SG11201810801QA - Brain delivery protein - Google Patents
Brain delivery proteinInfo
- Publication number
- SG11201810801QA SG11201810801QA SG11201810801QA SG11201810801QA SG11201810801QA SG 11201810801Q A SG11201810801Q A SG 11201810801QA SG 11201810801Q A SG11201810801Q A SG 11201810801QA SG 11201810801Q A SG11201810801Q A SG 11201810801QA SG 11201810801Q A SG11201810801Q A SG 11201810801QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- brain
- stockholm
- uppsala
- brain delivery
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70582—CD71
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111110111011111111111111111111111111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/011353 Al 18 January 2018 (18.01.2018) W I P0 I PC T (51) International Patent Classification: (74) Agent: AWAPATENT AB; Box 45086, 104 30 Stockholm CO7K 16/18 (2006.01) A61K 39/00 (2006.01) (SE). C07K 16/28 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/EP2017/067727 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 13 July 2017 (13.07.2017) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (25) Filing Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (26) Publication Language: English MG, MK, MN, WV, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 1651065-3 14 July 2016 (14.07.2016) SE TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: BIOARCTIC AB [SE/SE]; Warfvinges vag 35, (84) Designated States (unless otherwise indicated, for every 112 51 Stockholm (SE). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: LANNFELT, Lars; c/o BioArctic AB, War- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, fvinges vag 35, 112 51 Stockholm (SE). SEHLIN, Dag; TM), European (AL, AT, BE, BG, DE, DK, — CH, CY, CZ, Basarbovagen 1, 752 73 Uppsala (SE). HULTQVIST, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Uppsala (SE). Greta; Hjalmar Brantingsgatan 2b, 753 27 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, SYVANEN, Stina; Akerholmsvagen 14, 755 98 Uppsala TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — (SE). KM, ML, MR, NE, SN, TD, TG). = = Title: BRAIN DELIVERY PROTEIN (54) = al = = = = = = = = = A B 1-1 .4 in en Figure 1 M Il (57) : The present invention relates to a brain delivery protein, comprising a target binding antibody which binds to a target 1-1 O in a mammalian brain; two carrier moieties, each of which being capable of monovalent interaction with a protein expressed on a -- -- GC blood brain barrier (BBB) endothelial cell, wherein each of said carrier moieties is linked to a C-terminal end of the target binding antibody. The present invention moreover relates to use of such brain delivery proteins in therapy or diagnosis or for research of e.g. 0 neurodegenerative disorders, and other brain diseases. ei C [Continued on next page] WO 2018/011353 Al DIII Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1651065 | 2016-07-14 | ||
PCT/EP2017/067727 WO2018011353A1 (en) | 2016-07-14 | 2017-07-13 | Brain delivery protein |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201810801QA true SG11201810801QA (en) | 2019-01-30 |
Family
ID=59593007
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912842VA SG10201912842VA (en) | 2016-07-14 | 2017-07-13 | Brain delivery protein |
SG11201810801QA SG11201810801QA (en) | 2016-07-14 | 2017-07-13 | Brain delivery protein |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912842VA SG10201912842VA (en) | 2016-07-14 | 2017-07-13 | Brain delivery protein |
Country Status (15)
Country | Link |
---|---|
US (1) | US11498974B2 (en) |
EP (1) | EP3484918A1 (en) |
JP (2) | JP2019529345A (en) |
KR (1) | KR20190039696A (en) |
CN (1) | CN109476728A (en) |
AU (1) | AU2017297804A1 (en) |
BR (1) | BR112019000098A2 (en) |
CA (1) | CA3028035A1 (en) |
IL (1) | IL263773A (en) |
MA (1) | MA45684A (en) |
MX (1) | MX2019000529A (en) |
PH (1) | PH12018502451A1 (en) |
RU (1) | RU2019102746A (en) |
SG (2) | SG10201912842VA (en) |
WO (1) | WO2018011353A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201906947SA (en) | 2017-02-17 | 2019-08-27 | Bristol Myers Squibb Co | Antibodies to alpha-synuclein and uses thereof |
PT3583120T (en) | 2017-02-17 | 2022-12-15 | Denali Therapeutics Inc | Engineered transferrin receptor binding polypeptides |
EP3877399A4 (en) * | 2018-11-06 | 2022-10-19 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
US20240141027A1 (en) | 2021-06-11 | 2024-05-02 | Bioarctic Ab | Bispecific binding molecule |
