TWI428336B - Ｐｉ３ｋ抑制劑及ｍｅｋ抑制劑之組合 - Google Patents
Ｐｉ３ｋ抑制劑及ｍｅｋ抑制劑之組合 Download PDFInfo
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
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| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| PT3111938T (pt) | 2011-04-01 | 2019-07-10 | Curis Inc | Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco |
| BR112014002353B1 (pt) | 2011-08-01 | 2022-09-27 | Genentech, Inc | Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit |
| CN103764144B (zh) * | 2011-08-31 | 2016-07-20 | 诺华股份有限公司 | Pi3k抑制剂与mek抑制剂的协同组合 |
| JP6062442B2 (ja) | 2011-10-13 | 2017-01-18 | ジェネンテック， インコーポレイテッド | 薬剤誘発性低酸症の治療 |
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| BR112017000672A2 (pt) | 2014-07-15 | 2017-11-14 | Genentech Inc | composições para tratamento de câncer utilizando antagonistas de ligação de eixo pd-1 e inibidores de mek |
| EP3193902A4 (en) * | 2014-09-11 | 2018-03-28 | The Regents of The University of California | mTORC1 INHIBITORS |
| EP3849554B1 (en) | 2018-09-11 | 2025-01-29 | Curis, Inc. | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
| CN110420330B (zh) * | 2019-07-19 | 2020-05-29 | 南京医科大学 | 一种pi3k与mth1靶向药组合物的制药用途 |
| WO2021047783A1 (en) | 2019-09-13 | 2021-03-18 | The Institute Of Cancer Research: Royal Cancer Hospital | Vs-6063 in combination with ch5126766 for the treatment of cancer |
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2010
- 2010-10-11 AU AU2010314287A patent/AU2010314287A1/en not_active Abandoned
- 2010-10-11 NZ NZ599939A patent/NZ599939A/en not_active IP Right Cessation
- 2010-10-11 JP JP2012533589A patent/JP2013507415A/ja not_active Ceased
- 2010-10-11 BR BR112012008483A patent/BR112012008483A2/pt not_active IP Right Cessation
- 2010-10-11 TW TW099134615A patent/TWI428336B/zh not_active IP Right Cessation
- 2010-10-11 MA MA34821A patent/MA33974B1/fr unknown
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- 2010-10-11 MX MX2012004286A patent/MX345155B/es active IP Right Grant
- 2010-10-11 ES ES10768448.2T patent/ES2609767T3/es active Active
- 2010-10-11 WO PCT/EP2010/065149 patent/WO2011054620A1/en not_active Ceased
- 2010-10-11 PE PE2012000470A patent/PE20121816A1/es not_active Application Discontinuation
- 2010-10-11 EP EP10768448.2A patent/EP2488178B1/en not_active Not-in-force
- 2010-10-11 CN CN2010800563069A patent/CN102740851B/zh not_active Expired - Fee Related
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- 2010-10-11 RU RU2012118974/15A patent/RU2563193C2/ru not_active IP Right Cessation
- 2010-10-11 KR KR1020127012069A patent/KR101489045B1/ko not_active Expired - Fee Related
- 2010-10-11 PH PH1/2012/500709A patent/PH12012500709A1/en unknown
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- 2012-04-10 CR CR20120173A patent/CR20120173A/es unknown
- 2012-04-11 CL CL2012000913A patent/CL2012000913A1/es unknown
- 2012-04-11 ZA ZA2012/02618A patent/ZA201202618B/en unknown
- 2012-04-20 CO CO12065784A patent/CO6531463A2/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| US20110086837A1 (en) | 2011-04-14 |
| KR20120064132A (ko) | 2012-06-18 |
| PH12012500709A1 (en) | 2012-10-29 |
| CO6531463A2 (es) | 2012-09-28 |
| EP2488178B1 (en) | 2016-11-16 |
| KR101489045B1 (ko) | 2015-02-02 |
| CR20120173A (es) | 2012-07-04 |
| TW201118082A (en) | 2011-06-01 |
| BR112012008483A2 (pt) | 2019-09-24 |
| JP5745678B2 (ja) | 2015-07-08 |
| MX345155B (es) | 2017-01-18 |
| MX2012004286A (es) | 2012-05-22 |
| RU2563193C2 (ru) | 2015-09-20 |
| JP2013507415A (ja) | 2013-03-04 |
| IL219105A0 (en) | 2012-06-28 |
| AR078588A1 (es) | 2011-11-16 |
| CN102740851A (zh) | 2012-10-17 |
| AU2010314287A1 (en) | 2012-05-03 |
| MA33974B1 (fr) | 2013-02-01 |
| WO2011054620A1 (en) | 2011-05-12 |
| ECSP12011865A (es) | 2012-06-29 |
| ES2609767T3 (es) | 2017-04-24 |
| CN102740851B (zh) | 2013-12-18 |
| CA2776944A1 (en) | 2011-05-12 |
| AU2010314287A2 (en) | 2012-07-12 |
| JP2015038110A (ja) | 2015-02-26 |
| EP2488178A1 (en) | 2012-08-22 |
| NZ599939A (en) | 2014-02-28 |
| ZA201202618B (en) | 2014-10-29 |
| PE20121816A1 (es) | 2013-01-02 |
| RU2012118974A (ru) | 2013-11-20 |
| HK1175125A1 (en) | 2013-06-28 |
| CL2012000913A1 (es) | 2012-09-14 |
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