation thereof |
BR9712530A (pt) | 1996-10-11 | 1999-10-19 | Warner Lambert Co | Inibidores de ésteres de asparato de enzima de conversão de interleucina-1beta |
AU741203B2 (en) | 1997-10-10 | 2001-11-22 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
JP2000026421A (ja) | 1998-01-29 | 2000-01-25 | Kumiai Chem Ind Co Ltd | ジアリ―ルスルフィド誘導体及び有害生物防除剤 |
WO1999041253A1 (en) * | 1998-02-17 | 1999-08-19 | Tularik Inc. | Anti-viral pyrimidine derivatives |
US6153591A (en) | 1998-03-16 | 2000-11-28 | Cytovia, Inc. | Dipeptide caspase inhibitors and the use thereof |
EP1082120A1 (en) | 1998-06-02 | 2001-03-14 | OSI Pharmaceuticals, Inc. | PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE |
ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
WO2000011003A1 (en) | 1998-08-21 | 2000-03-02 | Du Pont Pharmaceuticals Company | ISOXAZOLO[4,5-d]PYRIMIDINES AS CRF ANTAGONISTS |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
KR100860295B1 (ko) | 1998-10-08 | 2008-09-25 | 아스트라제네카 아베 | 퀴나졸린 유도체 |
GB9828640D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
DK1171465T3 (da) | 1999-03-29 | 2004-12-13 | Uutech Ltd | Analoger til gastroinhibitorisk peptid og deres anvendelse til behandling af diabetes |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
BR0104424A (pt) * | 2000-02-05 | 2002-01-08 | Vertex Pharma | Composições de pirazol úteis como inibidores de erk |
AU3704101A (en) | 2000-02-17 | 2001-08-27 | Amgen Inc | Kinase inhibitors |
GB0004887D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
ES2240446T3 (es) | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
PL360439A1 (en) * | 2000-06-28 | 2004-09-06 | Astrazeneca Ab | Substituted quinazoline derivatives and their use as inhibitors |
HU229997B1 (en) | 2000-07-21 | 2015-04-28 | Dendreon Corp San Diego | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
AP2001002266A0 (en) | 2000-08-31 | 2001-09-30 | Pfizer Prod Inc | Pyrazole derivatives. |
EP1317450B1 (en) * | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6613776B2 (en) | 2000-09-15 | 2003-09-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
HUP0302991A3 (en) | 2000-09-15 | 2009-10-28 | Vertex Pharma | Isoxazoles and their use as inhibitors of erk and pharmaceutical compositions containing the compounds |
US6610677B2 (en) * | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6641579B1 (en) | 2000-09-29 | 2003-11-04 | Spectrasonics Imaging, Inc. | Apparatus and method for ablating cardiac tissue |
US6716851B2 (en) * | 2000-12-12 | 2004-04-06 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof |
DE10061863A1 (de) | 2000-12-12 | 2002-06-13 | Basf Ag | Verfahren zur Herstellung von Triethylendiamin (TEDA) |
NZ526471A (en) * | 2000-12-21 | 2005-08-26 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
MY130778A (en) * | 2001-02-09 | 2007-07-31 | Vertex Pharma | Heterocyclic inhibitiors of erk2 and uses thereof |
US6759983B2 (en) * | 2001-03-28 | 2004-07-06 | Strategic Analysis, Inc. | Method and device for precise geolocation of low-power, broadband, amplitude-modulated signals |
MXPA03008888A (es) * | 2001-03-29 | 2005-03-07 | Vertex Pharma | Inhibidores de n-terminal c-jun cinasas (jnk) y otras proteinas cinasas. |
MXPA03009378A (es) * | 2001-04-13 | 2004-01-29 | Vertex Pharma | Inhibidores de cinasas c-jun n-terminales (jnk) y otras proteinas cinasas. |
