EA200600886A1 - Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции - Google Patents

Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции

Info

Publication number
EA200600886A1
EA200600886A1 EA200600886A EA200600886A EA200600886A1 EA 200600886 A1 EA200600886 A1 EA 200600886A1 EA 200600886 A EA200600886 A EA 200600886A EA 200600886 A EA200600886 A EA 200600886A EA 200600886 A1 EA200600886 A1 EA 200600886A1
Authority
EA
Eurasian Patent Office
Prior art keywords
salts
thiotropy
obtaining
dosage compositions
tiotropium
Prior art date
Application number
EA200600886A
Other languages
English (en)
Other versions
EA012326B1 (ru
Inventor
Рольф Банхольцер
Вальдемар Пфренгле
Петер Зигер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200600886(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200600886A1 publication Critical patent/EA200600886A1/ru
Publication of EA012326B1 publication Critical patent/EA012326B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны способ получения новых солей тиотропия формулы (I)в которой Х обозначает анион, эти новые соли тиотропия как таковые, содержащие их лекарственные композиции, а также их применение для получения лекарственного средства, предназначенного для лечения заболеваний дыхательных путей, прежде всего для лечения хронического обструктивного заболевания легких и астмы.
EA200600886A 2003-11-03 2004-10-29 Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции EA012326B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
PCT/EP2004/012268 WO2005042526A1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend

Publications (2)

Publication Number Publication Date
EA200600886A1 true EA200600886A1 (ru) 2006-10-27
EA012326B1 EA012326B1 (ru) 2009-08-28

Family

ID=34530660

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600886A EA012326B1 (ru) 2003-11-03 2004-10-29 Способ получения солей тиотропия, соли тиотропия, а также содержащие их лекарственные композиции

Country Status (35)

