EA038122B9 - Ингибитор поверхностного антигена вируса гепатита b - Google Patents

Ингибитор поверхностного антигена вируса гепатита b

Info

Publication number
EA038122B9
EA038122B9 EA201992082A EA201992082A EA038122B9 EA 038122 B9 EA038122 B9 EA 038122B9 EA 201992082 A EA201992082 A EA 201992082A EA 201992082 A EA201992082 A EA 201992082A EA 038122 B9 EA038122 B9 EA 038122B9
Authority
EA
Eurasian Patent Office
Prior art keywords
hepatitis
surface antigen
virus surface
antigen inhibitor
formula
Prior art date
Application number
EA201992082A
Other languages
English (en)
Other versions
EA201992082A1 (ru
EA038122B1 (ru
Inventor
Фэй Сунь
Цзиньхуа Ду
Яньбинь Ху
Лили Чжоу
Чарлз З. Дин
Шухуэй Чэнь
Original Assignee
Фуцзянь Косантер Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фуцзянь Косантер Фармасьютикал Ко., Лтд. filed Critical Фуцзянь Косантер Фармасьютикал Ко., Лтд.
Publication of EA201992082A1 publication Critical patent/EA201992082A1/ru
Publication of EA038122B1 publication Critical patent/EA038122B1/ru
Publication of EA038122B9 publication Critical patent/EA038122B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Производные 10-оксо-6,1-дигидробензо[е]пиридо[1,2-с][1,3]оксазин-9-карбоновой кислоты формулы (I) в качестве ингибиторов поверхностного антигена гепатита В или их фармацевтически приемлемые соли, пути применения соединения формулы (I) или его фармацевтически приемлемых солей и фармацевтические композиции на их основе в получении лекарственных препаратов для лечения вирусного гепатита B.
EA201992082A 2017-03-09 2018-03-09 Ингибитор поверхностного антигена вируса гепатита b EA038122B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710138275 2017-03-09
PCT/CN2018/078581 WO2018161960A1 (zh) 2017-03-09 2018-03-09 乙型肝炎病毒表面抗原抑制剂

Publications (3)

Publication Number Publication Date
EA201992082A1 EA201992082A1 (ru) 2020-02-12
EA038122B1 EA038122B1 (ru) 2021-07-09
EA038122B9 true EA038122B9 (ru) 2021-09-14

Family

ID=63447286

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992082A EA038122B9 (ru) 2017-03-09 2018-03-09 Ингибитор поверхностного антигена вируса гепатита b

Country Status (25)

Country Link
US (1) US11008331B2 (ru)
EP (1) EP3590942B1 (ru)
JP (1) JP6783424B2 (ru)
KR (1) KR102087397B1 (ru)
CN (1) CN109071564B (ru)
AU (1) AU2018232071B2 (ru)
BR (1) BR112019018650B1 (ru)
CA (1) CA3055442C (ru)
DK (1) DK3590942T3 (ru)
EA (1) EA038122B9 (ru)
ES (1) ES2879930T3 (ru)
HR (1) HRP20211331T1 (ru)
HU (1) HUE055170T2 (ru)
IL (1) IL269142B (ru)
LT (1) LT3590942T (ru)
MX (1) MX2019010736A (ru)
MY (1) MY174224A (ru)
PH (1) PH12019502052A1 (ru)
PL (1) PL3590942T3 (ru)
PT (1) PT3590942T (ru)
RS (1) RS62094B1 (ru)
SG (1) SG11201908101YA (ru)
SI (1) SI3590942T1 (ru)
WO (1) WO2018161960A1 (ru)
ZA (1) ZA201906252B (ru)

