MX2019007585A - Profarmacos de ester alifatico antiviricos de tenofovir. - Google Patents

Profarmacos de ester alifatico antiviricos de tenofovir.

Info

Publication number
MX2019007585A
MX2019007585A MX2019007585A MX2019007585A MX2019007585A MX 2019007585 A MX2019007585 A MX 2019007585A MX 2019007585 A MX2019007585 A MX 2019007585A MX 2019007585 A MX2019007585 A MX 2019007585A MX 2019007585 A MX2019007585 A MX 2019007585A
Authority
MX
Mexico
Prior art keywords
antiviral
tenofovir
aliphatic ester
compounds
ester prodrugs
Prior art date
Application number
MX2019007585A
Other languages
English (en)
Inventor
Rahali Houcine
Dukhan David
RAHEEM Izzat
- Laurent PAPARIN Jean
Da Costa Daniel
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2019007585A publication Critical patent/MX2019007585A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Los compuestos de fórmula I: (ver fórmula) y sus sales farmacéuticamente aceptables son útiles para la inhibición de la transcriptasa inversa del VIH. Los compuestos también pueden ser útiles para la profilaxis o tratamiento de infección por el VIH y en la profilaxis, retraso en la aparición o progresión, y tratamiento del sida. Los compuestos y sus sales se pueden emplear como ingredientes en composiciones farmacéuticas, opcionalmente en combinación con otros agentes antivíricos, inmunomoduladores, antibióticos o vacunas.
MX2019007585A 2016-12-22 2017-12-20 Profarmacos de ester alifatico antiviricos de tenofovir. MX2019007585A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662437753P 2016-12-22 2016-12-22
US201762574493P 2017-10-19 2017-10-19
PCT/US2017/067470 WO2018119013A1 (en) 2016-12-22 2017-12-20 Antiviral aliphatic ester prodrugs of tenofovir

Publications (1)

Publication Number Publication Date
MX2019007585A true MX2019007585A (es) 2019-09-09

Family

ID=60972454

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007585A MX2019007585A (es) 2016-12-22 2017-12-20 Profarmacos de ester alifatico antiviricos de tenofovir.

Country Status (13)

Country Link
US (1) US10519159B2 (es)
EP (1) EP3559011B1 (es)
JP (1) JP6938637B2 (es)
KR (1) KR20190100250A (es)
CN (1) CN110099912B (es)
AU (1) AU2017379850B2 (es)
BR (1) BR112019013017A2 (es)
CA (1) CA3047573A1 (es)
MA (1) MA47094A (es)
MX (1) MX2019007585A (es)
RU (1) RU2759902C2 (es)
TW (1) TW201829412A (es)
WO (1) WO2018119013A1 (es)

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Also Published As

Publication number Publication date
KR20190100250A (ko) 2019-08-28
EP3559011B1 (en) 2022-04-13
TW201829412A (zh) 2018-08-16
BR112019013017A2 (pt) 2020-01-14
CN110099912A (zh) 2019-08-06
AU2017379850B2 (en) 2022-03-24
RU2019122414A (ru) 2021-01-25
CA3047573A1 (en) 2018-06-28
US20180179208A1 (en) 2018-06-28
WO2018119013A1 (en) 2018-06-28
EP3559011A1 (en) 2019-10-30
US10519159B2 (en) 2019-12-31
JP2020504733A (ja) 2020-02-13
RU2019122414A3 (es) 2021-04-26
CN110099912B (zh) 2021-10-15
MA47094A (fr) 2021-05-26
RU2759902C2 (ru) 2021-11-18
AU2017379850A1 (en) 2019-06-13
JP6938637B2 (ja) 2021-09-22

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