Country Link
US (1) US8686148B2 (ru)
EP (3) EP2067779B9 (ru)
JP (1) JP5165244B2 (ru)
KR (1) KR20060117334A (ru)
CN (3) CN101407514B (ru)
AR (1) AR046317A1 (ru)
AT (1) ATE460414T1 (ru)
AU (1) AU2004285683C1 (ru)
BR (1) BRPI0416136A (ru)
CA (1) CA2544348A1 (ru)
CO (1) CO5690553A2 (ru)
CY (2) CY1110048T1 (ru)
DE (1) DE502004010885D1 (ru)
DK (2) DK2067779T3 (ru)
EA (1) EA012326B1 (ru)
ES (2) ES2422729T3 (ru)
HK (3) HK1099748A1 (ru)
HR (1) HRP20100149T1 (ru)
IL (1) IL175023A (ru)
ME (1) ME00361B (ru)
MX (1) MXPA06004697A (ru)
MY (1) MY143364A (ru)
NO (1) NO335814B1 (ru)
NZ (1) NZ547276A (ru)
PE (1) PE20050446A1 (ru)
PL (2) PL2067779T3 (ru)
PT (2) PT1682541E (ru)
RS (2) RS51758B (ru)
SG (1) SG137859A1 (ru)
SI (2) SI1682541T1 (ru)
TW (2) TWI363758B (ru)
UA (1) UA82413C2 (ru)
UY (1) UY28590A1 (ru)
WO (1) WO2005042526A1 (ru)
ZA (1) ZA200602342B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2067779T3 (pl) 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
KR20060102561A (ko) * 2003-11-03 2006-09-27 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로피움염, 이의 제조 방법 및 이를 함유하는약제학적 제형
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
NZ583872A (en) * 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
DK1869035T4 (en) * 2005-12-19 2015-11-16 Sicor Inc HIS UNKNOWN CRYSTALLIC FORM OF THIOTROPIUM BROMIDE AND PROCEDURE FOR PREPARING THEREOF
ME01205B (me) * 2006-01-04 2013-03-20 Boehringer Ingelheim Int Upotreba soli tiotropijuma u liječenju umjerene trajne astme
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) * 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2597329A (en) 1947-08-06 1952-05-20 Merck & Co Inc Process for anion exchange of thiamin salts
US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
JPS6165885A (ja) 1984-09-07 1986-04-04 Tanabe Seiyaku Co Ltd 新規合成中間体及びその製法
NO166268C (no) 1985-07-30 1991-07-03 Glaxo Group Ltd Innretning for administrering av medikamenter til pasienter.
US5610163A (en) 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JP3302647B2 (ja) 1992-04-24 2002-07-15 小野薬品工業株式会社 フェニルアルカン酸エステルの塩酸塩、およびその製造方法
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) 1999-12-27 2007-12-19 和光純薬工業株式会社 スルホニウム塩化合物
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
RS50218B (sr) 2000-10-12 2009-07-15 Boehringer Ingelheim Pharma Gmbh. & Co.Kg., Kristalni monohidrat, postupak za njegovo pripremanje i njegova primena za pripremanje leka
DZ3477A1 (ru) 2000-10-12 2002-04-18
US20020137764A1 (en) 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193393A1 (en) 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20020183292A1 (en) 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
BRPI0115076B8 (pt) * 2000-10-31 2021-05-25 Boehringer Ingelheim Pharma preparação farmacêutica, sua aplicação farmacêutica, bem como processo para preparação da mesma
US20020111363A1 (en) 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193392A1 (en) 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
DE10061877A1 (de) 2000-12-12 2002-06-13 Basf Ag Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de) 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
DE10111843A1 (de) 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20020193394A1 (en) 2001-03-13 2002-12-19 Bernd Disse Compounds for treating inflammatory diseases
US20030070679A1 (en) 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6919325B2 (en) 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
WO2003068233A1 (en) 2002-02-11 2003-08-21 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
GB0203193D0 (en) 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
CA2479919C (en) 2002-04-04 2011-05-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations suitable for inhalation
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
DE10216036A1 (de) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
US6908055B2 (en) 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
PL2067779T3 (pl) 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
KR20060102561A (ko) 2003-11-03 2006-09-27 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로피움염, 이의 제조 방법 및 이를 함유하는약제학적 제형
SE0303270L (sv) 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
NZ583872A (en) 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
DE502004010885D1 (de) 2010-04-22
ZA200602342B (en) 2007-06-27
DK1682541T3 (da) 2010-06-28
SG137859A1 (en) 2007-12-28
EP2067779A1 (de) 2009-06-10
MY143364A (en) 2011-04-29
HK1129111A1 (en) 2009-11-20
MEP51308A (en) 2011-05-10
JP5165244B2 (ja) 2013-03-21
RS51758B (en) 2011-12-31
TW200526653A (en) 2005-08-16
ES2342468T3 (es) 2010-07-07
ATE460414T1 (de) 2010-03-15
NO335814B1 (no) 2015-02-23
BRPI0416136A (pt) 2007-01-02
HRP20100149T1 (hr) 2010-04-30
PT1682541E (pt) 2010-04-14
CN102070630A (zh) 2011-05-25
SI1682541T1 (sl) 2010-06-30
PL1682541T3 (pl) 2010-08-31
CO5690553A2 (es) 2006-10-31
CY1114157T1 (el) 2016-08-31
AU2004285683B2 (en) 2011-04-21
EP2336126A1 (de) 2011-06-22
AU2004285683C1 (en) 2011-09-08
PL2067779T3 (pl) 2013-09-30
ES2422729T3 (es) 2013-09-13
SI2067779T1 (sl) 2013-08-30
HK1099748A1 (en) 2007-08-24
CN101407514B (zh) 2013-05-29
EA012326B1 (ru) 2009-08-28
EP2067779B1 (de) 2013-04-24
CN1882582A (zh) 2006-12-20
UA82413C2 (ru) 2008-04-10
IL175023A (en) 2011-02-28
WO2005042526A1 (de) 2005-05-12
PT2067779E (pt) 2013-07-25
TWI363758B (en) 2012-05-11
RS20060292A (en) 2008-08-07
NZ547276A (en) 2009-08-28
TWI435876B (zh) 2014-05-01
NO20061440L (no) 2006-07-12
AR046317A1 (es) 2005-11-30
CY1110048T1 (el) 2015-01-14
MXPA06004697A (es) 2006-07-05
JP2007509893A (ja) 2007-04-19
EP1682541B1 (de) 2010-03-10
CN102070630B (zh) 2013-04-17
UY28590A1 (es) 2005-06-30
ME00361B (me) 2011-10-10
EP2067779B9 (de) 2013-10-16
CN100549010C (zh) 2009-10-14
US20050131007A1 (en) 2005-06-16
CN101407514A (zh) 2009-04-15
IL175023A0 (en) 2006-08-20
EP1682541A1 (de) 2006-07-26
TW201231465A (en) 2012-08-01
PE20050446A1 (es) 2005-08-02
HK1153409A1 (en) 2012-03-30
AU2004285683A1 (en) 2005-05-12
US8686148B2 (en) 2014-04-01
CA2544348A1 (en) 2005-05-12
DK2067779T3 (da) 2013-07-29
KR20060117334A (ko) 2006-11-16