WO2023215697A1 (en) * | 2022-05-05 | 2023-11-09 | Eli Lilly And Company | Multispecific binding molecules and methods of use thereof |
WO2024080843A1 (en) * | 2022-10-14 | 2024-04-18 | 주식회사 아임뉴런 | Blood-brain barrier permeable fusion protein and use thereof |
WO2024123052A1 (en) * | 2022-12-08 | 2024-06-13 | 주식회사 아델 | Fusion comprising anti-tau antibody and peptide and use thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2082749A3 (en) | 2000-07-07 | 2010-06-30 | Bioarctic Neuroscience AB | Prevention and treatment of Alzheimer's disease |
SE0401601D0 (en) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
CA2630344C (en) | 2006-03-23 | 2015-04-28 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
JP5959795B2 (en) * | 2006-08-18 | 2016-08-02 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | Substances for blood-brain barrier delivery |
BRPI0911482A2 (en) | 2008-04-24 | 2017-08-29 | Bristol Myers Squibb Co | USE OF EPOTHYLONE D IN THE TREATMENT OF TAU-ASSOCIATED DISEASES INCLUDING ALZHEIMER DISEASES |
SI2282758T1 (en) | 2008-04-29 | 2019-03-29 | Bioarctic Ab | Antibodies and vaccines for use in therapeutic and diagnostic methods for alpha-synuclein-related disorders |
EP2769711A1 (en) | 2008-07-10 | 2014-08-27 | ESBATech, an Alcon Biomedical Research Unit LLC | Methods and Compositions for Enhanced Delivery of Macromolecules |
US20120100129A1 (en) | 2009-06-29 | 2012-04-26 | Gellerfors Paer | N-Terminal Truncated Protofibrils/Oligomers for Use in Therapeutic and Diagnostic Methods for Alzheimer's Disease and Related Disorders |
ES2661925T3 (en) | 2010-02-26 | 2018-04-04 | Bioarctic Ab | Protofibril binding antibodies and their use in diagnostic therapeutic methods for Parkinson's disease, dementia with Lewy bodies and other alpha-synucleinopathies |
WO2011160083A1 (en) * | 2010-06-17 | 2011-12-22 | Trellis Bioscience, Inc. | Antibodies useful in passive influenza immuization |
US20120171120A1 (en) | 2010-11-30 | 2012-07-05 | Genentech, Inc. | Low affinity blood brain barrier receptor antibodies and uses therefor |
SG11201500583PA (en) * | 2012-08-29 | 2015-04-29 | Hoffmann La Roche | Blood brain barrier shuttle |
KR20160054501A (en) * | 2013-08-26 | 2016-05-16 | 맵백스 테라퓨틱스, 인코포레이티드 | Nucleic acids encoding human antibodies to sialyl-lewis a |
JP6744856B2 (en) * | 2014-04-08 | 2020-08-19 | プロセナ・バイオサイエンシズ・リミテッド | Blood-brain barrier shuttle containing antibody that recognizes α-synuclein |
SG11201610734RA (en) | 2014-07-10 | 2017-01-27 | Bioarctic Neuroscience Ab | IMPROVED Aß PROTOFIBRIL BINDING ANTIBODIES |
-
2017
- 2017-07-13 JP JP2019501707A patent/JP2019529345A/en active Pending
- 2017-07-13 US US16/317,156 patent/US11498974B2/en active Active
- 2017-07-13 MX MX2019000529A patent/MX2019000529A/en unknown
- 2017-07-13 KR KR1020197002785A patent/KR20190039696A/en not_active Application Discontinuation
- 2017-07-13 RU RU2019102746A patent/RU2019102746A/en not_active Application Discontinuation
- 2017-07-13 SG SG10201912842VA patent/SG10201912842VA/en unknown
- 2017-07-13 AU AU2017297804A patent/AU2017297804A1/en not_active Abandoned
- 2017-07-13 BR BR112019000098-4A patent/BR112019000098A2/en not_active Application Discontinuation
- 2017-07-13 MA MA045684A patent/MA45684A/en unknown
- 2017-07-13 SG SG11201810801QA patent/SG11201810801QA/en unknown
- 2017-07-13 WO PCT/EP2017/067727 patent/WO2018011353A1/en unknown
- 2017-07-13 CN CN201780042832.1A patent/CN109476728A/en active Pending
- 2017-07-13 EP EP17751619.2A patent/EP3484918A1/en active Pending
- 2017-07-13 CA CA3028035A patent/CA3028035A1/en not_active Abandoned
-
2018
- 2018-11-21 PH PH12018502451A patent/PH12018502451A1/en unknown
- 2018-12-17 IL IL263773A patent/IL263773A/en unknown
-
2022
- 2022-06-30 JP JP2022106495A patent/JP2022130646A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
SG10201912842VA (en) | 2020-02-27 |
BR112019000098A2 (en) | 2019-04-09 |
US20190225699A1 (en) | 2019-07-25 |
CN109476728A (en) | 2019-03-15 |
RU2019102746A (en) | 2020-08-14 |
MX2019000529A (en) | 2020-01-15 |
AU2017297804A1 (en) | 2019-01-24 |
MA45684A (en) | 2019-05-22 |
EP3484918A1 (en) | 2019-05-22 |
RU2019102746A3 (en) | 2020-11-30 |
JP2019529345A (en) | 2019-10-17 |
WO2018011353A1 (en) | 2018-01-18 |
US11498974B2 (en) | 2022-11-15 |
IL263773A (en) | 2019-02-28 |
KR20190039696A (en) | 2019-04-15 |
CA3028035A1 (en) | 2018-01-18 |
PH12018502451A1 (en) | 2019-09-30 |
JP2022130646A (en) | 2022-09-06 |
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