TWI428336B - Ｐｉ３ｋ抑制劑及ｍｅｋ抑制劑之組合 - Google Patents
Ｐｉ３ｋ抑制劑及ｍｅｋ抑制劑之組合 Download PDFInfo
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
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| US25085209P | 2009-10-12 | 2009-10-12 |
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| EA024252B1 (ru) | 2009-01-08 | 2016-08-31 | Кьюрис, Инк. | Ингибиторы фосфоинозитид-3-киназ с цинксвязывающей группой |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| CA2830822C (en) | 2011-04-01 | 2018-10-02 | Curis, Inc. | A thienopyrimidine phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
| AR087405A1 (es) | 2011-08-01 | 2014-03-19 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek |
| US9675595B2 (en) | 2011-08-31 | 2017-06-13 | Novartis Ag | Synergistic combinations of PI3K- and MEK-inhibitors |
| CN103957902A (zh) | 2011-10-13 | 2014-07-30 | 基因泰克公司 | 药理学诱导的胃酸过少的治疗 |
| EP2776051A4 (en) * | 2011-10-28 | 2015-06-17 | Hoffmann La Roche | THERAPEUTIC COMBINATIONS AND METHOD FOR THE TREATMENT OF MELANOMA |
| WO2013082511A1 (en) | 2011-12-02 | 2013-06-06 | Genentech, Inc. | Methods for overcoming tumor resistance to vegf antagonists |
| PE20142020A1 (es) * | 2012-04-06 | 2014-12-24 | Sanofi Sa | Metodos para tratar el cancer usando inhibidor de pi3k e inhibidor de mek |
| JP6093757B2 (ja) * | 2012-04-19 | 2017-03-08 | 国立大学法人九州大学 | 医薬組成物 |
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| RS59113B1 (sr) * | 2012-08-17 | 2019-09-30 | Hoffmann La Roche | Kombinovane terapije za melanom koje uključuju davanje kobimetiniba i vemurafiniba |
| SG11201507477XA (en) * | 2013-03-14 | 2015-10-29 | Genentech Inc | Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use |
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| ES2779975T3 (es) | 2014-02-07 | 2020-08-21 | Verastem Inc | Métodos y composiciones para tratar el crecimiento celular anormal |
| SG10202007111TA (en) | 2014-07-15 | 2020-09-29 | Genentech Inc | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| WO2016040806A1 (en) * | 2014-09-11 | 2016-03-17 | The Regents Of The University Of California | mTORC1 INHIBITORS |
| ES3014591T3 (en) | 2018-09-11 | 2025-04-23 | Curis Inc | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
| CN110420330B (zh) * | 2019-07-19 | 2020-05-29 | 南京医科大学 | 一种pi3k与mth1靶向药组合物的制药用途 |
| JP2022547358A (ja) | 2019-09-13 | 2022-11-14 | ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル | 治療組成物、組み合わせ、及び使用方法 |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
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| BE759493A (fr) * | 1969-11-26 | 1971-05-25 | Thomae Gmbh Dr K | Nouvelles 2-(5-nitro-2-furyl)-thieno(3,2-d) pyrimidines et procedes pour les fabriquer |
| US3763156A (en) * | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
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| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| US4510139A (en) * | 1984-01-06 | 1985-04-09 | Sterling Drug Inc. | Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity |
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| US7517994B2 (en) * | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
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| WO2008021389A2 (en) * | 2006-08-16 | 2008-02-21 | Exelixis, Inc. | Using pi3k and mek modulators in treatments of cancer |
