JP2013519645A5 - - Google Patents
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- Publication number
- JP2013519645A5 JP2013519645A5 JP2012552369A JP2012552369A JP2013519645A5 JP 2013519645 A5 JP2013519645 A5 JP 2013519645A5 JP 2012552369 A JP2012552369 A JP 2012552369A JP 2012552369 A JP2012552369 A JP 2012552369A JP 2013519645 A5 JP2013519645 A5 JP 2013519645A5
- Authority
- JP
- Japan
- Prior art keywords
- methylbutyl
- piperidinyl
- dihydro
- oxy
- pentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 7
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 7
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 6
- RYAOUIHHQJNSJV-INIZCTEOSA-N 2-[(2s)-pentan-2-yl]oxy-9-(5-piperidin-1-ylpentyl)-7,8-dihydropurin-6-amine Chemical compound C1NC=2C(N)=NC(O[C@@H](C)CCC)=NC=2N1CCCCCN1CCCCC1 RYAOUIHHQJNSJV-INIZCTEOSA-N 0.000 claims 5
- 150000002689 maleic acids Chemical class 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000006806 disease prevention Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- BOUNFBOFBGBYBT-UHFFFAOYSA-N purin-8-one Chemical compound C1=NC=NC2=NC(=O)N=C21 BOUNFBOFBGBYBT-UHFFFAOYSA-N 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002688 maleic acid derivatives Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30301010P | 2010-02-10 | 2010-02-10 | |
| US61/303,010 | 2010-02-10 | ||
| PCT/EP2011/051830 WO2011098452A1 (en) | 2010-02-10 | 2011-02-08 | 6-amino-2-{ [ (1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519645A JP2013519645A (ja) | 2013-05-30 |
| JP2013519645A5 true JP2013519645A5 (enExample) | 2014-03-27 |
| JP5922587B2 JP5922587B2 (ja) | 2016-05-24 |
Family
ID=43836817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552369A Active JP5922587B2 (ja) | 2010-02-10 | 2011-02-08 | ６−アミノ−２−｛［（１ｓ）−１−メチルブチル］オキシ｝−９−［５−（１−ピペリジニル）ペンチル］−７，９−ジヒドロ−８ｈ−プリン−８−オンマレイン酸塩 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8703754B2 (enExample) |
| EP (1) | EP2534149B1 (enExample) |
| JP (1) | JP5922587B2 (enExample) |
| KR (1) | KR101773541B1 (enExample) |
| CN (1) | CN102753553B (enExample) |
| AU (1) | AU2011214468B2 (enExample) |
| BR (1) | BR112012018904A2 (enExample) |
| CA (1) | CA2786973C (enExample) |
| DK (1) | DK2534149T3 (enExample) |
| EA (1) | EA021048B1 (enExample) |
| ES (1) | ES2525826T3 (enExample) |
| HR (1) | HRP20141258T1 (enExample) |
| IL (1) | IL220845A (enExample) |
| ME (1) | ME01926B (enExample) |
| MX (1) | MX2012009316A (enExample) |
| PL (1) | PL2534149T3 (enExample) |
| PT (1) | PT2534149E (enExample) |
| RS (1) | RS53745B1 (enExample) |
| SG (1) | SG182471A1 (enExample) |
| SI (1) | SI2534149T1 (enExample) |
| SM (1) | SMT201400196B (enExample) |
| WO (1) | WO2011098452A1 (enExample) |
| ZA (1) | ZA201205995B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| ES2616051T3 (es) | 2008-12-02 | 2017-06-09 | Wave Life Sciences Japan, Inc. | Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| SG10201406813RA (en) | 2009-10-22 | 2014-11-27 | Gilead Sciences Inc | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
| EP2620428B1 (en) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| JP6128529B2 (ja) | 2011-07-19 | 2017-05-17 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | 官能化核酸の合成のための方法 |
| KR101916928B1 (ko) * | 2011-07-22 | 2018-11-08 | 글락소스미스클라인 엘엘씨 | 조성물 |