EP1383771A1 (en) * | 2001-04-20 | 2004-01-28 | Vertex Pharmaceuticals Incorporated | 9-deazaguanine derivatives as inhibitors of gsk-3 |
EP1404669A2 (en) * | 2001-05-16 | 2004-04-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
EP1399440B1 (en) | 2001-06-15 | 2009-06-03 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl)benzisoxazoles as protein kinase inhibitors |
WO2003004492A1 (en) * | 2001-07-03 | 2003-01-16 | Vertex Pharmaceuticals Incorporated | Isoxazolyl-pyrimidines as inhibitors of src and lck protein kinases |
US6698980B2 (en) * | 2001-07-30 | 2004-03-02 | Stewart Mining Products Inc. | Rock stabilizing apparatus and method |
WO2003026664A1 (en) | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
US6569499B2 (en) * | 2001-10-02 | 2003-05-27 | Xerox Corporation | Apparatus and method for coating photoreceptor substrates |
ATE466581T1 (de) * | 2001-12-07 | 2010-05-15 | Vertex Pharma | Verbindungen auf pyrimidin-basis als gsk-3-hemmer |
US7863282B2 (en) * | 2003-03-14 | 2011-01-04 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
US7091343B2 (en) * | 2002-03-15 | 2006-08-15 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
EP1485380B1 (en) | 2002-03-15 | 2010-05-19 | Vertex Pharmaceuticals Incorporated | Azolylaminoazines as inhibitors of protein kinases |
ES2289279T3 (es) * | 2002-03-15 | 2008-02-01 | Vertex Pharmaceuticals Incorporated | Composiciones utiles como inhibidores de proteinquinasas. |
WO2003078426A1 (en) * | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazine as inhibitors of protein kinases |
US20030207873A1 (en) * | 2002-04-10 | 2003-11-06 | Edmund Harrington | Inhibitors of Src and other protein kinases |
EP1506189A1 (en) * | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
JP4570955B2 (ja) * | 2002-07-09 | 2010-10-27 | バーテクス ファーマスーティカルズ インコーポレイテッド | プロテインキナーゼ阻害活性を持つイミダゾール類 |
PT1532145E (pt) * | 2002-08-02 | 2007-01-31 | Vertex Pharma | Composiçoes de pirazole úteis como inibidores de gsk-3 |
US7262200B2 (en) | 2002-10-25 | 2007-08-28 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
JP2004224944A (ja) * | 2003-01-24 | 2004-08-12 | Kuraray Plast Co Ltd | 高周波接着性に優れた熱可塑性樹脂組成物 |
DE602004022187D1 (de) | 2003-10-17 | 2009-09-03 | Astrazeneca Ab | 4-(pyrazol-3-ylamino)pyrimidinderivate zur verwendung bei der behandlung von krebs |
MY141220A (en) * | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
GB0402653D0 (en) * | 2004-02-06 | 2004-03-10 | Cyclacel Ltd | Compounds |
KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
CA2619517A1 (en) | 2005-08-18 | 2007-02-22 | Michael Mortimore | Pyrazine kinase inhibitors |
WO2007023382A2 (en) | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
WO2007041358A2 (en) * | 2005-09-30 | 2007-04-12 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
CA2627857A1 (en) * | 2005-11-03 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
AU2006315334B2 (en) | 2005-11-16 | 2011-05-19 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
CA2668429A1 (en) * | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
CA2673353A1 (en) * | 2006-12-19 | 2008-06-26 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
ES2523863T3 (es) * | 2006-12-29 | 2014-12-02 | Janssen R&D Ireland | Pirimidinas 5,6-sustituidas inhibidoras del VIH |
NZ579485A (en) | 2007-03-09 | 2012-02-24 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