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WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
ES2938341T3 (es) 2016-03-07 2023-04-10 Enanta Pharm Inc Agentes antivirales contra la hepatitis B
CN110066278B (zh) 2017-06-01 2021-06-08 广东东阳光药业有限公司 稠合三环类化合物及其在药物中的应用
WO2019046271A1 (en) 2017-08-28 2019-03-07 Enanta Pharmaceuticals, Inc. ANTIVIRAL AGENTS AGAINST HEPATITIS B
WO2019143902A2 (en) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019169539A1 (en) * 2018-03-05 2019-09-12 Pharmaresources (Shanghai) Co., Ltd. Novel oxa-and aza-tricyclic 4-pyridone-3-carboxylic acid for treatment and prophylaxis of hepatitis b virus infection
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
CA3111792A1 (en) 2018-09-05 2020-03-12 Children's Medical Center Corporation Papd5 inhibitors and methods of use thereof
MX2021003253A (es) 2018-09-21 2021-08-11 Enanta Pharm Inc Heterociclos funcionalizados como agentes antivirales.
EP3856740A4 (en) 2018-09-30 2021-12-15 Sunshine Lake Pharma Co., Ltd. CONDENSED TETRACYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
AU2019385477A1 (en) 2018-11-21 2021-06-10 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11807647B2 (en) 2019-09-19 2023-11-07 Fujian Akeylink Biotechnology Co., Ltd. Crystal form of hepatitis B surface antigen inhibitor and application thereof
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN115515595A (zh) * 2020-05-15 2022-12-23 福建广生中霖生物科技有限公司 用于治疗乙肝的组合
WO2021228213A1 (zh) 2020-05-15 2021-11-18 福建广生堂药业股份有限公司 包含三并环类化合物的组合及其在制备治疗hbv药物中的应用
EP4251621A1 (en) * 2020-11-25 2023-10-04 F. Hoffmann-La Roche AG Aromatic spiro ring amide derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN116744932A (zh) * 2021-01-15 2023-09-12 福建广生中霖生物科技有限公司 一种手性噁嗪类化合物的制备方法

Citations (3)

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CN103450184A (zh) * 2012-05-29 2013-12-18 上海壹志医药科技有限公司 斯氏紫堇碱衍生物的盐
WO2016128335A1 (en) * 2015-02-11 2016-08-18 F. Hoffmann-La Roche Ag Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN107759585A (zh) * 2016-07-29 2018-03-06 银杏树药业(苏州)有限公司 一种异喹啉类化合物及其药用组合物和作为抗病毒药物的应用

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US20130251647A1 (en) * 2011-09-20 2013-09-26 Basf Se Low molecular weight modulators of the cold menthol receptor trpm8 and use thereof
WO2015113990A1 (en) 2014-01-30 2015-08-06 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
JP6598974B2 (ja) 2015-07-21 2019-10-30 エフ．ホフマン−ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症の治療および予防のための新規な三環式４−ピリドン−３−カルボン酸誘導体
WO2017017043A1 (en) 2015-07-28 2017-02-02 F. Hoffmann-La Roche Ag Novel 6,7-dihydropyrido[2,1-a]phthalazin-2-ones for the treatment and prophylaxis of hepatitis b virus infection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103450184A (zh) * 2012-05-29 2013-12-18 上海壹志医药科技有限公司 斯氏紫堇碱衍生物的盐
WO2016128335A1 (en) * 2015-02-11 2016-08-18 F. Hoffmann-La Roche Ag Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN107759585A (zh) * 2016-07-29 2018-03-06 银杏树药业(苏州)有限公司 一种异喹啉类化合物及其药用组合物和作为抗病毒药物的应用

Also Published As

Publication number Publication date
KR102087397B1 (ko) 2020-03-11
ZA201906252B (en) 2021-04-28
AU2018232071A1 (en) 2019-10-17
SI3590942T1 (sl) 2021-11-30
US11008331B2 (en) 2021-05-18
HRP20211331T1 (hr) 2021-11-26
EA201992082A1 (ru) 2020-02-12
EP3590942A4 (en) 2020-01-08
HUE055170T2 (hu) 2021-11-29
SG11201908101YA (en) 2019-10-30
MX2019010736A (es) 2019-11-05
DK3590942T3 (da) 2021-09-06
KR20190117799A (ko) 2019-10-16
IL269142B (en) 2020-07-30
JP2020509075A (ja) 2020-03-26
AU2018232071B2 (en) 2021-07-08
US20200039995A1 (en) 2020-02-06
PH12019502052A1 (en) 2020-07-06
BR112019018650A2 (pt) 2020-04-07
CA3055442A1 (en) 2018-09-13
RS62094B1 (sr) 2021-08-31
CN109071564B (zh) 2019-08-27
CA3055442C (en) 2021-03-23
CN109071564A (zh) 2018-12-21
LT3590942T (lt) 2021-07-12
PL3590942T3 (pl) 2021-12-13
EP3590942A1 (en) 2020-01-08
WO2018161960A1 (zh) 2018-09-13
MY174224A (en) 2020-03-23
ES2879930T3 (es) 2021-11-23
EA038122B1 (ru) 2021-07-09
JP6783424B2 (ja) 2020-11-11
EP3590942B1 (en) 2021-06-09
BR112019018650B1 (pt) 2021-12-14
PT3590942T (pt) 2021-07-28

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Legal Events

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TH4A Publication of the corrected specification to eurasian patent