EA201390755A1 - БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПРОИЗВОДСТВА - Google Patents
БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПРОИЗВОДСТВАInfo
- Publication number
- EA201390755A1 EA201390755A1 EA201390755A EA201390755A EA201390755A1 EA 201390755 A1 EA201390755 A1 EA 201390755A1 EA 201390755 A EA201390755 A EA 201390755A EA 201390755 A EA201390755 A EA 201390755A EA 201390755 A1 EA201390755 A1 EA 201390755A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pi3k
- methods
- petroxazepins
- manufacture
- mtor inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к ингибиторам PI3K и mTOR и их фармацевтически приемлемым солям или сольватам, а также способам их применения, в которых используются ингибиторы структурной формулы Iи их фармацевтически приемлемые соли, где переменные имеют значения, определенные в описании.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41714210P | 2010-11-24 | 2010-11-24 | |
PCT/US2011/062029 WO2012074869A1 (en) | 2010-11-24 | 2011-11-23 | Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201390755A1 true EA201390755A1 (ru) | 2013-11-29 |
Family
ID=45217715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390755A EA201390755A1 (ru) | 2010-11-24 | 2011-11-23 | БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПРОИЗВОДСТВА |
Country Status (11)
Country | Link |
---|---|
US (1) | US20140005172A1 (ru) |
EP (1) | EP2643319A1 (ru) |
JP (1) | JP2013544827A (ru) |
KR (1) | KR20140000706A (ru) |
CN (1) | CN103402999A (ru) |
AU (1) | AU2011336882A1 (ru) |
CA (1) | CA2818882A1 (ru) |
EA (1) | EA201390755A1 (ru) |
MX (1) | MX2013005819A (ru) |
WO (1) | WO2012074869A1 (ru) |
ZA (1) | ZA201303758B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011302196B2 (en) | 2010-09-14 | 2016-04-28 | Exelixis, Inc. | Inhibitors of PI3K-delta and methods of their use and manufacture |
AU2012332486A1 (en) | 2011-11-01 | 2014-06-19 | Arthur Decillis | N- (3- { [ (3- { [2-chloro-5- (methoxy) phenyl] amino} quinoxalin- 2 -yl) amino] sulfonyl} phe nyl) - 2 -methylalaninamide as phosphatidylinositol 3 - kinase inhibitor for the treatment of lymphoproliferative malignancies |
TWI597061B (zh) * | 2013-02-20 | 2017-09-01 | 國鼎生物科技股份有限公司 | 治療白血病之方法及組成物 |
PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
WO2020124397A1 (en) * | 2018-12-19 | 2020-06-25 | Inventisbio Shanghai Ltd. | C-terminal src kinase inhibitors |
CN118201896A (zh) * | 2021-09-10 | 2024-06-14 | 传达治疗有限公司 | PI3K-α抑制剂和其使用方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8044062B2 (en) * | 2005-10-07 | 2011-10-25 | Exelixis, Inc. | Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha |
EP2123644B1 (en) * | 2007-03-07 | 2014-12-17 | Takeda Pharmaceutical Company Limited | Benzoxazepine derivatives and use thereof |
WO2010118208A1 (en) * | 2009-04-09 | 2010-10-14 | Exelixis, Inc. | Benzoxazepin-4- (5h) -yl derivatives and their use to treat cancer |
KR20120034666A (ko) * | 2009-05-22 | 2012-04-12 | 엑셀리시스, 인코포레이티드 | 증식성 질환에 대한 벤족사제핀 기반 p13k/mt0r의 억제제 |
WO2010135568A1 (en) * | 2009-05-22 | 2010-11-25 | Exelixis, Inc. | Benzoxazepines as inhibitors of mtor and their use to treat cancer |
AU2010254200A1 (en) * | 2009-05-26 | 2011-12-08 | Exelixis, Inc. | Benzoxazepines as inhibitors of PI3K/m TOR and methods of their use and manufacture |
CN103459384A (zh) * | 2010-11-24 | 2013-12-18 | 埃克塞里艾克西斯公司 | 作为PI3K/mTOR抑制剂的苯并氧氮杂环庚三烯以及它们使用和制造方法 |
-
2011
- 2011-11-23 US US13/989,330 patent/US20140005172A1/en not_active Abandoned
- 2011-11-23 EA EA201390755A patent/EA201390755A1/ru unknown
- 2011-11-23 KR KR1020137016285A patent/KR20140000706A/ko not_active Application Discontinuation
- 2011-11-23 CN CN2011800658608A patent/CN103402999A/zh active Pending
- 2011-11-23 WO PCT/US2011/062029 patent/WO2012074869A1/en active Application Filing
- 2011-11-23 AU AU2011336882A patent/AU2011336882A1/en not_active Abandoned
- 2011-11-23 MX MX2013005819A patent/MX2013005819A/es not_active Application Discontinuation
- 2011-11-23 EP EP11793623.7A patent/EP2643319A1/en not_active Withdrawn
- 2011-11-23 JP JP2013541041A patent/JP2013544827A/ja active Pending
- 2011-11-23 CA CA2818882A patent/CA2818882A1/en not_active Abandoned
-
2013
- 2013-05-23 ZA ZA2013/03758A patent/ZA201303758B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2643319A1 (en) | 2013-10-02 |
MX2013005819A (es) | 2013-08-27 |
WO2012074869A1 (en) | 2012-06-07 |
US20140005172A1 (en) | 2014-01-02 |
CN103402999A (zh) | 2013-11-20 |
AU2011336882A1 (en) | 2013-06-20 |
JP2013544827A (ja) | 2013-12-19 |
KR20140000706A (ko) | 2014-01-03 |
ZA201303758B (en) | 2014-04-30 |
WO2012074869A8 (en) | 2013-07-18 |
CA2818882A1 (en) | 2012-06-07 |
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