EA201100114A1 - Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний - Google Patents

Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний

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Publication number
EA201100114A1
EA201100114A1 EA201100114A EA201100114A EA201100114A1 EA 201100114 A1 EA201100114 A1 EA 201100114A1 EA 201100114 A EA201100114 A EA 201100114A EA 201100114 A EA201100114 A EA 201100114A EA 201100114 A1 EA201100114 A1 EA 201100114A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
allergic
infectious diseases
inflammatory
purin
Prior art date
Application number
EA201100114A
Other languages
English (en)
Inventor
Элен Базин-Ли
Кейт Биггадайк
Дайан Мэри Коэ
Сяо Цин Льюэлл
Шарлотт Джейн Митчелл
Наимиша Триведи
Original Assignee
ГЛАКСОСМИТКЛАЙН ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ГЛАКСОСМИТКЛАЙН ЭлЭлСи filed Critical ГЛАКСОСМИТКЛАЙН ЭлЭлСи
Publication of EA201100114A1 publication Critical patent/EA201100114A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Abstract

Соединения формулы (I)где Rпредставляет собой Салкиламино, Cалкокси или Сциклоалкилокси; m означает целое число от 2 до 6; Rпредставляет собой водород, Салкил или СциклоалкилСалкил; и их соли являются индукторами человеческого интерферона. Соединения, которые индуцируют человеческий интерферон, могут быть полезными в лечении различных заболеваний, например в лечении аллергических заболеваний и других воспалительных состояний, например аллергического ринита и астмы, в лечении инфекционных заболеваний и рака, и могут быть полезными в качестве вакцинных адъювантов.
EA201100114A 2008-08-11 2009-08-07 Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний EA201100114A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8779008P 2008-08-11 2008-08-11
PCT/EP2009/060263 WO2010018131A1 (en) 2008-08-11 2009-08-07 Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases

Publications (1)

Publication Number Publication Date
EA201100114A1 true EA201100114A1 (ru) 2011-10-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100114A EA201100114A1 (ru) 2008-08-11 2009-08-07 Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний

Country Status (13)

Country Link
US (1) US20110135671A1 (ru)
EP (1) EP2324025A1 (ru)
JP (1) JP2011530562A (ru)
KR (1) KR20110042116A (ru)
CN (1) CN102203095A (ru)
AU (1) AU2009281195A1 (ru)
BR (1) BRPI0917458A2 (ru)
CA (1) CA2733743A1 (ru)
EA (1) EA201100114A1 (ru)
IL (1) IL210803A0 (ru)
MX (1) MX2011001662A (ru)
WO (1) WO2010018131A1 (ru)
ZA (1) ZA201101105B (ru)

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Also Published As

Publication number Publication date
CA2733743A1 (en) 2010-02-18
AU2009281195A1 (en) 2010-02-18
IL210803A0 (en) 2011-04-28
KR20110042116A (ko) 2011-04-22
US20110135671A1 (en) 2011-06-09
JP2011530562A (ja) 2011-12-22
BRPI0917458A2 (pt) 2015-12-01
EP2324025A1 (en) 2011-05-25
WO2010018131A1 (en) 2010-02-18
MX2011001662A (es) 2011-03-24
CN102203095A (zh) 2011-09-28
ZA201101105B (en) 2012-07-25

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