HK1099748A1 - Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same - Google Patents

Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same

Info

Publication number
HK1099748A1
HK1099748A1 HK07105532.7A HK07105532A HK1099748A1 HK 1099748 A1 HK1099748 A1 HK 1099748A1 HK 07105532 A HK07105532 A HK 07105532A HK 1099748 A1 HK1099748 A1 HK 1099748A1
Authority
HK
Hong Kong
Prior art keywords
tiotropium salts
same
pharmaceutical formulations
producing
salts
Prior art date
Application number
HK07105532.7A
Other languages
English (en)
Inventor
Rolf Banholzer
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1099748(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of HK1099748A1 publication Critical patent/HK1099748A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK07105532.7A 2003-11-03 2007-05-25 Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same HK1099748A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
PCT/EP2004/012268 WO2005042526A1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend

Publications (1)

Publication Number Publication Date
HK1099748A1 true HK1099748A1 (en) 2007-08-24

Family

ID=34530660

Family Applications (3)

Application Number Title Priority Date Filing Date
HK09108607.9A HK1129111A1 (en) 2003-11-03 2007-05-25 Tiotropium salts, pharmaceutical formulations containing the salts and the use thereof
HK07105532.7A HK1099748A1 (en) 2003-11-03 2007-05-25 Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
HK11107748.7A HK1153409A1 (en) 2003-11-03 2011-07-26 Crystalline tiotropium iodide, the pharmaceutical formulation containing the same and the use thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK09108607.9A HK1129111A1 (en) 2003-11-03 2007-05-25 Tiotropium salts, pharmaceutical formulations containing the salts and the use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK11107748.7A HK1153409A1 (en) 2003-11-03 2011-07-26 Crystalline tiotropium iodide, the pharmaceutical formulation containing the same and the use thereof

Country Status (35)

Country Link
US (1) US8686148B2 (xx)
EP (3) EP1682541B1 (xx)
JP (1) JP5165244B2 (xx)
KR (1) KR20060117334A (xx)
CN (3) CN101407514B (xx)
AR (1) AR046317A1 (xx)
AT (1) ATE460414T1 (xx)
AU (1) AU2004285683C1 (xx)
BR (1) BRPI0416136A (xx)
CA (1) CA2544348A1 (xx)
CO (1) CO5690553A2 (xx)
CY (2) CY1110048T1 (xx)
DE (1) DE502004010885D1 (xx)
DK (2) DK2067779T3 (xx)
EA (1) EA012326B1 (xx)
ES (2) ES2422729T3 (xx)
HK (3) HK1129111A1 (xx)
HR (1) HRP20100149T1 (xx)
IL (1) IL175023A (xx)
ME (1) ME00361B (xx)
MX (1) MXPA06004697A (xx)
MY (1) MY143364A (xx)
NO (1) NO335814B1 (xx)
NZ (1) NZ547276A (xx)
PE (1) PE20050446A1 (xx)
PL (2) PL2067779T3 (xx)
PT (2) PT1682541E (xx)
RS (2) RS51758B (xx)
SG (1) SG137859A1 (xx)
SI (2) SI1682541T1 (xx)
TW (2) TWI435876B (xx)
UA (1) UA82413C2 (xx)
UY (1) UY28590A1 (xx)
WO (1) WO2005042526A1 (xx)
ZA (1) ZA200602342B (xx)

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PT1682541E (pt) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
PL2083007T3 (pl) * 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
EP2123650B1 (en) 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
CA2634984C (en) * 2006-01-04 2014-05-06 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of moderate persistent asthma
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

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PL2083007T3 (pl) * 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
PT1682541E (pt) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
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AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
RS20060292A (xx) 2008-08-07
UA82413C2 (uk) 2008-04-10
TWI363758B (en) 2012-05-11
CY1114157T1 (el) 2016-08-31
NO335814B1 (no) 2015-02-23
US8686148B2 (en) 2014-04-01
CN102070630B (zh) 2013-04-17
CN102070630A (zh) 2011-05-25
ES2422729T3 (es) 2013-09-13
HRP20100149T1 (hr) 2010-04-30
SI1682541T1 (sl) 2010-06-30
HK1129111A1 (en) 2009-11-20
EP2067779B1 (de) 2013-04-24
PT1682541E (pt) 2010-04-14
ME00361B (me) 2011-10-10
EP2067779B9 (de) 2013-10-16
EA200600886A1 (ru) 2006-10-27
CN101407514A (zh) 2009-04-15
MY143364A (en) 2011-04-29
PE20050446A1 (es) 2005-08-02
EP1682541B1 (de) 2010-03-10
ZA200602342B (en) 2007-06-27
DK1682541T3 (da) 2010-06-28
EA012326B1 (ru) 2009-08-28
SI2067779T1 (sl) 2013-08-30
HK1153409A1 (en) 2012-03-30
RS51758B (en) 2011-12-31
MXPA06004697A (es) 2006-07-05
NO20061440L (no) 2006-07-12
PL1682541T3 (pl) 2010-08-31
UY28590A1 (es) 2005-06-30
KR20060117334A (ko) 2006-11-16
AU2004285683B2 (en) 2011-04-21
AR046317A1 (es) 2005-11-30
IL175023A (en) 2011-02-28
CN1882582A (zh) 2006-12-20
EP1682541A1 (de) 2006-07-26
WO2005042526A1 (de) 2005-05-12
AU2004285683A1 (en) 2005-05-12
PL2067779T3 (pl) 2013-09-30
JP5165244B2 (ja) 2013-03-21
BRPI0416136A (pt) 2007-01-02
MEP51308A (en) 2011-05-10
IL175023A0 (en) 2006-08-20
NZ547276A (en) 2009-08-28
SG137859A1 (en) 2007-12-28
CO5690553A2 (es) 2006-10-31
EP2067779A1 (de) 2009-06-10
US20050131007A1 (en) 2005-06-16
TW200526653A (en) 2005-08-16
CY1110048T1 (el) 2015-01-14
JP2007509893A (ja) 2007-04-19
CN100549010C (zh) 2009-10-14
EP2336126A1 (de) 2011-06-22
TW201231465A (en) 2012-08-01
ES2342468T3 (es) 2010-07-07
CA2544348A1 (en) 2005-05-12
AU2004285683C1 (en) 2011-09-08
PT2067779E (pt) 2013-07-25
DE502004010885D1 (de) 2010-04-22
CN101407514B (zh) 2013-05-29
TWI435876B (zh) 2014-05-01
DK2067779T3 (da) 2013-07-29
ATE460414T1 (de) 2010-03-15

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