EP2134709A1 (en) * | 2007-03-09 | 2009-12-23 | Vertex Pharmaceuticals, Inc. | Aminopyridines useful as inhibitors of protein kinases |
ES2435997T3 (es) * | 2007-03-09 | 2013-12-26 | Vertex Pharmaceuticals, Inc. | Aminopirimidinas útiles como inhibidores de las proteínas cinasas |
CA2682195A1 (en) * | 2007-03-20 | 2008-09-25 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
WO2008131103A2 (en) * | 2007-04-17 | 2008-10-30 | Vertex Pharmaceuticals Incorporated | Drug discovery methods for aurora kinase inhibitors |
EP2155730A2 (en) * | 2007-05-02 | 2010-02-24 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
CN101801959A (zh) | 2007-05-02 | 2010-08-11 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的氨基嘧啶类化合物 |
JP5389785B2 (ja) | 2007-05-02 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用なチアゾールおよびピラゾール |
CN101687852A (zh) * | 2007-05-24 | 2010-03-31 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的噻唑类和吡唑类化合物 |
WO2010108162A1 (en) | 2009-03-20 | 2010-09-23 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
-
2006
- 2006-11-03 CA CA002627857A patent/CA2627857A1/en not_active Abandoned
- 2006-11-03 NZ NZ594383A patent/NZ594383A/xx not_active IP Right Cessation
- 2006-11-03 TW TW095140891A patent/TW200736249A/zh unknown
- 2006-11-03 RU RU2008122048/04A patent/RU2427578C2/ru not_active IP Right Cessation
- 2006-11-03 WO PCT/US2006/043096 patent/WO2007056221A2/en active Application Filing
- 2006-11-03 US US11/592,114 patent/US7767672B2/en active Active
- 2006-11-03 EP EP06836938.8A patent/EP1954277B1/en not_active Not-in-force
- 2006-11-03 AR ARP060104842A patent/AR057874A1/es not_active Application Discontinuation
- 2006-11-03 JP JP2008539071A patent/JP5249771B2/ja not_active Expired - Fee Related
- 2006-11-03 CN CN2006800444148A patent/CN101316843B/zh not_active Expired - Fee Related
- 2006-11-03 BR BRPI0619704-3A patent/BRPI0619704A2/pt not_active IP Right Cessation
- 2006-11-03 KR KR1020087013424A patent/KR20080067694A/ko not_active Application Discontinuation
- 2006-11-03 CA CA002627808A patent/CA2627808A1/en not_active Abandoned
- 2006-11-03 AR ARP060104841A patent/AR056763A1/es not_active Application Discontinuation
- 2006-11-03 US US11/592,113 patent/US7820685B2/en active Active
- 2006-11-03 AU AU2006311831A patent/AU2006311831C1/en not_active Ceased
- 2006-11-03 CA CA002627830A patent/CA2627830A1/en not_active Abandoned
- 2006-11-03 JP JP2008539091A patent/JP5328361B2/ja not_active Expired - Fee Related
- 2006-11-03 AU AU2006311797A patent/AU2006311797A1/en not_active Abandoned
- 2006-11-03 TW TW095140878A patent/TW200734327A/zh unknown
- 2006-11-03 NZ NZ606259A patent/NZ606259A/en not_active IP Right Cessation
- 2006-11-03 SG SG201008116-4A patent/SG166827A1/en unknown
- 2006-11-03 MX MX2008005814A patent/MX2008005814A/es active IP Right Grant
- 2006-11-03 WO PCT/US2006/042994 patent/WO2007056164A2/en active Application Filing
- 2006-11-03 US US11/592,119 patent/US7528142B2/en active Active
- 2006-11-03 AR ARP060104843A patent/AR056764A1/es not_active Application Discontinuation
- 2006-11-03 NZ NZ594385A patent/NZ594385A/xx not_active IP Right Cessation
- 2006-11-03 EP EP06827465.3A patent/EP1951715B1/en not_active Not-in-force
- 2006-11-03 CN CN2012105636245A patent/CN103145702A/zh active Pending
- 2006-11-03 JP JP2008539070A patent/JP5249770B2/ja not_active Expired - Fee Related
