MX374497B - Inhibidor del antígeno de superficie del virus de la hepatitis b. - Google Patents
Inhibidor del antígeno de superficie del virus de la hepatitis b.Info
- Publication number
- MX374497B MX374497B MX2019010736A MX2019010736A MX374497B MX 374497 B MX374497 B MX 374497B MX 2019010736 A MX2019010736 A MX 2019010736A MX 2019010736 A MX2019010736 A MX 2019010736A MX 374497 B MX374497 B MX 374497B
- Authority
- MX
- Mexico
- Prior art keywords
- hepatitis
- surface antigen
- virus surface
- antigen inhibitor
- formula
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 241000700721 Hepatitis B virus Species 0.000 title 1
- 208000002672 hepatitis B Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YWXSFPWWJDMXTH-UHFFFAOYSA-N 10-oxo-2,6-dihydro-1H-pyrido[1,2-c][1,3]benzoxazine-9-carboxylic acid Chemical class O=C1C=C2N(COC3=C2CCC=C3)C=C1C(=O)O YWXSFPWWJDMXTH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Derivados de ácido 10-oxo-6,1-dihidrobenzo[e]pirido[1,2-c][1,3]oxazina-9-carboxílico de fórmula (I) como inhibidores del antígeno de superficie de la hepatitis B o sales farmacéuticamente aceptables de los mismos, y usos de un compuesto de fórmula (I) o sales farmacéuticamente aceptables del mismo y composiciones farmacéuticas del mismo en la preparación de medicamentos para el tratamiento de la hepatitis B viral (ver fórmula I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710138275 | 2017-03-09 | ||
| PCT/CN2018/078581 WO2018161960A1 (zh) | 2017-03-09 | 2018-03-09 | 乙型肝炎病毒表面抗原抑制剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019010736A MX2019010736A (es) | 2019-11-05 |
| MX374497B true MX374497B (es) | 2025-03-06 |
Family
ID=63447286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019010736A MX374497B (es) | 2017-03-09 | 2018-03-09 | Inhibidor del antígeno de superficie del virus de la hepatitis b. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11008331B2 (es) |
| EP (1) | EP3590942B1 (es) |
| JP (1) | JP6783424B2 (es) |
| KR (1) | KR102087397B1 (es) |
| CN (1) | CN109071564B (es) |
| AU (1) | AU2018232071B2 (es) |
| BR (1) | BR112019018650B1 (es) |
| CA (1) | CA3055442C (es) |
| DK (1) | DK3590942T3 (es) |
| EA (1) | EA038122B9 (es) |
| ES (1) | ES2879930T3 (es) |
| HR (1) | HRP20211331T1 (es) |
| HU (1) | HUE055170T2 (es) |
| IL (1) | IL269142B (es) |
| LT (1) | LT3590942T (es) |
| MX (1) | MX374497B (es) |
| MY (1) | MY174224A (es) |
| PH (1) | PH12019502052B1 (es) |
| PL (1) | PL3590942T3 (es) |
| PT (1) | PT3590942T (es) |
| RS (1) | RS62094B1 (es) |
| SG (1) | SG11201908101YA (es) |
| SI (1) | SI3590942T1 (es) |
| WO (1) | WO2018161960A1 (es) |
| ZA (1) | ZA201906252B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| BR112018067964B1 (pt) | 2016-03-07 | 2024-01-16 | Enanta Pharmaceuticals, Inc | Composto, composição farmacêutica que o compreende e uso do referido composto |
| CN110066278B (zh) | 2017-06-01 | 2021-06-08 | 广东东阳光药业有限公司 | 稠合三环类化合物及其在药物中的应用 |
| IL272941B2 (en) | 2017-08-28 | 2023-03-01 | Enanta Pharm Inc | Antiviral agents for viral hepatitis b |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2019169539A1 (en) * | 2018-03-05 | 2019-09-12 | Pharmaresources (Shanghai) Co., Ltd. | Novel oxa-and aza-tricyclic 4-pyridone-3-carboxylic acid for treatment and prophylaxis of hepatitis b virus infection |
| WO2019191166A1 (en) | 2018-03-29 | 2019-10-03 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2020043080A1 (en) | 2018-08-28 | 2020-03-05 | Sunshine Lake Pharma Co., Ltd. | Fused tricyclic compounds and uses thereof in medicine |
| EP3846808A4 (en) | 2018-09-05 | 2022-08-17 | Children's Medical Center Corporation | PAPD5 INHIBITORS AND METHODS OF USE THEREOF |
| WO2020061435A1 (en) | 2018-09-21 | 2020-03-26 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| JP2022511378A (ja) | 2018-09-30 | 2022-01-31 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | 縮合四環系化合物および医薬品におけるそれらの使用 |
| KR102819704B1 (ko) | 2018-11-21 | 2025-06-11 | 이난타 파마슈티칼스, 인코포레이티드 | 항바이러스제로서의 작용화된 헤테로사이클 |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| TWI746177B (zh) * | 2019-09-19 | 2021-11-11 | 大陸商福建廣生堂藥業股份有限公司 | 一種b肝表面抗原抑制劑的晶型及其應用 |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| JP2023526345A (ja) * | 2020-05-15 | 2023-06-21 | 福建▲広▼生中霖生物科技有限公司 | Ｂ型肝炎の治療に使用される組み合わせ |
| US12569500B2 (en) | 2020-05-15 | 2026-03-10 | Fujian Akeylink Biotechnology Co., Ltd. | Combination comprising tricycle compound and use thereof in preparation of medicament for treating HBV |
| WO2022112207A1 (en) * | 2020-11-25 | 2022-06-02 | F. Hoffmann-La Roche Ag | Aromatic spiro ring amide derivatives for the treatment and prophylaxis of hepatitis b virus infection |
| CN116744932B (zh) * | 2021-01-15 | 2025-08-08 | 福建广生中霖生物科技有限公司 | 一种手性噁嗪类化合物的制备方法 |
| WO2026052081A1 (zh) * | 2024-09-06 | 2026-03-12 | 福建广生中霖生物科技有限公司 | 用于治疗乙型肝炎的药物及组合 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130251647A1 (en) * | 2011-09-20 | 2013-09-26 | Basf Se | Low molecular weight modulators of the cold menthol receptor trpm8 and use thereof |
| CN103450184A (zh) * | 2012-05-29 | 2013-12-18 | 上海壹志医药科技有限公司 | 斯氏紫堇碱衍生物的盐 |
| WO2015113990A1 (en) * | 2014-01-30 | 2015-08-06 | F. Hoffmann-La Roche Ag | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection |
| WO2016128335A1 (en) * | 2015-02-11 | 2016-08-18 | F. Hoffmann-La Roche Ag | Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
| CN107849037B (zh) * | 2015-07-21 | 2020-04-17 | 豪夫迈·罗氏有限公司 | 用于治疗和预防乙型肝炎病毒感染的三环4-吡啶酮-3-甲酸衍生物 |
| EP3328858B1 (en) * | 2015-07-28 | 2019-05-15 | H. Hoffnabb-La Roche Ag | Novel 6,7-dihydropyrido[2,1-a]phthalazin-2-ones for the treatment and prophylaxis of hepatitis b virus infection |
| CN107759585A (zh) | 2016-07-29 | 2018-03-06 | 银杏树药业(苏州)有限公司 | 一种异喹啉类化合物及其药用组合物和作为抗病毒药物的应用 |
-
2018
- 2018-03-09 MY MYPI2019005107A patent/MY174224A/en unknown
- 2018-03-09 ES ES18763490T patent/ES2879930T3/es active Active
- 2018-03-09 US US16/491,769 patent/US11008331B2/en active Active
- 2018-03-09 EA EA201992082A patent/EA038122B9/ru unknown
- 2018-03-09 CN CN201880001647.2A patent/CN109071564B/zh active Active
- 2018-03-09 SI SI201830376T patent/SI3590942T1/sl unknown
- 2018-03-09 DK DK18763490.2T patent/DK3590942T3/da active
- 2018-03-09 MX MX2019010736A patent/MX374497B/es active IP Right Grant
- 2018-03-09 HR HRP20211331TT patent/HRP20211331T1/hr unknown
- 2018-03-09 LT LTEPPCT/CN2018/078581T patent/LT3590942T/lt unknown
- 2018-03-09 EP EP18763490.2A patent/EP3590942B1/en active Active
- 2018-03-09 SG SG11201908101Y patent/SG11201908101YA/en unknown
- 2018-03-09 CA CA3055442A patent/CA3055442C/en active Active
- 2018-03-09 KR KR1020197029437A patent/KR102087397B1/ko active Active
- 2018-03-09 PT PT187634902T patent/PT3590942T/pt unknown
- 2018-03-09 BR BR112019018650-6A patent/BR112019018650B1/pt active IP Right Grant
- 2018-03-09 AU AU2018232071A patent/AU2018232071B2/en active Active
- 2018-03-09 PL PL18763490T patent/PL3590942T3/pl unknown
- 2018-03-09 WO PCT/CN2018/078581 patent/WO2018161960A1/zh not_active Ceased
- 2018-03-09 RS RS20210851A patent/RS62094B1/sr unknown
- 2018-03-09 JP JP2019548977A patent/JP6783424B2/ja active Active
- 2018-03-09 PH PH1/2019/502052A patent/PH12019502052B1/en unknown
- 2018-03-09 HU HUE18763490A patent/HUE055170T2/hu unknown
-
2019
- 2019-09-05 IL IL269142A patent/IL269142B/en active IP Right Grant
- 2019-09-20 ZA ZA2019/06252A patent/ZA201906252B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| PD | Change of proprietorship |
Owner name: FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD. |
|
| PD | Change of proprietorship |
Owner name: FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD. |