ECSP024268A - Nuevos polvos para inhalacion que contienen tiotropio - Google Patents

Nuevos polvos para inhalacion que contienen tiotropio

Info

Publication number
ECSP024268A
ECSP024268A EC2002004268A ECSP024268A ECSP024268A EC SP024268 A ECSP024268 A EC SP024268A EC 2002004268 A EC2002004268 A EC 2002004268A EC SP024268 A ECSP024268 A EC SP024268A EC SP024268 A ECSP024268 A EC SP024268A
Authority
EC
Ecuador
Prior art keywords
tiotropy
new powder
inhalation containing
inhalation
preparation
Prior art date
Application number
EC2002004268A
Other languages
English (en)
Inventor
Michael Walz
Georg Boeck
Karoline Bechtold-Peters
Rolf Doerr
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP024268(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ECSP024268A publication Critical patent/ECSP024268A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

El invento se refiere a preparados en forma de polvo que contienen tiotropio para la inhalación, a procedimientos para su preparación, así como a su utilización para la preparación de un medicamento destinado al tratamiento de enfermedades de las vías respiratorias, particularmente para el tratamiento de la COPD (chronic obstructive pulmonary disease = enfermedad pulmonar obstructiva crónica) y del asma.
EC2002004268A 2000-10-12 2002-05-28 Nuevos polvos para inhalacion que contienen tiotropio ECSP024268A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050635 2000-10-12

Publications (1)

Publication Number Publication Date
ECSP024268A true ECSP024268A (es) 2002-08-01

Family

ID=7659578

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2002004268A ECSP024268A (es) 2000-10-12 2002-05-28 Nuevos polvos para inhalacion que contienen tiotropio
EC2003004546A ECSP034546A (es) 2000-10-12 2003-04-08 Procedimiento para la preparacion de formulaciones de polvos

Family Applications After (1)

Application Number Title Priority Date Filing Date
EC2003004546A ECSP034546A (es) 2000-10-12 2003-04-08 Procedimiento para la preparacion de formulaciones de polvos

Country Status (48)

