UY28590A1 - Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen. - Google Patents

Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.

Info

Publication number
UY28590A1
UY28590A1 UY28590A UY28590A UY28590A1 UY 28590 A1 UY28590 A1 UY 28590A1 UY 28590 A UY28590 A UY 28590A UY 28590 A UY28590 A UY 28590A UY 28590 A1 UY28590 A1 UY 28590A1
Authority
UY
Uruguay
Prior art keywords
tiotropio
new salts
preparation
well
formulations containing
Prior art date
Application number
UY28590A
Other languages
English (en)
Inventor
Dr Peter Sieger
Dr Rolf Banholzer
Dr Waldemar Pfrengle
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28590(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UY28590A1 publication Critical patent/UY28590A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Abstract

El invento se refiere a un procedimiento para la preparación de nuevas sales de tiotropio, a estas nuevas sales de tiotropio como tales, a las formulaciones medicamentosas que las contienen, así como a su utilización para la preparación de un medicamento para el tratamiento de enfermedades de las vías respiratorias, especialmente para el tratamietno de COPD (chronic obstructive pulmonary disease= enfermedades pulmonares crónicas obstructivas) y asma.
UY28590A 2003-11-03 2004-10-29 Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen. UY28590A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03

Publications (1)

Publication Number Publication Date
UY28590A1 true UY28590A1 (es) 2005-06-30

Family

ID=34530660

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28590A UY28590A1 (es) 2003-11-03 2004-10-29 Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.

Country Status (35)

Country Link
US (1) US8686148B2 (es)
EP (3) EP1682541B1 (es)
JP (1) JP5165244B2 (es)
KR (1) KR20060117334A (es)
CN (3) CN101407514B (es)
AR (1) AR046317A1 (es)
AT (1) ATE460414T1 (es)
AU (1) AU2004285683C1 (es)
BR (1) BRPI0416136A (es)
CA (1) CA2544348A1 (es)
CO (1) CO5690553A2 (es)
CY (2) CY1110048T1 (es)
DE (1) DE502004010885D1 (es)
DK (2) DK2067779T3 (es)
EA (1) EA012326B1 (es)
ES (2) ES2422729T3 (es)
HK (3) HK1129111A1 (es)
HR (1) HRP20100149T1 (es)
IL (1) IL175023A (es)
ME (1) ME00361B (es)
MX (1) MXPA06004697A (es)
MY (1) MY143364A (es)
NO (1) NO335814B1 (es)
NZ (1) NZ547276A (es)
PE (1) PE20050446A1 (es)
PL (2) PL2067779T3 (es)
PT (2) PT1682541E (es)
RS (2) RS51758B (es)
SG (1) SG137859A1 (es)
SI (2) SI1682541T1 (es)
TW (2) TWI435876B (es)
UA (1) UA82413C2 (es)
UY (1) UY28590A1 (es)
WO (1) WO2005042526A1 (es)
ZA (1) ZA200602342B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1682541E (pt) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
PL2083007T3 (pl) * 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
EP2123650B1 (en) 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
CA2634984C (en) * 2006-01-04 2014-05-06 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of moderate persistent asthma
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2597329A (en) * 1947-08-06 1952-05-20 Merck & Co Inc Process for anion exchange of thiamin salts
US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
JPS6165885A (ja) 1984-09-07 1986-04-04 Tanabe Seiyaku Co Ltd 新規合成中間体及びその製法
FI88112C (fi) 1985-07-30 1993-04-13 Glaxo Group Ltd Anordning foer administrering av laekemedel till patienter
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JP3302647B2 (ja) 1992-04-24 2002-07-15 小野薬品工業株式会社 フェニルアルカン酸エステルの塩酸塩、およびその製造方法
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) 1999-12-27 2007-12-19 和光純薬工業株式会社 スルホニウム塩化合物
ES2227268T3 (es) * 2000-10-12 2005-04-01 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO.KG Nuevos polvos para inhalacion con contenido en tiotropio.
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
TR200402579T4 (tr) 2000-10-12 2004-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
EA007604B1 (ru) * 2000-10-31 2006-12-29 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг Ингаляционная композиция в виде раствора с солью тиотропия
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193393A1 (en) * 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
DE10061877A1 (de) 2000-12-12 2002-06-13 Basf Ag Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20020193394A1 (en) * 2001-03-13 2002-12-19 Bernd Disse Compounds for treating inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
AU2003201745A1 (en) 2002-02-11 2003-09-04 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
GB0203193D0 (en) 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
WO2003084509A1 (en) 2002-04-04 2003-10-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations suitable for inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
DE10216036A1 (de) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
US6908055B2 (en) * 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
PL2083007T3 (pl) * 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
PT1682541E (pt) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
RS20060292A (en) 2008-08-07
UA82413C2 (uk) 2008-04-10
TWI363758B (en) 2012-05-11
CY1114157T1 (el) 2016-08-31
NO335814B1 (no) 2015-02-23
US8686148B2 (en) 2014-04-01
CN102070630B (zh) 2013-04-17
CN102070630A (zh) 2011-05-25
ES2422729T3 (es) 2013-09-13
HRP20100149T1 (hr) 2010-04-30
SI1682541T1 (sl) 2010-06-30
HK1129111A1 (en) 2009-11-20
EP2067779B1 (de) 2013-04-24
PT1682541E (pt) 2010-04-14
ME00361B (me) 2011-10-10
EP2067779B9 (de) 2013-10-16
EA200600886A1 (ru) 2006-10-27
CN101407514A (zh) 2009-04-15
MY143364A (en) 2011-04-29
PE20050446A1 (es) 2005-08-02
EP1682541B1 (de) 2010-03-10
ZA200602342B (en) 2007-06-27
DK1682541T3 (da) 2010-06-28
EA012326B1 (ru) 2009-08-28
SI2067779T1 (sl) 2013-08-30
HK1153409A1 (en) 2012-03-30
RS51758B (en) 2011-12-31
MXPA06004697A (es) 2006-07-05
NO20061440L (no) 2006-07-12
PL1682541T3 (pl) 2010-08-31
KR20060117334A (ko) 2006-11-16
AU2004285683B2 (en) 2011-04-21
AR046317A1 (es) 2005-11-30
IL175023A (en) 2011-02-28
CN1882582A (zh) 2006-12-20
EP1682541A1 (de) 2006-07-26
WO2005042526A1 (de) 2005-05-12
AU2004285683A1 (en) 2005-05-12
PL2067779T3 (pl) 2013-09-30
JP5165244B2 (ja) 2013-03-21
BRPI0416136A (pt) 2007-01-02
MEP51308A (en) 2011-05-10
IL175023A0 (en) 2006-08-20
NZ547276A (en) 2009-08-28
SG137859A1 (en) 2007-12-28
CO5690553A2 (es) 2006-10-31
HK1099748A1 (en) 2007-08-24
EP2067779A1 (de) 2009-06-10
US20050131007A1 (en) 2005-06-16
TW200526653A (en) 2005-08-16
CY1110048T1 (el) 2015-01-14
JP2007509893A (ja) 2007-04-19
CN100549010C (zh) 2009-10-14
EP2336126A1 (de) 2011-06-22
TW201231465A (en) 2012-08-01
ES2342468T3 (es) 2010-07-07
CA2544348A1 (en) 2005-05-12
AU2004285683C1 (en) 2011-09-08
PT2067779E (pt) 2013-07-25
DE502004010885D1 (de) 2010-04-22
CN101407514B (zh) 2013-05-29
TWI435876B (zh) 2014-05-01
DK2067779T3 (da) 2013-07-29
ATE460414T1 (de) 2010-03-15