| US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
| MX356830B (es) * | 2012-07-13 | 2018-06-15 | Shin Nippon Biomedical Laboratories Ltd | Adyuvante de acido nucleico quiral. |
| US9982257B2 (en) | 2012-07-13 | 2018-05-29 | Wave Life Sciences Ltd. | Chiral control |
| CA2880576A1 (en) | 2012-08-24 | 2014-02-27 | Glaxosmithkline Llc | Pyrazolopyrimidine compounds |
| PT2922549T (pt) | 2012-11-20 | 2017-09-01 | Glaxosmithkline Llc | Novos compostos |
| CN104780924B (zh) | 2012-11-20 | 2016-09-14 | 葛兰素史克有限责任公司 | 干扰素诱导剂化合物 |
| AU2013348216B2 (en) | 2012-11-20 | 2016-10-13 | Glaxosmithkline Llc | Novel compounds |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| DK3094728T3 (da) | 2014-01-16 | 2022-05-16 | Wave Life Sciences Ltd | Kiralt design |
| ES2944885T3 (es) * | 2014-08-29 | 2023-06-26 | Corium Pharma Solutions Inc | Matriz de microestructuras para administración de agentes activos |
| BR112017009648A2 (pt) * | 2014-11-13 | 2017-12-19 | Glaxosmithkline Biologicals Sa | composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto. |
| US12130267B2 (en) * | 2018-11-28 | 2024-10-29 | Shimadzu Corporation | Analyzing method for azo compound |
| KR20250106231A (ko) | 2023-12-29 | 2025-07-09 | (주)셀트리온 | 안정한 약제학적 제제 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| CA2156408C (en) | 1993-03-17 | 2005-02-15 | Daniel C. Duan | Aerosol formulation containing a polyester dispersing aid |
| US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| EP1065213A3 (en) | 1999-07-02 | 2003-11-05 | Japan Tobacco Inc. | HCV polymerase suitable for crystal structure analysis and method for using the enzyme |
| SK13752001A3 (sk) | 1999-12-27 | 2002-07-02 | Japan Tobacco, Inc. | Zlúčeniny s fúzovanými kruhmi a ich použitie ako liečiv |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| US6310224B1 (en) | 2001-01-19 | 2001-10-30 | Arco Chemical Technology, L.P. | Epoxidation catalyst and process |
| EA007491B1 (ru) | 2001-01-22 | 2006-10-27 | Мерк Энд Ко., Инк. | Производные нуклеозидов в качестве ингибиторов рнк-зависимой рнк вирусной полимеразы |
| EP1378509A4 (en) | 2001-03-19 | 2009-03-25 | Ono Pharmaceutical Co | DRUGS WITH TRIAZASPIRO ç5.5] UNDECANDERIVATES AS ACTIVE SUBSTANCE |
| AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| EP1411928A1 (en) | 2001-07-20 | 2004-04-28 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| US20030215917A1 (en) | 2002-04-04 | 2003-11-20 | Mingjun Huang | Assay for evaluation of activity of compounds against HCV using a novel detection system in the HCV replicon |
| DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| TW200418848A (en) | 2002-10-24 | 2004-10-01 | Glaxo Group Ltd | Compounds |
| ATE402176T1 (de) | 2002-12-13 | 2008-08-15 | Smithkline Beecham Corp | Pyrrolidin- und azetidinverbindungen alsccr5- antagonisten |
| AU2003300952A1 (en) | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Indane compounds as ccr5 antagonists |
| ES2298627T3 (es) | 2002-12-13 | 2008-05-16 | Smithkline Beecham Corporation | Compuestos de ciclopropilo como antagonistas de ccr5. |
| DE60324014D1 (de) | 2002-12-13 | 2008-11-20 | Smithkline Beecham Corp | Heterocyclische verbindungen alsccr5-antagonisten |
| EP1569646A2 (en) | 2002-12-13 | 2005-09-07 | Smithkline Beecham Corporation | Piperidine derivatives as ccr5 antagonists |
