EA201290631A1 - Малеат 6-амино-2-{[(1s)-1-метилбутил]окси}-9-[5-(1-пиперидинил)пентил]-7,9-дигидро-8н-пурин-8-она - Google Patents

Малеат 6-амино-2-{[(1s)-1-метилбутил]окси}-9-[5-(1-пиперидинил)пентил]-7,9-дигидро-8н-пурин-8-она

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Publication number
EA201290631A1
EA201290631A1 EA201290631A EA201290631A EA201290631A1 EA 201290631 A1 EA201290631 A1 EA 201290631A1 EA 201290631 A EA201290631 A EA 201290631A EA 201290631 A EA201290631 A EA 201290631A EA 201290631 A1 EA201290631 A1 EA 201290631A1
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EA
Eurasian Patent Office
Prior art keywords
methylbutyl
piperidinyl
oxy
amino
digidro
Prior art date
Application number
EA201290631A
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English (en)
Other versions
EA021048B1 (ru
Inventor
Роберт Херманн Гиббон
Аманда Лукас
Стивен Эндрю Хермитидж
Original Assignee
ГЛАКСОСМИТКЛАЙН ЭлЭлСи
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Publication date
Application filed by ГЛАКСОСМИТКЛАЙН ЭлЭлСи filed Critical ГЛАКСОСМИТКЛАЙН ЭлЭлСи
Publication of EA201290631A1 publication Critical patent/EA201290631A1/ru
Publication of EA021048B1 publication Critical patent/EA021048B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Abstract

Соединение, представляющее собой 6-амино-2-{[(1S)-1-метилбутил]окси}-9-[5-(1-пиперидинил)пентил]-7,9-дигидро-8H-пурин-8-онв форме малеатной соли, может быть полезным в лечении различных расстройств, например в лечении аллергических заболеваний и других воспалительных заболеваний, например аллергического ринита и астмы, в лечении инфекционных заболеваний и рака и может быть также полезным в качестве вакцинных адъювантов.
EA201290631A 2010-02-10 2011-02-08 Малеат 6-амино-2-{[(1s)-1-метилбутил]окси}-9-[5-(1-пиперидинил)пентил]-7,9-дигидро-8н-пурин-8-она EA021048B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30301010P 2010-02-10 2010-02-10
PCT/EP2011/051830 WO2011098452A1 (en) 2010-02-10 2011-02-08 6-amino-2-{ [ (1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate

Publications (2)

Publication Number Publication Date
EA201290631A1 true EA201290631A1 (ru) 2013-03-29
EA021048B1 EA021048B1 (ru) 2015-03-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290631A EA021048B1 (ru) 2010-02-10 2011-02-08 Малеат 6-амино-2-{[(1s)-1-метилбутил]окси}-9-[5-(1-пиперидинил)пентил]-7,9-дигидро-8н-пурин-8-она

Country Status (23)

Country Link
US (1) US8703754B2 (ru)
EP (1) EP2534149B1 (ru)
JP (1) JP5922587B2 (ru)
KR (1) KR101773541B1 (ru)
CN (1) CN102753553B (ru)
AU (1) AU2011214468B2 (ru)
BR (1) BR112012018904A2 (ru)
CA (1) CA2786973C (ru)
DK (1) DK2534149T3 (ru)
EA (1) EA021048B1 (ru)
ES (1) ES2525826T3 (ru)
HR (1) HRP20141258T1 (ru)
IL (1) IL220845A (ru)
ME (1) ME01926B (ru)
MX (1) MX2012009316A (ru)
PL (1) PL2534149T3 (ru)
PT (1) PT2534149E (ru)
RS (1) RS53745B1 (ru)
SG (1) SG182471A1 (ru)
SI (1) SI2534149T1 (ru)
SM (1) SMT201400196B (ru)
WO (1) WO2011098452A1 (ru)
ZA (1) ZA201205995B (ru)

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ES2525826T3 (es) 2014-12-30
JP2013519645A (ja) 2013-05-30
DK2534149T3 (da) 2015-01-05
EP2534149A1 (en) 2012-12-19
JP5922587B2 (ja) 2016-05-24
BR112012018904A2 (pt) 2020-09-01
PT2534149E (pt) 2014-12-23
CA2786973A1 (en) 2011-08-18
SMT201400196B (it) 2015-01-15
SG182471A1 (en) 2012-08-30
PL2534149T3 (pl) 2015-03-31
CA2786973C (en) 2018-04-10
KR20120135408A (ko) 2012-12-13
US20120308609A1 (en) 2012-12-06
US8703754B2 (en) 2014-04-22
RS53745B1 (en) 2015-06-30
SI2534149T1 (sl) 2015-02-27
KR101773541B1 (ko) 2017-08-31
CN102753553B (zh) 2016-03-30
HRP20141258T1 (hr) 2015-02-27
AU2011214468A1 (en) 2012-08-09
ZA201205995B (en) 2014-01-29
ME01926B (me) 2015-05-20
WO2011098452A1 (en) 2011-08-18
AU2011214468B2 (en) 2015-05-28
CN102753553A (zh) 2012-10-24
EP2534149B1 (en) 2014-10-15
IL220845A (en) 2016-08-31
MX2012009316A (es) 2012-09-12
EA021048B1 (ru) 2015-03-31

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Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU