SG11201907315PA - Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising tiotropium as active ingredient - Google Patents

Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising tiotropium as active ingredient

Info

Publication number
SG11201907315PA
SG11201907315PA SG11201907315PA SG11201907315PA SG11201907315PA SG 11201907315P A SG11201907315P A SG 11201907315PA SG 11201907315P A SG11201907315P A SG 11201907315PA SG 11201907315P A SG11201907315P A SG 11201907315PA SG 11201907315P A SG11201907315P A SG 11201907315PA
Authority
SG
Singapore
Prior art keywords
singapore
myopia
international
agent
osaka
Prior art date
Application number
SG11201907315PA
Inventor
Donald Tan
Roger Beuerman
Seang-Mei Saw
Aradhana Upadhyay
Masatomo Kato
Takaaki Inaba
Original Assignee
Singapore Health Serv Pte Ltd
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singapore Health Serv Pte Ltd, Santen Pharmaceutical Co Ltd filed Critical Singapore Health Serv Pte Ltd
Publication of SG11201907315PA publication Critical patent/SG11201907315PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Prostheses (AREA)
  • Undergarments, Swaddling Clothes, Handkerchiefs Or Underwear Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WI P0 I P C T omit olo 010TH olo 0111 X10111111 lII ow (10) International Publication Number WO 2018/174149 Al (51) International Patent Classification: A61K 31/439 (2006.01) A61P 27/10 (2006.01) (21) International Application Number: PCT/JP2018/011361 (22) International Filing Date: 22 March 2018 (22.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201702378S 23 March 2017 (23.03.2017) SG (71) Applicants: SINGAPORE HEALTH SERVICES PTE LTD [SG/SG]; 31 Third Hospital Avenue, #03-03 Bowyer Block C, Singapore, 168753 (SG). SANTEN PHARMA- CEUTICAL CO., LTD. [JP/JP]; 9-19, Shimoshinjo 3- chome, Higashiyodogawa-ku, Osaka-shi, Osaka, 5338651 (JP). (72) Inventors: TAN, Donald; c/o Singapore Eye Research In- stitute, 11 Third Hospital Ave, Singapore, 168751 (SG). BEUERMAN, Roger; c/o Singapore Eye Research In- stitute, 11 Third Hospital Ave, Singapore, 168751 (SG). SAW, Seang-Mei; c/o Singapore Eye Research Institute, 11 Third Hospital Ave, Singapore, 168751 (SG). UPAD- HYAY, Aradhana; 283, Bedok South Avenue 3, unit 14-43, Singapore, 465460 (SG). KATO, Masatomo; c/ o SANTEN PHARMACEUTICAL CO., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara, 6300101 (JP). INABA, Takaaki; c/o SANTEN PHARMACEUTICAL CO., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara, 6300101 (JP). (74) Agent: SAMEJIMA, Mutsumi et al.; AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower, 8-1, Kakuda-cho, Kita-ku, Osaka-shi, Osaka, 5300017 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) N 1-1 O \" (57) : The present invention relates to an agent for preventing myopia, treating myopia, and/or preventing myopia progression, 0 comprising tiotropium as an active ingredient. (54) Title: AGENT FOR PREVENTING MYOPIA, TREATING MYOPIA, AND/OR PREVENTING MYOPIA PROGRESSION COMPRISING TIOTROPIUM AS ACTIVE INGREDIENT
SG11201907315PA 2017-03-23 2018-03-22 Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising tiotropium as active ingredient SG11201907315PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201702378S 2017-03-23
PCT/JP2018/011361 WO2018174149A1 (en) 2017-03-23 2018-03-22 Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising tiotropium as active ingredient

Publications (1)

Publication Number Publication Date
SG11201907315PA true SG11201907315PA (en) 2019-09-27

Family

ID=63586549

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201907315PA SG11201907315PA (en) 2017-03-23 2018-03-22 Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising tiotropium as active ingredient

Country Status (11)

Country Link
US (1) US11642350B2 (en)
EP (1) EP3600306A4 (en)
JP (1) JP7016880B2 (en)
KR (1) KR102633606B1 (en)
CN (1) CN110505876A (en)
CA (1) CA3055891A1 (en)
EA (1) EA201992234A1 (en)
PH (1) PH12019502145A1 (en)
SG (1) SG11201907315PA (en)
TW (1) TWI816660B (en)
WO (1) WO2018174149A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020251926A1 (en) * 2019-06-10 2020-12-17 Jenivision Inc. Methods and formulations for treating vision disorders
CN116785286A (en) * 2020-10-10 2023-09-22 远大生命科学(武汉)有限公司 Use of penehyclidine in the treatment or prevention of vision-damaging ocular disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2200468A1 (en) * 1994-10-27 1996-05-09 Wayne J. Thompson Muscarine antagonists
KR100488644B1 (en) 2000-10-12 2005-05-11 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 Novel tiotropium-containing inhalation powder
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
SG151148A1 (en) 2007-10-05 2009-04-30 Singapore Health Services Pte Method and/or kit for determining response to muscarinic receptor antagonist treatment
WO2012161655A1 (en) 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine
US20160009705A1 (en) * 2014-06-24 2016-01-14 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) * 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
CN107920984A (en) 2015-06-18 2018-04-17 远视眼治疗有限责任公司 The composition of stable storing and the not positive method for the treatment of ophthalmic refractive
JP7095873B2 (en) * 2016-04-11 2022-07-05 ユニバーシティ・オブ・キャンベラ Ophthalmic composition comprising levodopa, antioxidant and aqueous carrier

Also Published As

Publication number Publication date
KR102633606B1 (en) 2024-02-02
PH12019502145A1 (en) 2020-06-15
WO2018174149A1 (en) 2018-09-27
EA201992234A1 (en) 2020-02-05
JP2020514347A (en) 2020-05-21
CA3055891A1 (en) 2018-09-27
JP7016880B2 (en) 2022-02-07
EP3600306A4 (en) 2020-12-02
EP3600306A1 (en) 2020-02-05
CN110505876A (en) 2019-11-26
TWI816660B (en) 2023-10-01
KR20190127885A (en) 2019-11-13
US20200147098A1 (en) 2020-05-14
TW201840313A (en) 2018-11-16
US11642350B2 (en) 2023-05-09

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