- 2006-11-03 TW TW095140900A patent/TW200736250A/zh unknown
- 2006-11-03 RU RU2008122070/04A patent/RU2008122070A/ru not_active Application Discontinuation
- 2006-11-03 ES ES06827465T patent/ES2435081T3/es active Active
- 2006-11-03 CN CN2006800445831A patent/CN101316597B/zh not_active Expired - Fee Related
- 2006-11-03 WO PCT/US2006/042993 patent/WO2007056163A2/en active Application Filing
- 2006-11-03 BR BRPI0619708-6A patent/BRPI0619708A2/pt not_active IP Right Cessation
- 2006-11-03 EP EP06836890.1A patent/EP1948193B1/en not_active Not-in-force
- 2006-11-03 NZ NZ606263A patent/NZ606263A/en not_active IP Right Cessation
- 2006-11-03 ES ES06836890.1T patent/ES2533241T3/es active Active
- 2006-11-03 BR BRPI0619706-0A patent/BRPI0619706A2/pt not_active IP Right Cessation
- 2006-11-03 MX MX2008005818A patent/MX2008005818A/es active IP Right Grant
- 2006-11-03 AU AU2006311830A patent/AU2006311830B2/en not_active Ceased
- 2006-11-03 MX MX2008005717A patent/MX2008005717A/es active IP Right Grant
- 2006-11-03 KR KR1020087013281A patent/KR20080066069A/ko not_active Application Discontinuation
- 2006-11-03 KR KR1020087013419A patent/KR20080067693A/ko not_active Application Discontinuation
- 2006-11-03 RU RU2008122046/04A patent/RU2423361C2/ru not_active IP Right Cessation
- 2006-11-03 SG SG201008117-2A patent/SG166828A1/en unknown
-
2008
- 2008-04-27 IL IL191043A patent/IL191043A0/en unknown
- 2008-04-27 IL IL191044A patent/IL191044A0/en unknown
- 2008-04-29 IL IL191140A patent/IL191140A0/en unknown
- 2008-05-30 NO NO20082517A patent/NO20082517L/no not_active Application Discontinuation
- 2008-05-30 NO NO20082514A patent/NO20082514L/no not_active Application Discontinuation
- 2008-05-30 NO NO20082508A patent/NO20082508L/no not_active Application Discontinuation
-
2009
- 2009-03-25 US US12/410,553 patent/US8129399B2/en active Active
-
2010
- 2010-06-08 US US12/796,297 patent/US8637511B2/en active Active
- 2010-09-30 US US12/894,465 patent/US8557833B2/en active Active
-
2011
- 2011-04-04 RU RU2011112948/15A patent/RU2011112948A/ru not_active Application Discontinuation
- 2011-05-05 RU RU2011118227/15A patent/RU2011118227A/ru not_active Application Discontinuation
- 2011-12-02 US US13/309,970 patent/US20120142660A1/en not_active Abandoned
-
2012
- 2012-12-12 JP JP2012271604A patent/JP2013049731A/ja active Pending
- 2012-12-19 JP JP2012276504A patent/JP2013075904A/ja active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2009514881A5 (ja) | ||
JP2009514880A5 (ja) | ||
RU2008122048A (ru) | Аминопиримины в качестве ингибиторов киназ | |
JP2010522194A5 (ja) | ||
JP2010523700A5 (ja) | ||
RU2475484C2 (ru) | Полициклические производные индазола и их применение в качестве ингибиторов erk для лечения рака | |
JP2015533176A5 (ja) | ||
JP2022017295A5 (ja) | ||
JP2010526097A5 (ja) | ||
JP2010528021A5 (ja) | ||
JP2010526096A5 (ja) | キナーゼ阻害剤として有用なチアゾールおよびピラゾール | |
JP2018525441A5 (ja) | ||
JP2012153722A5 (ja) | ||
JP2017530984A5 (ja) | ||
JP2018504418A5 (ja) | ||
JP2008528468A5 (ja) | ||
JP2016510748A5 (ja) | ||
JP2008527038A5 (ja) | ||
JP2014034576A5 (ja) | ||
JP2014518279A (ja) | がんの治療における使用のためのcdk4/6阻害剤およびpi3k阻害剤を含む併用療法 | |
JP2011522773A5 (ja) | ||
JP2016504365A5 (ja) | ||
HRP20131081T1 (hr) | Kombinirane terapije koje sadrže hinoksalin inhibitor p13k-alfa za uporabu u lijeäśenju kancera | |
JP2017528475A5 (ja) | ||
JP2008527039A5 (ja) |