Country Link
US (4) US7070800B2 (es)
EP (2) EP1292281B1 (es)
JP (1) JP3870159B2 (es)
KR (1) KR100488644B1 (es)
CN (1) CN1210017C (es)
AP (1) AP1712A (es)
AR (1) AR031819A1 (es)
AT (1) ATE275391T1 (es)
AU (1) AU757008B2 (es)
BG (1) BG65753B1 (es)
BR (1) BR0107304A (es)
CA (1) CA2395653C (es)
CR (1) CR6937A (es)
CU (1) CU23284B7 (es)
CZ (1) CZ301465B6 (es)
DE (1) DE50103551C5 (es)
DK (1) DK1292281T3 (es)
DZ (1) DZ3477A1 (es)
EA (1) EA004034B1 (es)
EC (2) ECSP024268A (es)
EE (1) EE04414B1 (es)
EG (1) EG24139A (es)
ES (1) ES2227268T3 (es)
GE (1) GEP20063865B (es)
HR (1) HRP20020437B1 (es)
HU (1) HU226982B1 (es)
IL (2) IL149984A0 (es)
IS (1) IS2360B (es)
MA (1) MA25843A1 (es)
ME (2) MEP40108A (es)
MX (1) MXPA02005666A (es)
MY (1) MY123544A (es)
NO (1) NO331956B1 (es)
NZ (1) NZ519406A (es)
OA (1) OA12522A (es)
PE (1) PE20020577A1 (es)
PL (1) PL200063B1 (es)
PT (1) PT1292281E (es)
RS (1) RS50197B (es)
SA (1) SA01220460B1 (es)
SI (1) SI1292281T1 (es)
SK (1) SK285389B6 (es)
TR (1) TR200402367T4 (es)
TW (1) TWI285553B (es)
UA (1) UA72014C2 (es)
UY (1) UY26959A1 (es)
WO (1) WO2002030389A1 (es)
ZA (1) ZA200204378B (es)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2395653C (en) 2000-10-12 2006-05-09 Boehringer Ingelheim Pharma Kg New inhalable powder containing tiotropium
EP1337239B2 (en) 2000-11-30 2015-11-25 Vectura Limited Particles for use in a pharmaceutical composition
EP2298285A3 (en) 2000-11-30 2011-07-27 Vectura Limited Method of making particles for use in a pharmaceutical composition
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20030008001A1 (en) * 2001-06-13 2003-01-09 Boehringer Ingelheim Pharma Kg Process for cleaning hard gelatine capsules
DE10128779A1 (de) * 2001-06-13 2003-01-02 Boehringer Ingelheim Pharma Verfahren zur Reinigung von Hartgelatinekapseln
DE10141376A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE60308497T2 (de) * 2002-04-04 2007-02-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverzubereitungen zur inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
CN101700247A (zh) * 2002-06-12 2010-05-05 埃匹吉尼斯医药有限公司 利用脱氢表雄酮甾体及抗毒蕈碱药物治疗呼吸道疾病及肺病的组合物、制剂和试剂盒
GB0219513D0 (en) 2002-08-21 2002-10-02 Norton Healthcare Ltd Inhalation compositions including coarse carrier
JP2006516531A (ja) * 2002-08-21 2006-07-06 ノートン ヘルスケアー リミテッド 吸入組成物
GB0219511D0 (en) * 2002-08-21 2002-10-02 Norton Healthcare Ltd Method of preparing dry powder inhalation compositions
US8273331B2 (en) * 2002-08-21 2012-09-25 Norton Healthcare Ltd. Inhalation compositions
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10255387A1 (de) * 2002-11-28 2004-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Tiotropium-haltige Pulverformulierung für die Inhalation
US20050058606A1 (en) * 2002-12-16 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing HFC solution formulations
US20040152720A1 (en) * 2002-12-20 2004-08-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powdered medicaments containing a tiotropium salt and salmeterol xinafoate
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
CA2528064C (en) 2003-06-13 2010-01-12 Advanced Inhalation Research, Inc. Low dose pharmaceutical powders for inhalation
TWI359675B (en) * 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
HRP20100149T1 (hr) * 2003-11-03 2010-04-30 Boehringer Ingelheim International Gmbh Postupak priprave tiotropijevih soli
ATE478071T1 (de) 2003-11-03 2010-09-15 Boehringer Ingelheim Int Verfahren zur herstellung neuer tiotropiumsalze
WO2005053647A1 (en) * 2003-12-03 2005-06-16 Microdrug Ag Medical product containing tiotropium
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
AU2004294890B2 (en) * 2003-12-03 2010-08-26 Boehringer Ingelheim International Gmbh Pre-metered dry powder inhaler for moisture-sensitive medicaments
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
EP3199164B1 (en) 2005-02-10 2020-03-18 Glaxo Group Limited Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
SI1881980T1 (sl) * 2005-05-02 2012-12-31 Boehringer Ingelheim International Gmbh Nove kristalinične oblike tiotropijevega bromida
CN101227905A (zh) * 2005-06-15 2008-07-23 贝林格尔·英格海姆国际有限公司 制备噻托铵盐的方法、噻托铵盐及其药物组合物
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
BRPI0608427A2 (pt) 2005-12-19 2009-12-29 Sicor Inc novas formas de brometo de tiotrópio e processos para seu preparo
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
CN101360744A (zh) * 2005-12-19 2009-02-04 西科尔公司 纯和稳定的噻托溴铵
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2009016133A1 (en) * 2007-07-27 2009-02-05 Cargill, Incorporated Micronization of polyols
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
CN102014779B (zh) 2008-05-09 2014-10-22 赫莱拉公司 用于治疗支气管树的系统、组件和方法
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
NZ595723A (en) 2009-03-17 2012-10-26 Daiichi Sankyo Co Ltd Amide derivative
CA2779135C (en) 2009-10-27 2018-09-04 Innovative Pulmonary Solutions, Inc. Delivery devices with coolable energy emitting assemblies
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
EP2575786B1 (en) * 2010-06-03 2017-11-15 Sima Patent ve Lisanslama Hizmetleri Ltd.Sti. Process for dry powder formulations
TR201007251A2 (tr) * 2010-09-01 2012-03-21 Bi̇lgi̇ç Mahmut Kalsiyum kanal blokörü formülasyonu.
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2014007773A1 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions comprising muscarinic receptor antagonist and sorbitol
WO2013127738A1 (de) 2012-02-28 2013-09-06 Boehringer Ingelheim International Gmbh Neue treibgashaltige tiotropium-formulierung
RU2522213C2 (ru) * 2012-06-07 2014-07-10 Шолекс Девелопмент Гмбх, Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащих в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
WO2014007781A2 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions
US10105316B2 (en) 2012-07-05 2018-10-23 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising muscarinic receptor antagonist
WO2014007770A2 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising corticosteroid and sorbitol
US20150150802A1 (en) 2012-07-05 2015-06-04 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscarinic antagonists
US20150174064A1 (en) * 2012-07-05 2015-06-25 Arven IIac Sanayi Ve Ticaret A.S. Compositions comprising muscarinic receptor antagonist and glucose anhydrous
US10111957B2 (en) 2012-07-05 2018-10-30 Arven Ilac Snayi ve Ticaret A.S. Inhalation compositions comprising glucose anhydrous
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
WO2015065222A1 (ru) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
BR112018008083A2 (pt) 2015-10-23 2018-10-23 Arven Ilac Sanayi Ve Ticaret As blister para formulação inalável de brometo de tiotrópio
KR101728116B1 (ko) * 2015-11-03 2017-04-18 한미약품 주식회사 티오트로피움 또는 이의 약학적으로 허용가능한 염을 함유하는 흡입용 건조분말 조성물
UA122699C2 (uk) * 2015-12-24 2020-12-28 Філіп Морріс Продактс С.А. Ароматизований нікотиновий порошок
CN110505876A (zh) 2017-03-23 2019-11-26 新加坡保健服务集团 包含噻托铵作为活性成分的用于预防近视、治疗近视、及/或预防近视进展的药剂
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation
GR1010358B (el) * 2021-09-14 2022-12-16 Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια, Σταθερο φαρμακευτικο σκευασμα που περιεχει βρωμιουχο τιοτροπιο, για χορηγηση απο το αναπνευστικο