Similar Documents

Publication Publication Date Title
EA200500902A1 (ru) Порошковые лекарственные средства, содержащие соль тиотропия и ксинафоат салметерола
EA200200551A1 (ru) Новые содержащие тиотропий порошки для ингаляции
DE602005026007D1 (de) Opioide zur behandlung von chronisch-obstruktiver lungenerkrankung (copd)
EA200602016A1 (ru) ПОРОШКОВЫЕ КОМПОЗИЦИИ ДЛЯ ИНГАЛЯЦИИ, СОДЕРЖАЩИЕ ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ
ATE330589T1 (de) Pharmazeutische zusammensetzung enthaltend resveratrol zur behandlung von entzündlichen erkrankungen der atemwege
EA200500715A1 (ru) Новые лекарственные средства для лечения хронического обструктивного заболевания лёгких
CY1114157T1 (el) Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν
ATE369353T1 (de) Medizinisch verwendbare arylethanolamin verbindungen
EA200401005A1 (ru) Дозированные ингаляторы под давлением, содержащие растворы бета-2-агонистов
EA200600854A1 (ru) Новые соли тиотропия, способ их получения, а также содержащие их лекарственные композиции
NO20032111L (no) Nye medikamentblandinger basert pa tiotropium-salter og pa salmeterol-salter
UA107578C2 (uk) Комбінована терапія при лікуванні діабету
NO20054767L (no) Sammensetninger omfattende apomorfin for inhalering i lunge
CY1106430T1 (el) Φαρμακα για εισπνοη που πepιλαμβανουν βηταμιμητικα και αντιχολινepγικο
EA200600853A1 (ru) Новый кристаллический ангидрат с антихолинергическим действием
RU2010120806A (ru) Композиции для ингаляции, содержащие кислоту монтелукаст и ингибитор pde-4 или ингаляционный кортикостероид
EA200500864A1 (ru) Новый, содержащий тиотропий порошковый препарат для ингаляции
MXPA04002401A (es) Nuevos medicamentos para inhalacion.
JP2009506029A5 (ru)
DK1494648T3 (da) Pulverpræparat til inhalation
RU2010154194A (ru) Эфиры n-алкилкарбониламинокислот и n-алкилкарбониламинолактоны и их применение
DK1581224T3 (da) Tiotropiumholdig lægemiddelsammensætning til inhalation
WO2005007134A8 (de) Pulverformulierungen für die inhalation enthaltend ein neues anticholinergikum
RU2006120506A (ru) Способ лечения псориаза у детей
CY1113392T1 (el) Νεες κρυσταλλικες μορφες του βρωμιουχου τιοτροπιου

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM