ME01926B - 6-am in0-2-{[(1s)-1-meti lbuti l]oksi }-9-[5-(1-piperidinil) pentil]-7,9-di hidro-8h- purin-8-0n maleat - Google Patents

6-am in0-2-{[(1s)-1-meti lbuti l]oksi }-9-[5-(1-piperidinil) pentil]-7,9-di hidro-8h- purin-8-0n maleat

Info

Publication number
ME01926B
ME01926B MEP-2014-154A MEP15414A ME01926B ME 01926 B ME01926 B ME 01926B ME P15414 A MEP15414 A ME P15414A ME 01926 B ME01926 B ME 01926B
Authority
ME
Montenegro
Prior art keywords
compound
dihydro
oxy
pentyl
purin
Prior art date
Application number
MEP-2014-154A
Other languages
English (en)
Inventor
Robert Hermann Gibbon
Amanda Lucas
Stephen Andrew Hermitage
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of ME01926B publication Critical patent/ME01926B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Claims (13)

1. Jedinjenje koje je 6-amino-2-{[(1S)-1-metllbutll]oksi}-9-[5-(1-piperidinil)pentil]-7, 9-dihidro-8H-purin-8-on: u obliku maleatnesoli.
2. Jedinjenje koje je 6-amino-2-{[(1S)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7, 9-dihidro-8H-purin-8-on u obliku maleatne soli za upotrebu u lečenju.
3. Jedinjenje koje je 6-amino-2-{[(1S)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7, 9-dihidro-8H-purin-8-on uobliku maleatne soli za upotrebu u lečenju alergijskih bolesti i drugih inflamatornih stanja, infektivnih bolesti i kancera.
4.    Jedinjenje za upotrebu prema zahtevu 3, što je inflamatorna ili alergijska bolest alergijski rinitis.
5.    Jedinjenje za upotrebu prema zahtevu 3, stoje inflamatorna ili alergijska bolest astma.
6.    Adjuvant za vakcinu koji obuhvata jedinjenje koje je 6-amino-2-{[(1S)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7, 9-dihidro-8H-purin-8-on u obliku maleatne soli.
7. Imunogena kompozicija koja sadrži antigen ili kompoziciju antigena i jedinjenje koje je 6-amino-2-{[(1S)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7; 9-dihidro-8H-purin-8-on u obliku maleatne soli.
8.    Kompozicija vakcine koja sadrži antigen ili kompoziciju antigena i jedinjenje koje je 6-amino-2-{[(1S)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7, 9-dihidro-8H-purin-8-on u obliku maleatne soli.
9.    Upotreba jedinjenja koje je 6-amino-2-{[(1S)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7, 9-dihidro-8H-purin-8-on u obliku maleatne soli za proizvodnju leka za lečenje alergijskih bolesti i drugih inflamatornih stanja, infektivnih bolesti i kancera.
10.    Upotreba jedinjenje prema patentnom zahtevu 9, što je inflamatorna ili alergijska bolest alergijski rinitis.
11.    Upotreba jedinjenja prema patentnom zahtevu 9, što je inflamatorna ili alergijska bolest astma.
12.    Farmaceutska kompozicija koja sadrži jedinjenje koje je 6-amino-2-{[(1S)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7, 9-dihidro-8H-purin-8-on u obliku maleatne soli i jedan ili više farmaceutski prihvatljivih razblaživača ili nosača.
13.    Farmaceutska kompozicija prema zahtevu 12 koja se daje intranazalno ili inhalacijom.
MEP-2014-154A 2010-02-10 2011-02-08 6-am in0-2-{[(1s)-1-meti lbuti l]oksi }-9-[5-(1-piperidinil) pentil]-7,9-di hidro-8h- purin-8-0n maleat ME01926B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30301010P 2010-02-10 2010-02-10
EP11709025.8A EP2534149B1 (en) 2010-02-10 2011-02-08 6-amino-2-{[(1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-one maleate
PCT/EP2011/051830 WO2011098452A1 (en) 2010-02-10 2011-02-08 6-amino-2-{ [ (1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate

Publications (1)

Publication Number Publication Date
ME01926B true ME01926B (me) 2015-05-20

Family

ID=43836817

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2014-154A ME01926B (me) 2010-02-10 2011-02-08 6-am in0-2-{[(1s)-1-meti lbuti l]oksi }-9-[5-(1-piperidinil) pentil]-7,9-di hidro-8h- purin-8-0n maleat

Country Status (23)

Country Link
US (1) US8703754B2 (me)
EP (1) EP2534149B1 (me)
JP (1) JP5922587B2 (me)
KR (1) KR101773541B1 (me)
CN (1) CN102753553B (me)
AU (1) AU2011214468B2 (me)
BR (1) BR112012018904A2 (me)
CA (1) CA2786973C (me)
DK (1) DK2534149T3 (me)
EA (1) EA021048B1 (me)
ES (1) ES2525826T3 (me)
HR (1) HRP20141258T1 (me)
IL (1) IL220845A (me)
ME (1) ME01926B (me)
MX (1) MX2012009316A (me)
PL (1) PL2534149T3 (me)
PT (1) PT2534149E (me)
RS (1) RS53745B1 (me)
SG (1) SG182471A1 (me)
SI (1) SI2534149T1 (me)
SM (1) SMT201400196B (me)
WO (1) WO2011098452A1 (me)
ZA (1) ZA201205995B (me)

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Also Published As

Publication number Publication date
CA2786973C (en) 2018-04-10
WO2011098452A1 (en) 2011-08-18
AU2011214468B2 (en) 2015-05-28
US20120308609A1 (en) 2012-12-06
EP2534149A1 (en) 2012-12-19
IL220845A (en) 2016-08-31
KR20120135408A (ko) 2012-12-13
DK2534149T3 (da) 2015-01-05
SG182471A1 (en) 2012-08-30
CN102753553A (zh) 2012-10-24
ES2525826T3 (es) 2014-12-30
EA201290631A1 (ru) 2013-03-29
CN102753553B (zh) 2016-03-30
PL2534149T3 (pl) 2015-03-31
HRP20141258T1 (hr) 2015-02-27
SMT201400196B (it) 2015-01-15
SI2534149T1 (sl) 2015-02-27
AU2011214468A1 (en) 2012-08-09
PT2534149E (pt) 2014-12-23
KR101773541B1 (ko) 2017-08-31
JP5922587B2 (ja) 2016-05-24
RS53745B1 (sr) 2015-06-30
BR112012018904A2 (pt) 2020-09-01
US8703754B2 (en) 2014-04-22
MX2012009316A (es) 2012-09-12
EP2534149B1 (en) 2014-10-15
JP2013519645A (ja) 2013-05-30
CA2786973A1 (en) 2011-08-18
ZA201205995B (en) 2014-01-29
EA021048B1 (ru) 2015-03-31

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