RU2015117251A - Новые соединения - Google Patents
Новые соединения Download PDFInfo
- Publication number
- RU2015117251A RU2015117251A RU2015117251A RU2015117251A RU2015117251A RU 2015117251 A RU2015117251 A RU 2015117251A RU 2015117251 A RU2015117251 A RU 2015117251A RU 2015117251 A RU2015117251 A RU 2015117251A RU 2015117251 A RU2015117251 A RU 2015117251A
- Authority
- RU
- Russia
- Prior art keywords
- paragraphs
- pharmaceutically acceptable
- compound according
- salt
- acceptable salt
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (24)
1. Соединение формулы (I) или его соль:
где R1 представляет собой н-С3-6алкил;
R2 представляет собой водород или метил;
R3 представляет собой водород или С1-6алкил;
m представляет собой целое число, имеющее значение от 0 до 3.
2. Соединение по п. 1 или его соль, где R1 представляет собой н-бутил.
3. Соединение по п. 1 или его соль, где R2 представляет собой водород.
4. Соединение по п. 1 или его соль, где m представляет собой целое число, имеющее значение 0 или 1.
5. Соединение по п. 1 или его соль, где R3 представляет собой изопропил.
6. Соединение по п. 1 или его соль, выбранное из группы, состоящей
из:
2-бутил-7-(3-(пиперидин-4-ил)пропил)-5H-пирроло[3,2-d]пиримидин-4-амина;
2-бутил-7-(3-(1-изопропилпиперидин-4-ил)пропил)-5Н-пирроло[3,2-d]пиримидин-4-амина; и
2-бутил-7-(2-(пиперидин-4-ил)этил)-5Н-пирроло[3,2-d]пиримидин-4-амина.
7. Соединение по любому из пп. 1-6 в форме фармацевтически приемлемой соли.
8. Соединение по любому из пп. 1-6 в форме свободного основания.
9. Фармацевтическая композиция, содержащая соединение по любому из пп. 1-6 или его фармацевтически приемлемую соль и один или более чем один фармацевтически приемлемый эксципиент.
10. Вакцинная композиция, содержащая соединение по любому из пп. 1-6 или его фармацевтически приемлемую соль и антиген или антигенную композицию.
11. Соединение по любому из пп. 1-6 или его фармацевтически приемлемая соль для применения в терапии.
12. Соединение по любому из пп. 1-6 или его фармацевтически приемлемая соль для применения в лечении аллергических заболеваний и других воспалительных состояний, инфекционных заболеваний и рака.
13. Соединение по любому из пп. 1-6 или его фармацевтически приемлемая соль для применения в лечении аллергического ринита.
14. Соединение по любому из пп. 1-6 или его фармацевтически приемлемая соль для применения в лечении астмы.
15. Применение соединения по любому из пп. 1-6 или его фармацевтически приемлемой соли в изготовлении лекарственного средства для лечения аллергических заболеваний и других воспалительных состояний, инфекционных заболеваний и рака.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728385P | 2012-11-20 | 2012-11-20 | |
| US61/728,385 | 2012-11-20 | ||
| PCT/US2013/070471 WO2014081644A1 (en) | 2012-11-20 | 2013-11-18 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015117251A true RU2015117251A (ru) | 2017-01-10 |
| RU2643371C2 RU2643371C2 (ru) | 2018-02-01 |
Family
ID=50776484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015117251A RU2643371C2 (ru) | 2012-11-20 | 2013-11-18 | Новые соединения |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9550785B2 (ru) |
| EP (1) | EP2922550B1 (ru) |
| JP (1) | JP6216387B2 (ru) |
| KR (1) | KR20150085080A (ru) |
| CN (1) | CN104780924B (ru) |
| AU (1) | AU2013348217B2 (ru) |
| BR (1) | BR112015011447A2 (ru) |
| CA (1) | CA2890201A1 (ru) |
| ES (1) | ES2632448T3 (ru) |
| RU (1) | RU2643371C2 (ru) |
| WO (1) | WO2014081644A1 (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA103195C2 (ru) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Производные пурина для применения в лечении аллергий, воспалительных и инфекционных заболеваний |
| KR101916928B1 (ko) | 2011-07-22 | 2018-11-08 | 글락소스미스클라인 엘엘씨 | 조성물 |
| TWI625331B (zh) | 2012-08-24 | 2018-06-01 | 葛蘭素史密斯克藍有限責任公司 | 可作為干擾素誘導物之化合物及其組合物及用途 |
| CA2890198A1 (en) | 2012-11-20 | 2014-05-30 | Diane Mary Coe | Novel compounds |
| WO2014081644A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
| WO2014081645A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
| CN106029668B (zh) * | 2014-02-20 | 2018-02-23 | 葛兰素史克知识产权第二有限公司 | 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂 |
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| US20120171229A1 (en) | 2010-12-30 | 2012-07-05 | Selecta Biosciences, Inc. | Synthetic nanocarriers with reactive groups that release biologically active agents |
| AU2012212323A1 (en) | 2011-02-01 | 2013-09-12 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods using the same |
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| WO2014081644A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
| WO2014081645A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
| CN106029668B (zh) | 2014-02-20 | 2018-02-23 | 葛兰素史克知识产权第二有限公司 | 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂 |
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2013
- 2013-11-18 WO PCT/US2013/070471 patent/WO2014081644A1/en active Application Filing
- 2013-11-18 EP EP13857520.4A patent/EP2922550B1/en active Active
- 2013-11-18 CN CN201380060298.9A patent/CN104780924B/zh not_active Expired - Fee Related
- 2013-11-18 KR KR1020157016435A patent/KR20150085080A/ko active IP Right Grant
- 2013-11-18 US US14/443,924 patent/US9550785B2/en active Active
- 2013-11-18 RU RU2015117251A patent/RU2643371C2/ru not_active IP Right Cessation
- 2013-11-18 AU AU2013348217A patent/AU2013348217B2/en not_active Ceased
- 2013-11-18 BR BR112015011447A patent/BR112015011447A2/pt not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20150085080A (ko) | 2015-07-22 |
| AU2013348217A1 (en) | 2015-06-04 |
| US9550785B2 (en) | 2017-01-24 |
| CN104780924A (zh) | 2015-07-15 |
| CN104780924B (zh) | 2016-09-14 |
| EP2922550A1 (en) | 2015-09-30 |
| BR112015011447A2 (pt) | 2017-07-11 |
| ES2632448T3 (es) | 2017-09-13 |
| EP2922550A4 (en) | 2016-06-15 |
| CA2890201A1 (en) | 2014-05-30 |
| AU2013348217B2 (en) | 2016-10-06 |
| JP2016500067A (ja) | 2016-01-07 |
| US20150266883A1 (en) | 2015-09-24 |
| WO2014081644A1 (en) | 2014-05-30 |
| RU2643371C2 (ru) | 2018-02-01 |
| JP6216387B2 (ja) | 2017-10-18 |
| EP2922550B1 (en) | 2017-04-19 |
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