| US7589207B2 (en) | 2002-12-13 | 2009-09-15 | Smithkline Beecham Corporation | Cyclohexyl compounds as CCR5 antagonists |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用 |
| PT1699512E (pt) | 2003-11-03 | 2012-09-11 | Glaxo Group Ltd | Dispositivo distribuidor de fluido |
| EP1718608B1 (en) | 2004-02-20 | 2013-07-17 | Boehringer Ingelheim International GmbH | Viral polymerase inhibitors |
| WO2005105761A1 (en) | 2004-04-28 | 2005-11-10 | Arrow Therapeutics Limited | Morpholinylanilinoquinazo- line derivatives for use as antiviral agents |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| MX2007001527A (es) | 2004-08-18 | 2007-03-27 | Pfizer | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan. |
| US20060045885A1 (en) | 2004-08-27 | 2006-03-02 | Kedl Ross M | Method of eliciting an immune response against HIV |
| GB0423673D0 (en) | 2004-10-25 | 2004-11-24 | Glaxo Group Ltd | Compounds |
| JP2008540537A (ja) | 2005-05-09 | 2008-11-20 | アキリオン ファーマシューティカルズ，インコーポレーテッド | チアゾール化合物および使用方法 |
| WO2007034881A1 (ja) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | 新規アデニン化合物 |
| GB0610666D0 (en) | 2006-05-30 | 2006-07-05 | Glaxo Group Ltd | Fluid dispenser |
| JP2010519186A (ja) | 2007-02-19 | 2010-06-03 | スミスクライン ビーチャム コーポレーション | 免疫調節物質としてのプリン誘導体 |
| JP5480637B2 (ja) * | 2007-03-19 | 2014-04-23 | アストラゼネカ・アクチエボラーグ | Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物 |
| PE20091156A1 (es) * | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
| US8777708B2 (en) | 2008-06-27 | 2014-07-15 | Microsoft Corporation | Targeting control in a simulated environment |
| UA103195C2 (uk) * | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
-
2011
- 2011-02-08 SI SI201130364T patent/SI2534149T1/sl unknown
- 2011-02-08 MX MX2012009316A patent/MX2012009316A/es active IP Right Grant
- 2011-02-08 EA EA201290631A patent/EA021048B1/ru not_active IP Right Cessation
- 2011-02-08 CN CN201180009082.0A patent/CN102753553B/zh not_active Expired - Fee Related
- 2011-02-08 EP EP11709025.8A patent/EP2534149B1/en active Active
- 2011-02-08 WO PCT/EP2011/051830 patent/WO2011098452A1/en not_active Ceased
- 2011-02-08 SG SG2012051140A patent/SG182471A1/en unknown
- 2011-02-08 ES ES11709025.8T patent/ES2525826T3/es active Active
- 2011-02-08 ME MEP-2014-154A patent/ME01926B/me unknown
- 2011-02-08 RS RS20150005A patent/RS53745B1/sr unknown
- 2011-02-08 PT PT117090258T patent/PT2534149E/pt unknown
- 2011-02-08 HR HRP20141258AT patent/HRP20141258T1/hr unknown
- 2011-02-08 CA CA2786973A patent/CA2786973C/en not_active Expired - Fee Related
- 2011-02-08 PL PL11709025T patent/PL2534149T3/pl unknown
- 2011-02-08 KR KR1020127023687A patent/KR101773541B1/ko not_active Expired - Fee Related
- 2011-02-08 JP JP2012552369A patent/JP5922587B2/ja active Active
- 2011-02-08 DK DK11709025.8T patent/DK2534149T3/da active
- 2011-02-08 AU AU2011214468A patent/AU2011214468B2/en not_active Ceased
- 2011-02-08 US US13/578,020 patent/US8703754B2/en not_active Expired - Fee Related
- 2011-02-08 BR BR112012018904-2A patent/BR112012018904A2/pt not_active IP Right Cessation
-
2012
- 2012-07-10 IL IL220845A patent/IL220845A/en not_active IP Right Cessation
- 2012-08-08 ZA ZA2012/05995A patent/ZA201205995B/en unknown
-
2014
- 2014-12-30 SM SM201400196T patent/SMT201400196B/xx unknown
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