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860618A (en) * 1967-08-08 1975-01-14 Philip Saxton Hartley Chromone
US3957965A (en) * 1967-08-08 1976-05-18 Fisons Limited Sodium chromoglycate inhalation medicament
GB1242211A (en) * 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
DE2540633A1 (de) * 1975-09-12 1977-04-28 Boehringer Sohn Ingelheim Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung
DE3211185A1 (de) * 1982-03-26 1983-09-29 Boehringer Ingelheim KG, 6507 Ingelheim Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung
DE3215493A1 (de) * 1982-04-26 1983-11-03 Boehringer Ingelheim KG, 6507 Ingelheim Neue zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung
JPS60172442A (ja) 1984-02-20 1985-09-05 Fanuc Ltd ならい加工およびνc加工による機械加工装置
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
ATE170745T1 (de) * 1991-04-08 1998-09-15 Nippon Shinyaku Co Ltd Kapsel mit langzeitwirkung fuer die adhäsion im gastrointestinaltrakt
DE4140689B4 (de) * 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE4318455A1 (de) * 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
US5819730A (en) 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
ATE198041T1 (de) * 1993-09-28 2000-12-15 Scherer Gmbh R P Herstellung von weichgelatinekapseln
GB9322014D0 (en) * 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
GB9404945D0 (en) * 1994-03-15 1994-04-27 Glaxo Group Ltd Pharmaceutical composition
DE4425255A1 (de) 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern
FR2757173A1 (fr) * 1996-12-17 1998-06-19 Warner Lambert Co Compositions polymeres d'origine non-animale pour la formation de films
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
US6235725B1 (en) * 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
DK1131059T3 (da) * 1998-11-13 2003-06-30 Jago Res Ag Tørpulver til inhalation
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
US20040002548A1 (en) * 1999-05-12 2004-01-01 Boehringer Ingelheim Pharma Kg Medicament compositions containing anticholinergically-effective compounds and betamimetics
JP3931486B2 (ja) * 1999-06-24 2007-06-13 住友化学株式会社 ポジ型レジスト組成物
CA2395653C (en) 2000-10-12 2006-05-09 Boehringer Ingelheim Pharma Kg New inhalable powder containing tiotropium
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
UA75375C2 (en) * 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
DE10126924A1 (de) 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
US6482429B1 (en) * 2001-06-20 2002-11-19 Boehringer Ingelheim Pharmaceuticals, Inc. Stable powder inhalation dosage formulation
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10141376A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
DE60308497T2 (de) * 2002-04-04 2007-02-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverzubereitungen zur inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation

Also Published As

Publication number Publication date
AU8993501A (en) 2002-04-22
BR0107304A (pt) 2002-08-13
AP1712A (en) 2007-01-24
KR20020063912A (ko) 2002-08-05
UY26959A1 (es) 2002-06-20
MY123544A (en) 2006-05-31
TR200402367T4 (tr) 2004-12-21
US20060039868A1 (en) 2006-02-23
ATE275391T1 (de) 2004-09-15
NO20022414D0 (no) 2002-05-22
DE50103551C5 (de) 2014-08-21
BG65753B1 (bg) 2009-10-30
HK1051812A1 (en) 2003-08-22
HU226982B1 (en) 2010-04-28
PL356840A1 (en) 2004-07-12
MXPA02005666A (es) 2002-11-29
OA12522A (en) 2006-05-30
NZ519406A (en) 2003-07-25
HUP0203885A3 (en) 2005-01-28
EP1292281A1 (de) 2003-03-19
TWI285553B (en) 2007-08-21
IS2360B (is) 2008-05-15
BG106730A (bg) 2003-03-31
ECSP034546A (es) 2003-06-25
HUP0203885A2 (hu) 2003-03-28
SI1292281T1 (sl) 2004-12-31
MEP40108A (en) 2011-02-10
ES2227268T3 (es) 2005-04-01
EE04414B1 (et) 2005-02-15
CU23284B7 (es) 2008-06-30
UA72014C2 (en) 2005-01-17
RS50197B (sr) 2009-05-06
CZ301465B6 (cs) 2010-03-10
JP3870159B2 (ja) 2007-01-17
DZ3477A1 (es) 2002-04-18
EE200200428A (et) 2003-02-17
US20020110529A1 (en) 2002-08-15
DK1292281T3 (da) 2004-10-11
CA2395653C (en) 2006-05-09
AP2003002774A0 (en) 2003-03-31
CN1210017C (zh) 2005-07-13
EP1292281B1 (de) 2004-09-08
HRP20020437A2 (en) 2004-08-31
EP1430887A1 (de) 2004-06-23
IS6771A (is) 2003-04-08
AU757008B2 (en) 2003-01-30
ME00245B (me) 2011-02-10
US20040228806A1 (en) 2004-11-18
SA01220460B1 (ar) 2006-10-31
EA004034B1 (ru) 2003-12-25
DE50103551D1 (de) 2004-10-14
CN1392795A (zh) 2003-01-22
CA2395653A1 (en) 2002-04-18
EA200200551A1 (ru) 2002-12-26
JP2004510805A (ja) 2004-04-08
IL149984A (en) 2007-06-03
NO20022414L (no) 2002-05-30
AR031819A1 (es) 2003-10-08
CR6937A (es) 2003-11-28
CZ20021785A3 (cs) 2002-09-11
MA25843A1 (fr) 2003-07-01
ZA200204378B (en) 2003-05-19
NO331956B1 (no) 2012-05-14
YU36302A (sh) 2002-09-19
US20080292563A1 (en) 2008-11-27
SK7062002A3 (en) 2002-10-08
PE20020577A1 (es) 2002-08-08
US7070800B2 (en) 2006-07-04
KR100488644B1 (ko) 2005-05-11
GEP20063865B (en) 2006-07-10
EG24139A (en) 2008-08-06
PL200063B1 (pl) 2008-12-31
SK285389B6 (sk) 2006-12-07
HRP20020437B1 (en) 2005-10-31
WO2002030389A1 (de) 2002-04-18
IL149984A0 (en) 2002-12-01
PT1292281E (pt) 2004-11-30

Similar Documents

Publication Publication Date Title
ECSP024268A (es) Nuevos polvos para inhalacion que contienen tiotropio
ECSP055855A (es) Medicamentos en polvo para inhalación que contiene una sal de tiotropio y salmeterolxinafoato
UY31235A1 (es) Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente
MEP30108A (en) Formoterol superfine formulation
MY155912A (en) New inhalable powder containing tiotropium
ATE421325T1 (de) Kombination von methylxanthinverbindungen und steroiden zur behandlung chronischer atemwegserkrankungen
EA201401354A1 (ru) Новая дозированная форма и препарат, содержащий абедитерол
UY28589A1 (es) Nuevas sales de tiotropio, procedimientos para su preparación , así como formulaciones medicamentosas que las contienen
CY1108420T1 (el) Προτοτυπο τιοτροπιουχο κονιωδες σκευασμα για εισπνοη
UY28590A1 (es) Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
EA201201393A1 (ru) Ингалятор, разработанный для доставки лекарственного средства в виде сухого порошка
UA115989C2 (uk) Фармацевтична композиція для інгалятора сухого порошку, що містить антагоністи мускаринових рецепторів тривалої дії
ATE339951T1 (de) Pulverzubereitungen zur inhalation
WO2007046113A3 (en) Novel pharmaceutical composition comprising alkaloid and process thereof
BRPI0415685A (pt) sais de tiotrópio, processos para sua produção, bem como formulações de medicamentos contendo os mesmos