SI1682541T1 - Postopek za pripravo tiotropijevih soli - Google Patents

Postopek za pripravo tiotropijevih soli

Info

Publication number
SI1682541T1
SI1682541T1 SI200431403T SI200431403T SI1682541T1 SI 1682541 T1 SI1682541 T1 SI 1682541T1 SI 200431403 T SI200431403 T SI 200431403T SI 200431403 T SI200431403 T SI 200431403T SI 1682541 T1 SI1682541 T1 SI 1682541T1
Authority
SI
Slovenia
Prior art keywords
tiotropium salts
producing tiotropium
producing
salts
tiotropium
Prior art date
Application number
SI200431403T
Other languages
English (en)
Inventor
Rolf Banholzer
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1682541(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of SI1682541T1 publication Critical patent/SI1682541T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200431403T 2003-11-03 2004-10-29 Postopek za pripravo tiotropijevih soli SI1682541T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
PCT/EP2004/012268 WO2005042526A1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend
EP04791028A EP1682541B1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalzen

Publications (1)

Publication Number Publication Date
SI1682541T1 true SI1682541T1 (sl) 2010-06-30

Family

ID=34530660

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200431403T SI1682541T1 (sl) 2003-11-03 2004-10-29 Postopek za pripravo tiotropijevih soli
SI200432055T SI2067779T1 (sl) 2003-11-03 2004-10-29 Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200432055T SI2067779T1 (sl) 2003-11-03 2004-10-29 Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo

Country Status (35)

Country Link
US (1) US8686148B2 (sl)
EP (3) EP2067779B9 (sl)
JP (1) JP5165244B2 (sl)
KR (1) KR20060117334A (sl)
CN (3) CN101407514B (sl)
AR (1) AR046317A1 (sl)
AT (1) ATE460414T1 (sl)
AU (1) AU2004285683C1 (sl)
BR (1) BRPI0416136A (sl)
CA (1) CA2544348A1 (sl)
CO (1) CO5690553A2 (sl)
CY (2) CY1110048T1 (sl)
DE (1) DE502004010885D1 (sl)
DK (2) DK2067779T3 (sl)
EA (1) EA012326B1 (sl)
ES (2) ES2422729T3 (sl)
HK (3) HK1099748A1 (sl)
HR (1) HRP20100149T1 (sl)
IL (1) IL175023A (sl)
ME (1) ME00361B (sl)
MX (1) MXPA06004697A (sl)
MY (1) MY143364A (sl)
NO (1) NO335814B1 (sl)
NZ (1) NZ547276A (sl)
PE (1) PE20050446A1 (sl)
PL (2) PL2067779T3 (sl)
PT (2) PT1682541E (sl)
RS (2) RS51758B (sl)
SG (1) SG137859A1 (sl)
SI (2) SI1682541T1 (sl)
TW (2) TWI363758B (sl)
UA (1) UA82413C2 (sl)
UY (1) UY28590A1 (sl)
WO (1) WO2005042526A1 (sl)
ZA (1) ZA200602342B (sl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2067779T3 (pl) 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
KR20060102561A (ko) * 2003-11-03 2006-09-27 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로피움염, 이의 제조 방법 및 이를 함유하는약제학적 제형
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
NZ583872A (en) * 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
DK1869035T4 (en) * 2005-12-19 2015-11-16 Sicor Inc HIS UNKNOWN CRYSTALLIC FORM OF THIOTROPIUM BROMIDE AND PROCEDURE FOR PREPARING THEREOF
ME01205B (me) * 2006-01-04 2013-03-20 Boehringer Ingelheim Int Upotreba soli tiotropijuma u liječenju umjerene trajne astme
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) * 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

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US20020193393A1 (en) 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
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BRPI0115076B8 (pt) * 2000-10-31 2021-05-25 Boehringer Ingelheim Pharma preparação farmacêutica, sua aplicação farmacêutica, bem como processo para preparação da mesma
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DE10216036A1 (de) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
US6908055B2 (en) 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
PL2067779T3 (pl) 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
KR20060102561A (ko) 2003-11-03 2006-09-27 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로피움염, 이의 제조 방법 및 이를 함유하는약제학적 제형
SE0303270L (sv) 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
NZ583872A (en) 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
DE502004010885D1 (de) 2010-04-22
ZA200602342B (en) 2007-06-27
DK1682541T3 (da) 2010-06-28
SG137859A1 (en) 2007-12-28
EP2067779A1 (de) 2009-06-10
MY143364A (en) 2011-04-29
HK1129111A1 (en) 2009-11-20
MEP51308A (en) 2011-05-10
JP5165244B2 (ja) 2013-03-21
RS51758B (en) 2011-12-31
TW200526653A (en) 2005-08-16
ES2342468T3 (es) 2010-07-07
ATE460414T1 (de) 2010-03-15
NO335814B1 (no) 2015-02-23
BRPI0416136A (pt) 2007-01-02
HRP20100149T1 (hr) 2010-04-30
PT1682541E (pt) 2010-04-14
CN102070630A (zh) 2011-05-25
PL1682541T3 (pl) 2010-08-31
CO5690553A2 (es) 2006-10-31
CY1114157T1 (el) 2016-08-31
AU2004285683B2 (en) 2011-04-21
EP2336126A1 (de) 2011-06-22
AU2004285683C1 (en) 2011-09-08
PL2067779T3 (pl) 2013-09-30
ES2422729T3 (es) 2013-09-13
SI2067779T1 (sl) 2013-08-30
HK1099748A1 (en) 2007-08-24
CN101407514B (zh) 2013-05-29
EA012326B1 (ru) 2009-08-28
EP2067779B1 (de) 2013-04-24
CN1882582A (zh) 2006-12-20
UA82413C2 (uk) 2008-04-10
IL175023A (en) 2011-02-28
WO2005042526A1 (de) 2005-05-12
PT2067779E (pt) 2013-07-25
TWI363758B (en) 2012-05-11
RS20060292A (en) 2008-08-07
NZ547276A (en) 2009-08-28
TWI435876B (zh) 2014-05-01
NO20061440L (no) 2006-07-12
AR046317A1 (es) 2005-11-30
CY1110048T1 (el) 2015-01-14
EA200600886A1 (ru) 2006-10-27
MXPA06004697A (es) 2006-07-05
JP2007509893A (ja) 2007-04-19
EP1682541B1 (de) 2010-03-10
CN102070630B (zh) 2013-04-17
UY28590A1 (es) 2005-06-30
ME00361B (me) 2011-10-10
EP2067779B9 (de) 2013-10-16
CN100549010C (zh) 2009-10-14
US20050131007A1 (en) 2005-06-16
CN101407514A (zh) 2009-04-15
IL175023A0 (en) 2006-08-20
EP1682541A1 (de) 2006-07-26
TW201231465A (en) 2012-08-01
PE20050446A1 (es) 2005-08-02
HK1153409A1 (en) 2012-03-30
AU2004285683A1 (en) 2005-05-12
US8686148B2 (en) 2014-04-01
CA2544348A1 (en) 2005-05-12
DK2067779T3 (da) 2013-07-29
KR20060117334A (ko) 2006-11-16

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