Similar Documents

Publication Publication Date Title
ECSP066545A (es) Procedimiento para la preparación de sales de tiotropio, sales de tiotropio, así como formulaciones medicamentosas que las contienen
ECSP024268A (es) Nuevos polvos para inhalacion que contienen tiotropio
ECSP055855A (es) Medicamentos en polvo para inhalación que contiene una sal de tiotropio y salmeterolxinafoato
ECSP034571A (es) Nuevas composiciones de medicamentos a base de sales de tiotropio y sales del salmeterol
UY31235A1 (es) Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente
MEP30108A (en) Formoterol superfine formulation
CY1114157T1 (el) Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν
PH12017502087A1 (en) Tiotropium inhalation solution for nebulization
ATE302774T1 (de) Arzneimittel enthaltend betamimetika und ein neues anticholinergikum
ECSP055821A (es) Nueva formulacion pulverulenta que contiene tiotropio destinado a la inhalación
EA201201397A1 (ru) Ингалятор, содержащий расслаиваемую блистерную упаковку
EA201201391A1 (ru) Ингалятор
EA201171087A1 (ru) СПОСОБЫ ВВЕДЕНИЯ (4aR,10aR)-1-н-ПРОПИЛ-1,2,3,4,4a,5,10,10a-ОКТАГИДРОБЕНЗО[g]ХИНОЛИН-6,7-ДИОЛА И РОДСТВЕННЫХ СОЕДИНЕНИЙ ЧЕРЕЗ СЛИЗИСТУЮ ОБОЛОЧКУ ПОЛОСТИ РТА, СЛИЗИСТУЮ ОБОЛОЧКУ НОСА ИЛИ КОЖУ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ
EA201201393A1 (ru) Ингалятор, разработанный для доставки лекарственного средства в виде сухого порошка
ECSP045355A (es) Medicamento que contiene esteroides y un nuevo anticolinérgico
BR0308984A (pt) Formulações em pó adequadas para inalação
ECSP045357A (es) Medicamento que contiene betamiméticos y un nuevo anticolerígeno
BRPI0415685A (pt) sais de tiotrópio, processos para sua produção, bem como formulações de medicamentos contendo os mesmos
MX2014001940A (es) Producto farmaceutico de aerosol para administracion por inhalacion oral o nasal.
UY27686A1 (es) Nuevas sales del ácido cinámico, procedimientos para su preparación y su utilización como medicamentos.

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20160617