CY1110048T1 - Μεθοδος για την παραγωγη αλατων του τιοτροπιου - Google Patents

Μεθοδος για την παραγωγη αλατων του τιοτροπιου

Info

Publication number
CY1110048T1
CY1110048T1 CY20101100435T CY101100435T CY1110048T1 CY 1110048 T1 CY1110048 T1 CY 1110048T1 CY 20101100435 T CY20101100435 T CY 20101100435T CY 101100435 T CY101100435 T CY 101100435T CY 1110048 T1 CY1110048 T1 CY 1110048T1
Authority
CY
Cyprus
Prior art keywords
production
salts
tiotropio
treatment
tiotropium salts
Prior art date
Application number
CY20101100435T
Other languages
English (en)
Inventor
Rolf Banholzer
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110048(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of CY1110048T1 publication Critical patent/CY1110048T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αφορά μια μέθοδο για την παραγωγή νέων αλάτων του τιοτροπίου, όπου Χ σημαίνει ένα ανιόν, αυτά τα νέα άλατα του τιοτροπίου ως τέτοια, φαρμακευτικά σκευάσματα που τα περιέχουν, καθώς και τη χρήση τους για την παραγωγή ενός φαρμάκου για τη θεραπεία παθήσεων των αναπνευστικών οδών, ιδιαιτέρως για τη θεραπεία της ΧΑΠ (COPD = chronic obstructive pulmonary disease = χρόνιας αποφρακτικής πνευμονοπάθειας) και του άσθματος.
CY20101100435T 2003-11-03 2010-05-17 Μεθοδος για την παραγωγη αλατων του τιοτροπιου CY1110048T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
EP04791028A EP1682541B1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalzen

Publications (1)

Publication Number Publication Date
CY1110048T1 true CY1110048T1 (el) 2015-01-14

Family

ID=34530660

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20101100435T CY1110048T1 (el) 2003-11-03 2010-05-17 Μεθοδος για την παραγωγη αλατων του τιοτροπιου
CY20131100607T CY1114157T1 (el) 2003-11-03 2013-07-17 Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20131100607T CY1114157T1 (el) 2003-11-03 2013-07-17 Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν

Country Status (35)

Country Link
US (1) US8686148B2 (el)
EP (3) EP1682541B1 (el)
JP (1) JP5165244B2 (el)
KR (1) KR20060117334A (el)
CN (3) CN101407514B (el)
AR (1) AR046317A1 (el)
AT (1) ATE460414T1 (el)
AU (1) AU2004285683C1 (el)
BR (1) BRPI0416136A (el)
CA (1) CA2544348A1 (el)
CO (1) CO5690553A2 (el)
CY (2) CY1110048T1 (el)
DE (1) DE502004010885D1 (el)
DK (2) DK2067779T3 (el)
EA (1) EA012326B1 (el)
ES (2) ES2342468T3 (el)
HK (3) HK1129111A1 (el)
HR (1) HRP20100149T1 (el)
IL (1) IL175023A (el)
ME (1) ME00361B (el)
MX (1) MXPA06004697A (el)
MY (1) MY143364A (el)
NO (1) NO335814B1 (el)
NZ (1) NZ547276A (el)
PE (1) PE20050446A1 (el)
PL (2) PL1682541T3 (el)
PT (2) PT1682541E (el)
RS (2) RS20060292A (el)
SG (1) SG137859A1 (el)
SI (2) SI2067779T1 (el)
TW (2) TWI435876B (el)
UA (1) UA82413C2 (el)
UY (1) UY28590A1 (el)
WO (1) WO2005042526A1 (el)
ZA (1) ZA200602342B (el)

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US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
NZ583872A (en) * 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
ES2396978T5 (es) * 2005-12-19 2015-12-04 Sicor, Inc. Forma cristalina novedosa de bromuro de tiotropio y procedimiento para la preparación de la misma
EA015353B1 (ru) * 2006-01-04 2011-06-30 Бёрингер Ингельхайм Интернациональ Гмбх Применение солей тиотропия для лечения персистирующей астмы средней тяжести
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

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Also Published As

Publication number Publication date
US8686148B2 (en) 2014-04-01
CY1114157T1 (el) 2016-08-31
EP2067779B9 (de) 2013-10-16
ZA200602342B (en) 2007-06-27
CN102070630B (zh) 2013-04-17
UY28590A1 (es) 2005-06-30
JP2007509893A (ja) 2007-04-19
ME00361B (me) 2011-10-10
CA2544348A1 (en) 2005-05-12
JP5165244B2 (ja) 2013-03-21
SI1682541T1 (sl) 2010-06-30
HRP20100149T1 (hr) 2010-04-30
CN1882582A (zh) 2006-12-20
HK1153409A1 (en) 2012-03-30
CN102070630A (zh) 2011-05-25
RS51758B (en) 2011-12-31
TW200526653A (en) 2005-08-16
PL1682541T3 (pl) 2010-08-31
AU2004285683C1 (en) 2011-09-08
AU2004285683A1 (en) 2005-05-12
ES2342468T3 (es) 2010-07-07
AU2004285683B2 (en) 2011-04-21
ATE460414T1 (de) 2010-03-15
WO2005042526A1 (de) 2005-05-12
HK1129111A1 (en) 2009-11-20
DK1682541T3 (da) 2010-06-28
EP1682541B1 (de) 2010-03-10
IL175023A0 (en) 2006-08-20
TWI363758B (en) 2012-05-11
NO20061440L (no) 2006-07-12
NO335814B1 (no) 2015-02-23
EP2067779B1 (de) 2013-04-24
PL2067779T3 (pl) 2013-09-30
HK1099748A1 (en) 2007-08-24
IL175023A (en) 2011-02-28
TW201231465A (en) 2012-08-01
ES2422729T3 (es) 2013-09-13
CN101407514A (zh) 2009-04-15
UA82413C2 (uk) 2008-04-10
EP2336126A1 (de) 2011-06-22
RS20060292A (en) 2008-08-07
EP1682541A1 (de) 2006-07-26
BRPI0416136A (pt) 2007-01-02
PE20050446A1 (es) 2005-08-02
PT1682541E (pt) 2010-04-14
DK2067779T3 (da) 2013-07-29
US20050131007A1 (en) 2005-06-16
EA012326B1 (ru) 2009-08-28
MEP51308A (en) 2011-05-10
AR046317A1 (es) 2005-11-30
CN101407514B (zh) 2013-05-29
PT2067779E (pt) 2013-07-25
EP2067779A1 (de) 2009-06-10
SG137859A1 (en) 2007-12-28
TWI435876B (zh) 2014-05-01
CO5690553A2 (es) 2006-10-31
CN100549010C (zh) 2009-10-14
NZ547276A (en) 2009-08-28
SI2067779T1 (sl) 2013-08-30
KR20060117334A (ko) 2006-11-16
EA200600886A1 (ru) 2006-10-27
MY143364A (en) 2011-04-29
DE502004010885D1 (de) 2010-04-22
MXPA06004697A (es) 2006-07-05

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