| AU2007329352B2 (en) * | 2006-12-07 | 2013-01-17 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| EP2205242B1 (en) * | 2007-09-12 | 2015-04-15 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
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2010
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- 2010-10-11 JP JP2012533589A patent/JP2013507415A/ja not_active Ceased
- 2010-10-11 AU AU2010314287A patent/AU2010314287A1/en not_active Abandoned
- 2010-10-11 TW TW099134615A patent/TWI428336B/zh not_active IP Right Cessation
- 2010-10-11 EP EP10768448.2A patent/EP2488178B1/en not_active Not-in-force
- 2010-10-11 PE PE2012000470A patent/PE20121816A1/es not_active Application Discontinuation
- 2010-10-11 US US12/902,062 patent/US20110086837A1/en not_active Abandoned
- 2010-10-11 NZ NZ599939A patent/NZ599939A/en not_active IP Right Cessation
- 2010-10-11 WO PCT/EP2010/065149 patent/WO2011054620A1/en not_active Ceased
- 2010-10-11 RU RU2012118974/15A patent/RU2563193C2/ru not_active IP Right Cessation
- 2010-10-11 BR BR112012008483A patent/BR112012008483A2/pt not_active IP Right Cessation
- 2010-10-11 CN CN2010800563069A patent/CN102740851B/zh not_active Expired - Fee Related
- 2010-10-11 MX MX2012004286A patent/MX345155B/es active IP Right Grant
- 2010-10-11 ES ES10768448.2T patent/ES2609767T3/es active Active
- 2010-10-11 MA MA34821A patent/MA33974B1/fr unknown
- 2010-10-11 KR KR1020127012069A patent/KR101489045B1/ko not_active Expired - Fee Related
- 2010-10-11 CA CA2776944A patent/CA2776944A1/en not_active Abandoned
- 2010-10-12 AR ARP100103706A patent/AR078588A1/es not_active Application Discontinuation
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- 2012-04-05 IL IL219105A patent/IL219105A0/en unknown
- 2012-04-10 CR CR20120173A patent/CR20120173A/es unknown
- 2012-04-11 CL CL2012000913A patent/CL2012000913A1/es unknown
- 2012-04-11 ZA ZA2012/02618A patent/ZA201202618B/en unknown
- 2012-04-20 CO CO12065784A patent/CO6531463A2/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| CO6531463A2 (es) | 2012-09-28 |
| US20110086837A1 (en) | 2011-04-14 |
| CR20120173A (es) | 2012-07-04 |
| WO2011054620A1 (en) | 2011-05-12 |
| HK1175125A1 (en) | 2013-06-28 |
| EP2488178A1 (en) | 2012-08-22 |
| PE20121816A1 (es) | 2013-01-02 |
| AU2010314287A1 (en) | 2012-05-03 |
| JP2015038110A (ja) | 2015-02-26 |
| RU2012118974A (ru) | 2013-11-20 |
| NZ599939A (en) | 2014-02-28 |
| IL219105A0 (en) | 2012-06-28 |
| CL2012000913A1 (es) | 2012-09-14 |
| CN102740851B (zh) | 2013-12-18 |
| ES2609767T3 (es) | 2017-04-24 |
| PH12012500709A1 (en) | 2012-10-29 |
| KR101489045B1 (ko) | 2015-02-02 |
| JP2013507415A (ja) | 2013-03-04 |
| AU2010314287A2 (en) | 2012-07-12 |
| JP5745678B2 (ja) | 2015-07-08 |
| EP2488178B1 (en) | 2016-11-16 |
| MX345155B (es) | 2017-01-18 |
| AR078588A1 (es) | 2011-11-16 |
| BR112012008483A2 (pt) | 2019-09-24 |
| ZA201202618B (en) | 2014-10-29 |
| ECSP12011865A (es) | 2012-06-29 |
| MX2012004286A (es) | 2012-05-22 |
| RU2563193C2 (ru) | 2015-09-20 |
| CN102740851A (zh) | 2012-10-17 |
| CA2776944A1 (en) | 2011-05-12 |
| MA33974B1 (fr) | 2013-02-01 |
| TW201118082A (en) | 2011-06-01 |
| KR20120064132A (ko) | 2012-06-18 |
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